@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_TAOK3_: (2014-08-20 )
MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR
Atome Classification :
(18 SA)
.........10........20........30........40........50........60........70........80........90....-------....100..-.-.-...110.........120.......130.......140.......150.......160.......170.-.----.----....180.......190--.......200.......210.......220.......230.......240--..-......250.......260.......270....-...-280.........290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRKGVLKDP
E
I
A
D
L
FYKD
D
P
E
E
L
F
I
G
L
H
E
IGHGS
F
G
A
V
Y
F
A
TNAHT
S
E
V
V
A
I
K
KMSYSGKQ
T
H
E
K
W
Q
D
I
L
K
E
V
K
F
L
R
QLKHPNTIEYK
G
C
Y
L
K
E
H
-------
T
A
W
L
V
M
E
Y
C
-L-G-
S
A
S
D
--
L
L
E
V
H
K
K
P
L
Q
E
V
E
I
A
A
I
T
H
G
A
L
H
G
L
A
Y
L
H
S
H
A
L
I
H
R
DIKAG
N
I
L
LTEPG
Q
V
K
L
ADFGSASMAS-P----
A
----
N
SFVGTPYWMA
P
E
V
I
L
A
--MDEGQYDG
K
V
D
I
W
S
L
G
I
T
C
I
E
L
A
ERKPPLFN
M
N
A
M
S
A
L
Y
H
I
AQNDSPTL---QS-NE
W
T
D
S
F
R
R
F
V
D
Y
C
L
Q
KIPQERP
T
S
A
E
L
L
R
H
D
F
-VRR-D--R
P
L
R
V
L
I
D
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
ETRNGPLNESQEDEEDSEHGT
S
L
N
R
E
M
D
SLGSNHSIP
S
M
S
VSTGSQSS
S
V
N
S
M
Q
E
V
M
DESSS
E
L
V
M
M
HDDESTINSSS
S
V
V
HKK
D
H
V
F
I
RDEAGHGDPRPEPR
P
T
Q
S
V
Q
S
Q
A
L
H
Y
R
N
R
E
R
F
A
T
I
K
S
A
S
L
V
T
R
Q
I
H
E
H
E
Q
E
N
E
L
R
E
Q
M
S
G
Y
K
R
M
R
R
Q
H
Q
K
Q
L
I
A
L
E
N
K
L
K
A
E
M
D
E
H
R
L
K
L
Q
K
E
V
E
THANNSS
I
E
L
E
K
L
A
K
K
Q
V
A
I
IEKEAKVAAA
D
E
K
K
F
Q
Q
Q
I
L
A
Q
Q
K
K
D
L
T
T
F
L
E
S
Q
K
K
Q
Y
K
I
C
K
E
K
I
K
E
E
M
NEDHST
P
K
K
E
K
Q
E
R
I
S
K
H
K
E
N
L
QH
T
Q
A
E
E
E
A
H
L
L
T
Q
Q
R
L
Y
YDKN
C
R
F
F
K
R
K
I
M
I
K
RH
E
V
E
Q
Q
N
I
R
E
E
L
N
K
K
R
T
Q
K
E
M
E
H
A
M
L
I
RHDEST
R
E
L
E
Y
R
Q
L
H
T
L
Q
K
L
R
M
D
L
I
R
L
Q
H
Q
T
E
L
E
N
Q
L
E
Y
N
K
R
R
E
R
E
L
H
R
K
H
V
M
E
L
R
QQPKN
L
K
A
M
E
M
Q
I
K
K
Q
F
Q
D
T
C
K
V
Q
T
K
Q
Y
K
A
LKN
H
Q
L
E
VTPKN
E
H
K
T
I
L
K
T
L
K
D
E
Q
T
R
K
L
A
I
L
A
E
Q
Y
E
Q
S
I
N
E
M
M
A
S
Q
A
LRLDEAQE
A
E
C
Q
A
L
R
L
Q
L
Q
Q
E
M
E
L
L
N
A
Y
Q
S
K
I
K
M
Q
T
E
A
Q
H
E
R
E
L
Q
K
L
E
Q
R
V
S
L
R
R
A
H
L
E
Q
K
I
E
E
E
L
A
A
L
Q
K
E
R
S
E
R
I
K
N
L
L
E
R
Q
E
R
E
I
E
T
F
D
M
E
S
L
R
MGFG
N
L
V
T
L
DFPKEDYR
2
PsiBlast_PDB
97.27
81%
-87
- C1 -
1U5R
1
TAOK2_RAT
A:
[40-348]
-------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
-------
T
A
W
L
V
M
E
Y
C
-
L
-
G
-
S
A
S
D
--
L
L
E
V
H
K
K
P
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P
G
L
V
K
L
G
D
F
G
S
A
S
I
M
A
-
P
----
A
----
N
S
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
--
M
D
E
G
Q
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
A
Q
N
E
S
P
A
L
---
Q
S
-
G
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
-
V
L
R
-
E
--
R
P
P
T
V
I
M
D
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.75
81%
-86
- C1 -
2GCD
1
TAOK2_RAT
A:
[1-309]
-------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
-------
T
A
W
L
V
M
E
Y
C
-
L
-
G
-
S
A
S
D
--
L
L
E
V
H
K
K
P
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P
G
L
V
K
L
G
D
F
G
S
A
S
I
M
A
-
P
----
A
----
N
S
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
--
M
D
E
G
Q
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
A
Q
N
E
S
P
A
L
---
Q
S
-
G
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
-
V
L
R
-
E
--
R
P
P
T
V
I
M
D
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
77.26
81%
-54
- C1 -
1U5R
1
TAOK2_RAT
B:
[40-348]
-------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
-------
T
A
W
L
V
M
E
Y
C
-
L
-
G
-
S
A
S
D
--
L
L
E
V
H
K
K
P
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P
G
L
V
K
L
G
D
F
G
S
A
S
I
M
A
-
P
----
A
----
N
-
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
--
M
D
E
G
Q
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
A
Q
N
E
S
P
A
L
---
Q
S
-
G
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
-
V
L
R
-
E
--
R
P
P
T
V
I
M
D
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
73.26
81%
-53
- C1 -
2GCD
1
TAOK2_RAT
B:
[1-309]
-------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
-------
T
A
W
L
V
M
E
Y
C
-
L
-
G
-
S
A
S
D
--
L
L
E
V
H
K
K
P
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P
G
L
V
K
L
G
D
F
G
S
A
S
I
M
A
-
P
----
A
----
N
-
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
--
M
D
E
G
Q
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
A
Q
N
E
S
P
A
L
---
Q
S
-
G
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
-
V
L
R
-
E
--
R
P
P
T
V
I
M
D
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
65.24
41%
-77
- C1 -
3FXZ
1
?
