@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00088_SUIS_R: (2014-08-22 )
MAKKKFSALEISLIVLFIIVTAIAIALVTVLATKVPAVEEIKSPTPTSNSTPTSTPTSTSTPTSTSTPSPGKCPPEQGEPINERINCIPEQHPTKAICEERGCCWRPWNNTVIPWCFFADNHGYNAESITNENAGLKATLNRIPSPTLFGEDIKSVILTTQTQTGNRFRFKITDPNNKRYEVPHQFVKEETGIPAADTLYDVQVSENPFSIKVIRKSNNKVLCDTSVGPLLYSNQYLQISTRLPSEYIYGFGGHIHKRFRHDLYWKTWPIFTRDEIPGDNNHNLYGHQTFFMGIGDTSGKSYGVFLMNSNAMEVFIQPTPIITYRVTGGILDFYIFLGDTPEQVVQQYQEVHWRPAMPAYWNLGFQLSRWNYGSLDTVSEVVRRNREAGIPYDAQVTDIDYMEDHKEFTYDRVKFNGLPEFAQDLHNHGKYIIILDPAISINKRANGAEYQTYVRGNEKNVWVNESDGTTPLIGEVWPGLTVYPDFTNPQTIEWWANECNLFHQQVEYDGLWIDMNEVSSFIQGSLNLKGVLLIVLNYPPFTPGILDKVMYSKTLCMDAVQHWGKQYDVHSLYGYSMAIATEQAVERVFPNKRSFILTRSTFGGSGRHANHWLGDNTASWEQMEWSITGMLEFGIFGMPLVGATSCGFLADTTEELCRRWMQLGAFYPFSRNHNAEGYMEQDPAYFGQDSSRHYLTIRYTLLPFLYTLFYRAHMFGETVARPFLYEFYDDTNSWIEDTQFLWGPALLITPVLRPGVENVSAYIPNATWYDYETGIKRPWRKERINMYLPGDKIGLHLRGGYIIPTQEPDVTTTASRKNPLGLIVALDDNQAAKGELFWDDGESKDSIEKKMYILYTFSVSNNELVLNCTHSSYAEGTSLAFKTIKVLGLREDVRSITVGENDQQMATHTNFTFDSANKILSITALNFNLAGSFIVRWCRTFSDNEKFTCYPDVGTATEGTCTQRGCLWQPVSGLSNVPPYYFPPENNPYTLTSIQPLPTGITAELQLNPPNARIKLPSNPISTLRVGVKYHPNDMLQFKIYDAQHKRYEVPVPLNIPDTPTSSNERLYDVEIKENPFGIQVRRRSSGKLIWDSRLPGFGFNDQFIQISTRLPSNYLYGFGEVEHTAFKRDLNWHTWGMFTRDQPPGYKLNSYGFHPYYMALENEGNAHGVLLLNSNGMDVTFQPTPALTYRTIGGILDFYMFLGPTPEIATRQYHEVIGFPVMPPYWALGFQLCRYGYRNTSEIEQLYNDMVAANIPYDVQYTDINYMERQLDFTIGERFKTLPEFVDRIRKDGMKYIVILAPAISGNETQPYPAFERGIQKDVFVKWPNTNDICWPKVWPDLPNVTIDETITEDEAVNASRAHVAFPDFFRNSTLEWWAREIYDFYNEKMKFDGLWIDMNEPSSFGIQMGGKVLNECRRMMTLNYPPVFSPELRVKEGEGASISEAMCMETEHILIDGSSVLQYDVHNLYGWSQVKPTLDALQNTTGLRGIVISRSTYPTTGRWGGHWLGDNYTTWDNLEKSLIGMLELNLFGIPYIGADICGVFHDSGYPSLYFVGIQVGAFYPYPRESPTINFTRSQDPVSWMKLLLQMSKKVLEIRYTLLPYFYTQMHEAHAHGGTVIRPLMHEFFDDKETWEIYKQFLWGPAFMVTPVVEPFRTSVTGYVPKARWFDYHTGADIKLKGILHTFSAPFDTINLHVRGGYILPCQEPARNTHLSRQNYMKLIVAADDNQMAQGTLFGDDGESIDTYERGQYTSIQFNLNQTTLTSTVLANGYKNKQEMRLGSIHIWGKGTLRISNANLVYGGRKHQPPFTQEEAKETLIFDLKNMNVTLDEPIQITWS
Atome Classification :
(8 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.....-..-130--........140.......150.......160.......170.......180.......190.-------......200.-......210.......220......------.230.......240..--.....250.......260.......270.......280.......290....--...300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410....--...420.......-430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.--......540....--...550.......560..-.....570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680......-----.-----690.......700.......710.......720.......730.......740.......750.......760.......770......--.780.......790.......800.......810.......820.......830.......840....-...850.......860----.......870.......880.......890--.......900.......910......--.920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKKKF
S
A
L
E
I
S
L
I
V
L
F
I
I
V
T
A
I
A
I
A
L
V
T
V
L
A
TKVP
A
V
E
E
IKSPTPTSNSTPTSTPTSTSTPTSTSTPSPGKCPPEQGE
P
I
N
E
R
I
NCIPEQH
P
T
K
A
I
C
E
ERG
C
C
WRPWNN
T
V
I
P
W
C
F
FADNHGYNAE-SI-TN---ENAG
L
K
A
T
L
NRIPSP
T
L
F
G
E
D
I
K
S
V
I
L
T
T
QTQTG
N
R
F
R
F
K
ITDPNNKRYEV
P
H
Q
F
V
K
E
ETGI-------PAA
D
T
L
Y
D
V
Q
-VSEN
P
F
S
I
K
V
I
RKSN
N
K
V
L
CDTSVG------
P
L
L
YSN
Q
Y
L
Q
I
S
TRL
P
--
S
E
Y
I
Y
GFG
G
H
I
H
K
R
F
R
HDL
Y
W
KTWP
I
F
TRDEIPGDNNHNLYG
H
Q
T
F
F
M
G
IGD--TSGK
S
Y
G
V
F
L
MNSN
A
M
E
V
F
IQPT
P
I
I
T
Y
R
VTGG
I
L
D
F
Y
I
F
LGD
T
P
E
Q
V
V
Q
Q
Y
Q
E
V
HWRPAM
P
A
Y
W
NLG
F
Q
L
SRWNYG
S
L
D
T
V
S
E
V
V
R
RNREAGIPYDAQVT
D
I
D
Y
M
E
D
H
K
EFTY
D
R
V
KFN--G
L
P
E
F
A
Q
D
L
H
NHG-
K
Y
I
I
I
LDPA
I
S
INKRANGAE
Y
Q
T
Y
V
RGNEK
N
V
W
V
NESDGTTP
L
I
G
EVWPG
L
T
VYPDFTNP
Q
T
I
E
W
W
A
N
E
C
N
L
F
H
Q
QVEYD
G
L
W
I
D
M
N
E
V
S
S
F
I
QGSLNL
K
G
V
L
L
--
I
V
LNYPPF
