@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_TAOK1_: (2014-08-20 )
MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT
Atome Classification :
(18 SA)
.........10........20........30........40........50........60........70........80........90........100.......-110........120.......130.......140.......150.......160.......170......----.----180---........190.......200.......210.......220.......230.......240....-.-..-250.......260.......270.......280.....-.-.290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPSTNRAGSLKD
P
E
I
A
E
L
F
F
KE
D
P
E
K
L
F
T
D
L
R
E
IGHGSF
G
A
V
Y
F
A
RDVRTN
E
V
V
A
I
K
K
MSYSGKQS
T
E
K
W
Q
D
I
I
K
E
V
K
F
L
Q
R
IKHPNSIEYK
G
C
Y
L
R
E
H
T
A
W
L
V
M
E
Y
C
L-G-
S
A
S
D
L
L
E
V
H
K
K
P
L
Q
E
V
E
I
A
A
I
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
T
M
I
H
R
DIKAG
N
I
L
LTEPG
Q
V
K
L
ADFGSASMASP----
A
----
N
S----FVGTPYWMA
P
E
V
I
L
A
MDEGQYDG
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
ERKPPLF
N
M
N
A
M
S
A
L
Y
H
I
AQNESPTLQ-S-N
E
-
W
S
D
Y
F
R
N
F
V
D
S
C
L
Q
KIPQDRP
T
S
E
E
L
L
K
H
I
F
V
L
RERP
E
-
T
-
V
L
I
D
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
L
L
F
Q
EAHNGPAVEA
Q
E
E
E
E
E
Q
DHGVGRTGTVNSVGSNQSIP
S
M
S
I
SASSQSSSVNSLPDVSD
D
K
S
E
L
D
MMEGD
H
T
VMSNS
S
V
I
H
LKPEEENYREEGDPRTRASDPQSP
P
Q
V
S
R
H
K
S
H
YRN
R
E
H
F
A
T
I
R
T
A
S
L
V
T
R
Q
M
Q
E
H
E
Q
D
S
E
L
R
E
Q
M
S
G
Y
K
R
M
R
R
Q
H
Q
K
Q
L
M
T
L
E
N
K
L
K
A
E
M
D
E
H
R
L
RLDK
D
L
E
T
Q
RN
N
F
A
A
E
M
E
K
L
I
K
K
H
Q
A
A
M
E
K
E
A
K
V
MS
N
E
E
K
K
F
Q
Q
H
I
Q
A
Q
Q
K
K
E
L
N
S
F
L
E
S
Q
K
R
E
Y
K
L
R
K
E
Q
L
K
E
E
L
NENQST
P
K
K
E
K
Q
E
W
L
S
K
Q
K
E
N
I
Q
H
F
Q
A
E
E
E
A
N
L
L
R
R
Q
R
Q
Y
L
E
L
E
C
R
R
F
K
R
R
M
L
LGRH
N
L
E
Q
D
L
V
R
E
E
L
N
K
R
Q
T
Q
K
D
L
E
H
A
M
L
L
R
Q
H
E
S
M
Q
E
L
E
F
R
H
L
N
T
I
Q
K
M
R
C
E
L
I
R
L
Q
H
Q
T
E
L
T
N
Q
L
E
Y
N
K
R
R
E
R
E
L
R
R
K
H
V
M
E
V
R
QQ
P
K
SL
K
S
K
E
L
Q
I
K
K
Q
F
Q
D
T
C
K
I
Q
T
R
Q
Y
K
A
L
R
N
H
L
LETTP
K
S
E
H
K
A
V
L
K
R
L
K
E
E
Q
T
R
K
L
A
I
L
A
E
Q
Y
D
H
S
I
N
E
M
L
S
T
Q
A
LRLDEA
Q
E
A
E
C
Q
V
L
K
M
Q
L
Q
Q
E
L
E
L
L
N
A
Y
Q
S
K
I
K
M
Q
A
E
A
Q
H
D
R
E
L
R
E
L
E
Q
R
V
S
L
R
R
A
L
L
E
Q
K
I
E
E
E
M
L
A
L
Q
N
E
R
T
E
R
I
R
S
L
L
E
R
Q
A
R
E
I
E
AFDSE
S
M
RLG
F
S
N
M
V
L
SNL
S
P
E
A
FSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNS
P
Q
A
L
R
R
TASGGRTEQGMSRST
S
V
T
SQISNGSHMSYT
2
PsiBlast_PDB
98.42
88%
-85
- C1 -
1U5R
1
TAOK2_RAT
A:
[40-348]
-----------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
W
L
V
M
E
Y
C
L
-
G
-
S
A
S
D
L
L
E
V
H
K
K
P
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P
G
L
V
K
L
G
D
F
G
S
A
S
I
M
A
P
----
A
----
N
S
----
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
M
D
E
G
Q
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
A
Q
N
E
S
P
A
L
Q
-
S
-
G
H
-
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
R
E
R
P
P
-
T
-
V
I
M
D
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
96.15
88%
-85
- C1 -
2GCD
1
TAOK2_RAT
A:
[1-309]
-----------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
W
L
V
M
E
Y
C
L
-
G
-
S
A
S
D
L
L
E
V
H
K
K
P
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P
G
L
V
K
L
G
D
F
G
S
A
S
I
M
A
P
----
A
----
N
S
----
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
M
D
E
G
Q
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
A
Q
N
E
S
P
A
L
Q
-
S
-
G
H
-
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
R
E
R
P
P
-
T
-
V
I
M
D
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
80.46
88%
-53
- C1 -
1U5R
1
TAOK2_RAT
B:
[40-348]
-----------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
W
L
V
M
E
Y
C
L
-
G
-
S
A
S
D
L
L
E
V
H
K
K
P
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P
G
L
V
K
L
G
D
F
G
S
A
S
I
M
A
P
----
A
----
N
-----
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
M
D
E
G
Q
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
A
Q
N
E
S
P
A
L
Q
-
S
-
G
H
-
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
R
E
R
P
P
-
T
-
V
I
M
D
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
77.27
88%
-53
- C1 -
2GCD
1
TAOK2_RAT
B:
[1-309]
-----------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
W
L
V
M
E
Y
C
L
-
G
-
S
A
S
D
L
L
E
V
H
K
K
P
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P
G
L
V
K
L
G
D
F
G
S
A
S
I
M
A
P
----
A
----
N
-----
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
M
D
E
G
Q
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
A
Q
N
E
S
P
A
L
Q
-
S
-
G
H
-
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
R
E
R
P
P
-
T
-
V
I
M
D
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
69.25
43%
-73
- C1 -
3FXZ
1
?
