@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_TBK1_M: (2014-08-20 )
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAETSDVLHRMVIHVFSLQHMTAHKIYIHSYNTAAVFHELVYKQTKIVSSNQELIYEGRRLVLELGRLAQHFPKTTEENPIFVTSREQLNTVGLRYEKISLPKIHPRYDLDGDASMAKAVTGVVCYACRTASTLLLYQELMRKGVRWLVELVKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVNLEAAELGEISDIHTKLLRLSSSQGTIESSLQDISSRLSPGGLLADTWAHQEGTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSHFSEECVRKYEAFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDYTNELQETLPQKMLAASGGVKHAMAPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL
Atome Classification :
(14 SA)
-.....-....10........20......---..30........40.....--...------50........60.-.......70.........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MQSTS-NH
L
W
L
L
S
D
I
LGQGATA
N
V
FRGR---HKKTG
D
L
Y
A
V
K
V
FNNISFL--RPV------D
V
Q
M
R
E
F
E
V
L
K
K
L-NHK
N
I
V
K
L
-
F
A
IEEETTTR
H
K
V
L
I
M
E
FCPCG
S
L
Y
T
V
L
EEPSNAYGL
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
ENG
I
V
HRDIKPG
N
I
M
R
V
IGEDG
Q
S
V
Y
K
LTDFGAARELE
D
D
E
Q
F
V
S
L
YG
T
E
E
YL
H
P
D
M
Y
E
R
A
V
L
R
K
D
H
Q
K
KYG
A
T
V
D
L
W
S
V
G
V
T
F
Y
HAATGSLPFRPFEGPRRN
K
E
V
M
Y
K
I
ITGKPSGAISG
V
Q
KAENGPIDWSGDMPLS
C
S
L
S
Q
G
L
Q
A
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
CW
G
F
D
Q
F
F
A
E
T
S
D
V
L
H
R
M
V
I
H
V
F
S
L
Q
HM
T
A
H
K
I
Y
I
HSY
N
T
A
A
V
F
H
E
L
V
Y
K
Q
T
KIVSSN
Q
E
L
I
Y
E
G
R
R
L
V
L
E
L
G
R
L
A
Q
HFPKTTEEN
P
I
F
V
TSREQLNTV
G
L
R
Y
E
KISLPKIHPRYDLDG
D
A
S
M
A
K
A
V
T
G
V
V
C
Y
A
C
R
T
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
V
R
W
L
V
E
L
V
KDD
Y
N
E
T
VHKK
T
E
V
V
I
T
L
D
F
C
I
R
N
I
E
K
T
V
K
V
Y
E
K
L
M
K
VNL
E
A
A
ELG
E
I
S
D
I
H
T
K
L
L
RLSSSQG
T
I
E
S
S
L
Q
D
I
S
S
RLSPGG
L
L
A
D
TWAHQEGTHPRDR
N
V
E
K
L
Q
V
L
L
N
C
I
T
E
I
Y
Y
Q
F
K
K
DK
A
E
R
RLAY
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
S
H
F
S
E
E
C
V
R
K
Y
E
A
F
KD
K
S
E
E
W
M
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
CF
D
I
E
E
E
V
S
K
Y
Q
D
Y
T
N
E
L
Q
E
T
L
P
Q
K
M
L
A
ASGGVKHAMAPIYPSSN
T
L
V
E
M
T
L
G
M
K
K
L
K
E
E
M
E
G
V
V
K
E
L
AEN
N
H
I
L
E
R
FGSLTMDGGLRNVDCL
7
PsiBlast_PDB
96.53
94%
-100
- C1 -
4IW0
1
TBK1_HUMAN
A:
[3-658]
--
Q
S
T
S
-
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
---
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
L
--
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
-
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
P
L
N
T
I
G
L
I
Y
E
K
I
S
L
P
K
V
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
I
T
G
V
V
C
Y
A
C
R
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
I
R
W
L
I
E
L
I
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
E
K
T
V
K
V
Y
E
K
----------
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
S
L
Q
D
I
D
S
R
L
S
P
G
G
S
L
A
D
A
W
A
H
Q
E
G
T
H
P
K
D
R
N
V
E
K
L
Q
V
L
L
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
T
H
F
T
D
E
C
V
K
K
Y
E
A
F
L
N
K
S
E
E
W
I
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
E
Y
T
N
E
L
Q
E
T
------------------------------------------------------------------------
1
PsiBlast_PDB
95.87
100%
-103
- C1 -
4JL9
1
TBK1_MOUSE
A:
[3-657]
--
Q
S
T
S
-
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
---
H
K
K
T
G
D
L
Y
A
V
K
V
F
N
N
I
S
F
L
--
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
-
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
D
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
-------
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
V
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
L
S
C
S
L
S
Q
G
L
Q
A
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
V
L
H
R
M
V
I
H
V
F
S
L
Q
H
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
A
V
F
H
E
L
V
Y
K
Q
T
K
I
V
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
L
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
T
S
R
E
Q
L
N
T
V
G
L
R
Y
E
K
I
S
L
P
K
I
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
V
T
G
V
V
C
Y
A
C
R
T
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
V
R
W
L
V
E
L
V
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
E
K
T
V
K
V
Y
E
K
L
M
K
V
N
----
E
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
S
S
L
Q
D
I
S
S
R
L
S
P
G
G
L
L
A
D
T
W
A
H
Q
E
G
T
H
P
R
D
R
N
V
E
K
L
Q
V
L
L
N
C
I
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
S
H
F
S
E
E
C
V
R
K
Y
E
A
F
K
D
K
S
E
E
W
M
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
D
Y
T
N
E
L
Q
E
-------------------------------------------------------------------------
2
PsiBlast_PDB
95.55
100%
-103
