@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00089_THRB_M: (2014-08-23 )
MSHVRGLGLPGCLALAALVSLVHSQHVFLAPQQALSLLQRVRRANSGFLEELRKGNLERECVEEQCSYEEAFEALESPQDTDVFWAKYTVCDSVRKPRETFMDCLEGRCAMDLGVNYLGTVNVTHTGIQCQLWRSRYPHKPEINSTTHPGADLKENFCRNPDSSTTGPWCYTTDPTVRREECSVPVCGQEGRTTVVMTPRSGGSKDNLSPPLGQCLTERGRLYQGNLAVTTLGSPCLPWNSLPAKTLSKYQDFDPEVKLVENFCRNPDWDEEGAWCYVAGQPGDFEYCNLNYCEEAVGEENYDVDESIAGRTTDAEFHTFFNEKTFGLGEADCGLRPLFEKKSLKDTTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISMLEKIYVHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLRAGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRKGKYGFYTHVFRLKRWIQKVIDQFG
Atome Classification :
(44 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.-......460.......470.......480.......490.......500.......510.......520.......530.......-----540.......550.......560.......570.......580.......590.......600.......610......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSHVRGLG
L
P
G
C
L
A
L
A
A
L
V
S
L
V
HSQH
V
F
L
A
P
Q
Q
A
L
S
L
L
Q
R
V
R
RANS
G
F
L
E
E
L
R
KGN
L
E
R
E
C
V
E
E
QC
S
Y
E
E
A
F
E
A
LESPQDT
D
V
F
W
A
K
Y
T
V
C
D
SVR
K
P
R
E
T
F
M
D
C
L
EGR
C
A
M
DLGV
N
Y
L
G
T
V
N
V
T
HTG
I
Q
C
Q
L
W
R
SRYPHKPEINSTTHPG
A
D
L
K
E
N
FCRNPDSSTTG
P
W
C
YTTDPTVRREECSVPVCGQEG
R
T
T
V
V
M
TPRSGGSKDNLSP
P
L
G
Q
C
L
T
ERG
R
L
YQG
N
L
A
V
T
TLGSPCLPWNSL
P
A
K
T
L
S
K
YQDFDP
E
V
K
L
V
E
N
F
CRNPDWDEEG
A
W
C
Y
VAGQPGD
F
E
YC
N
L
N
Y
C
E
E
A
VGEENYDV
D
E
S
IAGRTTD
A
E
F
H
T
F
FNEKTFGLGEADCGLRP
L
F
E
KKSLKD
T
T
E
K
E
L
L
D
S
YID
G
R
I
VEGWDAEKGIAPW
Q
V
M
L
FRK
S
P
Q
E
L
L
CG
A
S
LISD
R
W
V
L
T
A
A
H
C
I
L
YPPWDKNFTEND
L
L
V
R
IGKHS
R
T
R
Y
E
R
N
V
E
K
I
S
M
L
E
K
I
Y
VHPRYN
W
R
-
E
NLDRD
I
A
L
L
KLKKPVPFSDYIHPVCLP
D
K
Q
T
V
T
S
L
L
RAGYKGRVTGWGN
L
R
E
T
WTT
N
I
N
EI
Q
P
S
V
L
Q
V
VNLPIVERPVCKAS
T
R
I
-----
R
I
TDN
M
F
C
AGFKVNDTKRGDACEGDSGG
P
F
V
M
KSPFNN
R
W
Y
Q
MGIVSWGEGCDRKGKY
G
F
Y
T
H
V
F
R
L
K
R
W
I
Q
K
V
I
D
QFG
4
PsiBlast_PDB
91.00
88%
-95
- C4 -
1DOJ
3
?
A:
[1-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
G
S
G
E
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
D
--
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
21
PsiBlast_CBE
90.12
88%
-92
- C4 -
1NU9
1
?
D:
[1-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
D
G
R
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
11
PsiBlast_PDB
90.12
88%
-95
- C4 -
1D9I
2
?
A:
[1-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
D
--
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
6
PsiBlast_PDB
89.99
88%
-96
- C4 -
1JWT
1
A:
[1-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
G
S
G
E
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
D
G
R
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
12
PsiBlast_PDB
89.88
88%
-100
- C4 -
1EOJ
2
?
A:
[1-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
-
20
PsiBlast_PDB
89.84
88%
-98
- C4 -
1ZRB
2
A:
[1-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
74
HHSearch
89.69
89%
-94
- C4 -
2BDY
2
?
A:
[1-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
--
14
PsiBlast_PDB
89.60
88%
-96
- C4 -
1NM6
1
?
A:
[1-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
23
PsiBlast_CBE
89.57
88%
-98
- C4 -
1ZGV
2
?
A:
[1-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
16
PsiBlast_PDB
89.56
88%
-96
- C4 -
1TA2
1
?
A:
[1-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
5
PsiBlast_PDB
89.33
88%
-96
- C4 -
1XM1
2
?
A:
[7-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
-
13
PsiBlast_PDB
89.32
88%
-99
- C4 -
1EOL
2
?