T
P
G
I
L
--
D
K
V
M
Y
S
K
T
L
C
M
D
A
V
Q
H
W
G
-KQYDV
H
S
LYGY
S
M
A
I
A
T
E
Q
A
V
E
R
VFPNK
R
S
F
I
L
T
RSTFGGSGRHANHWLGDNTAS
W
E
Q
M
E
W
S
I
T
G
M
L
EFGIFGMPLVGATSCGFLAD
T
T
E
E
L
C
R
R
W
M
QLGAFYPFSRNHNAEGYMEQDPAYFGQ-----D-----SS
R
H
Y
L
T
I
R
Y
T
L
L
P
F
L
Y
T
L
F
Y
R
A
H
M
F
G
E
T
V
A
R
P
F
L
Y
E
F
YDDT
N
S
W
I
E
DTQFLWG
P
A
L
L
I
T
P
VLRPGV
E
N
V
S
A
YIPNA
T
W
YDYETGIKRP--
W
R
K
E
R
I
N
M
Y
LPG
D
K
I
G
L
H
L
RG
G
Y
I
I
PTQEPDVTTTASRKNP
L
G
L
I
V
A
LDDNQAAKG
E
L
F
WDDGESKDS-IE
K
K
M
Y
I
L
Y
T
F
S
VSNN----
E
L
V
L
NCTHSSYAEGT
S
L
A
F
K
T
I
K
V
LG
L
R
E
D
--
V
R
S
I
TVGENDQ
Q
M
A
THT
N
F
T
FDSAN
K
--
I
L
S
I
T
A
L
N
FN
L
A
G
S
F
I
V
R
W
C
R
TFSDNE
K
F
T
CYPDVGTATEGTCTQRGCLWQPVSGLSNVPPYYFPPENN
P
Y
T
L
T
SIQPLPTG
I
T
A
E
L
Q
LNPPN
A
R
I
KLPSNPI
S
T
L
R
V
G
V
K
YHPND
M
L
Q
F
K
I
YDAQH
K
R
YEVPVPLNIPDTPTSSN
E
R
L
Y
D
V
E
IKENPF
G
I
Q
V
R
RRSSG
K
L
I
WDSRLPGFGFND
Q
F
I
Q
I
S
TRLPSN
Y
L
YGFGEV
E
H
T
A
F
KRDLNWHTWGMFTRDQPPGYKLNSYGF
H
P
Y
Y
M
A
L
ENEGNA
H
G
V
L
L
LNSNG
M
D
V
T
FQPTP
A
L
T
Y
R
T
I
G
G
I
L
D
F
Y
M
FLGPTP
E
I
A
T
R
Q
Y
H
E
VIGFPVM
P
P
Y
W
A
L
G
F
Q
L
C
R
YGYR
N
T
S
E
I
E
Q
L
Y
N
D
M
V
AANIPY
D
V
Q
YT
D
I
N
Y
M
E
R
Q
L
D
F
T
I
G
E
R
F
K
T
L
P
E
F
V
D
R
I
R
KDG
M
K
Y
I
V
I
L
A
PAISGNETQP
Y
P
A
F
E
RGIQK
D
V
F
V
KWPNTNDICWPKVWPDLPNVTIDETITEDEAVNASRAHVA
F
P
D
F
F
RNS
T
L
E
W
W
A
R
E
I
Y
D
F
Y
N
EKMKFD
G
L
W
I
DMNEPSS
F
G
I
Q
M
G
G
K
V
L
N
E
C
R
R
M
MTLNYPPVFSP
E
L
R
V
KEGEGAS
I
S
E
A
M
CMET
E
H
I
L
IDGS
S
V
L
Q
Y
D
V
H
N
LYGWSQV
K
P
T
L
D
A
L
QNTTG
L
R
G
I
V
I
SRSTYPTTGRWG
G
H
WLGDNYT
T
W
D
N
L
E
K
S
L
I
G
M
L
E
L
N
LFGIPYI
G
A
D
I
C
G
V
FHDSGY
P
S
L
Y
F
V
G
I
Q
V
G
A
FYPYPRESP
T
I
N
FTRSQD
P
V
S
W
M
K
L
L
L
Q
M
S
K
K
V
L
E
I
R
Y
T
L
L
P
Y
F
Y
T
Q
M
H
E
AHAHG
G
T
V
I
R
P
L
M
H
E
FFDD
K
E
T
W
E
I
Y
K
Q
FLWGP
A
F
M
VTPVV
E
P
F
R
T
S
VTGYVPK
A
R
W
F
DYHTGA
D
I
K
L
K
G
I
L
H
TFSAPF
D
T
I
N
L
H
V
RG
G
Y
I
L
PCQEPARNTHL
S
R
Q
N
Y
M
K
L
I
V
AADDNQMAQG
T
L
FGDDGESIDTYERG
Q
Y
T
S
I
Q
F
NLNQ
T
T
L
T
S
T
V
L
ANGYK
N
K
Q
E
M
RL
G
S
I
H
I
W
GK
G
T
L
R
ISNA
N
L
V
YGGRKHQPPF
T
Q
E
E
A
K
E
T
L
I
F
D
LKNM
N
V
T
LDE
P
I
Q
I
TWS
27
Fugue
92.71
60%
-81
- C3 -
2QMJ
13
MGA_HUMAN
A:
[7-870]
------------------------------------------------------------------------------
V
N
E
L
E
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
N
L
-
V
N
---
T
N
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
E
Y
Q
T
S
N
R
F
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
E
H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
L
E
D
--
A
S
G
L
S
F
G
V
F
L
M
N
S
N
A
M
E
V
V
L
Q
P
A
P
A
I
T
Y
R
T
I
G
G
I
L
D
F
Y
V
F
L
G
N
T
P
E
Q
V
V
Q
E
Y
L
E
L
I
G
R
P
A
L
P
S
Y
W
A
L
G
F
H
L
S
R
Y
E
Y
G
T
L
D
N
M
R
E
V
V
E
R
N
R
A
A
Q
L
P
Y
D
V
Q
H
A
D
I
D
Y
M
D
E
R
R
D
F
T
Y
D
S
V
D
F
K
--
G
F
P
E
F
V
N
E
L
H
N
N
G
Q
K
L
V
I
I
V
D
P
A
I
S
N
N
S
S
S
S
K
-
P
Y
G
P
Y
D
R
G
S
D
M
K
I
W
V
N
S
S
D
G
V
T
P
L
I
G
E
V
W
P
G
Q
T
V
F
P
D
Y
T
N
P
N
C
A
V
W
W
T
K
E
F
E
L
F
H
N
Q
V
E
F
D
G
I
W
I
D
M
N
E
V
S
N
F
V
D
G
S
V
S
--
G
C
S
T
--
N
N
L
N
N
P
P
F
T
P
R
I
L
--
D
G
Y
L
F
C
K
T
L
C
M
D
A
V
Q
H
W
G
-
K
Q
Y
D
I
H
N
L
Y
G
Y
S
M
A
V
A
T
A
E
A
A
K
T
V
F
P
N
K
R
S
F
I
L
T
R
S
T
F
A
G
S
G
K
F
A
A
H
W
L
G
D
N
T
A
T
W
D
D
L
R
W
S
I
P
G
V
L
E
F
N
L
F
G
I
P
M
V
G
P
D
I
C
G
F
A
L
D
T
P
E
E
L
C
R
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
G
Q
G
Y
K
D
Q
D
P
A
S
F
G
A
DS
L
L
L
N
-----
S
S
R
H
Y
L
N
I
R
Y
T
L
L
P
Y
L
Y
T
L
F
F
R
A
H
S
R
G
D
T
V
A
R
P
L
L
H
E
F
Y
E
D
N
S
T
W
D
V
H
Q
Q
F
L
W
G
P
G
L
L
I
T
P
V
L
D
E
G
A
E
K
V
M
A
Y
V
P
D
A
V
W
Y
D
Y
E
T
G
S
Q
V
R
--
W
R
K
Q
K
V
E
M
E
L
P
G
D
K
I
G
L
H
L
R
G
G
Y
I
F
P
T
Q
Q
P
N
T
T
T
L
A
S
R
K
N
P
L
G
L
I
I
A
L
D
E
N
K
E
A
K
G
E
L
F
W
D
D
G
E
T
K
D
T
-
V
A
N
