@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_PHKG1_: (2014-08-19 )
MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFSPRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPKAVLLSLAEEDY
Atome Classification :
(16 SA)
.........10........20.-.......30........40........50.....---...60......-..70..-......80........90........100.......110.......-120--.........130.......140.......150.....---.---.160-..----.---......170.......-180--.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.....----------.-----------.290---------------.--------------......300.......310.......320.......330.......340.......350.......360.......370.......380.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTRDEALPDSH
S
A
Q
D
F
Y
ENY
E
P
-
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
IHKPTSQ
E
Y
A
V
K
V
I
D
VTGG---GSF
S
P
E
E
V
R
E
L
-
R
E
A
T
L
K
-
E
V
D
I
L
R
K
VSGHP
N
I
I
Q
L
K
DTYET
N
T
F
F
F
L
V
F
D
L
M
KR
G
E
L
F
D
Y
L
T
E
K-V----TL
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
T
L
H
K
L
N
I
V
HRDLKPE
N
I
L
---L---DD---NM----
N
---
I
K
L
TDF
G
F
S
C
QLE
P
G
E
-
R
L
R
--
E
V
CGTP
S
Y
L
A
P
E
I
I
E
CSMNEDHPGYGKEVDMWSTG
V
I
M
Y
TLLAGSPP
F
W
H
R
K
Q
M
L
M
L
R
M
I
MSGNYQFGSPEWD
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
VQPQNRY
T
A
E
E
A
L
A
H
P
F
----------
F
-----------
Q
Q
Y
L
---------------
V
--------------
E
E
V
R
HFSPRG
K
F
K
V
I
A
L
T
V
L
A
S
V
R
I
Y
Y
Q
Y
RRVKPVT
R
E
I
V
IRDP
Y
A
L
R
P
L
R
R
L
I
D
A
Y
A
F
R
I
Y
G
H
W
V
KKGQQQ
N
R
A
A
L
FENT
P
K
A
V
L
L
S
L
AEEDY
3
PsiBlast_PDB
98.26
95%
-130
- C1 -
2PHK
3
PHKG1_RABIT
A:
[2-277]
---------------
F
Y
E
N
Y
E
P
-
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
---
G
S
F
S
A
E
E
V
Q
E
L
-
R
E
A
T
L
K
-
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
-
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
---
D
M
----
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
-
K
L
R
--
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
----------
F
-----------
Q
Q
Y
-----------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
95.21
93%
-121
- C1 -
1QL6
1
PHKG1_RABIT
A:
[11-291]
-----------
S
T
H
G
F
Y
E
N
Y
E
P
-
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
---
G
S
F
S
A
E
E
V
Q
E
L
-
R
E
A
T
L
K
-
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
-
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
---
D
M
----
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
-
K
L
R
--
S
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
----------
F
-----------
Q
Q
Y
V
----------------------------------------------------------------------------------------------------------------------------
30
HHSearch
94.88
94%
-126
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-291]
---------------
F
Y
E
N
Y
E
P
-
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
---
G
S
F
S
A
E
E
V
Q
E
L
-
R
E
A
T
L
K
-
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
-
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
---
D
M
----
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
-
K
L
R
--
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
----------
F
-----------
Q
Q
Y
V
----------------------------------------------------------------------------------------------------------------------------
31
HHSearch
83.54
69%
-118
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[82-365]
-----
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
----
R
L
S
P
E
Q
L
E
E
V
-
R
E
A
T
R
R
-
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
-
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
---
N
M
----
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-
K
L
R
--
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
----------
F
-----------
E
R
------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
61.43
38%
-118
- C1 -
3LIJ
1
?
A:
[33-337]
-------------
G
H
L
S
E
M
Y
Q
R
-
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
-----------
S
S
N
-----
S
K
L
L
E
-
E
V
A
V
L
K
L
L
-
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
-
M
----
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KEK
D
A
----
L
---
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
K
-
K
M
K
--
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
-------
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
----------
I
-----------
K
E
M
C
---------------
S
K
K
E
SL
P
S
L
A
N
A
I
--
E
N
M
R
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
Y
M
A
S
------------------------------------------------------------------------
6
PsiBlast_PDB
60.63
37%
-116
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[4-306]
-----------------
D
E
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
------
K
L
S
A
R
D
H
Q
K
L
-
E
----
R
-
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
ASK
S
K
---
G
A
----
A
---
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
-
Q
A
W
F-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
----------
I
CQRSM
M
H
----
R
Q
E
T
---------------
V
--------------
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
--------------------------------------------------------------------
35
HHSearch
59.39
37%
-102
- C1 -
3C0I
1
CSKP_HUMAN
A:
[21-317]
--------------
L
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
G
L
S
T
E
--------
D
L
K
R
-
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
-
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
---
L
---
A
S
---
K
E
----
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
--
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
-
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
----------
L
-----------
K
E
R
D
RYAYKIHL
P
E
T
----
V
--------------
E
Q
L
R
K
F
N
A
R
R
K
-----------------------------------------------------------------------------------
10
PsiBlast_PDB
59.39
37%
-109
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[4-300]
-----------------
D
E
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
------
K
L
S
A
R
D
H
Q
K
L
-
E
----
R
-
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
ASK
S
K
---
G
A
----
A
---
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
-
Q
A
W
F-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
----------
I
CQRSTVASMMH
R
Q
E
T
---------------
V
--------------
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
--------------------------------------------------------------------------
50
HHSearch
59.31
36%
-119
- C1 -
3Q5I
1
?
