@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_OXSR1_: (2014-08-19 )
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60....-....70........80........90........100.......110.......120.......130.......-140........150.......160.......170.......180-.......190.......200.......210.......220.......230----------...---....240.......250.......260.......270.......280.......290..-.-.....300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSEDSSALPWSINRD
D
Y
E
L
Q
E
V
IGS
G
A
T
A
V
V
Q
A
A
YCAPKK
E
K
V
A
I
K
RI
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
-
A
M
S
QCHHP
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
LSGG
S
V
L
D
I
I
K
H
I
V
AKGEHKSGVL
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K-N-G
Q
I
H
R
D
VKAG
N
I
L
LGEDG
S
V
Q
I
A
D
FG
V
S
A
F
LATGGD
I
T
R
N
K
V
-
R
K
TFVGTPCWM
A
P
E
V
M
E
Q
V
RGYDFK
A
D
I
W
SFG
I
T
A
I
E
LATGAAPYHKYPP----------
M
K
V
---
L
M
L
T
LQNDPPSLETGV
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
QKDPEKR
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-A-K
N
K
E
F
L
Q
E
K
T
LQRAP
T
I
S
E
R
A
K
K
V
R
RVPGSSGRLHKTEDGGWEWSDDEFDEE
S
E
E
G
K
A
A
I
S
Q
LRSP
R
V
K
ESISNSELFPTTDP
V
G
T
L
L
Q
V
P
E
Q
I
S
A
HLPQP
A
G
QIATQP
T
Q
VSLPPTAE
P
A
K
T
A
Q
A
L
SSGSGSQETK
I
P
I
S
L
V
L
R
L
RNSKKELN
D
I
R
F
E
FTPGR
D
T
A
E
G
V
S
Q
E
L
I
S
A
GLVDG
R
D
L
V
I
V
A
A
N
L
Q
K
I
V
EEPQSN
R
S
V
T
F
K
LASGVEGSDIPDDG
K
L
I
G
F
A
Q
L
SIS
2
PsiBlast_PDB
96.92
100%
-117
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[1-290]
-----
S
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
-
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
------------
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
----------
M
K
V
---
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
96.80
100%
-114
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[2-290]
------
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
-
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
---------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
----------
M
K
V
---
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
96.44
100%
-113
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[2-290]
------
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
-
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
I
T
R
N
------
F
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
----------
M
K
V
---
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
95.50
100%
-114
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[1-290]
-----
S
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
-
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
-------------
T
P
C
W
M
A
P
E
V
M
E
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
----------
M
K
V
---
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
94.92
100%
-110
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[6-298]
-----
S
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
-
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
----------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
----------
M
K
V
---
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
-
K
N
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
88.21
100%
-119
- C1 -
2VWI
1
OXSR1_HUMAN
B:
[9-292]
--------
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
-
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
-------------
T
P
C
W
M
A
P
E
V
M
E
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
----------
M
K
V
---
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
-----
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
68.06
46%
-91
- C1 -
2XIK
2
STK25_HUMAN
A:
[27-283]
----------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
-
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
---------
P
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
-
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
----------
M
R
V
---
L
F
L
I
P
K
N
S
P
P
T
L
E
G
---------
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
T
-
K
K
T
S
F
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.99
44%
-98
- C1 -
4FZD
1
MST4_HUMAN
B:
[14-272]
--------------------
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
----------
M
R
V
---
L
F
L
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
-
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
67.83
47%
-92
- C1 -
3A7I
1
STK24_HUMAN
A:
[17-286]
---------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
-----
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
----------
M
K
V
---
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
L
R
-
N
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
67.34
43%
-88
- C1 -
3FXZ
1
?
A:
[18-283]
------------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
I
I
N
E
I
L
-
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
---------
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
-----
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
----------
L
R
A
---
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
-
K
P
L
S
S
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
65.54
40%
-95
- C1 -
3FY0
1
PAK1_HUMAN
A:
[19-277]
-------------
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
I
I
N
E
I
L
-
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
----------
L
R
A
---
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
65.50
44%
-99
- C1 -
3GGF
1
MST4_HUMAN
A:
[29-287]
--------------------
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
---------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
----------
M
R
V
---
L
F
L
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
-
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.95
45%
-91
- C1 -
3A7J
1
STK24_HUMAN
A:
[28-286]
--------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
Q
I
K
R
N
-----
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
----------
M
K
V
---
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
-
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.74
45%
-93
- C1 -
3A7H
1
STK24_HUMAN
A:
[28-286]
--------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
Q
I
K
R
N
-----
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
----------
M
K
V
---
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
-
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
63.75
39%
-90
* C1 *
4JDI
2
?
A:
[74-334]
--------------
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
-
Q
R
R
E
L
L
F
N
E
V
V
-
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
---------
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
-----
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
----------
L
K
A
---
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-
G
P
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.66
45%
-93
- C1 -
3CKX
1
STK24_HUMAN
A:
[13-271]
--------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
--
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
Q
I
K
R
N
-----
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
----------
M
K
V
---
L
F
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
-
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.21
44%
-91
- C1 -
4FZA
3
MST4_HUMAN
B:
[14-272]
--------------------
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
----------
M
R
V
---
L
F
L
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
-
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
61.92
32%
-104
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[14-294]
------
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
L
M
S
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
---
L
D
D
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
-
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
----------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
-------------------
T
Q
V
V
K
G
D
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
-
I
L
M
-
Y
-
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
59.40
44%
-90
- C1 -
4FZF
1
?
B:
[14-272]
--------------------
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
----------
M
R
V
---
L
F
L
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
-
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
58.34
31%
-104
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[28-332]
---------
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
-
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
--------
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
-
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
-------
S
M
-
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
GCP
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
-
I
K
R
-
S
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------