K
V
Y
L
L
C
E
F
S
V
T
Q
N
----
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
A
F
N
E
I
K
I
L
G
T
E
E
---
P
S
N
V
T
V
K
H
N
G
V
P
-
S
T
S
P
T
V
T
Y
D
S
N
L
K
--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
92.67
60%
-81
- C3 -
3L4Y
9
MGA_HUMAN
A:
[7-870]
------------------------------------------------------------------------------
V
N
E
L
E
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
-
G
N
L
V
N
---
T
N
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
E
Y
Q
T
S
N
R
F
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
E
H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
L
E
D
--
A
S
G
L
S
F
G
V
F
L
M
N
S
N
A
M
E
V
V
L
Q
P
A
P
A
I
T
Y
R
T
I
G
G
I
L
D
F
Y
V
F
L
G
N
T
P
E
Q
V
V
Q
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Y
L
E
L
I
G
R
P
A
L
P
S
Y
W
A
L
G
F
H
L
S
R
Y
E
Y
G
T
L
D
N
M
R
E
V
V
E
R
N
R
A
A
Q
L
P
Y
D
V
Q
H
A
D
I
D
Y
M
D
E
R
R
D
F
T
Y
D
S
V
D
F
K
--
G
F
P
E
F
V
N
E
L
H
N
N
G
Q
K
L
V
I
I
V
D
P
A
I
S
N
N
S
S
S
S
K
-
P
Y
G
P
Y
D
R
G
S
D
M
K
I
W
V
N
S
S
D
G
V
T
P
L
I
G
E
V
W
P
G
Q
T
V
F
P
D
Y
T
N
P
N
C
A
V
W
W
T
K
E
F
E
L
F
H
N
Q
V
E
F
D
G
I
W
I
D
M
N
E
V
S
N
F
V
D
G
S
V
--
S
G
C
S
T
--
N
N
L
N
N
P
P
F
T
P
R
I
L
--
D
G
Y
L
F
C
K
T
L
C
M
D
A
V
Q
H
W
G
-
K
Q
Y
D
I
H
N
L
Y
G
Y
S
M
A
V
A
T
A
E
A
A
K
T
V
F
P
N
K
R
S
F
I
L
T
R
S
T
F
A
G
S
G
K
F
A
A
H
W
L
G
D
N
T
A
T
W
D
D
L
R
W
S
I
P
G
V
L
E
F
N
L
F
G
I
P
M
V
G
P
D
I
C
G
F
A
L
D
T
P
E
E
L
C
R
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
G
Q
G
Y
K
D
Q
D
P
A
S
F
G
A
-----
D
S
L
L
L
N
S
S
R
H
Y
L
N
I
R
Y
T
L
L
P
Y
L
Y
T
L
F
F
R
A
H
S
R
G
D
T
V
A
R
P
L
L
H
E
F
Y
E
D
N
S
T
W
D
V
H
Q
Q
F
L
W
G
P
G
L
L
I
T
P
V
L
D
E
G
A
E
K
V
M
A
Y
V
P
D
A
V
W
Y
D
Y
E
T
G
S
Q
V
R
--
W
R
K
Q
K
V
E
M
E
L
P
G
D
K
I
G
L
H
L
R
G
G
Y
I
F
P
T
Q
Q
P
N
T
T
T
L
A
S
R
K
N
P
L
G
L
I
I
A
L
D
E
N
K
E
A
K
G
E
L
F
W
D
D
G
E
T
K
D
T
-
V
A
N
K
V
Y
L
L
C
E
F
S
V
T
Q
N
----
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
A
F
N
E
I
K
I
L
G
T
-
E
E
--
P
S
N
V
T
V
K
H
N
G
V
P
S
-
T
S
P
T
V
T
Y
D
S
N
L
K
--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
92.40
60%
-81
- C3 -
3L4X
7
MGA_HUMAN
A:
[11-869]
----------------------------------------------------------------------------------
E
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
N
L
-
V
N
---
T
N
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
E
Y
Q
T
S
N
R
F
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
E
H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
L
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--
A
S
G
L
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F
G
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F
L
M
N
S
N
A
M
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V
L
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G
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V
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A
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A
L
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L
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A
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I
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M
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--
G
F
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V
N
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L
H
N
N
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L
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V
D
P
A
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-
N
N
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S
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I
