@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_MYLK3_: (2014-08-18 )
MSGTSKESLGHGGLPGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHLERGLHRLEASRAPGPGGADGVPHIDTQAGWPEVLELVRAMQQDAAQHGARLEALFRMVAAVDRAIALVGATFQKSKVADFLMQGRVPWRRGSPGDSPEENKERVEEEGGKPKHVLSTSGVQSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHLPLPTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP
Atome Classification :
(16 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......----550.---.------.------......560.......570.......580.......590.......600.---.----------------------------------.....610.......620.......630.......640....-.-.--.-650.........660....---.-..670.......680.....--..690.......700.......710.......-720.......730.......740.......750.......760.......770......---.780-..-....--..790....--...800.......810.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSGTSKESLGHGGLPGL
G
K
T
C
L
T
T
M
D
T
K
L
N
M
L
N
E
K
V
D
Q
L
L
H
F
Q
E
D
V
T
E
K
L
Q
S
M
C
R
D
M
G
H
L
E
R
G
L
H
R
L
EASRAPGPGGADGVPHIDTQAG
W
P
E
V
L
E
L
V
R
A
M
Q
Q
D
A
A
QH
G
A
R
L
E
A
L
F
R
M
V
A
A
V
D
R
A
I
A
L
VGAT
F
Q
K
S
K
V
A
D
F
L
M
QGRVPWRRGSPGDS
P
E
E
N
K
E
R
V
E
EEGGKP
K
H
V
L
STSGVQSDAREPG
E
E
S
Q
K
A
D
V
L
E
G
T
A
E
RLPPIRASGLGA
D
P
A
Q
A
VVSPGQGDGVPGPAQAFPGHLPLPTKVEAKAPETP
S
E
N
L
R
TGLELAPAPG
R
V
N
V
VSPS
L
E
VAPGAGQGASSSRPD
P
E
P
L
EEGTRLTPGPGPQCPGPPGLPAQARATHSGGETP
P
R
I
S
I
H
I
Q
EMDTPG
E
M
L
MTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTP
E
G
A
R
ELSPLQESSSPGGV
K
A
E
E
E
Q
RAGAEPGTRPSLARSDDNDHEV
G
A
L
G
L
QQGKSPGAGNPE
P
E
Q
D
C
AARAP
V
R
A
E
A
V
RRMPPGAEA
G
S
V
V
L
DDSPAPPAPFE
H
R
V
V
S
V
K
ETSIS
A
G
Y
E
V
C
Q
H
EVLGGGRFG
Q
V
H
R
CTEKSTGL
P
L
A
A
K
I
I
K
VK----S--A---K------
D
------
R
E
D
V
K
N
E
I
N
I
M
N
Q
LSH
V
N
L
I
Q
L
Y
D
A
F
ESKH
S
C
T
L
V
M
E
YVD
G
G
E
L
F
D
R
ITD---E----------------------------------KYHL
T
E
L
D
V
V
L
F
T
R
Q
I
C
E
G
V
H
Y
L
H
Q
H
Y
I
L
H
L
DLKPE
N
I
L
C
VN-Q-T--G-
H
--
Q
I
K
I
I
D
F
G
L
ARRYKPR---
E
-
K
L
K
V
NFGTPEFLAPEVV
N
Y
E
--
F
VSFP
T
D
M
W
S
V
G
V
I
T
Y
M
L
L
SGL
S
P
F
LGETDA
E
-
T
M
N
F
I
V
N
C
SWDFD
A
D
T
F
E
G
L
S
E
E
A
K
D
F
V
S
R
L
L
V
K
EKSC
R
M
S
A
T
Q
C
L
K
H
E
W
L
NNLPAKA
S
---
R
S
K
--
T
R
-
L
K
S
Q
--
L
L
L
Q
K
Y
I
A
Q
--
R
K
W
K
K
H
F
Y
V
V
T
A
A
N
R
L
RKFPTSP
29
HHSearch
87.58
70%
-108
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-352]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
----
G
--
M
---
K
------
D
------
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
---
E
----------------------------------
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
-
R
-
D
--
A
-
K
--
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---
E
-
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
-
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
-----------------------------------------------------
8
PsiBlast_PDB
73.07
42%
-99
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[6-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
--
S
---
R
ASR
R
G
V
S
------
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
----
Q
----------------------------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
K
-
N
--
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
--
P
V
D
N
Q
---
Q
A
M
--
V
R
-
R
E
S
V
--
V
N
L
E
N
F
R
K
Q
YV-----------------------
6
PsiBlast_PDB
70.52
42%
-101
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[4-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
--
S
---
R
------
A
SRRGVC
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
----
Q
----------------------------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
K
-
N
--
I
-
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
--
P
V
D
T
Q
---
Q
A
M
--
V
R
-
R
E
S
V
--
V
N
L
E
N
F
K
K
Q
Y
V-----------------------
42
HHSearch
63.48
34%
-104
- C1 -
3Q5I
1
?
