@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_STK3_H: (2014-08-20 )
MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.---.--.....---.70.-.......80........90........100.......110.----......120.......130.......140........150.......160.......170.......180.......190.-----.-----.....200.......210.......220.....--..230----------........240.--......250.......260.......270......-.--280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEQPPA
P
K
S
K
L
K
K
L
S
E
D
SLTK
Q
P
E
E
V
F
D
V
L
E
K
LGEGS
Y
G
S
V
F
K
A
I
H
KESG
Q
V
V
A
I
K
QVP
V
E
S
---
D
--
L
Q
E
I
I
---
K
E
I
S
-
I
M
Q
QCDS
P
Y
V
V
K
Y
Y
G
S
YFKNT
D
L
W
I
V
M
EYCGAG
S
V
S
D
I
I
R
L----RNKT
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
-
R
K
I
H
R
D
IKAG
N
I
L
L
NTEGH
A
K
LADFGVA
G
Q
L
T
D
T
M
AKRNTVIGT
P
F
WM
A
P
E
V
I
-----
Q
-----
E
IG
Y
N
C
V
A
D
I
W
S
LGI
T
S
I
EMAEGKPPYADIH
P
M
--
R
A
I
F
-----------
M
I
PTNPPPTFRK--PELW
S
D
D
F
T
D
F
V
K
K
C
L
VKNP
E
Q
R
A
T
A
T
Q
L
L
QHPFI-K--NA
K
P
V
S
I
L
R
D
L
I
T
E
A
M
E
I
K
A
K
R
H
E
E
Q
Q
R
E
L
E
EEEENS
D
E
D
ELDS
H
T
M
V
K
T
S
V
E
S
VGTMRAT
S
T
M
S
E
G
A
Q
T
M
I
EHN
S
T
M
L
ESDL
G
T
M
V
INSEDEEEEDGTMKRNATSPQVQR
P
S
F
M
D
Y
F
D
K
Q
DFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDG
D
F
D
F
L
K
NL
S
L
E
E
L
Q
M
R
L
K
AL
D
P
M
M
E
R
E
I
E
E
L
R
Q
R
YTAKRQP
I
L
D
A
M
D
A
K
K
R
R
QQNF
8
PsiBlast_PDB
78.31
54%
-90
- C1 -
3A7I
1
STK24_HUMAN
A:
[15-298]
-----------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
--
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
--
L
----
E
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
--
N
--
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
--
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.30
54%
-88
- C1 -
3A7H
1
STK24_HUMAN
A:
[15-298]
-----------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
--
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
--
L
----
E
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
--
N
--
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
--
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
77.80
54%
-91
- C1 -
3A7J
1
STK24_HUMAN
A:
[15-298]
-----------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
--
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
--
L
----
E
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
--
N
--
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
--
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.79
54%
-91
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-283]
----------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-------
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
--
L
----
E
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
--
N
--
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
--
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
77.48
38%
-96
- C1 -
4FIE
1
PAK4_HUMAN
A:
[151-420]
------------------------
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
QQ-
R
--
R
E
L
L
F
---
N
E
V
V
-
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
--
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.78
55%
-97
- C1 -
4FZD
1
MST4_HUMAN
B:
[6-282]
----------------------
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
--
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
--
L
----
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
--
R
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
V
G
--
D
--
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
--
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
75.56
44%
-103
- C1 -
4AOT
1
STK10_HUMAN
A:
[17-295]
----------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
---
E
E
E
L
E
D
Y
I
---
V
E
I
E
-
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-------------
G
T
P
Y
W
M
A
P
E
V
V
M-------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
--
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
--
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.34
55%
-89
- C1 -
4FZA
3
MST4_HUMAN
B:
[6-282]
----------------------
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
--
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
--
L
----
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
--
R
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
V
G
--
D
--
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
--
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.11
55%
-86
- C1 -
4FZF
1
?
B:
[6-282]
----------------------
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
--
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
--
L
----
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
--
R
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
V
G
--
D
--
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
--
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.84
55%
-96
- C1 -
3GGF
1
MST4_HUMAN
A:
[21-300]
----------------------
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
--
E
D
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
--
L
----
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
---------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
--
R
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
V
G
--
D
--
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
--
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
74.17
44%
-98
- C1 -
3FXZ
1
?
A:
[17-292]
---------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
QP-
K
--
K
E
L
I
I
---
N
E
I
L
-
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
--
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
74.02
44%
-95
- C1 -
2J7T
1
STK10_HUMAN
A:
[16-297]
---------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--
E
---
E
--
L
E
D
Y
I
---
V
E
I
E
-
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
-----
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
--
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
--
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.26
54%
-89
- C1 -
2XIK
2
STK25_HUMAN
A:
[17-285]
----------------------
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
---
A
--
E
-
E
I
E
D
I
Q
Q
E
I
T
-
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
--
L
----
K
P
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
--
R
V
L
F
-----------
L
I
P
K
N
S
P
P
T
L
E
G
--
Q
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
--
Y
T
K
K
T
S
F
L
T
E
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
73.05
44%
-97
- C1 -
4BC6
2
STK10_HUMAN
A:
[9-287]
----------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
---
E
E
E
L
E
D
Y
I
---
V
E
I
E
-
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
--
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
--
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
72.14
44%
-98
- C1 -
4EQU
2
STK10_HUMAN
A:
[17-295]
----------------------
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---------
L
E
D
Y
I
---
V
E
I
E
-
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
--
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
--
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.90
43%
-93
- C1 -
2J51
5
SLK_HUMAN
A:
[35-312]
----------------------
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
---
E
EE
L
E
D
Y
M
---
V
E
I
D
-
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----
L
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
-----
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
E
P
P
T
L
A
Q
--
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
VD
S
N
K
P
I
---
R
E
L
I
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
70.84
39%
-99
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[32-333]
-----------------------
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
--
R
N
Q
I
I
---
R
E
L
Q
-
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
-----
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
GCPMA
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
--
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
70.21
39%
-90
- C1 -
4JDI
2
?
A:
[72-342]
----------------------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
QQ-
R
--
R
E
L
L
F
---
N
E
V
V
-
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
------
T
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
--
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
68.91
40%
-94
* C1 *
4KS7
2
A:
[20-286]
---------------------
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
QQ-
R
--
R
E
L
L
F
---
N
E
V
V
-
I
M
R
D
Y
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
------
S
Q
V
R
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
S
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
--
Q
A
M
K
-----------
R
L
R
D
S
P
P
P
K
L
K
N
--
S
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
-
L
--
Q
T
G
L
P
E
C
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
62.98
37%
-100
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[22-292]
------------------------
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
DEK
E
--
Q
K
Q
L
L
---
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
L
M
S
-
T
S
F
D
K
F
Y
K
Y
V
Y
SV
L
D
D
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
-------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
--------
T
-----------
Q
V
V
K
G
D
P
P
Q
L
S
N
SE
E
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
-
L
--
M
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------