@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00089_FA10_R: (2014-08-23 )
MANPLHLVLLGAALAGLLLSGSSVFISRRAANDVLARTRRANSFLEELKKGNLERECMEENCSYEEALEVFEDREKTNEFWNKYVDGDQCESNPCQNQGTCKDGLGMYTCSCVEGYEGQDCEPVTRKLCSLDNGGCDQFCKEEENSVLCSCASGYTLGDNGKSCISTELFPCGKVTLGRWRRSPATNSSEGPPEAPGPEQQDDGNLTATENPFNLLDSPEPPPEDDSSSLVRIVGGQDCRDGECPWQALLVNEENEGFCGGTILSEYHVLTAAHCLHQAKRFKVRVGDRDTEHEEGNEETHEVEVVVKHNRFVKETYDFDIAVLRLKTPITFRRNVAPACLPQKDWAESTLMAQKTGIVSGFGRTHEMGRLSTTLKMLEVPYVDRNSCKRSSSFTITQNMFCAGYDARPEDACQGDSGGPHVTRFRDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIEKSMRARAVPVAEAAGTPGPTQPTIKGSPS
Atome Classification :
(44 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250-.--......260.......270.....--------.--------.---280.......290...-....300.......310.-.--.....320.......330.......340.......350.-......360.....-----.----.-370-........380.......390.-.-----.....400.....---..410.......420...--....430.......440.......450.......460.......470.......480.......490
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MANP
L
H
L
V
L
L
G
A
A
L
A
G
L
L
LSG
S
S
V
F
I
SRRAA
N
D
V
L
A
R
T
R
R
A
N
S
F
L
E
E
L
K
KGN
L
E
R
E
C
M
E
ENC
S
Y
E
E
A
L
E
V
F
E
D
R
E
K
T
N
E
F
W
N
KYVDGDQCESNPCQNQGTCKDGL
G
M
Y
T
C
S
CVEGYEGQDC
E
P
V
T
R
K
L
CSLDNG
G
C
D
Q
F
C
K
EEEN
S
V
L
C
SCASG
Y
T
LGDNGK
S
C
I
STELFPCGKV
T
L
G
R
WRRSPATNSSEGPPEAPGPEQQDDGNLTATENPFNLLDSPEPPPEDDSS
S
L
V
R
I
VGGQDCRDGECP
W
Q
A
L
L
V
N-E--ENEGFCG
G
T
I
L
S
E
Y
H
V
L
T
A
A
H
C
L
H
--------
Q
--------
A
---
K
R
F
K
V
R
VGDRDTEHEE-GNEE
T
H
E
V
E
V
V
V
KHN
R
F
V
-
K
--ETYDF
D
I
A
V
L
R
LKT
P
I
T
FRRNVAPACL
P
Q
K
D
W
A
E
S
T
L
M
A
-
Q
KTGIVSGFGRTHE-----M----G-
R
-
L
-
S
T
T
L
K
M
L
EVPYVDRNSCKRSS
S
-
F
-----
T
I
T
Q
N
M
F
CAGYDA---RPEDACQGDSGGP
H
V
T
R
F
--
R
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
CARKGK
F
G
V
Y
T
K
V
S
N
F
L
K
W
I
E
K
S
M
RARAVPVAEAAGTPGPTQPTIKGSPS
57
PsiBlast_CBE
94.39
84%
-98
- C3 -
3HPT
5
?
D:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
----------
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
G
L
P
--------------------
56
PsiBlast_CBE
94.06
84%
-99
- C3 -
3K9X
3
?
B:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
G
L
P
--------------------
55
PsiBlast_CBE
93.80
84%
-98
- C3 -
3K9X
3
?
D:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
G
L
P
--------------------
34
PsiBlast_CBE
93.58
83%
-101
- C3 -
2WYG
1
FA10_HUMAN
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
-------
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
58
PsiBlast_CBE
93.47
84%
-97
- C3 -
3HPT
4
?
B:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
G
L
P
--------------------
41
PsiBlast_CBE
93.36
83%
-96
- C3 -
2J94
1
?