A:
[12-293]
-----------------
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
L
T
D
V
V
T
--
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
EQSK
R
----
S
T
----
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
-
N
P
E
K
-
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-
S
-
S
L
T
P
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
68.15
49%
-69
* C1 *
3A7I
1
STK24_HUMAN
A:
[15-294]
------------------
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
--
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
A
L
D
L
L
E
--
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
TQIK
R
----
N
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
K
---
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
E
---
G
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
66.58
37%
-67
- C1 -
4FIE
1
PAK4_HUMAN
A:
[145-421]
-------------------
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
---
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
-
A
L
T
D
I
V
T
--
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
EVPR
R
----
K
S
----
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
---
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
-
N
L
H
K
-
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
-
A
-
S
I
V
P
L
M
R
Q
N
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
63.26
42%
-66
- C1 -
3FY0
1
PAK1_HUMAN
A:
[17-293]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
---
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
-
G
G
S
L
T
D
V
--
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
----
E
----
Q
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
-
N
-
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-
S
-
S
L
T
P
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.31
47%
-60
- C1 -
3A7H
1
STK24_HUMAN
A:
[16-292]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
-
G
G
S
A
L
D
L
L
E
--
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
----
T
QIKR
N
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
---
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
E
-
G
-
N
--
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-
T
S
Y
L
T
E
L
I
D
R
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
61.86
39%
-76
- C1 -
4KS7
2
A:
[15-290]
-----------------
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
Q
Q
R
---
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
-
A
L
T
D
I
V
S
--
Q
V
R
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
DVPK
R
----
K
S
----
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
---
R
S
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
P
P
K
L
K
N
S
-
H
K
-
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
T
G
L
P
-
E
-
C
L
V
P
L
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.62
47%
-59
- C1 -
3A7J
1
STK24_HUMAN
A:
[16-292]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
-
G
G
S
A
L
D
L
L
E
--
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
----
T
QIKR
N
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
---
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
E
-
G
-
N
--
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-
T
S
Y
L
T
E
L
I
D
R
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.19
47%
-62
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-277]
-----------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
--
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
-
G
G
S
A
L
D
L
L
E
--
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
----
T
QIKR
N
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
---
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
E
-
G
-
N
--
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-
T
S
Y
L
T
E
L
I
D
R
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
58.68
37%
-64
- C1 -
4JDI
2
?
A:
[69-344]
--------------------
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
---
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
-
A
L
T
D
I
V
T
--
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
EVPR
R
----
K
S
----
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
---
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
-
N
L
H
K
-
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
-
A
-
S
I
V
P
L
M
R
Q
N
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
58.20
46%
-52
- C1 -
2XIK
2
STK25_HUMAN
A:
[16-289]
----------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
-
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
-
L
-
G
-
G
G
S
A
L
D
L
L
K
P
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
----
T
QIKR
N
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
---
K
Q
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
N
S
P
P
T
L
E
-
G
-
Q
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
-
T
S
F
L
T
E
L
I
D
R
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
55.43
44%
-47
- C1 -
4FZA
3
MST4_HUMAN
B:
[5-278]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
-
L
-
G
-
G
G
S
A
L
D
L
L
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
----
T
QIKR
N
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
---
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
-
G
D
-
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
-
T
S
Y
L
T
E
L
I
D
R
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
53.93
44%
-51
- C1 -
4FZD
1
MST4_HUMAN
B:
[5-278]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
-
L
-
G
-
G
G
S
A
L
D
L
L
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
----------
N
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
---
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
-
G
D
-
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
-
T
S
Y
L
T
E
L
I
D
R
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
53.89
44%
-49
- C1 -
4FZF
1
?
B:
[5-278]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
-
L
-
G
-
G
G
S
A
L
D
L
L
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
----
T
QIKR
N
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
---
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
-
G
D
-
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
-
T
S
Y
L
T
E
L
I
D
R
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
50.51
44%
-51
- C1 -
3GGF
1
MST4_HUMAN
A:
[20-293]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
-
L
-
G
-
G
G
S
A
L
D
L
L
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------R---
N
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
---
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
-
G
D
-
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
-
T
S
Y
L
T
E
L
I
D
R
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------