@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_MK07_HUMAN: (2014-08-18 )
MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
Atome Classification :
(14 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120-.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAEPLKEEDGEDGSAEPPGPVKAEPA
H
T
A
A
S
V
A
A
K
N
L
A
L
L
K
AR
S
F
D
V
T
F
DVGD
E
Y
E
I
I
E
T
IGNG
A
Y
G
V
V
S
S
A
R
R
RLTG
Q
Q
V
A
I
K
KIP
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
FKHD
N
I
I
A
I
K
D
I
LR-PTVPYGE
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
IHSSQPL
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
RDLKPS
N
L
L
VNENC
E
L
K
IGDFGMARGLCTSP
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
WYR
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
RQLFPG
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
LGTP
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
SLPPRQPVPWETVYPGA
D
R
Q
A
L
S
L
L
G
R
M
LRFEPSA
R
I
S
A
A
A
A
LRH
P
F
L
AKYHDPDDEPDCAPPFDFAF
D
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
R
Q
Q
IRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAP
D
T
I
D
L
TLQPPPPVSEPAPPKKDGAISD
N
T
K
A
A
L
K
A
A
L
L
K
S
L
R
S
R
LRDGPSAPLEAPEPRKPV
T
A
Q
E
R
Q
R
E
R
E
E
K
R
R
R
R
Q
E
R
A
K
E
R
E
K
R
R
Q
E
R
E
R
K
ERGAGASGGPSTD
P
L
A
G
L
V
LSDN
D
R
S
L
L
E
R
W
T
R
MARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIAT
S
T
S
L
L
A
A
Q
SLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESP
D
V
N
L
V
T
Q
Q
L
S
K
S
QVEDPLPPVFSGTPKGSGAGYGVGF
D
L
E
E
F
L
N
Q
SFDMGVADGPQDGQA
D
S
A
S
L
S
A
S
L
L
A
D
W
L
EGHGM
N
P
A
D
I
E
S
L
Q
R
E
IQMDS
P
M
L
L
ADLPDLQDP
21
PsiBlast_CBE
97.29
100%
-130
* C1 *
4IC7
1
MK07_HUMAN
D:
[49-401]
----------------------------------------------
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
R
Q
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.07
100%
-129
- C1 -
4IC7
1
MK07_HUMAN
A:
[48-402]
---------------------------------------------
D
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
R
Q
Q
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.04
100%
-135
- C1 -
4B99
1
MK07_HUMAN
A:
[48-394]
----------------------------------------------
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
-------
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
-----
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
79.57
51%
-124
- C1 -
3ERK
1
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
78.63
51%
-127
- C1 -
2Z7L
4
MK01_RAT
A:
[24-360]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
---
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
--------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
77.96
51%
-125
- C1 -
4ERK
1
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
77.17
51%
-123
- C1 -
4H3P
2
MK01_HUMAN
A:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.08
51%
-118
- C1 -
3TEI
2
MK01_HUMAN
A:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
76.90
46%
-126
- C1 -
1BL6
1
MK14_HUMAN
A:
[35-367]
----------------------------------------------
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
-
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
A
D
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
76.35
46%
-126
- C1 -
1BL7
1
MK14_HUMAN
A:
[35-367]
----------------------------------------------
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
-
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
A
D
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
76.27
50%
-116
- C1 -
2GPH
1
MK01_RAT
A:
[22-359]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
--
A
P
T
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
-
C
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
74.18
46%
-123
- C1 -
1A9U
1
MK14_HUMAN
A:
[35-367]
----------------------------------------------
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
-
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
A
D
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
73.51
46%
-125
- C1 -
3HA8
1
MK14_HUMAN
A:
[35-367]
----------------------------------------------
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
-
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
-------
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
A
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Y
D
Q
S
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R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
69.29
46%
-119
- C1 -
2EWA
1
MK14_MOUSE
A:
[35-367]
----------------------------------------------
T
I
W
E
V
P
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L
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A
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N
I
------
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G
---------------------
T
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--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------