@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_PIM1_H: (2014-08-19 )
MPHEPHEPLTPPFSALPDPAGAPSRRQSRQRPQLSSDSPSAFRASRSHSRNATRSHSHSHSPRHSLRHSPGSGSCGSSSGHRPCADILEVGMLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
Atome Classification :
(49 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170...-......180.......--190.......200.......210.......220.......230.......240.......250.......260.......270-.........280...-.-...290.......300....-----...310.......320.......330....------.------..340.....----..350.......360.......370.......380.......390.......400..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPHEPHEPLTPPFSALPDPAGAPSRRQSRQRPQLSSDSP
S
A
F
R
ASRSHSRNATRSHSHSHSP
R
H
SLRHSPGSGSCGSSSGHR
P
C
A
D
I
L
E
V
G
M
L
L
S
K
I
N
S
L
A
H
L
RAAPCNDLHATKLAPGKEKEP
L
E
SQYQVG
P
L
LGSGG
F
G
S
V
YSG
I
R
VSDNL
P
V
A
I
K
HV
E
K
D
RIS
D
W
GE--LPN-GTRV
P
M
E
V
V
L
L
K
K
V
SS--
G
F
S
G
V
I
R
L
L
D
W
F
ERPD
S
F
V
L
I
LERPE
P
V
Q
D
L
F
D
F
I
T
ERG
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
NCG
V
L
HRDIKDE
N
I
L
I
D
LNR---G
E
L
K
L
I
DFGSG
A
L
L
K-D-
T
V
YTDFDGTRVYS
P
P
E
W
I
R
Y
-----
H
RYHGR
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
VCGDIPFEH
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
ALRPSDRP
T
F
E
E
I
QNHP
W
M
Q
DVLLPQE
T
A
E
I
H
L
H
SLSPGPSK
45
PsiBlast_CBE
93.14
100%
-124
- C1 -
2O65
2
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
24
PsiBlast_CBE
92.80
99%
-127
- C1 -
2J2I
1
PIM1_HUMAN
B:
[33-305]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
14
PsiBlast_CBE
92.73
99%
-121
- C1 -
2OI4
5
PIM1_HUMAN
X:
[32-306]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
18
PsiBlast_CBE
92.55
99%
-126
- C1 -
2BZH
2
PIM1_HUMAN
B:
[32-306]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
22
PsiBlast_CBE
92.13
99%
-128
- C1 -
3QF9
2
PIM1_HUMAN
A:
[33-306]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
17
PsiBlast_CBE
91.87
99%
-127
- C1 -
2BZJ
1
PIM1_HUMAN
A:
[33-305]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
11
PsiBlast_CBE
91.82
99%
-129
- C1 -
3CY2
3
PIM1_HUMAN
A:
[34-306]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
---
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
2
PsiBlast_PDB
91.70
100%
-127
- C1 -
4JX7
2
PIM1_HUMAN
A:
[33-306]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
23
PsiBlast_CBE
91.38
99%
-127
- C1 -
3JPV
2
PIM1_HUMAN
A:
[34-306]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
3
PsiBlast_PDB
91.29
98%
-127
- C1 -
3DCV
1
PIM1_HUMAN
A:
[47-320]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
6
PsiBlast_PDB
91.04
98%
-128
- C1 -
4N6Z
4
PIM1_HUMAN
A:
[48-320]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
7
PsiBlast_PDB
90.88
98%
-126
- C1 -
4N70
1
PIM1_HUMAN
A:
[47-321]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
38
PsiBlast_CBE
90.77
100%
-129
- C1 -
3R02
4
PIM1_HUMAN
A:
[8-278]
-----------------------------------------------------------------------------------------------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
13
PsiBlast_CBE
90.67
99%
-125
- C1 -
3BWF
1
PIM1_HUMAN
A:
[33-305]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
48
PsiBlast_CBE
90.36
100%
-127
- C1 -
2O3P
3
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
12
PsiBlast_CBE
90.25
99%
-127
- C1 -
3CXW
2
PIM1_HUMAN
A:
[34-307]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
---
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
5
PsiBlast_PDB
90.08
98%
-127
- C1 -
4N6Y
1
PIM1_HUMAN
A:
[47-320]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
19
PsiBlast_CBE
89.99
99%
-123
- C1 -
2BIL
1
PIM1_HUMAN
B:
[33-306]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
4
PsiBlast_PDB
89.95
98%
-129
- C1 -
3T9I
1
PIM1_HUMAN
A:
[48-321]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
49
PsiBlast_CBE
89.60
100%
-125
- C1 -
1YXX
2
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
21
PsiBlast_CBE
89.39
99%
-126
- C1 -
4GW8
3
PIM1_HUMAN
A:
[34-306]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
31
PsiBlast_CBE
89.32
100%
-128
- C1 -
3UIX
2
PIM1_HUMAN
A:
[10-278]
-------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
----
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
10
PsiBlast_CBE
89.31
99%
-126
- C1 -
4ALV
2
PIM1_HUMAN
A:
[48-321]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
27
PsiBlast_CBE
89.12
100%
-126
- C1 -
3A99
1
PIM1_HUMAN
A:
[40-312]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
16
PsiBlast_CBE
88.96
99%
-131
- C1 -
2BZK
2
PIM1_HUMAN
B:
[33-305]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
-----
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
25
PsiBlast_CBE
88.86
100%
-127
- C1 -
1XR1
1
PIM1_HUMAN
A:
[19-295]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
S
-----
35
PsiBlast_CBE
88.70
100%
-126
- C1 -
3VBV
1
PIM1_HUMAN
A:
[8-278]
-----------------------------------------------------------------------------------------------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
----
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
20
PsiBlast_CBE
88.61
99%
-120
- C1 -
4ALU
2
PIM1_HUMAN
A:
[48-321]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
S
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
47
PsiBlast_CBE
88.47
100%
-124
- C1 -
2O63
4
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
46
PsiBlast_CBE
88.31
100%
-125
- C1 -
2O64
3
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
