@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00089_FA10_B: (2014-08-23 )
ANSFLEEVKQGNLERECLEEACSLEEAREVFEDAEQTDEFWSKYKDGDQCEGHPCLNQGHCKDGIGDYTCTCAEGFEGKNCEFSTREICSLDNGGCDQFCREERSEVRCSCAHGYVLGDDSKSCVSTERFPCGKFTQGRSRRWAIHTSEDALDASELEHYDPADLSPTESSLDLLGLNRTEPSAGEDGSQVVRIVGGRDCAEGECPWQALLVNEENEGFCGGTILNEFYVLTAAHCLHQAKRFTVRVGDRNTEQEEGNEMAHEVEMTVKHSRFVKETYDFDIAVLRLKTPIRFRRNVAPACLPEKDWAEATLMTQKTGIVSGFGRTHEKGRLSSTLKMLEVPYVDRSTCKLSSSFTITPNMFCAGYDTQPEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIDKIMKARAGAAGSRGHSEAPATWTVPPPLPL
Atome Classification :
(50 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.-.--.....220.......230......--------.--------240-.........250....-...260.......270..-.--....280.......290.......300.......310..-.....320......-----.----330-.-.......340.......350.-..-----....360......---.370.......380....--...390.......400.......410.......420.......430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
AN
S
F
L
E
E
V
K
QGN
L
E
R
E
C
L
E
E
A
C
S
L
E
E
A
R
E
V
F
E
D
A
E
Q
T
D
E
F
W
S
KYKDGDQCEGHPCLNQGHCKDGIG
D
Y
T
C
T
CAEGFEGKNCEF
S
T
R
E
ICSLDNG
G
C
D
Q
F
C
R
E
E
R
S
E
V
R
C
SCAH
G
Y
V
LGDDSKSCVSTERFPCGKFTQGRS
R
R
W
A
I
HTSEDAL
D
A
S
E
LEHYDPADLSPTESS
L
D
L
L
GLNRTEPSAGED
G
S
Q
V
V
R
I
VGGRDCAEGECP
W
Q
A
L
L
V
N-E--ENEGFC
G
G
T
I
L
N
E
F
Y
V
L
T
A
A
H
C
L
H
--------Q--------A---
K
R
F
T
V
R
VGDRNT
E
Q
E
E
-
G
N
E
M
A
H
E
V
E
M
T
V
K
H
S
R
F
V
-
K
--
E
TYDF
D
I
A
V
L
R
LKT
P
I
RFRRNVAPACL
P
E
K
DWAE
A
T
L
M
T
-QKTGIVSGFGRTHE-----K----G-
R
-
L
-
S
S
T
L
K
M
L
EVPYVDRS
T
C
K
LSS-
S
F
-----
T
ITPN
M
F
CAGYDT---QPEDACQGDSGGPH
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
CARKGK
F
G
V
Y
T
K
V
S
N
F
L
K
W
I
D
K
I
M
K
A
RAGAAGSRGHSEAPATWTVPPPLPL
34
PsiBlast_CBE
91.14
80%
-111
- C4 -
2WYG
1
FA10_HUMAN
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
-------
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
38
PsiBlast_CBE
90.72
80%
-105
- C4 -
2UWO
1
FA10_HUMAN
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
---
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
45
PsiBlast_CBE
90.49
80%
-110
- C4 -
2J2U
1
A:
[1-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
-----
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
--------------------------
42
PsiBlast_CBE
90.35
80%
-105
- C4 -
2J4I
1
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
---
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
40
PsiBlast_CBE
90.32
80%
-107
- C4 -
2J95
1
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
41
PsiBlast_CBE
90.03
80%
-104
- C4 -
2J94
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
15
PsiBlast_PDB
89.96
80%
-105
- C4 -
1LPG
1
?
B:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
36
PsiBlast_CBE
89.73
80%
-103
- C4 -
2VH0
1
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
8
PsiBlast_PDB
89.44
80%
-104
- C4 -
1F0R
1
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
44
PsiBlast_CBE
89.39
80%
-104
- C4 -
2J34
1
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
46
PsiBlast_CBE
89.28
80%
-104
- C4 -
2CJI
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
43
PsiBlast_CBE
89.19
80%
-107
- C4 -
2J38
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
18
PsiBlast_PDB
89.18
80%
-105
- C4 -
1LQD
1
?
B:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
39
PsiBlast_CBE
89.14
80%
-104
- C4 -
2UWL
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
14
PsiBlast_PDB
89.10
80%
-105
- C4 -
1NFY
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
4
PsiBlast_PDB
89.06
80%
-98
- C4 -
2BQ7
1
?
B:
[16-249]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
50
PsiBlast_CBE
89.01
84%
-104
- C4 -
1XKA
1
?
C:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
29
PsiBlast_CBE
88.97
80%
-103
- C4 -
2Y81
1
?
A:
[1-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
--------------------------
11
PsiBlast_PDB
88.84
80%
-104
- C4 -
1NFU
1
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
16
PsiBlast_PDB
88.83
80%
-100
- C4 -
1LPK
1
?
B:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
17
PsiBlast_PDB
88.80
80%
-104
- C4 -
1LPZ
1
?
B:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
13
PsiBlast_PDB
88.75
80%
-101
- C4 -
1NFX
1
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
35
PsiBlast_CBE
88.72
80%
-100
- C4 -
2VH6
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
---
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
12
PsiBlast_PDB
88.53
80%
-99
- C4 -
1NFW
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
52
PsiBlast_CBE
88.52
84%
-102
- C4 -
1IQM
1
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
27
PsiBlast_CBE
88.46
80%
-98
- C4 -
4A7I
1
?
B:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
58
PsiBlast_CBE
88.40
84%
-100
- C4 -
1IQG
1
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
7
PsiBlast_PDB
88.29
80%
-105
- C4 -
1EZQ
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
5
PsiBlast_PDB
88.13
80%
-102
- C4 -
2BQW
1
?
B:
[16-249]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
33
PsiBlast_CBE
88.08
80%
-107
- C4 -
2WYJ
1
?
A:
[1-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
----
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
--------------------------
9
PsiBlast_PDB
87.99
80%
-98
- C4 -
1F0S
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
48
PsiBlast_CBE
87.68
84%
-99
- C4 -
1XKB
1
?
D:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
51
PsiBlast_CBE
87.55
84%
-97
- C4 -
1IQN
1
?
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
49
PsiBlast_CBE
87.21
84%
-98
- C4 -
1XKB
1
?
C:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
60
PsiBlast_CBE
87.20
84%
-100
- C4 -
1IQE
1
?
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
56
PsiBlast_CBE
87.05
84%
-99
- C4 -
1IQI
1
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
61
PsiBlast_CBE
86.93
84%
-99
- C4 -
1IOE
1
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
3
PsiBlast_PDB
86.72
80%
-98
- C4 -
2BQ6
1
?
B:
[16-249]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
-------------------------
57
PsiBlast_CBE
86.18
84%
-97
- C4 -
1IQH
1
?
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
54
PsiBlast_CBE
86.09
84%
-100
- C4 -
1IQK
1
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
59
PsiBlast_CBE
86.05
84%
-97
- C4 -
1IQF
1
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
55
PsiBlast_CBE
85.97
84%
-99
- C4 -
1IQJ
1
?
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
53
PsiBlast_CBE
85.28
84%
-99
- C4 -
1IQL
1
?
A:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
-
S
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
------------------------
88
HHSearch
80.24
61%
-90
- C4 -
1FXY
2
TRY1_HUMAN
A:
[1-227]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Y
N
C
K
D
G
E
V
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
S
L
P
T
A
P
-----
P
A
T
-
G
T
K
C
L
I
S
G
W
G
N
T
A
S
-----
S
----
G
A
D
-
Y
-
P
D
E
L
Q
C
L
D
A
P
V
L
S
Q
A
K
C
E
A
S
Y
-
P
G
-----
K
I
T
S
N
M
F
C
V
G
F
L
E
---
G
G
K
D
S
C
Q
G
D
S
G
G
P
V
V
C
----
N
G
--
Q
L
Q
G
V
V
S
W
G
D
G
C
A
Q
K
N
K
P
G
V
Y
T
K
V
Y
N
Y
V
K
W
I
K
N
T
I
A
A
N
------------------------
78
HHSearch
79.20
41%
-99
- C4 -
4JZE
4
?
