@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_PHO85_: (2014-08-19 )
MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS
Atome Classification :
(20 SA)
.........10........20......--..30........40..-.-.....50........60........70...------.------....80........90........-100.......110.......120.......130.......140---...-.....150.......160.......170.......180.......190.......200..-----------.....210.-------.----.....220.......230....---..--.240..-....-----.250-.......260.......270.......280.......290.......300...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSS
S
S
Q
F
K
Q
L
E
K
LGNG
T
Y
A
T
V
Y
KGLNK--TT
G
V
Y
V
A
L
K
E
V
KLDSE-E-GTP
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
IHT------E------N
K
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
DSRTVG-NTPRGL
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
HENK
I
L
HRDLKPQ
N
L
L
I----NKR-G
Q
L
KLGDFG
L
A
R
AFGIPVNTFSS
E
V
V
T
L
W
YRAPD
V
L
MGSRTY
S
T
S
I
D
IW
S
C
G
C
I
L
A
E
M
IT-----------GKPLFPGT
N
-------
D
----
E
E
Q
L
K
L
I
F
DIMGTPNESLWP
S
V
---TK--LPKYNP-NIQQ-----R
P
P
R
-
D
L
R
Q
V
LQPHTKEPLDG
N
L
M
D
F
L
H
G
L
L
QLNPDMR
L
S
A
K
Q
ALH
H
P
W
F
A
E
Y
Y
HHAS
3
PsiBlast_PDB
96.94
100%
-111
- C1 -
4KRC
1
PHO85_YEAST
A:
[2-302]
-
S
S
S
S
Q
F
K
Q
L
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
K
--
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
S
E
-
E
-
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
H
T
------
E
------
N
K
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
S
R
-----
T
P
R
G
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
K
R
-
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-----------
G
K
P
L
F
P
G
T
N
-------
D
----
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
---
T
K
--
L
P
K
Y
N
P
-
N
I
Q
Q
-----
R
P
P
R
-
D
L
R
Q
V
L
Q
P
H
T
K
E
P
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
E
Y
Y
H
---
2
PsiBlast_PDB
90.53
100%
-115
- C1 -
2PMI
2
PHO85_YEAST
A:
[19-302]
------------------
A
T
V
Y
K
G
L
N
K
--
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
S
E
-
E
-
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
H
T
------
E
------
N
K
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
S
R
T
V
G
-
N
T
P
R
G
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
K
R
-
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-----------
G
K
P
L
F
P
G
T
N
-------
D
----
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
---
T
K
--
L
P
K
Y
N
P
-
N
I
Q
Q
-----
R
P
P
R
-
D
L
R
Q
V
L
Q
P
H
T
K
E
P
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
E
Y
Y
H
---
10
PsiBlast_PDB
82.09
55%
-115
- C1 -
1H1S
1
CDK2_HUMAN
A:
[5-293]
--
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
-----
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
---
T
S
--
M
P
D
Y
K
P
-
S
F
P
K
-----
W
A
R
Q
-
D
F
S
K
V
V
-----
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------
19
PsiBlast_PDB
82.05
55%
-116
- C1 -
4EOQ
1
CDK2_HUMAN
A:
[3-292]
-
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
-----
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
---
T
S
--
M
P
D
Y
K
P
-
S
F
P
K
-----
W
A
R
Q
-
D
F
S
K
V
V
-----
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------
9
PsiBlast_PDB
81.81
55%
-115
- C1 -
1H1R
1
CDK2_HUMAN
A:
[5-293]
--
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
-----
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
---
T
S
--
M
P
D
Y
K
P
-
S
F
P
K
-----
W
A
R
Q
-
D
F
S
K
V
V
-----
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------
7
PsiBlast_PDB
81.64
55%
-116
- C1 -
1H1P
1
CDK2_HUMAN
A:
[5-293]
--
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
-----
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
---
T
S
--
M
P
D
Y
K
P
-
S
F
P
K
-----
W
A
R
Q
-
D
F
S
K
V
V
-----
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------
18
PsiBlast_PDB
81.55
55%
-115
- C1 -
4CFW
1
CDK2_HUMAN
A:
[4-293]
-
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
-----
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
---
T
S
--
M
P
D
Y
K
P
-
S
F
P
K
-----
W
A
R
Q
-
D
F
S
K
V
V
-----
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------
20
PsiBlast_PDB
80.93
55%
-116
- C1 -
1E9H
1
CDK2_HUMAN
A:
[2-289]
---
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
-----
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
---
T
S
--
M
P
D
Y
K
P
-
S
F
P
K
-----
W
A
R
Q
-
D
F
S
K
V
V
-----
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------
8
PsiBlast_PDB
80.70
55%
-112
- C1 -
1H1Q
1
CDK2_HUMAN
A:
[5-293]
--
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
-----
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
---
T
S
--
M
P
D
Y
K
P
-
S
F
P
K
-----
W
A
R
Q
-
D
F
S
K
V
V
-----
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------
5
PsiBlast_PDB
78.38
55%
-116
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-290]
---
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
-----
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
---
T
S
--
M
P
D
Y
K
P
-
S
F
P
K
-----
W
A
R
Q
-
D
F
S
K
V
V
-----
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------
6
PsiBlast_PDB
78.32
55%
-115
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-290]
---
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
-----
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
---
T
S
--
M
P
D
Y
K
P
-
S
F
P
K
-----
W
A
R
Q
-
D
F
S
K
V
V
-----
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
------
47
HHSearch
77.25
56%
-109
* C1 *
3NIZ
1
?