A:
[33-346]
--------------
K
I
G
E
S
Y
F
K
-
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
---------------
K
F
-
H
E
E
I
Y
N
-
E
I
S
L
L
K
S
L
-
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
-
H
----
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
---
L
---
E
N
---
K
N
SLL-
N
---
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
Y
-
K
L
R
--
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
-------
K
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
D
Q
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
----------
I
-----------
K
K
Y
A
---------------
N
NINKSD
Q
K
T
L
C
G
A
L
S
N
M
R
K
F
E
G
S
Q
K
L
A
Q
A
A
I
L
F
I
G
S
------------------------------------------------------------------------
8
PsiBlast_PDB
58.80
37%
-109
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[29-321]
---------------
F
T
D
D
Y
Q
L
-
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
------
K
L
S
A
R
D
H
Q
K
L
-
E
----
R
-
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
C
----
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
E
-
Q
Q
A
WF
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
----------
V
C
Q
RSTVASMMH
R
Q
E
T
---------------
V
--------------
E
C
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------
19
PsiBlast_PDB
54.86
37%
-117
- C1 -
3HX4
3
?
A:
[43-317]
----------
H
S
T
A
I
F
S
D
R
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-----------
S
K
------D
K
E
S
L
L
R
-
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
A
----
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
-
K
M
K
--
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
----------
I
-----------
Q
T
Y
T
---------------
K
--------------
E
Q
I
-------------------------------------------------------------------------------------------
39
HHSearch
53.84
38%
-114
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[8-280]
--------------
N
V
D
D
Y
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
---
K
S
S
---
R
R
G
V
S
-
R
E
D
I
E
R
-
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
---
R
N
VP
K
P
R
---
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
--
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
------
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
P
K
D
---------------
T
------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
52.86
36%
-101
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[9-311]
---------------
F
T
E
E
Y
Q
L
-
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
------
K
L
S
A
R
D
H
Q
K
L
-
E
----
R
-
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
---
A
S
---
K
L
----
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
E
-
G
E
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
----------
I
SHRSTVASCMH
R
Q
E
T
---------------
V
--------------
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
----------------------------------------------------------------------
51
HHSearch
48.90
35%
-108
- C1 -
3LM5
1
ST17B_HUMAN
A:
[22-299]
-----------
S
M
E
N
F
N
N
F
Y
I
L
T
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
R
------
G
Q
D
----
C
-
R
A
E
I
L
H
-
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
L
E
----
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
---
L
---
S
S
IYP
L
G
----
D
---
I
K
I
V
D
F
G
M
S
R
K
I
------------
M
G
T
P
E
Y
L
A
P
E
I
L
N
Y
------
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
N
Q
E
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
----------
L
-----------
Q
Q
W
D
---------------
F
--------------
E
N
L
-------------------------------------------------------------------------------------------
40
HHSearch
47.30
37%
-101
- C1 -
3MWU
1
?
A:
[14-322]
---------
L
Y
F
Q
G
T
F
A
E
R
Y
N
I
-
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
------
K
N
K
D
-----
T
S
T
I
L
R
-
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
-
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
KEK
D
C
----
D
---
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
-------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-------
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
----------
I
-----------
Q
K
Y
S
S
E
T
P
T
ISD
L
P
S
L
E
S
A
M
--------------
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
------------------------------------------------------------------------
12
PsiBlast_PDB
42.27
35%
-109
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[10-314]
---------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
------------
A
K
E
----------
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
---
D
S
----
K
---
I
M
I
S
D
F
---------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
IAGDTALDKN
I
-----------
H
Q
S
V
---------------
S
--------------
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
-
A
F
N
A
T
A
V
V
R
----------------------------------------------------------------------