@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00089_THRB_B: (2014-08-23 )
ANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS
Atome Classification :
(45 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340...-....350.......360.......370.......380.......390.......400.......410....-...420.......430.......440.......450........460.......470.......480.......490.......500.-----.......510.......520.......530.......540.......550.......560.......570.......580
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ANK
G
F
L
E
E
V
R
KGNL
E
R
E
C
L
EEPC
S
R
E
E
A
F
E
A
L
E
SLSA
T
D
A
F
W
A
K
Y
T
A
C
E
SAR
N
P
R
E
K
L
N
E
C
L
EGNCAEGVGMNYRG
N
V
S
V
TRSG
I
E
C
Q
L
W
R
SRYPHKPEINSTTHP
G
A
D
L
R
E
N
F
CRNPDGSITG
P
W
C
YTTSPTLRREECSVPVCGQ
D
R
V
T
V
E
V
I
PRSGGSTTSQSP
L
L
E
TCVPDRGREYR
G
R
L
A
V
TTSG
S
R
C
L
AW
S
S
E
Q
A
K
ALSKDQDFNPAV
P
L
A
E
N
FCRNPDGDEEG
A
W
C
Y
VADQPGDFEYCDLNYCEEPVDG
D
L
G
DRLGEDPDPDAAIEGRTSEDHF
Q
P
F
FNEKTFGAGEADCGLRP
L
F
E
K
K
Q
VQ
D
Q
T
E
K
E
L
F
E
S
Y
IE
G
R
IVEGQDAEVGLSP
W
Q
V
M
L
FRKS-
P
Q
E
L
L
CG
A
S
LISD
R
W
V
L
T
A
A
H
C
L
LYPPWDKNF
T
V
D
D
L
L
V
R
IGKH
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
IHPRYN
W
K
-ENLDR
D
I
A
L
LKLKRPIELSDYIHPVCLP
D
K
Q
T
A
A
K
-
L
L
H
AGFKGRVTGWGNR
R
E
T
W
T
T
S
V
A
EV
Q
P
S
V
L
Q
V
VNLPLVERPVCKAS
T
-
R
I
-----
R
I
TDN
M
F
CAGYKPGEGKRGDACEGDSGG
P
F
V
M
KSPYNN
R
W
Y
Q
M
GIVSWGEGCDRDGK
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
LGS
32
PsiBlast_CBE
94.15
86%
-100
- C4 -
1EOJ
2
?
A:
[1-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
--
34
PsiBlast_CBE
93.74
86%
-98
- C4 -
1ZRB
2
A:
[1-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
31
PsiBlast_CBE
93.61
86%
-100
- C4 -
1EOL
2
?
A:
[1-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
--
39
PsiBlast_CBE
93.58
86%
-97
- C4 -
1TA2
1
?
A:
[1-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
35
PsiBlast_CBE
93.41
86%
-98
- C4 -
1ZGV
2
?
A:
[1-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
33
PsiBlast_CBE
93.16
86%
-98
- C4 -
3C1K
2
?
A:
[1-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
30
PsiBlast_CBE
93.10
86%
-95
- C4 -
1D9I
2
?
A:
[1-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
D
--
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
42
PsiBlast_CBE
93.09
86%
-97
- C4 -
1NM6
1
?
A:
[1-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
36
PsiBlast_CBE
93.07
86%
-96
- C4 -
1ZGI
2
?
A:
[1-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
40
PsiBlast_CBE
93.03
86%
-97
- C4 -
1SL3
2
?
A:
[1-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
37
PsiBlast_CBE
92.99
86%
-95
- C4 -
1Z71
2
A:
[1-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
43
PsiBlast_CBE
92.81
86%
-99
- C4 -
1D6W
2
A:
[1-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
D
--
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
--
77
HHSearch
92.55
86%
-93
- C4 -
2BDY
2
?
A:
[1-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
---
38
PsiBlast_CBE
92.49
86%
-99
- C4 -
1TA6
2
?