A:
[20-310]
---
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
---
S
Q
G
R
I
V
A
L
K
R
I
R
-------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
S
------
E
------
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
N
------
K
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
S
D
-
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-----------
G
K
P
L
F
P
G
V
T
-------
D
----
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
---
Q
E
--
L
P
L
W
K
Q
R
T
F
Q
V
-----
F
E
K
K
-
P
W
S
S
I
I
-----
P
G
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
--
42
HHSearch
76.35
59%
-110
- C1 -
4AU8
2
CDK5_HUMAN
A:
[5-293]
---
S
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
---------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
------
N
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
----------
G
R
P
L
F
P
G
N
D
-------
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
---
T
K
--
L
P
D
Y
K
P
--
Y
P
M
-----
Y
P
A
T
T
S
L
V
N
V
V
-----
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----
40
HHSearch
72.03
38%
-102
- C1 -
3N9X
2
?
A:
[26-370]
----
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
--
N
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
-
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
S
D
Y
I
I
R
L
Y
D
L
I
I
P
------
D
DLLKF-
D
E
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
K
T
P
-------
I
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
----
N
Q
D
-
C
S
V
K
V
C
D
F
G
L
A
R
T
I
---------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
----
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
K
N
I
---
N
K
P
E
V
I
K
Y
I
K
-
L
F
P
H
-----
R
K
P
I
-
N
L
K
Q
K
Y
-----
P
S
I
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
K
---
52
HHSearch
71.06
35%
-105
- C1 -
2B9H
2
FUS3_YEAST
A:
[11-314]
----
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
--
P
T
G
E
I
V
A
I
K
K
I
E
P
F
D
K
-
P
-
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
P
DSFEN-
F
------
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
--------
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
----
N
S
N
-
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-----------
R
R
P
I
F
P
G
R
D
-------
Y
----
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
IES
P
R
--
A
R
E
Y
I
K
-
S
L
P
M
-----
Y
P
A
A
-
P
L
E
K
M
F
-----
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
---
54
HHSearch
70.42
32%
-118
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[55-345]
-----
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
--
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
R
-------
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
GEKKD
E
------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
---
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
----
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
-
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
----
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
---
N
----
P
N
Y
T
E
F
K
F
P
Q
-----
I
K
A
H
-
P
W
T
K
V
F
R
----
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
---
50
HHSearch
64.94
37%
-116
- C1 -
2FST
3
MK14_HUMAN
X:
[29-319]
----
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
-
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
------
A
RSLEEF
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
-------------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
D
-
C
E
L
K
I
L
D
------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
---
S
S
ES
A
R
N
Y
I
Q
-
S
L
T
Q
-----
M
P
K
M
-
N
F
A
N
V
F
-----
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
----
36
HHSearch
64.45
41%
-99
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-298]
-------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
--
N
T
N
Q
I
V
A
I
K
K
I
----------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
H
------
K
------
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
N
------
S
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
----
D
E
N
-
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-----------
R
V
P
F
L
P
G
D
S
-------
D
----
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
---
C
S
--
L
P
D
Y
V
--
T
F
K
S
-----
F
P
G
I
-
P
L
H
H
I
F
-----
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
-----
49
HHSearch
64.12
37%
-101
- C1 -
4F6U
10
CDK8_HUMAN
A:
[27-340]
----------
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
DG
K
D
D
K
D
Y
A
L
K
Q
I
E
G
----
T
-
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
HA----
D
------
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K---
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
R
-
G
R
V
K
I
A
D
M
G
F
--------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-----------
S
E
P
I
F
H
C
R
Q
-------
E
NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
---
K
K
--
M
P
E
H
S
T
-
L
M
K
D
F
RRNT
Y
T
N
C
-
S
L
I
K
Y
M
E
K
H
-
K
V
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
-----
35
HHSearch
33.80
57%
13
- C1 -
4EK4
1
CDK2_HUMAN
A:
[3-293]
--
E
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
------
E
------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
-----
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
---
T
S
--
M
P
D
Y
K
P
-
S
F
P
K
-----
W
A
R
Q
-
D
F
S
K
V
V
-----
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--