@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_PIM3_H: (2014-08-19 )
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
Atome Classification :
(42 SA)
.........10........20........30........40........50........60........70........80.-.......90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240......------.250.......260.......270.......280.......290.......300........310.......320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
L
S
K
F
G
S
L
A
H
LCGPGGVDHL
P
V
K
ILQPAKA
D
K
E
S
F
E
K
A
Y
Q
V
G
A
V
LGSGGFGTVYAGSRIADG
L
P
V
A
V
K
H
V
V
K
E
R
V
T
E
WGSL-GG
A
T
V
P
L
E
V
V
L
L
R
KVGAAGG
A
R
G
V
I
R
L
L
D
W
F
ERPD
G
F
L
L
V
LERPE
P
A
Q
D
L
F
D
F
I
T
ERGAL
D
E
P
L
A
R
R
F
F
A
Q
V
L
A
A
V
R
H
C
H
SCGVVHRDIKDE
N
L
L
V
D
LRSG
E
L
K
L
I
DFGSG
A
L
L
KD
T
V
YTDFDGTRVYS
P
P
E
W
I
R
Y
H
RYHGRS
A
T
V
W
S
L
G
V
L
L
Y
D
M
VCGDIPFE
Q
D
------
E
E
I
L
R
G
R
L
L
F
RRRV
S
P
E
C
Q
Q
L
I
R
W
C
L
SLRPSERP
S
L
D
Q
I
AAHP
W
M
LGADGGVP-ESC
D
L
R
L
C
TL
D
P
D
DVASTTSSSESL
30
PsiBlast_CBE
90.91
75%
-138
- C1 -
4DTK
7
PIM1_HUMAN
A:
[4-261]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
----------------------------------
35
PsiBlast_CBE
90.46
75%
-129
- C1 -
4K18
1
PIM1_HUMAN
A:
[1-259]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
----------------------------------
2
PsiBlast_PDB
89.53
69%
-121
- C1 -
4JX7
2
PIM1_HUMAN
A:
[33-306]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
22
PsiBlast_CBE
89.14
71%
-120
- C1 -
1YXX
2
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
37
PsiBlast_CBE
89.09
75%
-130
- C1 -
4K0Y
1
PIM1_HUMAN
A:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
----------------------------------
7
PsiBlast_CBE
89.00
71%
-122
- C1 -
3VBV
1
PIM1_HUMAN
A:
[8-278]
------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
---
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
29
PsiBlast_CBE
88.98
71%
-121
- C1 -
1YWV
1
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
39
PsiBlast_CBE
88.94
75%
-131
- C1 -
3C4E
2
PIM1_HUMAN
D:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
----------------------------------
21
PsiBlast_CBE
88.83
71%
-121
- C1 -
2O3P
3
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
27
PsiBlast_CBE
88.79
71%
-121
- C1 -
1YXU
2
PIM1_HUMAN
A:
[5-277]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
13
PsiBlast_CBE
88.72
71%
-122
- C1 -
3A99
1
PIM1_HUMAN
A:
[40-312]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
10
PsiBlast_CBE
88.64
71%
-127
- C1 -
3R02
4
PIM1_HUMAN
A:
[8-278]
------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
23
PsiBlast_CBE
88.45
71%
-122
- C1 -
1YXV
2
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
24
PsiBlast_CBE
88.40
71%
-123
- C1 -
1YXU
2
PIM1_HUMAN
D:
[5-277]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
33
PsiBlast_CBE
88.24
71%
-121
- C1 -
1YXS
1
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
M
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
38
PsiBlast_CBE
88.11
75%
-130
- C1 -
4K1B
1
PIM1_HUMAN
A:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
----------------------------------
25
PsiBlast_CBE
88.00
71%
-122
- C1 -
1YXU
2
PIM1_HUMAN
C:
[6-277]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
41
PsiBlast_CBE
87.91
75%
-125
- C1 -
3C4E
2
PIM1_HUMAN
B:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
----------------------------------
43
PsiBlast_CBE
87.83
75%
-132
- C1 -
4AS0
1
PIM1_HUMAN
A:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
----------------------------------
3
PsiBlast_CBE
87.58
71%
-121
- C1 -
1XR1
1
PIM1_HUMAN
A:
[19-295]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
S
--------------
12
PsiBlast_CBE
87.45
71%
-122
- C1 -
3R00
2
PIM1_HUMAN
A:
[6-279]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
5
PsiBlast_CBE
86.99
71%
-122
- C1 -
3VBX
1
PIM1_HUMAN
A:
[8-278]
------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
---
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
9
PsiBlast_CBE
86.98
71%
-122
- C1 -
3R04
4
PIM1_HUMAN
A:
[8-278]
------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
17
PsiBlast_CBE
86.77
71%
-122
- C1 -
3JXW
1
PIM1_HUMAN
A:
[6-279]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
40
PsiBlast_CBE
86.73
75%
-128
- C1 -
3C4E
2
PIM1_HUMAN
C:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
----------------------------------
42
PsiBlast_CBE
86.56
75%
-128
- C1 -
3C4E
2
PIM1_HUMAN
A:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
----------------------------------
18
PsiBlast_CBE
86.53
71%
-118
- C1 -
2O65
2
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
20
PsiBlast_CBE
86.50
71%
-120
- C1 -
2O63
4
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
15
PsiBlast_CBE
85.99
71%
-119
- C1 -
3JYA
1
PIM1_HUMAN
A:
[6-279]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
26
PsiBlast_CBE
85.59
71%
-118
- C1 -
1YXU
2
PIM1_HUMAN
B:
[5-277]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
19
PsiBlast_CBE
85.43
71%
-121
- C1 -
2O64
3
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
16
PsiBlast_CBE
85.32
71%
-121
- C1 -
3JY0
1
PIM1_HUMAN
A:
[6-280]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
---------------
4
PsiBlast_CBE
85.32
71%
-119
- C1 -
3VC4
2
PIM1_HUMAN
A:
[6-279]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
28
PsiBlast_CBE
85.12
71%
-115
- C1 -
1YXT
1
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
6
PsiBlast_CBE
84.34
71%
-122
- C1 -
3VBW
1
PIM1_HUMAN
A:
[8-278]
------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
----
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
---
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
14
PsiBlast_CBE
84.29
71%
-118
- C1 -
4MBI
1
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
11
PsiBlast_CBE
84.08
71%
-121
- C1 -
3R01
3
PIM1_HUMAN
A:
[6-279]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
34
PsiBlast_CBE
83.68
71%
-108
- C1 -
3F2A
1
PIM1_HUMAN
A:
[19-295]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
S
--------------
32
PsiBlast_CBE
82.44
71%
-114
- C1 -
4IAA
1
PIM1_HUMAN
A:
[9-281]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
31
PsiBlast_CBE
80.59
71%
-114
- C1 -
4MED
1
?
A:
[9-281]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
55
HHSearch
70.70
63%
-129
- C1 -
2IWI
1
PIM2_HUMAN
A:
[33-289]
---------------------------------------
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
--------
V
T
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
H
P
G
V
I
R
L
L
D
W
F
-----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
C
A
K
L
I
D
F
G
S
G
A
L
L
H
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
------
Q
E
I
L
E
A
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
T
--------------------------------
57
HHSearch
50.77
34%
-123
- C1 -
4BKY
1
MELK_HUMAN
A:
[4-267]
-------------------------------
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--
D
-----
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
----
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
-
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
-
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
-------------------------------