@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_STK25_: (2014-08-19 )
MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHNRNHLTSTR
Atome Classification :
(19 SA)
------------------------------------------------.........10..--......20...-.....30........40........50.....-...60........70........80......--..90........100--......-----.-110.......120.......130..-.....140.......150-.......160.......170.......180.....-----.-----.190.......200.......210.......220.------..---------....230...--.--...240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------M
A
H
L
R
G
F
A
N
QHSR--V
D
P
E
E
L
F
T
K
L
D
-
R
IGKG
S
F
G
E
V
Y
K
G
IDNHT
K
E
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
QCD
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
--S
T
K
L
W
I
I
M
E
Y
LGGG
S
--
A
L
DLLK-----P-GPL
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
H
R
D
I
K
A
A
N
V
L
LSEQG-
D
V
K
L
ADFGVAGQLTD
T
Q
I
KRNTFVGT
P
F
WM
A
P
E
V
I
-----
K
-----QSAYDF
K
A
D
I
W
S
LG
I
T
A
I
E
LAKGEPPNSDLH
P
M
R
V
------
L
F
---------
L
I
PKNSPPTL--E--GQHSK
P
F
K
E
F
V
E
A
C
LNKDPRFR
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
KSEGHGEESSSEDSDIDGEAEDGEQGPIWTFPPTIRPSP
H
S
K
LHKGTALHSSQKPA
E
P
V
KRQ
P
R
S
Q
C
L
S
T
L
V
R
P
V
F
G
E
L
K
E
K
H
K
QSGGSVG
A
L
E
E
L
E
N
A
F
S
L
A
E
ESCPG
I
S
D
K
L
M
V
H
L
V
E
R
V
Q
R
FSHNRNHLTSTR
1
PsiBlast_PDB
97.39
99%
-94
- C1 -
2XIK
2
STK25_HUMAN
A:
[4-293]
--------------------------------------------------
H
L
R
G
F
A
N
Q
H
S
R
--
V
D
P
E
E
L
F
T
K
L
D
-
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
-
E
-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
--
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
K
-----
P
-
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
------
L
F
---------
L
I
P
K
N
S
P
P
T
L
--
E
--
G
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
--------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
89.62
84%
-98
- C1 -
4FZD
1
MST4_HUMAN
B:
[3-283]
------------------------------------------------------------
M
--
A
D
P
E
E
L
F
T
K
L
E
-
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
R
-----
A
-
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
------
L
F
---------
L
I
P
K
N
N
P
P
T
L
--
V
--
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
89.30
84%
-86
- C1 -
3A7I
1
STK24_HUMAN
A:
[13-299]
--------------------------------------------------------
M
Q
N
L
K
--
A
D
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
E
-----
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
------
L
F
---------
L
I
P
K
N
N
P
P
T
L
--
E
--
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
-----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.44
85%
-88
- C1 -
3A7H
1
STK24_HUMAN
A:
[14-298]
---------------------------------------------------------
Q
N
L
K
--
A
D
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
E
-----
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
------
L
F
---------
L
I
P
K
N
N
P
P
T
L
--
E
--
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.54
85%
-88
- C1 -
3A7J
1
STK24_HUMAN
A:
[14-299]
---------------------------------------------------------
Q
N
L
K
--
A
D
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
E
-----
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
------
L
F
---------
L
I
P
K
N
N
P
P
T
L
--
E
--
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
-----------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.09
87%
-89
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-282]
-----------------------------------------------------------------
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
E
-----
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
------
L
F
---------
L
I
P
K
N
N
P
P
T
L
--
E
--
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
86.12
84%
-97
- C1 -
3GGF
1
MST4_HUMAN
A:
[18-300]
------------------------------------------------------------
I
--
A
D
P
E
E
L
F
T
K
L
E
-
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
R
-----
A
-
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
V
K
L
A
D
F
G
V
A
---------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
------
L
F
---------
L
I
P
K
N
N
P
P
T
L
--
V
--
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
-----------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
85.30
84%
-93
- C1 -
4FZF
1
?
