@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_MK06_H: (2014-08-18 )
MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYSTEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHLN
Atome Classification :
(11 SA)
.........10..--......20........30........--40........50.--.--..-...-.60........70........80...-.....90........100.......110.......120----........130.......140.......150.......160--........170.......180........190.......200.......210.......220.......230.....----..240.......250..-.....260......---..-270.--..-...---...280---...--.....290.......300.......310.......320.......330--.........340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
E
K
F
E
S
L
M
N
I
HG--FDLGS
R
Y
M
D
L
K
PLGCGGN
G
L
V
F
S
AVD--NDCDK
R
V
A
I
K
K
I
V
--L--T
D
-
P
Q
S
-
V
K
H
A
L
R
E
I
K
I
I
R
RLDH
D
N
I
V
K
V
F
E
I
L-GPSGS
Q
L
T
D
D
VG
S
L
TEL
N
S
V
Y
I
V
Q
E
Y
M
E
T
D
L
A
N
V
L
E
Q-----GP
L
L
E
E
H
A
R
L
F
M
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
RDLKP
A
N
L
F
I
N---TE
D
L
V
L
K
IGDF
G
L
A
R
IMDPH-YSHKGHLSE
G
L
V
T
K
W
YRSP
R
L
L
LSPNNYT
K
A
I
D
M
W
A
A
G
C
I
F
A
E
M
LTGK
T
L
F
A
G
A
H
E
----
L
E
Q
M
Q
L
I
L
E
SIPVV
H
E
E
-
D
R
Q
E
L
L
S
-
V
I
P
V
Y
I
---RN-D--M--TE-PHK---
P
L
T
Q
L
----LPG--I
S
R
E
A
L
D
F
L
E
Q
I
LTFS
P
M
D
R
L
T
A
E
E
A
LSH
P
Y
M
S
I
YSFPMDEPISSH----PFHIEDEVD
D
I
L
L
MDET
H
S
HIYNWE
R
Y
HDCQFSEHDWPVHNNFD
I
D
E
V
QL
D
P
R
ALSDVTD
E
E
EVQV
D
P
R
KYLDG
D
R
E
K
YLEDPAFDTNYSTEPCWQYSDHHENK
Y
C
D
L
E
CSHTCNYKTR
S
S
S
Y
L
D
N
L
V
WRESEVNHYYE
P
K
L
I
I
DLSN
W
K
E
Q
S
KEKSDKKGK
S
K
C
ERNG
L
V
K
A
Q
I
A
L
E
E
A
S
Q
Q
L
AGKEREKNQGFD
F
D
S
F
I
A
G
T
I
Q
LSSQHE
P
T
D
V
V
D
K
L
N
D
L
N
S
S
V
S
Q
L
E
L
K
S
L
I
S
K
S
V
S
Q
E
K
Q
E
K
G
M
A
N
L
A
Q
L
E
A
L
Y
Q
SSWDSQFVSGGE
D
C
F
F
I
N
Q
F
C
E
VRKDEQVEKEN
T
Y
T
S
Y
L
D
K
F
FSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSG
E
F
L
F
N
K
Q
L
E
SIGIPQFHSPVG
S
P
L
K
S
I
Q
A
TLT
P
S
A
MKSSPQI
P
H
Q
T
Y
S
S
I
L
K
HLN
18
PsiBlast_PDB
76.26
41%
-102
- C1 -
4ERK
1
MK01_RAT
A:
[22-361]
------------
V
--
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
L
N
K
V
R
V
A
I
K
K
I
S
P-
F
--
E
H
-
Q
T
Y
-
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
-
R
A
P
T
---------
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
-
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
---
L
S
-
L
--
P
--
H
K
-
N
K
V
---
P
W
N
R
L
----
F
P
N
--
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
----
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
75.37
40%
-103
- C1 -
4IC7
1
MK07_HUMAN
A:
[50-386]
------------
T
--
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
--
R
L
T
G
Q
Q
V
A
I
K
K
I
P
NA
F
--
D
V
-
V
T
N
-
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
-
R
P
T
V
P
--------
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S----
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
---
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
----
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
-
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
---
Q
S
-
L
--
P
--
P
R
-
Q
P
V
---
P
W
E
T
V
----
Y
P
G
--
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
----
P
F
D
F
A
F
D
R
E
A
-
L
T
R
E
R
I
K
E
A
I
V
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.87
41%
-99
- C1 -
3ERK
1
MK01_RAT
A:
[22-361]
------------
V
--
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
L
N
K
V
R
V
A
I
K
K
I
S
P-
F
--
E
H
-
Q
T
Y
-
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
-
R
A
P
T
---------
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
-
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
---
L
S
-
L
--
P
--
H
K
-
N
K
V
---
P
W
N
R
L
----
F
P
N
--
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
----
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.49
41%
-96
- C1 -
1WZY
1
MK01_HUMAN
A:
[26-363]
------------
V
--
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
V
N
K
V
R
V
A
I
K
K
I
S
P
-
F
--
E
H
-
Q
T
Y
-
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
-
R
A
P
T
---------
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
-
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
---
L
S
-
L
--
P
--
H
K
-
N
K
V
---
P
W
N
R
L
----
F
P
N
--
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
----
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.03
45%
-104
- C1 -
4FMQ
2
MK01_HUMAN
A:
[21-340]
---------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
V
N
K
V
R
V
A
I
K
K