40
PsiBlast_CBE
88.12
100%
-125
- C1 -
3R00
2
PIM1_HUMAN
A:
[6-279]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
29
PsiBlast_CBE
88.09
100%
-127
- C1 -
4ENX
1
PIM1_HUMAN
A:
[10-278]
-------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
----
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
33
PsiBlast_CBE
87.61
100%
-126
- C1 -
3VBX
1
PIM1_HUMAN
A:
[8-278]
-----------------------------------------------------------------------------------------------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
----
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
37
PsiBlast_CBE
87.33
100%
-125
- C1 -
3R04
4
PIM1_HUMAN
A:
[8-278]
-----------------------------------------------------------------------------------------------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
15
PsiBlast_CBE
87.22
99%
-124
- C1 -
2C3I
2
PIM1_HUMAN
B:
[37-305]
-------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
------
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
42
PsiBlast_CBE
87.18
100%
-122
- C1 -
3JYA
1
PIM1_HUMAN
A:
[6-279]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
41
PsiBlast_CBE
86.99
100%
-122
- C1 -
4MBI
1
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
28
PsiBlast_CBE
86.65
100%
-128
- C1 -
4ENY
3
PIM1_HUMAN
A:
[10-278]
-------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
-
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
---------
R
V
P
M
E
V
V
L
L
K
K
V
S
S
---
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
9
PsiBlast_CBE
86.51
99%
-123
- C1 -
4ALW
3
PIM1_HUMAN
A:
[49-321]
----------------------------------------------------------------------------------------------------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
34
PsiBlast_CBE
86.40
100%
-126
- C1 -
3VBW
1
PIM1_HUMAN
A:
[8-278]
-----------------------------------------------------------------------------------------------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
----
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
----
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
30
PsiBlast_CBE
86.00
100%
-130
- C1 -
3UMW
2
PIM1_HUMAN
A:
[10-277]
-------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
-----
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
---------
43
PsiBlast_CBE
85.99
100%
-125
- C1 -
3JY0
1
PIM1_HUMAN
A:
[6-280]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
------
44
PsiBlast_CBE
85.86
100%
-124
- C1 -
3JXW
1
PIM1_HUMAN
A:
[6-279]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
32
PsiBlast_CBE
85.72
100%
-124
- C1 -
3VC4
2
PIM1_HUMAN
A:
[6-279]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
39
PsiBlast_CBE
85.40
100%
-124
- C1 -
3R01
3
PIM1_HUMAN
A:
[6-279]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
--
L
P
N
-
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
-
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
-----
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
------
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
59
HHSearch
64.42
61%
-134
* C1 *
2IWI
1
PIM2_HUMAN
A:
[33-289]
--------------------------------------------------------------------------------------------------------------------------------
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
-----------
V
T
C
P
L
E
V
A
L
L
W
K
V
G
A
GG
G
H
P
G
V
I
R
L
L
D
W
F
-----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
---
G
C
A
K
L
I
D
F
G
S
G
A
L
L
H
-
D
-
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
-----
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
------
Q
------
E
I
L
E
A
E
L
H
F
P
----
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
T
---------------------
61
HHSearch
46.25
33%
-127
- C1 -
4BKY
1
MELK_HUMAN
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
---------
D
-
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
----
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
-
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
-
E
Y
---
H
K
L
K
L
I
D
F
G
L
C
A
--------------
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
------
K
I
M
R
G
K
Y
D
V
P
----
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
--------------------
74
HHSearch
45.91
30%
-117
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-290]
----------------------------------------------------------------------------------------------------------------------------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
---
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
-
K
G
E
L
F
D
Y
L
T
E
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
-
D
D
---
M
N
I
K
L
T
D
F
G
F
S
C
Q
L
D
-
P
G
E
K
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
DN
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
------
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
SPEW
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
Y
--------------------
65
HHSearch
45.40
30%
-113
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[6-278]
-------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
--
G
V
S
-
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
----
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
-
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
-----
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
------
N
V
S
A
V
N
Y
E
F
E
DEYF
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
--------------------