- C1 -
4JLC
1
TBK1_MOUSE
A:
[3-657]
--
Q
S
T
S
-
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
---
H
K
K
T
G
D
L
Y
A
V
K
V
F
N
N
I
S
F
L
--
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
-
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
D
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
-------
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
V
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
L
S
C
S
L
S
Q
G
L
Q
A
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
V
L
H
R
M
V
I
H
V
F
S
L
Q
H
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
A
V
F
H
E
L
V
Y
K
Q
T
K
I
V
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
L
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
T
S
R
E
Q
L
N
T
V
G
L
R
Y
E
K
I
S
L
P
K
I
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
V
T
G
V
V
C
Y
A
C
R
T
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
V
R
W
L
V
E
L
V
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
E
K
T
V
K
V
Y
E
K
L
M
K
V
N
----
E
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
S
S
L
Q
D
I
S
S
R
L
S
P
G
G
L
L
A
D
T
W
A
H
Q
E
G
T
H
P
R
D
R
N
V
E
K
L
Q
V
L
L
N
C
I
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
S
H
F
S
E
E
C
V
R
K
Y
E
A
F
K
D
K
S
E
E
W
M
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
D
Y
T
N
E
L
Q
E
-------------------------------------------------------------------------
6
PsiBlast_PDB
94.99
94%
-104
- C1 -
4IWO
1
TBK1_HUMAN
A:
[5-660]
--
Q
S
T
S
-
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
---
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
L
--
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
-
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
D
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
----------
G
T
E
E
Y
L
H
P
D
M
Y
E
------------
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
P
L
N
T
I
G
L
I
Y
E
K
I
S
L
P
K
V
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
I
T
G
V
V
C
Y
A
C
R
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
I
R
W
L
I
E
L
I
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
E
K
T
V
K
V
Y
---------
A
A
E
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
S
L
Q
D
I
D
S
R
L
S
P
G
G
S
L
A
D
A
W
A
H
Q
E
G
T
H
P
K
D
R
N
V
E
K
L
Q
V
L
L
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
T
H
F
T
D
E
C
V
K
K
Y
E
A
F
L
N
K
S
E
E
W
I
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
E
Y
T
N
E
L
Q
E
T
------------------------------------------------------------------------
3
PsiBlast_PDB
94.89
94%
-106
- C1 -
4IM3
1
TBK1_HUMAN
A:
[7-663]
-
M
Q
S
T
S
-
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
---
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
------
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
-
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
----------------------------------------
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
P
L
N
T
I
G
L
I
Y
E
K
I
S
L
P
K
V
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
I
T
G
V
V
C
Y
A
C
R
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
I
R
W
L
I
E
L
I
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
E
K
T
V
K
V
----------
A
A
E
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
S
L
Q
D
I
D
S
R
L
S
P
G
G
S
L
A
D
A
W
A
H
Q
E
G
T
H
P
K
D
R
N
V
E
K
L
Q
V
L
L
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
T
H
F
T
D
E
C
V
K
K
Y
E
A
F
L
N
K
S
E
E
W
I
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
E
Y
T
N
E
L
Q
E
T
------------------------------------------------------------------------
5
PsiBlast_PDB
93.80
94%
-101
- C1 -
4IWQ
1
TBK1_HUMAN
A:
[4-659]
--
Q
S
T
S
-
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
---
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
L
--
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
-
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
D
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
----------
G
T
E
E
Y
L
H
P
D
M
Y
E
------------
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
P
L
N
T
I
G
L
I
Y
E
K
I
S
L
P
K
V
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
I
T
G
V
V
C
Y
A
C
R
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
I
R
W
L
I
E
L
I
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
E
K
T
V
K
V
Y
E
-----------
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
S
L
Q
D
I
D
S
R
L
S
P
G
G
S
L
A
D
A
W
A
H
Q
E
G
T
H
P
K
D
R
N
V
E
K
L
Q
V
L
L
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
T
H
F
T
D
E
C
V
K
K
Y
E
A
F
L
N
K
S
E
E
W
I