A:
[11-292]
------------
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
-------
E
L
W
V
V
M
E
Y
L
-
A
G
G
-
S
L
T
D
--
V
V
T
--
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-
P
EQSK
R
----
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
---
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
--
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
64.86
38%
-77
- C1 -
4FIE
1
PAK4_HUMAN
A:
[144-420]
--------------
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
---
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
-------
E
L
W
V
V
M
E
F
L
-
E
G
G
-
A
L
T
D
--
I
V
T
--
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
EVPR
R
----
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
---
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
--
G
P
P
A
S
I
V
P
L
M
R
Q
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.73
46%
-69
- C1 -
3A7I
1
STK24_HUMAN
A:
[17-292]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
L
E
--
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-
D
----
T
QIKR
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
---
E
G
-
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
L
R
-
N
A-
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.66
46%
-71
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-277]
-------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
--
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
L
E
--
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-
D
----
T
QIKR
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
---
E
G
-
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
L
R
-
N
A-
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.96
46%
-67
- C1 -
3A7H
1
STK24_HUMAN
A:
[17-292]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
L
E
--
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-
D
----
T
QIKR
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
---
E
G
-
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
L
R
-
N
A-
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.68
46%
-63
- C1 -
2XIK
2
STK25_HUMAN
A:
[16-289]
------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
-
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
-------
K
L
W
I
I
M
E
Y
--
L
-
G
-
G
G
S
A
--
L
D
L
L
K
P
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
-
D
----
T
QIKR
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
N
S
P
P
T
L
---
E
G
-
Q
H
-
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
T
--
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.23
46%
-66
- C1 -
3A7J
1
STK24_HUMAN
A:
[17-292]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
L
E
--
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-
D
----
T
QIKR
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
---
E
G
-
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
L
R
-
N
A-
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
55.13
38%
-72
- C1 -
4JDI
2
?
A:
[69-343]
----------------
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
---
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
-------
E
L
W
V
V
M
E
F
L
-
E
G
G
-
A
L
T
D
--
I
V
T
--
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
EVPR
R
----
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
---
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
--
G
P
P
A
S
I
V
P
L
M
R
Q
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
54.25
45%
-54
- C1 -
4FZA
3
MST4_HUMAN
B:
[5-278]
------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
--
L
-
G
-
G
G
S
A
--
L
D
L
L
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-
D
----
T
QIKR
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
----
V
-
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
-
S
--
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
51.84
45%
-57
- C1 -
4FZD
1
MST4_HUMAN
B:
[5-278]
------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
--
L
-
G
-
G
G
S
A
--
L
D
L
L
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-----------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
----
V
-
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
-
S
--
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
51.45
45%
-54
- C1 -
4FZF
1
?
B:
[5-278]
------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
--
L
-
G
-
G
G
S
A
--
L
D
L
L
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-
D
----
T
QIKR
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
----
V
-
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
-
S
--
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
48.95
45%
-56
- C1 -
3GGF
1
MST4_HUMAN
A:
[20-293]
------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
--
L
-
G
-
G
G
S
A
--
L
D
L
L
R
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
-----------R---
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
----
V
-
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
-
S
--
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
48.42
40%
-66
- C1 -
2J51
5
SLK_HUMAN
A:
[34-309]
------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
-------
N
L
W
I
L
I
E
F
C
-
A
-
G
-
G
A
V
D
A
V
M
L
E
L
-
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
-
R
----
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
ET
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
A--
Q
P
-
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
-
D
SN
K
P
I
R
E
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
33.17
30%
-66
- C1 -
1ZY4
1
GCN2_YEAST
A:
[8-298]
-----------------------
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
----
H
T
E
E
K
L
S
T
I
L
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
R
R
N
F
VK
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
-
G
-
T
L
Y
D
--
L
I
H
S
E
N
L
N
Q
Q
R
D
E
Y
W
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
N
V
K
I
G
D
F
G
L
A
K
N
V
H
R----------------
A
M
Y
V
A
T
E
V
L
D
----
G
T
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
---
P
F
S
T
G
M
E
R
V
N
I
L
K
K
L
R
S
V
S
I
E
F
PPD
F
D
-
D
N
K
M
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
-
L
P
V
-
K
--
H
Q
D
E
V
I
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------