A:
[1-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
21
PsiBlast_CBE
92.36
86%
-93
- C4 -
1NU9
1
?
D:
[1-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
D
G
R
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
41
PsiBlast_CBE
92.16
86%
-99
- C4 -
1NT1
2
A:
[1-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
11
PsiBlast_PDB
89.67
100%
-115
- C4 -
1ETT
1
?
H:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
E
T
W
T
T
S
V
A
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
L
G
S
27
PsiBlast_CBE
89.57
100%
-111
- C4 -
1BBR
2
?
N:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
E
T
W
T
T
S
V
A
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
L
G
S
10
PsiBlast_PDB
89.11
100%
-112
- C4 -
1ETS
1
?
H:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
E
T
W
T
T
S
V
A
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
L
G
S
8
PsiBlast_PDB
88.59
100%
-116
- C4 -
1BBR
2
?
K:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
E
T
W
T
T
S
V
A
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
L
G
S
9
PsiBlast_PDB
88.48
100%
-119
- C4 -
1ETR
1
?
H:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
E
T
W
T
T
S
V
A
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
L
G
S
16
PsiBlast_PDB
88.43
100%
-109
- C4 -
2A1D
2
?
B:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
E
T
W
T
T
S
V
A
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
L
G
S
15
PsiBlast_PDB
88.15
100%
-111
- C4 -
1A0H
3
?
B:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
E
T
W
T
T
S
V
A
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
L
G
S
25
PsiBlast_CBE
88.13
100%
-110
- C4 -
2A1D
1
?
F:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
E
T
W
T
T
S
V
A
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
L
G
S
12
PsiBlast_PDB
88.06
100%
-108
- C4 -
1UCY
1
?
K:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
E
T
W
T
T
S
V
A
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
L
G
S
28
PsiBlast_CBE
88.03
100%
-110
- C4 -
1A0H
3
?
E:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
E
T
W
T
T
S
V
A
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
L
G
S
26
PsiBlast_CBE
87.54
100%
-108
- C4 -
1UCY
1
?
N:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
E
T
W
T
T
S
V
A
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
L
G
S
14
PsiBlast_PDB
87.07
100%
-115
- C4 -
1YCP
1
?
H:
[1-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
--------
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
----
13
PsiBlast_PDB
86.76
100%
-104
- C4 -
1VIT
2
H:
[1-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
Q
D
A
E
V
G
L
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
V
D
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
K
V
E
K
I
S
M
L
D
K
I
Y
I
H
P
R
Y
N
W
K
-
E
N
L
D
R
D
I
A
L
L
K
L
K
R
P
I
E
L
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
A
A
K
-
L
L
H
A
G
F
K
G
R
V
T
G
W
G
N
R
R
E
T
W
T
T
S
V
A
E
V
Q
P
S
V
L
Q
V
V
N
L
P
L
V
E
R
P
V
C
K
A
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
G
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
Y
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
R
L
G
S
52
PsiBlast_CBE
85.77
87%
-111
- C4 -
1SB1
2
?
H:
[1-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
58
PsiBlast_CBE
85.73
87%
-110
- C4 -
4NZE
8
?
H:
[1-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
--
80
HHSearch
85.57
88%
-111
- C4 -
3RM2
5
?
H:
[1-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
50
PsiBlast_CBE
85.57
87%
-108
- C4 -
3DD2
7
?
H:
[1-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
59
PsiBlast_CBE
85.55
87%
-112
- C4 -
4N3L
8
?
H:
[1-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
---------
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
---
53
PsiBlast_CBE
85.48
87%
-108
- C4 -
1GJ5
2
H:
[1-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
--
54
PsiBlast_CBE
85.27
87%
-109
- C4 -
1GJ4
2
?
H:
[1-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
55
PsiBlast_CBE
84.98
87%
-107
- C4 -
7KME
3
H:
[1-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
62
PsiBlast_CBE
84.97
87%
-110
- C4 -
4LZ1
3
?
H:
[1-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
--------
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
--
60
PsiBlast_CBE
84.84
87%
-108
- C4 -
4LZ4
3
?