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
E
Y
T
N
E
L
Q
E
T
------------------------------------------------------------------------
4
PsiBlast_PDB
93.30
94%
-99
- C1 -
4IWP
1
TBK1_HUMAN
A:
[4-659]
--
Q
S
T
S
-
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
---
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
L
--
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
-
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
D
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
----------
G
T
E
E
Y
L
H
P
D
M
Y
E
------------
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
P
L
N
T
I
G
L
I
Y
E
K
I
S
L
P
K
V
H
P
R
Y
D
L
D
G
D
A
S
M
A
K
A
I
T
G
V
V
C
Y
A
C
R
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
I
R
W
L
I
E
L
I
K
D
D
Y
N
E
T
V
H
K
K
T
E
V
V
I
T
L
D
F
C
I
R
N
I
E
K
T
V
K
V
Y
---------
A
A
E
L
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
S
L
Q
D
I
D
S
R
L
S
P
G
G
S
L
A
D
A
W
A
H
Q
E
G
T
H
P
K
D
R
N
V
E
K
L
Q
V
L
L
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
T
H
F
T
D
E
C
V
K
K
Y
E
A
F
L
N
K
S
E
E
W
I
R
K
M
L
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
E
E
V
S
K
Y
Q
E
Y
T
N
E
L
Q
E
T
------------------------------------------------------------------------
21
PsiBlast_CBE
61.94
96%
-101
- C1 -
4EUT
1
TBK1_HUMAN
B:
[4-387]
--
Q
S
T
S
-
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
---
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
L
--
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
-
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
-------
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
58.94
95%
-93
- C1 -
4EUT
1
TBK1_HUMAN
A:
[2-387]
G
S
Q
S
T
S
-
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
---
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
L
--
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
-
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
D
--
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
50.61
96%
-87
- C1 -
4EUU
6
TBK1_HUMAN
A:
[3-309]
-
S
Q
S
T
S
-
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
---
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
L
--
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
-
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
35.84
30%
-87
- C1 -
1PHK
1
PHKG1_RABIT
A:
[19-281]
----------
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
---
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
G
SF
S
A
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
-
K
D
T
Y
E
T
--
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
---
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
--
L
D
D
D
M
--
N
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
K
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
--
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
-
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
----------
G
S
P
E
W
D
-----------
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
34.40
97%
-45
- C1 -
4EUU
6
TBK1_HUMAN
B:
[4-309]
--
Q
S
T
S
-
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
---
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
L
--
R
P
V
------
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
-
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
Q
F
V
-
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
P
F
E
G
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
23.48
33%
-72
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[24-246]
--
K
A
D
P
-
S
H
F
E
L
L
K
-
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VT
R
P
D
S
G
H
L
Y
A
M
K
V
L
-------------------------
I
L
A
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
---
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
---
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
--
L
D
E
E
G
H
--
I
K
L
T
D
F
G
L
S
K
E
-----------
G
T
V
E
Y
M
A
P
E
V
V
N
R
--------
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
---
P
F
Q
G
K
D
R
-
K
E
T
M
T
L
I
L
K
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
19.93
33%
-65
- C1 -
2JAM
4
KCC1G_HUMAN
A:
[6-207]
-----
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
---
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
--------------
S
L
E
-
N
E
I
A
V
L
K
K
I
-
K
H
E
N
I
V
T
L
-
E
D
I
Y
E
S
T
T
--
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
-
R
G
V
Y
T
--
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
I
M
-
I
T
D
F
G
L
S
K
-
M
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
--------
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------