@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_PHKG2_: (2014-08-19 )
MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG
Atome Classification :
(15 SA)
.........-10........20........30........40........50........----60.........70........80........90........100.......110.......120.----......130.......140.......150.......160-...---...---...170.......180-..-.--....190.......200........210.......220.......230.....-..240.......250.......260.......270.......280.......290-----...------..-----------.------------...--300---.........310.......320.......330.......340.......350.......360.......370.......380.......390.......400....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTLDVGPED-ELP
D
W
A
A
A
K
E
F
Y
Q
KYD
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
AT
G
H
E
F
A
V
K
I
M
E
V
T
A
----
E
-RL
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
VAGHP
H
I
I
T
L
I
DSYESS
S
F
M
F
L
V
F
D
L
M
RK
G
E
L
F
D
Y
L
T
E
K
V----AL
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
ANNIVHRDLKPE
N
I
L
---LDD---N
M
Q
---
I
R
L
SDF
G
F
S
C
HLE
P
G
E
-
K
L
-
R
--
E
L
CGTPG
Y
L
A
P
E
I
L
K
-CSMDETHPGYGKE
V
D
L
W
A
C
G
V
I
L
F
T
L
LAGSPP
F
W
H
R
R
-
Q
I
L
M
L
R
M
I
MEG
Q
Y
QFSSPEWDD
R
S
S
T
V
K
D
L
I
S
R
L
LQVDPEARL
T
A
E
Q
A
L
Q
H
P
F
-------
F
E
R------CE-----------G------------SQP--W-----NL
T
P
R
Q
R
F
R
V
A
V
W
T
V
L
AA
G
R
V
A
LSTHRVRPLTKNALLR
D
P
Y
A
L
R
S
V
R
H
L
I
D
N
C
A
F
R
L
Y
G
H
W
V
KKGEQQ
N
R
A
A
L
FQHRPPGPFPIMGPEEEGDSAAITED
E
A
V
L
V
LG
22
PsiBlast_CBE
95.56
99%
-133
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[82-365]
----------
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
----
E
-
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
D
---
N
M
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-
K
L
-
R
--
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
-
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-------
F
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.25
99%
-130
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[82-365]
----------
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
--------
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
D
---
N
M
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-
K
L
-
R
--
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
-
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-------
F
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
93.21
100%
-132
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[82-365]
----------
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
----
E
-
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
D
---
N
M
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-
K
L
-
R
--
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
-
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-------
F
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.69
67%
-124
- C1 -
1QL6
1
PHKG1_RABIT
A:
[11-289]
----------------
S
T
H
G
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
----
G
G
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
D
---
D
M
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
-
K
L
-
R
--
S
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
-
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
-------
F
Q
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.68
69%
-134
- C1 -
2PHK
3
PHKG1_RABIT
A:
[2-276]
--------------------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
----
G
G
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
D
---
D
M
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
-
K
L
-
R
--
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
-
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
-------
F
Q
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
81.67
65%
-127
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-291]
--------------------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G---
G
-
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
D
---
D
M
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
-
K
L
-
R
--
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
-
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
-------
F
Q
Q
------
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
62.61
36%
-122
- C1 -
3LIJ
1
?
A:
[33-337]
------------------
G
H
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
------------
S
S
----
N
S
K
L
L
E
E
V
A
V
L
K
L
L
-
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
----
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KEK
D
A
L
---
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
K
-
K
M
-
K
--
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
--------
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
-
D
Q
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
-------
I
K
E
------
M
C
-----------
S
K
K
E
SL
P
S
L
A
N
A
I
E
N
M
--
R
-----
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
Y
M
A
S
----------------------------------------------------------------------------------------
14
PsiBlast_PDB
57.06
38%
-109
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[15-304]
------
T
E
N
L
Y
F
Q
S
M
A
T
C
T
R
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
--
I
N
T
----
K
-
K
L
S
A
R
D
H
Q
K
L
E
----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
---
L
A
S
---
K
C
K
GAA
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
E
-
Q
Q
-
A
WF
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
-------
V
--------
C
Q
-----------
R
------------
S
T
V
--
A
-----
S
M
M
H
R
Q
----------------------------------------------------------------------------------------------------
38
HHSearch
54.67
36%
-107
- C1 -
3C0I
1
CSKP_HUMAN
A:
[21-317]
-------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
-------
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
---
L
A
S
---
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
-
G
--
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
-
R
------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
-
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-------
L
K
E
------
R
D
RYAYKIHL
P
E
T
V
------------
E
Q
L
--
R
-----
K
F
N
A
R
R
K
---------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
53.12
40%
-128
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[12-277]
------------------------------
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
----
K
-
K
L
S
A
R
D
H
Q
K
L
E
----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
A
S
---
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
-
Q
A
W
F
--
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
-------
I
--------
C
Q
-----------
R
-----------------------
S
M
M
H
R
Q
----------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
51.58
40%
-121
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[6-277]
---------------------
Y
Q
L
Y
E
D
---
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
----
K
-
K
L
S
A
R
D
H
Q
K
L
----
E
R
E
A
R
I
C
R
-
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
A
S
---
K
C
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
-
Q
A
W
F
--
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
-------
V
--------
C
Q
-----------
R
------------
S
T
V
--
A
-----
S
M
M
H
R
Q
----------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
49.95
40%
-119
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[12-277]
------------------------------
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
----
K
-
K
L
S
A
R
D
H
Q
K
L
E
----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
A
S
---
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
-
Q
A
W
F
--
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
-------
I
--------
C
Q
-----------
R
------------
S
T
V
--
A
-----
S
M
M
H
R
Q
----------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
48.70
37%
-104
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[9-311]
--------------------
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
--
I
N
T
----
K
-
K
L
S
A
R
D
H
Q
K
L
E
----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
A
S
---
K
L
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
E
-
G
E
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
-------
I
S
H
RSTVAS
C
M
-----------
H
------------
R
Q
E
--
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
--------------------------------------------------------------------------------------
8
PsiBlast_PDB
47.18
40%
-134
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[10-276]
--------------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
------------
I
A
K
E
---------
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
S
K
---
I
M
I
S
D
F
----------------------
P
G
Y
V
A
P
E
V
L
-------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
35.19
37%
-112
- C1 -
2W4O
1
KCC4_HUMAN
A:
[61-346]
------------------------------
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
-------------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
----
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
A
T
PAP
D
A
P
---
L
K
I
A
D
F
--------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
-------
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
VTGKAAN
F
V
H
------
M
D
-----------
T
------------
A
Q
K
K
L
Q
-----
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
---------------------------------------------------------------------------------------