A:
[27-346]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
K
K
E
G
K
I
G
E
S
Y
F
K
--
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
------------
K
------
F
------
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
--------------------------------------
R
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
-
K
-
N
--
S
L
L
--
N
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
---
Y
-
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
---
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
D
Q
D
-
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
Y
A
N
N
I
N
---
K
S
D
--
Q
K
-
T
L
C
G
A
L
S
N
M
R
K
F
E
G
S
--
Q
K
L
A
Q
A
A
I
L
F
I
G
S
----------
37
HHSearch
61.87
43%
-91
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[4-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
D
T
--
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
--
T
---
K
SSRRGV
S
------
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--------------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
-
N
VP
K
-
P
--
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
---
L
S
R
--
K
A
S
A
V
N
M
--
E
K
F
K
K
F
A
A
R
-------------------------
15
PsiBlast_PDB
59.07
44%
-96
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[17-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
--
T
---
K
------
S
SRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
----
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
-
N
VP
K
-
P
--
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--
P
K
D
T
Q
---
Q
A
L
--
S
R
-
K
A
S
A
--
V
N
M
E
K
F
----------------------------
44
HHSearch
58.76
33%
-92
- C1 -
3NYV
1
?
A:
[20-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
A
I
F
S
D
R
Y
K
G
--
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
--
V
KQK
T
------
D
------
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
-----------------------------------
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
-
S
K-
D
-
A
--
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
--------
D
VP
S
L
-
D
N
A
I
--
L
N
I
R
Q
F
Q
G
T
--
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
----------
41
HHSearch
57.86
32%
-93
- C1 -
3MWU
1
?
A:
[14-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
G
T
F
A
E
R
Y
N
I
--
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
----
S
AK
N
---
K
------
D
------
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
---
R
-----------------------------------
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
-
K
-
E
K-
D
-
C
--
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
--------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
---
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
IS
D
L
P
--
S
L
-
E
S
A
M
--
T
N
I
R
Q
F
Q
A
E
--
K
K
L
A
Q
A
A
L
L
Y
-------------
49
HHSearch
56.96
35%
-104
* C1 *
3F3Z
5
?
A:
[6-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
N
Q
Y
Y
T
L
--
E
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
K
Y
----
F
--
V
---
E
------
D
------
V
D
R
F
K
Q
E
I
E
I
M
K
S
L
D
H
P
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
---
K
-----------------------------------
R
V
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
L
T
-
D
S
P
--
D
-
S
--
P
L
K
L
I
D
F
G
L
A
A
R
F
K
P
G
---
K
-
M
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
G
---
L
Y
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
P
T
D
S
E
-
V
M
L
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
F
E
K
Q
--------------------------------------------------------
16
PsiBlast_PDB
56.95
46%
-109
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[19-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
--
T
---
K
------
S
SRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
----
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
-
N
VP
K
-
P
--
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------
39
HHSearch
56.55
37%
-109
- C1 -
3LIJ
1
?
A:
[29-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
K
K
G
H
L
S
E
M
Y
Q
R
--
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
------------
S
------
S
------
N
S
K
L
L
E
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
--------------------------------------
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
-
E
K-
D
-
A
--
L
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
---
K
-
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
---
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
-
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
M
C
S
K
-----------------------------------------------------
38
HHSearch
56.38
34%
-79
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
T
E
E
Y
Q
L
--
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
----
K
LS
A
---
R
------
D
------
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---
R
----------------------------------
E
-
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
-
K
-
L
K-
G
-
A
--
A
V
K
L
A
D
F
G
L
A
I
E
V
E
G
E
---
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
--
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
---
C
-
M
--
H
R
-
Q
E
T
V
--
D
C
L
K
K
F
N
A
R
--
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
--------
46
HHSearch
53.71
34%
-100
- C1 -
3HKO
2
?
A:
[24-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
K
K
Y
H
L
--
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q-------
K
------
D
------
V
E
R
I
K
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
D
D
STG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
-
N
-
K
--
S
-
F
--
E
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
L
NNG-------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
NE
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
D
-
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
D
------------------------------------------------------
20
PsiBlast_PDB
50.97
46%
-98
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
--
T
---
K
------
S
SRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
----
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
-
N
VP
K
-
P
--
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------
40
HHSearch
47.14
38%
-93
- C1 -
2W4O
1
KCC4_HUMAN
A:
[49-346]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
D
F
F
E
V
--
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
---------------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
---
K
----------------------------------
G
-
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
-
P
-
A
P-
D
-
A
--
P
L
K
I
A
D
F
--------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
--
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
A
N
F
------
V
--
H
M
-
D
T
A
Q
--
K
K
L
Q
E
F
N
A
R
--
R
K
L
K
A
A
V
K
A
V
V
A
S
S
---------
43
HHSearch
46.57
35%
-90
- C1 -
2JAM
4
KCC1G_HUMAN
A:
[6-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
K
T
F
I
F
--
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
---------------------------
S
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---
R
-----------------------------------
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
--
N
-
S
--
K
I
M
I
T
D
F
G
L
S
K
M
E
Q
N
G
-----
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
---
D
I
Y
--
P
S
-
V
S
L
----
Q
I
Q
K
N
F
A
K
--
S
----------------------