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M
N
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V
S
N
F
V
D
G
S
V
S
--
G
C
S
T
--
N
N
L
N
N
P
P
F
T
P
R
I
L
--
D
G
Y
L
F
C
K
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M
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A
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-
K
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L
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A
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P
N
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A
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F
A
A
H
W
L
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D
N
T
A
T
W
D
D
L
R
W
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I
P
G
V
L
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F
N
L
F
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I
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M
V
G
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C
G
F
A
L
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P
E
E
L
C
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W
M
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L
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A
F
Y
P
F
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N
H
N
G
Q
G
Y
K
D
Q
D
P
A
S
F
G
A
-----
D
S
L
L
L
N
S
S
R
H
Y
L
N
I
R
Y
T
L
L
P
Y
L
Y
T
L
F
F
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A
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D
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A
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L
L
H
E
F
Y
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S
T
W
D
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Q
Q
F
L
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G
P
G
L
L
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V
L
D
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A
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K
V
M
A
Y
V
P
D
A
V
W
Y
D
Y
E
T
G
S
Q
V
R
--
W
R
K
Q
K
V
E
M
E
L
P
G
D
K
I
G
L
H
L
R
G
G
Y
I
F
P
T
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P
N
T
T
T
L
A
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R
K
N
P
L
G
L
I
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D
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N
K
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E
L
F
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D
G
E
T
K
D
T
-
V
A
N
K
V
Y
L
L
C
E
F
S
V
T
Q
N
----
R
L
E
V
N
I
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Q
S
T
Y
K
D
P
N
N
L
A
F
N
E
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K
I
L
G
-
T
E
E
--
P
S
N
V
T
V
K
H
N
G
V
P
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-
T
S
P
T
V
T
Y
D
S
N
L
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--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
92.13
60%
-82
- C3 -
3L4Z
8
MGA_HUMAN
A:
[11-869]
----------------------------------------------------------------------------------
E
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
N
L
-
V
N
---
T
N
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
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A
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N
R
F
H
F
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L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
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------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
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H
V
H
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Q
Y
R
H
D
M
N
W
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T
