@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_MP2K6_: (2014-08-18 )
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
Atome Classification :
(18 SA)
.........10........20........30........40.-.......50........60........70........80........90........100.......110.......120.......130.-.-.....140....-...150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250....---------------.---..260-----------..-----......270.......280--........290.......300.......310.......320.......330..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQSKGKKRNPGLKI
P
K
E
A
FEQPQTSSTPPRDLD
S
K
A
C
ISIG-NQ
N
F
E
V
KAD
D
L
E
P
I
M
E
LGR
G
A
Y
G
V
V
E
K
M
R
HVPSG
Q
I
M
A
V
K
R
I
R
A
TVN
S
Q
E
Q
K
R
L
L
M
DLD
I
S
M
R
TVDC
P
F
T
V
T
F
Y
G
A
L
FREG
D
V
W
I
C
M
E
L
M
D
-
T
-
S
L
D
K
F
Y
K
Q
V
I
DK-GQTI
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
HRDVKP
S
N
V
L
I
N
ALGQ
V
K
M
C
DFGIS
G
Y
L
V
D
S
V
A
K
T
I
DAGCKPYMAPERINP
E
L
NQKGYS
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
RFP---------------Y---DSWG------------
T
P
-----
F
Q
Q
L
K
Q
V
V
EEPSPQLP
A
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
KKNSKERPT
Y
P
E
L
M
QHP
F
F
T
L
HESKGT
D
V
A
S
F
V
K
L
I
LGD
1
PsiBlast_PDB
88.63
100%
-114
- C1 -
3VN9
1
MP2K6_HUMAN
A:
[44-334]
--------------------------------------------
Q
N
F
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
A
T
V
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
L
M
D
-
T
-
S
L
D
K
F
Y
K
Q
V
I
D
K
-
G
Q
T
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
G
I
S
G
Y
L
V
D
S
V
A
K
T
I
D
A
G
C
K
P
Y
M
A
P
E
R
I
N
P
E
L
N
Q
K
G
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
---------------
Y
---
D
S
W
G
------------
T
P
-----
F
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
D
32
HHSearch
87.24
99%
-125
- C1 -
3FME
1
MP2K6_HUMAN
A:
[2-289]
----------------------------------------------
M
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
L
M
D
-
T
-
S
L
D
K
F
Y
K
Q
V
I
D
K
-
G
Q
T
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
---------------
A
G
C
K
P
Y
M
A
P
E
R
I
N
P
E
L
N
Q
--
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
---------------
Y
---
D
S
W
G
------------
T
P
-----
F
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
-
35
HHSearch
76.93
43%
-115
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[30-347]
------------------------------------------------
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
L
D
Q
V
L
K
K
-----
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
----
V
G
T
R
S
Y
M
S
P
E
R
L
Q
----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---------------
I
---
P
P
P
D
A
K
E
L
E
L
M
F
GCPM
A
I
-----
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
19
PsiBlast_PDB
74.19
37%
-120
- C1 -
3PP1
1
MP2K1_HUMAN
A:
[1-320]
----------------------------------------------
M
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F------------------------PMA
I
-
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
11
PsiBlast_PDB
73.90
42%
-114
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[5-281]
-----------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
--
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---------------
R
---
P
P
M
A
------------
I
------
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
16
PsiBlast_PDB
73.79
37%
-121
- C1 -
2P55
2
MP2K1_HUMAN
A:
[1-320]
----------------------------------------------
M
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
----
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F------------------------PPMA
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
20
PsiBlast_PDB
73.09
37%
-125
- C1 -
3DV3
3
MP2K1_HUMAN
A:
[1-320]
----------------------------------------------
M
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
----
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F------------------------PMA
I
-
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
18
PsiBlast_PDB
72.79
37%
-121
- C1 -
3MBL
2
MP2K1_HUMAN
A:
[1-320]
----------------------------------------------
M
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F------------------------PMA
I
-
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
17
PsiBlast_PDB
72.36
37%
-122
- C1 -
3EQB
2
MP2K1_HUMAN
A:
[1-320]
----------------------------------------------
M
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
----
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F------------------------PPMA
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
5
PsiBlast_PDB
72.07
58%
-120
- C1 -
3ALO
2
MP2K4_HUMAN
A:
[17-307]
----------------------------------------------
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
L
M
S
-
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
L
D
D
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
D
S
I
A
K
T
R
D
A
G
C
R
P
Y
M
A
P
E
R
I
D
P
------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
---------------
Y
---
P
K
W
N
------------
S
V
-----
F
D
Q
L
T
Q
V
V
K
G
D
P
P
Q
L
S
N
S
EE
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
--
33
HHSearch
71.84
57%
-126
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[5-308]
----------------------------------
S
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
L
M
S
-
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
L
D
D
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
---------------
Y
---
P
K
W
------------------------
T
Q
V
V
K
G
D
P
P
Q
L
S
N
S
EER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
12
PsiBlast_PDB
70.56
42%
-117
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[5-281]
-----------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---------------
R
---
P
P
M
A
------------
I
------
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
10
PsiBlast_PDB
70.49
42%
-113
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[5-281]
-----------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
---
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---------------
R
---
P
P
M
A
------------
I
------
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
8
PsiBlast_PDB
70.25
42%
-119
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[21-301]
-----------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
------
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---------------
I
---
G
-----------------A
I
---
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
9
PsiBlast_PDB
68.72
42%
-115
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[5-281]
-----------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---------------
R
---
P
P
M
A
------------
I
------
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
13
PsiBlast_PDB
68.44
41%
-111
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[1-288]
----------------------------------------------
M
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---------------
I
PPP----PM----------
A
I
-----
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
14
PsiBlast_PDB
64.28
41%
-115
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[2-286]
-----------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---------------
I
P------M-----------
A
I
-----
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
-----
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
---
15
PsiBlast_PDB
63.54
37%
-114
- C1 -
2Y4I
1
MP2K1_RABIT
C:
[64-382]
-----------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
-
G
G
S
L
D
----
Q
V
L
K
K
-
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPDAKELELMFGC----------------------PMAI-
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-