B:
[3-283]
------------------------------------------------------------
M
--
A
D
P
E
E
L
F
T
K
L
E
-
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
R
-----
A
-
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
------
L
F
---------
L
I
P
K
N
N
P
P
T
L
--
V
--
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
84.97
84%
-90
- C1 -
4FZA
3
MST4_HUMAN
B:
[3-283]
------------------------------------------------------------
M
--
A
D
P
E
E
L
F
T
K
L
E
-
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
R
-----
A
-
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
------
L
F
---------
L
I
P
K
N
N
P
P
T
L
--
V
--
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.04
84%
-99
- C1 -
3GGF
1
MST4_HUMAN
B:
[19-298]
---------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
-
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
R
-----
A
-
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
V
K
L
A
D
F
G
V
A
----------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
------
L
F
---------
L
I
P
K
N
N
P
P
T
L
--
V
--
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
65.75
45%
-89
- C1 -
3FXZ
1
?
A:
[17-293]
----------------------------------------------------------------
D
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
-
P
-
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
T
-----
E
-
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
-
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
------
L
Y
---------
L
I
A
T
N
G
T
P
E
L
--
Q
NP
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
-
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
---------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
62.03
44%
-92
- C1 -
2J7T
1
STK10_HUMAN
A:
[13-297]
-----------------------------------------------------------
R
D
--
L
D
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
--
V
D
A
I
M
L
E
L
---
D
-
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
-----
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
------
L
L
---------
K
I
A
K
S
D
P
P
T
L
LT
P
--
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
-
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
-----------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
59.51
43%
-82
- C1 -
4AOT
1
STK10_HUMAN
A:
[2-296]
------------------------------------------------
M
R
K
S
R
E
Y
E
H
V
R
R
D
--
L
D
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
-
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-----
D
-
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
I
R
L
A
D
F
G
V
S
A
-------------
G
T
P
Y
W
M
A
P
E
V
V
M-------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
------
L
L
---------
K
I
A
K
S
D
P
P
T
L
LT
P
--
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
57.82
37%
-93
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[37-331]
-----------------------------------------------------------------------
K
I
S
-
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
V
L
K
-----
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
GC--PMA
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P-
S
--
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
56.16
43%
-83
- C1 -
4EQU
2
STK10_HUMAN
A:
[9-296]
-------------------------------------------------------
E
H
V
R
R
D
--
L
D
P
N
E
V
W
E
I
V
G
-
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--------
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-----
D
-
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
------
L
L
---------
K
I
A
K
S
D
P
P
T
L
LT
P
--
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
55.98
44%
-78
- C1 -
4BC6
2
STK10_HUMAN
A:
[1-288]
---------------------------------------------------------
E
H
V
R
RD
L
D
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
-
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-----
D
-
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
------
L
L
---------
K
I
A
K
S
D
P
P
T
L
LT
P
--
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
54.24
85%
-44
- C1 -
3A7H
1
STK24_HUMAN
B:
[14-298]
---------------------------------------------------------
Q
N
L
K
--
A
D
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
E
-----
P
-
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
------
L
F
---------
L
I
P
K
N
N
P
P
T
L
--
E
--
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
50.81
30%
-65
- C1 -
4DN5
7
M3K14_HUMAN
A:
[8-351]
S
V
E
E
Y
L
V
H
A
L
QG
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
RSREPSPKTE
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
--
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
-------
F
R
A
E
E
L
M
A
C
A
G
L
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
--
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
--
L
G
Q
L
V
K
-----
E
Q
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
--------
I
P
G
T
E
T
H
M
A
P
E
V
V
-----
L
-----
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
F
F
R
G
P
L
------
C
L
---------
K
I
A
S
E
P
P
P
V
R
--
E
IP
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
-
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
-------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
50.76
30%
-101
- C1 -
2W5A
5
NEK2_HUMAN
A:
[8-272]
---------------------------------------------------------------------
Y
E
V
L
Y
-
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
--
L
A
S
V
I
T
K
G
T
K
E
R
-
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
-
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-----
N
-----
R
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
------
A
G
---------
K
I
R
E
G
K
F
R
R
I
--
P
--
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------