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
38
PsiBlast_CBE
93.13
83%
-97
- C3 -
2UWO
1
FA10_HUMAN
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
---
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
20
PsiBlast_PDB
93.13
83%
-102
- C3 -
2J2U
1
A:
[1-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
-----
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
-------------------------
36
PsiBlast_CBE
93.12
83%
-96
- C3 -
2VH0
1
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
42
PsiBlast_CBE
93.04
83%
-98
- C3 -
2J4I
1
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
---
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
12
PsiBlast_PDB
92.91
83%
-96
- C3 -
1NFY
1
?
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
40
PsiBlast_CBE
92.88
83%
-97
- C3 -
2J95
1
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
14
PsiBlast_PDB
92.82
83%
-92
- C3 -
1LPK
1
?
B:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
60
PsiBlast_CBE
92.64
84%
-95
- C3 -
3ENS
4
?
B:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
G
L
P
--------------------
19
PsiBlast_PDB
92.64
83%
-95
- C3 -
2CJI
1
?
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
59
PsiBlast_CBE
92.60
84%
-96
- C3 -
3ENS
5
?
D:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
R
G
L
P
--------------------
29
PsiBlast_CBE
92.50
83%
-95
- C3 -
2Y81
1
?
A:
[1-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
-------------------------
9
PsiBlast_PDB
92.46
83%
-95
- C3 -
1NFU
1
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
13
PsiBlast_PDB
92.38
83%
-97
- C3 -
1LPG
1
?
B:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
7
PsiBlast_PDB
92.28
83%
-90
- C3 -
1F0S
1
?
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
15
PsiBlast_PDB
92.26
83%
-96
- C3 -
1LPZ
1
?
B:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
43
PsiBlast_CBE
92.25
83%
-98
- C3 -
2J38
1
?
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
6
PsiBlast_PDB
92.19
83%
-95
- C3 -
1F0R
1
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
39
PsiBlast_CBE
92.16
83%
-97
- C3 -
2UWL
1
?
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
44
PsiBlast_CBE
91.97
83%
-94
- C3 -
2J34
1
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
16
PsiBlast_PDB
91.90
83%
-96
- C3 -
1LQD
1
?
B:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
5
PsiBlast_PDB
91.63
83%
-96
- C3 -
1EZQ
1
?
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
27
PsiBlast_CBE
91.61
83%
-91
- C3 -
4A7I
1
?
B:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
11
PsiBlast_PDB
91.59
83%
-93
- C3 -
1NFX
1
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
3
PsiBlast_PDB
91.39
82%
-90
- C3 -
2BQ7
1
?
B:
[16-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
10
PsiBlast_PDB
91.29
83%
-90
- C3 -
1NFW
1
?
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
45
PsiBlast_CBE
91.25
83%
-96
- C3 -
3KL6
4
A:
[1-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
--------------------------
33
PsiBlast_CBE
91.09
83%
-99
- C3 -
2WYJ
1
?
A:
[1-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
----
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
-------------------------
35
PsiBlast_CBE
91.07
83%
-92
- C3 -
2VH6
1
?
A:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
---
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
54
PsiBlast_CBE
90.56
84%
-97
- C3 -
3SW2
2
?
B:
[1-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
-------------------------
4
PsiBlast_PDB
90.30
82%
-94
- C3 -
2BQW
1
?
B:
[16-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
2
PsiBlast_PDB
89.85
82%
-91
- C3 -
2BQ6
1
?
B:
[16-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
-----
K
----
G
-
R
-
Q
-
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
------------------------
89
HHSearch
79.96
62%
-82
- C3 -
1FXY
2
TRY1_HUMAN
A:
[1-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Y
N
C
K
D
G
E
V
P
W
Q
A
L
L
I
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
S
L
P
T
A
P
-----
P
A
T
-
G
T
K
C
L
I
S
G
W
G
N
T
A
S
-----
S
----
G
A
D
-
Y
-
P
D
E
L
Q
C
L
D
A
P
V
L
S
Q
A
K
C
E
A
S
Y
P
-
G
-----
K
I
T
S
N
M
F
C
V
G
F
L
E
---
G
G
K
D
S
C
Q
G
D
S
G
G
P
V
V
C
----
N
G
--
Q
L
Q
G
V
V
S
W
G
D
G
C
A
Q
K
N
K
P
G
V
Y
T
K
V
Y
N
Y
V
K
W
I
K
N
T
I
A
A
N
-----------------------
80
HHSearch
78.25
42%
-83
- C3 -
3NXP
5
THRB_HUMAN
A:
[163-421]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
R
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
--
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
YPPWD
K
N
F
T
--------
E
---
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
--
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
-
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
-----
T
W
T
A
N-----Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
-
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
DEG
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
PF
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
------------------------
77
HHSearch
78.22
41%
-91
- C3 -
4JZE
4
?
H:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
K
V
C
P
K
G
E
C
P
W
Q
V
L
L
L
--
V
--
N
G
A
Q
L
C
G
G
T
L
I
N
T
I
W
V
V
S
A
A
H
C
F
D
--------
K
--------
I
KNW
R
N
L
I
A
V
L
G
E
H
D
L
S
E
H
D
-
G
D
E
Q
S
R
R
V
A
Q
V
I
I
P
S
T
Y
V
-
P
--
G
T
T
N
H
D
I
A
L
L
R
L
H
Q
P
V
V
L
T
D
H
V
V
P
L
C
L
P
E
R
T
F
S
E
R
T
L
A
F
-
V
R
F
S
L
V
S
G
W
G
Q
L
L
D
-----
R
----
G
-
A
-
T
-
A
L
E
L
M
V
L
N
V
P
R
L
M
T
Q
D
C
L
Q
Q
S
R
-
K
VGDSP
N
I
T
E
Y
M
F
C
A
G
Y
S
D
---
G
S
K
D
S
C
K
G
D
S
G
G
P
H
A
T
H
Y
--
R
G
T
W
Y
L
T
G
I
V
S
W
G
Q
G
C
A
T
V
G
H
F
G
V
Y
T
R
V
S
Q
Y
I
E
W
L
Q
K
L
M
R
S
E
P
R
P
G
V
------------------
87
HHSearch
75.82
42%
-82
- C3 -
3RM2
5
?
H:
[1-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
--
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
--------
Y
PPWDKNFT
E
---
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
--
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
-
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
-----
T
-------G
Q
-
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
-
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
DEG
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
PF
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
------------------------
78
HHSearch
74.38
45%
-88
- C3 -
2WPH
3
?
S:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
-
N
-
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
--------
T
--------
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
F
N
-
A
AI
N
T
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
N
I
F
L
K
F
-
G
S
-
G
Y
V
S
G
W
G
R
V
F
H
-----
K
----
G
-
R
-
S
-
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
T
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
------------------------
79
HHSearch
70.70
37%
-82
- C3 -
1AUT
1
PROC_HUMAN
C:
[1-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
D
G
K
M
T
R
R
G
D
S
P
W
Q
V
V
L
L
D
-
S
--
K
K
K
L
A
C
G
A
V
L
I
H
P
S
W
V
L
T
A
A
H
C
M
D
--------
E
--------
S
---
K
K
L
L
V
R
L
G
E
Y
D
L
R
R
W
E
-
K
W
E
L
D
L
D
I
K
E
V
F
V
H
P
N
Y
S
-
K
--
S
T
T
D
N
D
I
A
L
L
H
L
A
Q
P
A
T
L
S
Q
T
I
V
P
I
C
L
P
D
S
G
L
A
E
R
E
L
N
Q
A
G
Q
E
T
L
V
T
G
W
G
Y
H
S
S
REKEA
K
----
R
-
N
-
R
-
T
F
V
L
N
F
I
K
I
P
V
V
P
H
N
E
C
S
E
V
M
S
-
N
-----
M
V
S
E
N
M
L
C
A
G
I
L
G
---
D
R
Q
D
A
C
E
G
D
S
G
G
P
M
V
A
S
F
--
H
G
T
W
F
L
V
G
L
V
S
W
G
E
G
C
G
L
L
H
N
Y
G
V
Y
T
K
V
S
R
Y
L
D
W
I
H
G
H
I
R
D
------------------------
95
HHSearch
67.05
33%
-83
- C3 -
3BG8
1
A:
[1-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
-
T
SP
T
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
--------
G
VES-----
P
---
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
-
E
D
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
-
M
--
A
E
S
G
Y
D
I
A
L
L
K
L
E
T
T
V
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
E
R
---
N
V
I
-
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
-
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
R
G
H
-----
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
------------------------