@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_MYLK2_: (2014-08-18 )
MATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVPMTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
Atome Classification :
(17 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320-..------.------......330.......340.......350.......360.......370.......380.......390.......400.......410...--.-.-.--.-420-........430.....-..440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550-.-.....--..-560.......570.......580.......590....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATEN
G
A
V
E
L
G
IQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQDPGKPRVGKKAAEG
Q
A
AARRGS
P
A
F
L
HSPSCPAIISSS
E
K
L
LAKKPPSEASE
L
T
FEGVPMTHSPTDPRPA
K
A
E
E
G
K
N
I
L
A
E
S
Q
K
E
VGEKTPGQAGQAKMQGDTSRG
I
E
F
Q
AVPS
E
K
S
E
V
G
Q
A
L
C
LTAR
E
E
D
C
F
Q
I
L
DDCPPPPAPFP
H
R
M
V
E
L
RTGNVSSEFSMNSKEALGGG
K
F
G
A
V
C
T
C
M
E
KAT
G
L
K
L
A
A
K
V
I
K
KQT---PK------D------K
E
M
V
L
L
E
I
E
V
M
N
QLN
H
R
N
L
I
Q
L
Y
A
A
IETPH
E
I
V
L
F
M
E
Y
IE
G
G
E
L
F
E
R
I
V
DEDYHL
T
E
V
D
T
M
V
F
V
R
Q
I
C
D
G
I
L
F
M
H
K
M
R
V
L
H
L
DLKPE
N
I
L
C
V--N-T-T--G-H
L
--
V
K
I
I
D
F
G
L
ARRYNPNE-
K
L
K
V
NFGTPEFLSPEVV
N
Y
DQISDKTD
M
W
S
M
G
V
I
T
Y
M
L
L
SGL
S
P
FLGDD
D
T
E
T
L
N
N
V
LSG
N
W
Y
F
D
E
E
T
F
E
A
V
S
D
E
A
K
D
F
V
S
N
L
I
V
K
D
Q
R
ARM
N
A
A
Q
C
L
A
H
P
W
L
N
N
L
A
E
K
A
K
R
C
N
--
R
-
R
L
K
S
Q
--
I
L
-
L
K
K
Y
L
M
K
R
R
WKK
N
F
I
A
V
S
A
A
N
R
F
K
K
ISSSG
A
L
M
A
LGV
1
PsiBlast_PDB
93.88
60%
-119
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
---
M
K
------
D
------
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
--
N
-
R
-
D
--
A
-
K
Q
--
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
-
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
-----
H
K
L
H
--
S
-
R
L
S
A
Q
------------------------------------------
39
HHSearch
82.64
40%
-100
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[4-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
---
T
K
SSRRGV
S
------
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
-
R
-
N
VP
K
-
P
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
--
K
A
S
A
V
N
M
--
E
K
-
F
K
K
F
A
A
R
------------------------------
13
PsiBlast_PDB
81.07
42%
-112
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
---
T
K
------
S
SRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
DR
N
-
V
-
P
--
K
-
P
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
--------------------------------------------------------------
12
PsiBlast_PDB
80.28
42%
-112
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
---
T
K
------
S
SRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
DR
N
-
V
-
P
--
K
-
P
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
--------------------------------------------------------------
10
PsiBlast_PDB
79.89
42%
-106
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
---
T
K
------
S
SRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
DR
N
-
V
-
P
--
K
-
P
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
--------------------------------------------------------------
16
PsiBlast_PDB
79.68
42%
-113
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
---
T
K
------
S
SRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
DR
N
-
V
-
P
--
K
-
P
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
--------------------------------------------------------------
15
PsiBlast_PDB
79.37
42%
-101
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
---
T
K
------
S
SRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
DR
N
-
V
-
P
--
K
-
P
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
--------------------------------------------------------------
46
HHSearch
77.79
32%
-102
- C1 -
3NYV
1
?
A:
[20-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
A
I
F
S
D
R
Y
K
G
Q
--
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
VKQ
K
T
------
D
------
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
--
S
-
K
-
S
K-
D
-
A
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
-----
D
VP
S
-
L
D
N
A
I
--
L
N
-
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
------------------
6
PsiBlast_PDB
77.47
40%
-109
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[18-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
---
S
R
ASR
R
G
V
S
------
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
-
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
-
K
-
N
--
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
V
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
--
R
-
E
S
V
V
N
--
L
E
N
F
R
K
Q
Y
V
-------------------------------
40
HHSearch
76.96
32%
-88
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
T
E
E
Y
Q
L
F
--
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
LS-
A
R
------
D
------
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
--
S
-
K
L
K
--
G
-
A
A
--
V
K
L
A
D
F
G
L
A
I
E
V
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
----
R
Q
E
T
V
--
D
C
-
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
---------------
43
HHSearch
76.79
33%
-115
- C1 -
3Q5I
1
?
A:
[26-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
R
K
K
E
G
K
I
G
E
S
Y
F
K
V
--
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
------
K
------
F
------
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
-
R
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
--
N
-
K
-
N
--
S
L
L
N
--
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
Y
-
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
-
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
D
Q
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
Y
A
N
N
I
N
K
S
D
--
Q
-
K
T
L
C
G
A
L
S
N
-
M
R
K
F
E
G
S
Q
K
L
A
Q
A
A
I
L
F
I
G
------------------
9
PsiBlast_PDB
76.66
40%
-109
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[18-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
---
S
R
------
A
SRRGVC
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
-
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
-
K
-
N
--
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
V
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
--
R
-
E
S
V
V
N
--
L
E
N
F
K
K
Q
Y
V
-------------------------------
18
PsiBlast_PDB
75.32
42%
-123
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
---
T
--------------
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
DR--
V
-
P
--
K
-
P
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
-------------
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
--------------------------------------------------------------
51
HHSearch
73.49
34%
-112
- C1 -
3F3Z
5
?
A:
[6-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
N
Q
Y
Y
T
L
E
--
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
K
Y
F
---
V
E
------
D
------
V
D
R
F
K
Q
E
I
E
I
M
K
S
L
D
H
P
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
K
-
R
V
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
L
--
T
-
D
S
P
--
D
-
S
P
--
L
K
L
I
D
F
G
L
A
A
R
F
K
P
G
K
-
M
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
G
-
L
Y
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
P
T
D
S
E
V
M
L
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
F
E
K
Q
-----------------------------------------------------------
41
HHSearch
72.16
35%
-121
* C1 *
3LIJ
1
?
A:
[28-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
S
K
K
G
H
L
S
E
M
Y
Q
R
V
--
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
------
S
------
S
------
N
S
K
L
L
E
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
-
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
--
S
-
K
-
E
K-
D
-
A
L
--
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
K
-
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
-
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
M
C
S
K
--------------------------------------------------------
47
HHSearch
70.40
36%
-104
- C1 -
3MWU
1
?
A:
[15-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
Q
G
T
F
A
E
R
Y
N
I
V
--
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
AK-
N
K
------
D
------
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
-
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
--
S
-
K
-
E
K-
D
-
C
D
--
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
-----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
-----------------------------------------------------------
44
HHSearch
68.55
30%
-103
- C1 -
2JAM
4
KCC1G_HUMAN
A:
[6-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
K
T
F
I
F
M
--
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
---------------------
S
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
-
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
--
T
P
E
-
E
--
N
-
S
K
--
I
M
I
T
D
F
G
L
S
K
M
E
Q
N
G
--
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
I
Y
--
P
-
S
V
S
L
----
Q
-
I
Q
K
N
F
A
K
S
-----------------------------