W
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R
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N
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N
G
T
N
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Y
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A
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F
L
C
L
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N
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--
G
C
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--
N
N
L
N
N
P
P
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--
D
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A
-----
D
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L
L
L
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----
R
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-
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--
P
S
N
V
T
V
K
H
N
G
V
P
S
-
T
S
P
T
V
T
Y
D
S
N
L
K
--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.76
60%
-80
- C3 -
3L4W
9
MGA_HUMAN
A:
[11-869]
----------------------------------------------------------------------------------
E
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
N
L
-
V
N
---
T
N
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
E
Y
Q
T
S
N
R
F
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
E
H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
L
E
D
--
A
S
G
L
S
F
G
V
F
L
M
N
S
N
A
M
E
V
V
L
Q
P
A
P
A
I
T
Y
R
T
I
G
G
I
L
D
F
Y
V
F
L
G
N
T
P
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Q
V
V
Q
E
Y
L
E
L
I
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R
P
A
L
P
S
Y
W
A
L
G
F
H
L
S
R
Y
E
Y
G
T
L
D
N
M
R
E
V
V
E
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N
R
A
A
Q
L
P
Y
D
V
Q
H
A
D
I
D
Y
M
D
E
R
R
D
F
T
Y
D
S
V
D
F
K
--
G
F
P
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F
V
N
E
L
H
N
N
G
Q
K
L
V
I
I
V
D
P
A
I
S
-
N
N
S
S
S
S
K
P
Y
G
P
Y
D
R
G
S
D
M
K
I
W
V
N
S
S
D
G
V
T
P
L
I
G
E
V
W
P
G
Q
T
V
F
P
D
Y
T
N
P
N
C
A
V
W
W
T
K
E
F
E
L
F
H
N
Q
V
E
F
D
G
I
W
I
D
M
N
E
V
S
N
F
V
D
G
S
V
S
--
G
C
S
T
--
N
N
L
N
N
P
P
F
T
P
R
I
L
--
D
G
Y
L
F
C
K
T
L
C
M
D
A
V
Q
H
W
G
-
K
Q
Y
D
I
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N
L
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M
A
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A
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A
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A
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P
N
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L
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T
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A
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K
F
A
A
H
W
L
G
D
N
T
A
T
W
D
D
L
R
W
S
I
P
G
V
L
E
F
N
L
F
G
I
P
M
V
G
P
D
I
C
G
F
A
L
D
T
P
E
E
L
C
R
R
W
M
Q
L
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A
F
Y
P
F
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R
N
H
N
G
Q
G
Y
K
D
Q
D
P
A
S
F
G
A
-----
D
S
L
L
L
N
S
S
R
H
Y
L
N
I
R
Y
T
L
L
P
Y
L
Y
T
L
F
F
R
A
H
S
R
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D
T
V
A
R
P
L
L
H
E
F
Y
E
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N
S
T
W
D
V
H
Q
Q
F
L
W
G
P
G
L
L
I
T
P
V
L
D
E
G
A
E
K
V
M
A
Y
V
P
D
A
V
W
Y
D
Y
E
T
G
S
Q
V
R
--
W
R
K
Q
K
V
E
M
E
L
P
G
D
K
I
G
L
H
L
R
G
G
Y
I
F
P
T
Q
Q
P
N
T
T
T
L
A
S
R
K
N
P
L
G
L
I
I
A
L
D
E
N
K
E
A
K
G
E
L
F
W
D
D
G
E
T
K
D
T
-
V
A
N
K
V
Y
L
L
C
E
F
S
V
T
Q
N
----
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
A
F
N
E
I
K
I
L
G
-
T
E
E
--
P
S
N
V
T
V
K
H
N
G
V
P
S
-
T
S
P
T
V
T
Y
D
S
N
L
K
--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