H:
[1-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
K
V
C
P
K
G
E
C
P
W
Q
V
L
L
L
--
V
--
N
G
A
Q
L
C
G
G
T
L
I
N
T
I
W
V
V
S
A
A
H
C
F
D
--------
K
--------
I
KNW
R
N
L
I
A
V
L
G
E
H
D
L
S
E
H
D
-
G
D
E
Q
S
R
R
V
A
Q
V
I
I
P
S
T
Y
V
-
P
--
G
T
T
N
H
D
I
A
L
L
R
L
H
Q
P
V
V
L
T
D
H
V
V
P
L
C
L
P
E
R
T
F
S
E
R
T
L
A
F
-
V
R
F
S
L
V
S
G
W
G
Q
L
L
D
-----
R
----
G
-
A
-
T
-
A
L
E
L
M
V
L
N
V
P
R
L
M
T
Q
D
C
L
Q
Q
S
-
R
K
VGDSP
N
I
T
E
Y
M
F
C
A
G
Y
S
D
---
G
S
K
D
S
C
K
G
D
S
G
G
P
H
A
T
H
Y
--
R
G
T
W
Y
L
T
G
I
V
S
W
G
Q
G
C
A
T
V
G
H
F
G
V
Y
T
R
V
S
Q
Y
I
E
W
L
Q
K
L
M
R
S
E
P
R
P
G
--------------------
87
HHSearch
76.67
41%
-90
- C4 -
3RM2
5
?
H:
[1-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
--
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
--------
Y
PPWDKNFT
E
---
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
--
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
-
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
-----
T
-------G
Q
-
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
DEG
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
PF
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
------------------------
80
HHSearch
76.56
41%
-89
- C4 -
3NXP
5
THRB_HUMAN
A:
[163-422]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
R
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
--
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
YPPWD
K
N
F
T
--------
E
---
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
--
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
-
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
-----
T
W
T
A
N-----Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
DEG
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
PF
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
------------------------
77
HHSearch
75.27
47%
-101
- C4 -
2WPH
3
?
S:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
N
--
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
--------
T
--------
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
F
N
-
A
AI
N
T
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
N
I
F
L
K
F
-
G
S
-
G
Y
V
S
G
W
G
R
V
F
H
-----
K
----
G
-
R
-
S
-
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
-
K
F
-----
T
I
T
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
-------------------------
96
HHSearch
72.52
33%
-89
- C4 -
3BG8
1
A:
[1-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
-
T
SP
T
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
--------
G
VES-----
P
---
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
-
E
D
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
-
M
--
A
E
S
G
Y
D
I
A
L
L
K
L
E
T
T
V
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
E
R
---
N
V
I
-
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
-
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
R
G
H
-----
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-------------------------
79
HHSearch
70.74
35%
-92
- C4 -
1AUT
1
PROC_HUMAN
C:
[1-240]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
D
G
K
M
T
R
R
G
D
S
P
W
Q
V
V
L
L
D
-
S
--
K
K
K
L
A
C
G
A
V
L
I
H
P
S
W
V
L
T
A
A
H
C
M
D
--------
E
--------
S
---
K
K
L
L
V
R
L
G
E
Y
D
L
R
R
W
E
-
K
W
E
L
D
L
D
I
K
E
V
F
V
H
P
N
Y
S
-
K
--
S
T
T
D
N
D
I
A
L
L
H
L
A
Q
P
A
T
L
S
Q
T
I
V
P
I
C
L
P
D
S
G
L
A
E
R
E
L
N
Q
A
G
Q
E
T
L
V
T
G
W
G
Y
H
S
S
REKEA
K
----
R
-
N
-
R
-
T
F
V
L
N
F
I
K
I
P
V
V
P
H
N
E
C
S
E
V
M
-
S
N
-----
M
V
S
E
N
M
L
C
A
G
I
L
G
---
D
R
Q
D
A
C
E
G
D
S
G
G
P
M
V
A
S
F
--
H
G
T
W
F
L
V
G
L
V
S
W
G
E
G
C
G
L
L
H
N
Y
G
V
Y
T
K
V
S
R
Y
L
D
W
I
H
G
H
I
R
D
-------------------------