I
S
--
P
--
F
E
-
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
-
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
---
I
L
G
S
P
-
S
Q
E
D
L
N
C
-
I
I
N
L
K
A
---
R
N
-
Y
--
L
--
L
S
L
P
H
K
NKV
P
W
N
R
L
----
F
P
N
--
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
----
P
F
K
F
D
M
E
L
D
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
73.53
38%
-105
- C1 -
2B9H
2
FUS3_YEAST
A:
[5-350]
-----------
I
V
--
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
--
K
P
T
G
E
I
V
A
I
K
K
I
E
--
P
--
F
D
K
P
L
F
-
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
-
R
P
D
---------
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
-----
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
---
S
-
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
----------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
----
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
---
K
S
-
L
--
P
--
M
Y
-
P
A
A
---
P
L
E
K
M
----
F
P
R
--
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
PS
F
F
E
F
D
H
Y
K
-
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.18
41%
-100
- C1 -
1TVO
1
MK01_HUMAN
A:
[18-355]
------------
V
--
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
V
N
K
V
R
V
A
I
K
K
I
S
P-
F
--
E
H
-
Q
T
Y
-
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
-
R
A
P
T
---------
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
-
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
---
L
S
-
L
--
P
--
H
K
-
N
K
V
---
P
W
N
R
L
----
F
P
N
--
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
----
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
69.30
38%
-97
- C1 -
4O2Z
1
?
A:
[34-369]
--------
Y
N
V
S
G
S
P
F
E
V
P
S
K
Y
T
L
L
K
I
L
G
M
G
A
Y
G
I
A
C
S
C
L
D
--
G
D
T
G
E
K
V
S
I
K
K
C
R
DV
F
--
R
D
-
V
E
D
-
G
K
R
V
L
R
E
I
D
M
M
R
F
F
H
H
E
N
L
L
N
V
V
N
I
L
-
P
P
L
K
R
-------
E
Y
H
S
F
E
D
V
Y
V
V
T
P
L
M
D
V
D
M
N
V
V
L
R
S
R----
Q
V
L
E
E
S
H
M
Q
Y
F
V
Y
Q
I
L
R
G
L
K
Y
L
H
S
A
N
V
A
H
R
D
L
K
P
A
N
L
V
T
N
---
I
-
S
C
E
L
K
I
I
D
F
G
L
S
R
S
--
V
P
-
Y
---
S
E
L
T
D
Y
V
I
T
R
W
Y
R
P
P
E
L
L
L
E
N
T
N
Y
S
T
A
V
D
I
W
S
V
G
C
I
F
A
E
M
Y
N
R
K
P
V
F
P
G
R
N
T
----
M
D
Q
L
R
M
I
A
Q
H
I
G
K
P
P
A
S
-
I
V
E
H
-
R
--
E
A
L
E
K
L
---
N
E
-
L
--
P
---
D
-
G
S
L
---
N
I
P
K
L
----
V
P
G
LA
G
N
T
E
G
I
D
F
L
S
K
M
W
T
L
D
P
S
K
R
P
T
A
A
D
M
L
A
H
P
Y
L
A
H
L
H
D
E
E
D
E
P
T
C
P
C
----
P
F
L
W
A
H
E
S
T
P
-
M
G
V
S
E
L
R
R
A
F
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
67.30
37%
-107
- C1 -
2FST
3
MK14_HUMAN
X:
[24-353]
------------
I
--
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
--
T
K
T
G
L
R
V
A
V
K
K
L
S
--
R
PF
Q
S
-
I
I
H
-
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
--------
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
----------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
---
E
-
D
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
---
Q
S
-
L
--
T
--
Q
M
-
P
K
M
---
N
F
A
N
V
----
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-----
P
Y
D
Q
S
L
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
56.57
31%
-108
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[10-301]
-----------------
V
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
--
K
E
T
H
E
I
V
A
I
K
K
F
K
----------
V
-
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
-
R
R
--------------
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P---
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
---
H
-
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
--------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
----
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
-
Q
M
K
L
F
Y
S
--
N
P
R
F
H
---
G
L
R
F
PA
V
--
N
H
-
P
Q
S
---
L
E
R
R
Y
----
L
G
I
--
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
55.02
33%
-97
- C1 -
4F6U
10
CDK8_HUMAN
A:
[27-348]
-------------------------
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
KD
G
K
D
D
K
D
Y
A
L
K
Q
I
E
--
G
--
T
G
-
I
---
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
-
L
S
H
------------
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
R
G
R
V
K
I
A
D
M
G
F
------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
E
NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
-
D
W
E
D
I
K
--
K
M
P
E
H
S
T
L
M
K
D
-
F
--
R
RN
T
Y
-
T
N
C
---
S
L
I
K
Y
M
E
K
H
K
V
K
--
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------