91.48
60%
-80
- C3 -
3L4U
4
MGA_HUMAN
A:
[11-869]
----------------------------------------------------------------------------------
E
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
N
L
-
V
N
---
T
N
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
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Y
Q
T
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N
R
F
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
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H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
L
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D
--
A
S
G
L
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F
G
V
F
L
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N
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N
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M
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A
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F
L
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N
T
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L
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A
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A
L
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F
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L
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T
L
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V
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N
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A
A
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D
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R
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--
G
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N
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L
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D
P
A
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-
N
N
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Y
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M
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L
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W
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W
I
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M
N
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S
N
F
V
D
G
S
V
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--
G
C
S
T
--
N
N
L
N
N
P
P
F
T
P
R
I
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--
D
G
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C
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-
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A
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P
N
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A
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F
A
A
H
W
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D
N
T
A
T
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D
D
L
R
W
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I
P
G
V
L
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F
N
L
F
G
I
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M
V
G
P
D
I
C
G
F
A
L
D
T
P
E
E
L
C
R
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W
M
Q
L
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A
F
Y
P
F
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N
H
N
G
Q
G
Y
K
D
Q
D
P
A
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F
G
A
-----
D
S
L
L
L
N
S
S
R
H
Y
L
N
I
R
Y
T
L
L
P
Y
L
Y
T
L
F
F
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A
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A
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L
