@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_MYLK4_: (2014-08-18 )
MLKVKRLEEFNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQKKKNRGSDAQDFVTK
Atome Classification :
(18 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140--.--.---.------.------.....150.......160.......170.......180.......190..---.----------------------------------....200.......210.......220.......230......-.--240--.--.......250.....---..-260.......270......--.280.......290.......300.......310........320.......330.......340.......350.......360.......370.......380......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLK
V
K
R
L
E
E
F
N
T
CYNS
N
Q
L
E
K
M
A
F
F
Q
C
R
E
E
V
E
K
V
K
C
F
L
EKNSGDQDSRSG
H
N
E
A
K
E
V
WSNAD
L
T
ERMPVKSKRT
S
A
L
A
V
DIPAPPAPFDH
R
I
V
T
AKQGAVN
S
F
Y
T
V
S
K
T
E
I
LGGGRFG
Q
V
H
K
C
E
E
TAT
G
L
K
L
A
A
K
I
I
K
TR----G--M---K------
D
------
K
E
E
V
K
N
E
I
S
V
M
N
QLD
H
A
N
L
I
Q
L
Y
D
A
FESKN
D
I
V
L
V
M
E
YVD
G
G
E
L
F
D
R
I
I
D---E----------------------------------SY
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
DLKPE
N
I
L
C
VNR-D--A-
K
--
Q
--
I
K
I
I
D
F
G
L
A
RRYKPR---
E
K
-
L
K
V
NFGTPEFLAPEVVNYD--FVSF
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
SGL
S
P
FLGDN
D
A
E
-
T
L
N
N
I
L
A
C
RWDL
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
IKEKS
W
R
I
S
A
S
E
ALKHPWLS
D
H
K
L
H
S
R
L
N
A
Q
K
KKNRGS
D
A
Q
D
FVTK
32
HHSearch
93.09
100%
-116
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-358]
-------------------------------------------------------------------------------
D
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
----
G
--
M
---
K
------
D
------
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
---
E
----------------------------------
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
-
D
--
A
-
K
--
Q
--
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---
E
K
-
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
-
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
S
R
L
S
A
Q
---------------
21
PsiBlast_CBE
90.80
99%
-121
- C1 -
2X4F
3
MYLK4_HUMAN
B:
[66-355]
--------------------------------------------------------------------------------
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
----
G
--
M
---
K
------
D
------
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
---
E
----------------------------------
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
-
D
--
A
-
K
--
Q
--
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---
E
K
-
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
-
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
S
R
L
------------------
12
PsiBlast_PDB
74.01
46%
-115
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[6-277]
-----------------------------------------------------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
--
S
---
R
ASR
R
G
V
S
------
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
---
Q
----------------------------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
--
I
-
P
I
P
H
--
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
--------------------------
6
PsiBlast_PDB
70.56
46%
-114
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[4-277]
---------------------------------------------------------------------------------------------
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
--
S
---
R
------
A
SRRGVC
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
---
Q
----------------------------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
--
I
-
P
I
P
H
--
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
--------------------------
13
PsiBlast_PDB
68.62
44%
-113
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[7-277]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
--
T
---
K
------
S
SRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
--
V
-
P
K
P
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------
14
PsiBlast_PDB
66.97
44%
-115
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
--
T
---
K
------
S
SRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
--
V
-
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------
37
HHSearch
65.58
45%
-105
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[5-281]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
--
T
---
K
SSRRGV
S
------
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--------------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
VP
K
-
P
--
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
---------------------
18
PsiBlast_PDB
64.20
44%
-115
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
--
T
---
K
------
S
SRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
--
V
-
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------
16
PsiBlast_PDB
62.39
44%
-104
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
--
T
---
K
------
S
SRRGVS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
--
V
-
P
--
K
PR
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------
47
HHSearch
61.44
39%
-108
* C1 *
3Q5I
1
?
A:
[28-307]
---------------------------------------------------------------------------------------------
R
K
K
E
G
K
I
G
E
S
Y
F
K
V
--
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
------------
K
------
F
------
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
---
R
-----------------------------------
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
-
N
--
S
L
L
--
N
--
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
---
Y
K
-
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
K
---
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
D
Q
D
-
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
-------------------------
44
HHSearch
58.19
34%
-109
- C1 -
3HKO
2
?
A:
[24-336]
---------------------------------------------------------------------------------------------------
L
Q
K
K
Y
H
L
K
--
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q-------
K
------
D
------
V
E
R
I
K
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
D
D
STG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
-
K
--
S
-
F
--
E
--
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
L
NNG-------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
NE
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
D
-
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
-------------------------
43
HHSearch
58.12
37%
-112
- C1 -
3LIJ
1
?
A:
[30-297]
----------------------------------------------------------------------------------------------
S
K
K
G
H
L
S
E
M
Y
Q
R
V
--
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
------------
S
------
S
------
N
S
K
L
L
E
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
--------------------------------------
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
E
K-
D
-
A
--
L
--
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
---
K
K
-
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
K
---
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
-
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
-------------------------
48
HHSearch
56.51
35%
-111
- C1 -
3F3Z
5
?
A:
[6-267]
--------------------------------------------------------------------------------------------------
D
I
N
Q
Y
Y
T
L
E
--
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
K
Y
----
F
--
V
---
E
------
D
------
V
D
R
F
K
Q
E
I
E
I
M
K
S
L
D
H
P
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
---
K
-----------------------------------
R
V
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
L
T
D
S
P
--
D
-
S
--
P
--
L
K
L
I
D
F
G
L
A
A
R
F
K
P
G
---
K
M
-
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
G
---
L
Y
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
P
T
D
S
E
-
V
M
L
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
F
E
K
-------------------------
46
HHSearch
55.70
39%
-103
- C1 -
3NYV
1
?
A:
[21-287]
------------------------------------------------------------------------------------------------
T
A
I
F
S
D
R
Y
K
G
Q
R
--
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
--
V
KQK
T
------
D
------
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
-----------------------------------
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K-
D
-
A
--
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
-------------------------
20
PsiBlast_PDB
54.01
44%
-121
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-275]
-------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
--
T
-----------------
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
----
V
-
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
----------------
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------
45
HHSearch
53.73
38%
-100
- C1 -
3MWU
1
?
A:
[17-282]
------------------------------------------------------------------------------------------------
Q
G
T
F
A
E
R
Y
N
I
V
--
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
----
S
AK
N
---
K
------
D
------
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
---
R
-----------------------------------
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
K-
D
-
C
--
D
--
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
--------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
---
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
-------------------------
52
HHSearch
50.57
36%
-120
- C1 -
2W4O
1
KCC4_HUMAN
A:
[49-312]
-------------------------------------------------------------------------------------------------
D
A
L
S
D
F
F
E
V
E
--
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
---------------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
---
K
-----------------------------------
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
-
A
P-
D
-
A
--
P
--
L
K
I
A
D
F
--------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
--
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
------------------------
40
HHSearch
48.87
35%
-96
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-273]
-------------------------------------------------------------------------------------------------
T
R
F
T
E
E
Y
Q
L
F
--
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
----
K
--
L
SA-
R
------
D
------
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---
R
----------------------------------
E
-
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
K
--
G
-
A
--
A
--
V
K
L
A
D
F
G
L
A
I
E
V
E
G
E
---
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
--
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
-------------------------