@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_ST32C_: (2014-08-19 )
MRSGAERRGSSAAASPGSPPPGRARPAGSDAPSALPPPAAGQPRARDSGDVRSQPRPLFQWSKWKKRMGSSMSAATARRPVFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRLSSLQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKNKSRDNSRDSSQSENDYLQDCLDAIQQDFVIFNREKLKRSQDLPREPLPAPESRDAAEPVEDEAERSALPMCGPICPSAGSG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110---.---.---.....120.......130.......140..-....-.150.......160.......170.......180..-.....190.......200.......-210........220.......230.......-240-....-..-..250.......260.......270.......280.......290.......300.......310.......---.320.......330.......340----.----.-----.-----.....350.......360.......370....----...380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRS
G
A
ERRGSSAAASPGSPPPGRARPAGSDAPSALPPPAAGQPRARDSGDVRSQPRPL
F
Q
W
S
K
W
K
K
RMGSSMSAATARRPVFDDKEDVN
F
D
H
F
Q
I
L
R
A
I
GKGSFG
K
V
C
I
V
QK---R---D---
T
E
K
M
Y
A
M
K
YM
N
K
Q
Q
CI
E
R
D
E
V
R
N
V
F
R
E
L
E
I
-
L
Q
E
I
-
E
H
V
F
L
V
N
L
W
Y
SFQDEE
D
M
F
M
V
V
D
L
L
LGG
D
L
R
Y
H
L
Q
Q-NVQFSED
T
V
R
L
Y
I
C
E
M
A
L
A
L
D
Y
L
RG-Q-
H
I
IHRDVKPD
N
I
L
LDERGHAHLTDF
N
I
A
T
-
I
-
I
-KDGE-RA-TALAGTKPYM
A
P
E
I
F
H
S
F
VNGGTG
Y
S
F
E
V
D
W
W
S
V
G
V
M
A
Y
E
L
L
RGWRPYDIHS
S
N
A
V
E
S
L
V
Q
L
F
S
-T
V
S
V
Q
YV---PTW
S
K
E
M
V
A
L
L
R
K
L
LTVN
P
E
H
R
L
-----
S
----
S
-----
L
-----
Q
D
V
Q
A
A
P
A
L
A
G
V
L
W
D
H
L
S
EKRVEPGFVPNKG
R
----
L
HCDP
T
F
E
L
E
E
M
I
L
ESRP
L
H
K
K
K
K
R
L
AKNKSRDNSRDSSQS
E
N
D
Y
L
Q
D
C
L
D
A
I
Q
Q
D
F
V
I
F
N
R
E
K
L
K
R
SQDLPREPLPAPESRDAAEP
V
E
D
E
A
E
RSALPMCGPICPSAGSG
32
HHSearch
66.49
36%
-122
- C1 -
4GV1
5
AKT1_HUMAN
A:
[4-290]
--------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
-
E
G
I
-
K
D
G
A
-
T
M
-
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
---
Q
D
H
E
K
L
F
E
L
I
L
-
M
E
E
I
R
F
P
---
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGS
E
D
-----
A
-----
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
-------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
61.96
34%
-118
- C1 -
3CQU
2
AKT1_HUMAN
A:
[7-290]
---------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
-
E
G
I
-
K
D
G
A
-
T
M
-
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
L
-
M
E
E
I
R
F
P
---
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
-----
G
----
G
GS
E
D
-
A
-----
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
---------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
61.18
34%
-119
- C1 -
3OW4
2
AKT1_HUMAN
A:
[6-289]
---------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
-
E
G
I
-
K
D
G
A
-
T
M
-
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
L
-
M
E
E
I
R
F
P
---
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
-----
G
----
G
GS
E
D
-
A
-----
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
---------------------------------------------------------------------------------------------------------------------
36
HHSearch
60.53
32%
-120
- C1 -
1RDQ
4
KAPCA_MOUSE
E:
[37-319]
--------------------------------------------------------------------------------------
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
-
R
-
V
-
K
G
---
R
T
-
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
-----
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
---
Q
P
I
Q
I
Y
E
K
I
V
-
S
G
K
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
-----
G
NLKN
G
-----
V
-----
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
60.51
34%
-117
- C1 -
3MV5
2
AKT1_HUMAN
A:
[7-290]
---------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
-
E
G
I
-
K
D
G
A
-
T
M
-
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
L
-
M
E
E
I
R
F
P
---
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
-----
G
----
G
GS
E
D
-
A
-----
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
---------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.23
34%
-129
- C1 -
3A8W
1
KPCI_HUMAN
A:
[11-299]
--------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
---
T
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
----
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
-
L
-
R
P
G
D
-
T
T
-
S
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
-----
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
-----
T
E
D
Y
L
F
Q
V
I
L
-
E
K
Q
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
GCHPQ
T
----
G
-----
F
-----
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
---------------------------------------------------------------------------------------------------------------------
44
HHSearch
59.62
32%
-109
- C1 -
4AW2
3
MRCKA_RAT
A:
[70-371]
--------------------------------------------------------------------------------------
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
---
K
---
N
---
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
-
L
V
N
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
-
K
-
L
-
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
G
G
K
G
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
--
S
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
F
Q
F
P
TQV
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
R
L
-----
G
QN--
G
-----
I
-----
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
E
V
S
S
----
P
T
D
T
S
N
F
D
------------------------------------------------------------------------------------------------------
41
HHSearch
58.63
36%
-121
- C1 -
4DC2
2
KPCI_MOUSE
A:
[49-343]
---------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
---
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
----
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
-
E
G
L
-
R
P
G
D
-
T
T
-
S
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
-----
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
G
S
N
T
E
D
Y
L
F
Q
V
I
L
-
E
K
Q
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
-----
G
----
C
HPQT
G
F
-----
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
--------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
57.57
34%
-122
- C1 -
3ZH8
3
KPCI_HUMAN
A:
[7-295]
--------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
---
T
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
-
E
G
L
-
R
P
G
D
-
T
T
-
S
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
-----
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
--
N
T
E
D
Y
L
F
Q
V
I
L
-
E
K
Q
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
GCHPQ
T
----
G
-----
F
-----
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
---------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
56.66
36%
-105
- C1 -
4NW5
1
?