L
H
E
F
Y
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N
S
T
W
D
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Q
Q
F
L
W
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P
G
L
L
I
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V
L
D
E
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A
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K
V
M
A
Y
V
P
D
A
V
W
Y
D
Y
E
T
G
S
Q
V
R
--
W
R
K
Q
K
V
E
M
E
L
P
G
D
K
I
G
L
H
L
R
G
G
Y
I
F
P
T
Q
Q
P
N
T
T
T
L
A
S
R
K
N
P
L
G
L
I
I
A
L
D
E
N
K
E
A
K
G
E
L
F
W
D
D
G
E
T
K
D
T
-
V
A
N
K
V
Y
L
L
C
E
F
S
V
T
Q
N
----
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
A
F
N
E
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K
I
L
G
-
T
E
E
--
P
S
N
V
T
V
K
H
N
G
V
P
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Q
T
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P
T
V
T
Y
D
S
N
L
K
--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
91.32
60%
-80
- C3 -
3L4V
4
MGA_HUMAN
A:
[11-869]
----------------------------------------------------------------------------------
E
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
N
L
-
V
N
---
T
N
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
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A
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Y
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N
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F
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F
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T
D
Q
T
N
N
R
F
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V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
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L
T
Y
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V
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-
I
S
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Q
P
F
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I
K
V
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R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
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F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
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H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
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N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
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F
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C
L
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--
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G
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-
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N
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--
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C
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--
N
N
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N
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P
P
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----
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Y
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--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
76.16
35%
-74
- C3 -
3W37
10
?
A:
[39-909]
---------------------------------------------------------------------------------------------------------------------
E
A
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---
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-----------------------
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-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------