@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_MST4_H: (2014-08-18 )
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
Atome Classification :
(16 SA)
.........10........20........30........40........50........60........70........80........90..-------......100.......110--.-.--.....120.......130......-.140.......150.......160.......170.......180.......190-----.-......200.......210.......220.....--.---.---------230--........--240-........250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAHS
P
V
A
V
QVPGMQNNIA
D
P
E
E
L
F
T
K
L
E
R
IGKG
S
F
G
E
V
F
K
G
IDNRT
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
QC
D
S
S
Y
V
T
K
Y
Y
G
S
YLKG
S
-------
K
L
W
I
I
M
E
Y
LGGG
S
A
L
D
L
L
R--A-G--PF
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
LSEQG
D
V
K
L
ADFGVAGQLTD
T
Q
I
KRNTFVGT
P
F
WM
A
P
E
V
I
Q
-----
Q
-SAYDSKA
D
I
W
S
LG
I
T
A
I
E
LAKGEPPNSDMH
P
M
R
V
--
L
---
F
---------
L
I
---PKNNPP
T
L
--
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
LNKDPSFR
P
T
A
K
E
L
L
K
H
K
F
I
VKNSK
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
KAEGHSDDESDSEGSDSESTSRENNTHPEW
S
F
T
TVRKKP
D
P
K
K
V
QNG
A
E
Q
D
L
V
Q
T
L
S
C
L
S
M
I
I
T
P
A
F
A
E
L
K
Q
QDENNA
S
R
N
Q
A
I
E
E
L
E
K
S
I
A
V
A
EAACPG
I
T
D
K
M
V
K
K
L
I
E
K
F
Q
K
CSADESP
1
PsiBlast_PDB
89.73
100%
-95
- C1 -
3GGF
1
MST4_HUMAN
A:
[18-301]
----------------
I
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
--
A
-
G
--
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
---------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
--
L
---
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
--------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.53
99%
-95
- C1 -
4FZD
1
MST4_HUMAN
B:
[3-283]
----------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
--
A
-
G
--
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
--
L
---
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.19
100%
-96
- C1 -
3GGF
1
MST4_HUMAN
B:
[19-298]
-----------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
--
A
-
G
--
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
--
L
---
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.82
86%
-85
- C1 -
3A7H
1
STK24_HUMAN
A:
[9-298]
--------
G
L
P
G
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
--
L
---
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.71
99%
-90
- C1 -
4FZF
1
?
B:
[3-283]
----------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
--
A
-
G
--
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
--
L
---
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
86.34
86%
-85
- C1 -
3A7J
1
STK24_HUMAN
A:
[13-299]
------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
--
L
---
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
---------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.24
99%
-88
- C1 -
4FZA
3
MST4_HUMAN
B:
[3-283]
----------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
--
A
-
G
--
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
--
L
---
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.71
86%
-85
- C1 -
3A7I
1
STK24_HUMAN
A:
[13-299]
------------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
--
L
---
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
---------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.09
88%
-85
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-282]
-------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
--
L
---
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
84.93
84%
-83
- C1 -
2XIK
2
STK25_HUMAN
A:
[11-293]
-------------
Q
H
S
R
V
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
--
P
-
G
--
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
-
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
--
L
---
F
---------
L
I
---
P
K
N
S
P
P
T
L
--
E
G
--
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
65.54
43%
-78
- C1 -
3FY0
1
PAK1_HUMAN
A:
[14-293]
---------------
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
--
E
-
T
--
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
--
L
---
Y
---------
L
I
---
A
T
N
G
T
P
E
L
--
Q
N
PE
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------
40
HHSearch
65.49
45%
-83
- C1 -
3FXZ
1
?
A:
[17-293]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
-
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
--
E
-
T
--
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
--
L
---
Y
---------
L
I
---
A
T
N
G
T
P
E
L
QN
P
E
--
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
-
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
60.13
86%
-47
- C1 -
3A7H
1
STK24_HUMAN
B:
[8-298]
-------
S
G
L
P
G
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
--
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
--
L
---
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------
37
HHSearch
55.37
42%
-82
- C1 -
2J7T
1
STK10_HUMAN
A:
[13-297]
---------------
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
-
R
--
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
--
L
---
L
---------
K
I
---
A
K
S
D
P
P
T
L
LT
P
S
--
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
-
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
---------------------------------------------------------------------------------------------------------------------------
47
HHSearch
51.64
37%
-86
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[35-331]
-----------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
-------
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
--
K
A
G
--
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
GC-PMA
I
F
E
L
L
D
Y
I
---
V
N
E
P
P
P
K
L
P-
S
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
43.33
30%
-95
- C1 -
1ZY4
1
GCN2_YEAST
A:
[8-290]
-----------------------
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
--
T
E
E
K
L
S
T
I
L
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
R
R
N
F
VK
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
--
S
-
E
NL
N
Q
Q
R
D
E
Y
W
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
-
G
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
N
V
K
I
G
D
F
G
L
A
K
N
V
H
R
-----------
A
M
Y
V
A
T
E
V
L
D
-----
G
T
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
--
P
F
S
T
G
M
E
R
V
N
I
--
L
---
K
---------
K
L
R
SV
S
I
E
F
P
P
D
F
--
D
D
--
N
K
M
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
K
-------------------------------------------------------------------------------------------------------------------------------------------