A:
[32-323]
--------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
R
T
K
M
-
E
R
D
I
-
L
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-
E
-
S
-
I
D
H
E
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
-
L
G
M
P
Q
F
L
------
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
-----
G
----
A
GPD
G
-
V
-----
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----T---
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
54.83
36%
-103
- C1 -
4NW6
1
?
A:
[32-323]
--------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
R
T
K
M
-
E
R
D
I
-
L
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-
E
-
S
-
I
D
H
E
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
-
L
G
M
P
Q
F
L
------
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
-----
G
----
A
GPD
G
-
V
-----
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----T---
F
Y
F
D
P
---------------------------------------------------------------------------------------------------------
34
HHSearch
51.95
35%
-122
- C1 -
2R5T
1
SGK1_HUMAN
A:
[33-320]
-------------------------------------------------------------------------------------
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
-
E
N
I
-
E
H
N
S
-
T
T
-
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
---
N
T
A
E
M
Y
D
N
I
L
-
N
K
P
L
Q
L
K
---
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
-----
G
----
A
KDD--
F
-----
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------------------------------------------------------------------
35
HHSearch
51.69
34%
-110
- C1 -
3TXO
1
A:
[23-321]
------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
---
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
-
L
S
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
-
E
-
G
I
C
-----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-----
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
---
N
E
D
D
L
F
E
A
I
L
-
N
D
E
V
V
Y
P
---
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
-----
G
----
S
-----
L
TQGG
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
REDV
S
N
F
D
P
D
F
I
K
E
----------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
50.75
35%
-112
- C1 -
3G51
1
KS6A3_MOUSE
A:
[5-304]
-----------------------------------------------------------------------
I
K
E
I
A
I
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
----------
I
-
L
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-
E
-
S
-
I
------------
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
-
L
G
M
P
Q
F
L
------
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
-----
G
----
A
GPD
G
-
V
-----
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------
53
HHSearch
48.54
37%
-114
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[17-304]
-----------------------------------------------------------------------------------
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
---
I
---
S
GSD
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
-------
D
I
-
L
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-
E
------
K
-
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
---
D
R
K
E
T
M
T
M
I
L
-
K
A
K
L
G
M
P
---
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
-----
G
AGPD
G
-----
V
-----
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
43.24
37%
-111
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[29-308]
-------------------------------------------------------------------------------------------
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
---
S
G
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
------------
I
-
L
A
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
-
L
G
M
P
Q
F
L
---
S
T
---
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
-----
G
----
S
GPDG-
A
-----
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
42.88
37%
-116
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[29-308]
-------------------------------------------------------------------------------------------
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
---
S
G
H
L
Y
A
M
K
V
L
K
------------------
I
-
L
A
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
-
L
G
M
P
Q
F
L
---
S
T
---
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
-----
G
----
S
GPD
G
-
A
-----
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
42.81
36%
-100
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[8-305]
------------------------------------------------------------------------
E
I
A
I
T
H
H
-
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
R
------
D
I
-
L
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-
E
-
S
----
E
K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
-
L
G
M
P
Q
F
L
------
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
-----
G
----
A
GPD
G
-
V
-----
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
40.39
36%
-101
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[7-305]
-----------------------------------------------------------------------
K
E
I
A
I
T
H
H
-
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
----------
L
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-
E
-------K
K
A
-
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
-
L
G
M
P
Q
F
L
------
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
-----
G
----
A
GPD
G
-
V
-----
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
40.30
37%
-116
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[29-308]
-------------------------------------------------------------------------------------------
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
---
S
G
H
L
Y
A
M
K
V
L
-------------------
I
-
L
A
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
-
L
G
M
P
Q
F
L
---
S
T
---
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
-----
G
----
S
GPD
G
-
A
-----
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------