D:
[1-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
61
PsiBlast_CBE
84.63
87%
-109
- C4 -
4LZ4
3
?
B:
[1-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
49
PsiBlast_CBE
83.56
87%
-105
- C4 -
1DM4
1
?
B:
[2-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
-
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
A
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
-
90
HHSearch
65.52
40%
-102
- C4 -
2WPH
3
?
S:
[1-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
N
G
K
---
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
T
--------
G
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
H
T
E
Q
K
R
-
N
V
I
R
I
I
P
H
H
N
F
N
A
A
I
N
T
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
N
I
-
F
L
K
F
G
S
-
G
Y
V
S
G
W
G
R
V
F
H
K
G
R
------
S
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
-
K
F
-----
T
I
T
N
N
M
F
C
A
G
F
H
E
G
G
---
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
---
102
HHSearch
64.24
40%
-110
- C4 -
1AUT
1
PROC_HUMAN
C:
[1-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
D
G
K
M
T
R
R
G
D
S
P
W
Q
V
V
L
L
D
S
--
K
K
K
L
A
C
G
A
V
L
I
H
P
S
W
V
L
T
A
A
H
C
M
D
--------
E
S
K
K
L
L
V
R
L
G
E
Y
D
L
R
R
W
E
K
W
E
L
D
L
-
D
I
K
E
V
F
V
H
P
N
Y
S
K
--
S
T
T
D
N
D
I
A
L
L
H
L
A
Q
P
A
T
L
S
Q
T
I
V
P
I
C
L
P
D
S
G
L
A
E
R
E
L
N
Q
A
G
Q
E
T
L
V
T
G
W
G
Y
H
S
S
R
E
K
E
A
-
K
R
N
R
T
F
V
L
N
F
I
K
I
P
V
V
P
H
N
E
C
S
E
V
M
-
S
N
-----
M
V
S
E
N
M
L
C
A
G
I
L
G
D
R
---
Q
D
A
C
E
G
D
S
G
G
P
M
V
A
S
F
--
H
G
T
W
F
L
V
G
L
V
S
W
G
E
G
C
G
L
L
H
N
Y
G
V
Y
T
K
V
S
R
Y
L
D
W
I
H
G
H
I
R
D
---
92
HHSearch
62.75
36%
-95
- C4 -
4JZE
4
?
H:
[1-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
K
V
C
P
K
G
E
C
P
W
Q
V
L
L
L
V
---
N
G
A
Q
L
C
G
G
T
L
I
N
T
I
W
V
V
S
A
A
H
C
F
D
-----
K
I
K
N
W
R
N
L
I
A
V
L
G
E
H
D
L
S
E
H
D
G
D
E
Q
S
R
-
R
V
A
Q
V
I
I
P
S
T
Y
V
P
--
G
T
T
N
H
D
I
A
L
L
R
L
H
Q
P
V
V
L
T
D
H
V
V
P
L
C
L
P
E
R
T
F
S
E
R
-
T
L
A
F
V
R
F
S
L
V
S
G
W
G
Q
L
L
D
R
G
A
------
T
A
L
E
L
M
V
L
N
V
P
R
L
M
T
Q
D
C
L
Q
Q
S
-
R
K
VGDSP
N
I
T
E
Y
M
F
C
A
G
Y
S
D
G
S
---
K
D
S
C
K
G
D
S
G
G
P
H
A
T
H
Y
--
R
G
T
W
Y
L
T
G
I
V
S
W
G
Q
G
C
A
T
V
G
H
F
G
V
Y
T
R
V
S
Q
Y
I
E
W
L
Q
K
L
M
R
S
E
P
-
96
HHSearch
61.86
37%
-99
- C4 -
3BG8
1
A:
[1-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
E
D
T
S
F
F
-
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
S
G
Y
D
I
A
L
L
K
L
E
T
T
V
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
E
----
R
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
R
D
K
------
I
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
R
G
H
-----
K
I
T
H
K
M
I
C
A
G
Y
R
E
G
G
---
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
---