@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_PAK1_H: (2014-08-19 )
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH
Atome Classification :
(18 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300...---..--..310.......320.......330....--...340.......350......-----------------.-----360---------------.........370.......380.......390.......400-........410......--.420.......430......--.440.......450.......460.......470.......480.....--..490.......500.......510.......520........530.......540...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSNNGLDIQDKPPAPPMRNT
S
T
M
IGAGSKDAGTLNHGSKPLPPN
P
E
E
K
K
K
K
D
R
F
Y
R
S
ILPGDKTNK
K
K
EKERPEISLPSDFE
H
T
I
H
V
GFDAVTGEFTG
M
P
E
Q
W
A
R
L
L
Q
TSNIT
K
S
E
QKK
N
P
Q
A
V
L
D
V
L
E
F
YNSKKTSNSQ
K
Y
M
SFTDKSAEDYNSSN
A
L
N
V
K
AVSETPAVPPVSEDEDDDDDDATPPPVIAPRPE
H
T
K
S
V
Y
T
R
SVIEPLPVTPTRDVATSPISPTENNTTP
P
D
A
LTRN
T
E
K
Q
KKKPKM
S
D
E
E
I
L
E
K
L
R
S
I
V
SVGD
P
K
K
K
Y
T
R
F
E
K
IGQGASG
T
V
Y
T
A
M
DVATGQ
E
V
A
I
K
Q
MNLQQ---Q
P
--
K
K
E
L
I
I
N
E
I
L
V
M
RENKNP
N
I
V
N
Y
L
D
S
Y
LV--
G
D
E
L
W
V
V
M
E
Y
LAGG
S
L
T
D
V
V
T
E
-----------------
T
-----C-----------------MDE
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
HSN
Q
V
I
H
R
DIKSD
N
I
L
L
GMDG--
S
V
K
L
TDF
G
F
C
AQITPEQ--SKRSTMVGTPYWM
A
P
E
V
V
TR--KAYGPKV
D
I
W
S
L
G
I
M
A
I
E
MIEGEPPYLNENP
L
R
A
L
Y
L
I
ATNGTPELQ
N
P
--
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
KRG
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
ATKNNH
34
HHSearch
93.12
100%
-110
- C1 -
3FXZ
1
?
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
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Y
T
R
F
E
K
I
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Q
G
A
S
G
T
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Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
---
Q
P
--
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-----------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
--
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
10
PsiBlast_PDB
92.30
99%
-110
- C1 -
4O0R
1
?
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
---
Q
P
--
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-----------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
--
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
--
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
2
PsiBlast_PDB
91.96
98%
-106
- C1 -
3Q53
1
PAK1_HUMAN
A:
[3-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
---
Q
P
--
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-----------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
--
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
9
PsiBlast_PDB
90.81
98%
-115
- C1 -
3Q4Z
1
PAK1_HUMAN
A:
[4-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
I
I
V
S
V
G
D
P
K
-----
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
Q
M
N
L
----------
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-----------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
--
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
3
PsiBlast_PDB
90.58
98%
-108
- C1 -
4EQC
1
PAK1_HUMAN
A:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
T
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
---
Q
P
--
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-----------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
--
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
11
PsiBlast_PDB
90.18
99%
-107
- C1 -
4O0T
1
?
A:
[3-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
---
Q
P
--
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-----------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
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I
K
S
D
N
I
L
L
G
M
D
G
--
S
V
K
L
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D
F
G
F
C
A
Q
I
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P
E
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--
S
K
R
S
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M
V
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T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
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P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
--
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
7
PsiBlast_PDB
89.50
99%
-108
- C1 -
3FY0
1
PAK1_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
---
Q
P
--
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-----------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
--
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
33
HHSearch
80.57
45%
-97
- C1 -
4FIE
1
PAK4_HUMAN
A:
[46-421]
-----------------------------------------------------------------------------------------------------------------------
R
P
K
P
L
V
D
-----------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
--
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-----------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
--
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
35
HHSearch
75.56
52%
-100
- C1 -
4JDI
2
?
A:
[55-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
--
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-----------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
--
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
14
PsiBlast_PDB
75.16
52%
-108
- C1 -
2CDZ
1
PAK4_HUMAN
A:
[11-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
--
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-----------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
--
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
-----------
19
PsiBlast_PDB
73.50
52%
-103
- C1 -
4FII
1
PAK4_HUMAN
A:
[54-340]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
--
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-----------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
--
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
-----------
15
PsiBlast_PDB
73.33
52%
-104
- C1 -
2J0I
4
PAK4_HUMAN
A:
[12-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
--
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-----------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
--
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
-----------
36
HHSearch
72.87
49%
-103
- C1 -
4KS7
2
A:
[4-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
---
Q
Q
--
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
--
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
Q
-----------------
V
-----
R
-----------------
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
D
V
--
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
R
--
S
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
P
P
K
L
K
N
S
--
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
-
L
Q
T
G
L
P
E
C
L
V
P
L
I
-----------
16
PsiBlast_PDB
72.09
52%
-96
- C1 -
4FIF
2
PAK4_HUMAN
A:
[51-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
--
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-----------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
--
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
-----------
17
PsiBlast_PDB
71.65
52%
-103
- C1 -
4FIG
1
?
A:
[53-340]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
--
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-----------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
--
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
-----------
44
HHSearch
61.70
45%
-98
* C1 *
3A7I
1
STK24_HUMAN
A:
[18-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
D-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-----------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
--
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
-----
45
HHSearch
48.19
34%
-96
- C1 -
3HKO
2
?
A:
[26-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q-
K
--
D
V
E
R
I
K
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
--
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQ
I
CPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
K
SF
E
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
L
N
NG------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
TN
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
D
T
I
S
Q
V
L
-
N
K
K
L
C
F
E
N
P
NY
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
-
S
Q
----------------------
47
HHSearch
40.45
31%
-96
- C1 -
2W5A
5
NEK2_HUMAN
A:
[6-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
---
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
-----------------
G
T
K
E
R
Q
Y
-----------------
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
--
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
--
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
--
I
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
-
L
E
----------------------