A:
[1-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
-
18
PsiBlast_PDB
89.27
88%
-95
- C4 -
1SL3
2
?
A:
[1-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
7
PsiBlast_PDB
89.16
88%
-93
- C4 -
1NU9
1
?
A:
[1-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
D
G
R
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
19
PsiBlast_PDB
89.08
88%
-94
- C4 -
1Z71
2
A:
[1-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
25
PsiBlast_CBE
89.04
88%
-99
- C4 -
1D6W
2
A:
[1-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
D
--
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
-
24
PsiBlast_CBE
88.85
88%
-95
- C4 -
1ZGI
2
?
A:
[1-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
22
PsiBlast_CBE
88.78
88%
-97
- C4 -
3C1K
2
?
A:
[1-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
17
PsiBlast_PDB
88.67
88%
-98
- C4 -
1TA6
2
?
A:
[1-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
15
PsiBlast_PDB
88.26
88%
-98
- C4 -
1NT1
2
A:
[1-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
29
PsiBlast_CBE
87.72
99%
-111
- C4 -
2PUX
2
?
B:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
W
D
A
E
K
G
I
A
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
I
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
V
E
K
I
S
M
L
E
K
I
Y
V
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
L
K
L
K
K
P
V
P
F
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
V
T
S
L
L
R
A
G
Y
K
G
R
V
T
G
W
G
N
L
R
E
T
W
T
T
N
I
N
E
I
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
A
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
F
K
V
N
D
T
K
R
G
D
A
C
E
G
D
A
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
K
G
K
Y
G
F
Y
T
H
V
F
R
L
K
R
W
I
Q
K
V
I
D
Q
F
G
32
PsiBlast_CBE
86.42
99%
-111
- C4 -
3HKI
2
?
B:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
W
D
A
E
K
G
I
A
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
I
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
V
E
K
I
S
M
L
E
K
I
Y
V
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
L
K
L
K
K
P
V
P
F
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
V
T
S
L
L
R
A
G
Y
K
G
R
V
T
G
W
G
N
L
R
E
T
W
T
---
N
E
I
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
A
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
F
K
V
N
D
T
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
A
G
A
G
C
D
R
K
G
K
Y
G
F
Y
T
H
V
F
R
L
K
R
W
I
Q
K
V
I
D
Q
F
G
31
PsiBlast_CBE
86.07
99%
-114
- C4 -
3HKI
2
E:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
W
D
A
E
K
G
I
A
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
I
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
V
E
K
I
S
M
L
E
K
I
Y
V
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
L
K
L
K
K
P
V
P
F
S
D
Y
I
H
P
V
C
L
P
D
K
Q
T
V
T
S
L
L
R
A
G
Y
K
G
R
V
T
G
W
G
N
L
R
E
T
W
T
---
N
E
I
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
A
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
F
K
V
N
D
T
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
A
G
A
G
C
---
G
K
Y
G
F
Y
T
H
V
F
R
L
K
R
W
I
Q
K
V
I
D
Q
F
G
76
HHSearch
84.36
89%
-111
- C4 -
3RM2
5
?
H:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
54
PsiBlast_CBE
84.18
89%
-114
- C4 -
4DII
3
?
H:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
--------
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
43
PsiBlast_CBE
84.15
89%
-110
- C4 -
4NZE
8
?
H:
[1-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
-
46
PsiBlast_CBE
84.00
89%
-108
- C4 -
4LZ4
3
?
B:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
36
PsiBlast_CBE
83.96
91%
-111
- C4 -
2OD3
2
?
B:
[1-256]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
F
K
V
N
D
T
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
K
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
--
55
PsiBlast_CBE
83.88
89%
-114
- C4 -
4DIH
3
?
H:
[1-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
--------
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
-
60
PsiBlast_CBE
83.87
89%
-108
- C4 -
4CH2
4
?
D:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
57
PsiBlast_CBE
83.84
89%
-110
- C4 -
4CH8
3
?
F:
[1-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
----
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
-
59
PsiBlast_CBE
83.80
89%
-112
- C4 -
4CH8
3
?
B:
[1-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
-
58
PsiBlast_CBE
83.61
89%
-110
- C4 -
4CH8
2
?
D:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
44
PsiBlast_CBE
83.61
89%
-110
- C4 -
4N3L
8
?
H:
[1-256]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
---------
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
--
45
PsiBlast_CBE
83.59
89%
-108
- C4 -
4LZ4
3
?
D:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
40
PsiBlast_CBE
83.46
89%
-109
- C4 -
7KME
3
H:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
47
PsiBlast_CBE
83.19
89%
-110
- C4 -
4LZ1
3
?
H:
[1-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
--------
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
-
51
PsiBlast_CBE
83.04
89%
-108
- C4 -
4E7R
4
?
G:
[1-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
-
48
PsiBlast_CBE
82.95
89%
-109
- C4 -
4I7Y
2
?
H:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
56
PsiBlast_CBE
82.84
89%
-105
- C4 -
4CH8
2
?
H:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
50
PsiBlast_CBE
82.83
89%
-109
- C4 -
4E7R
5
?
H:
[1-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
--------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
39
PsiBlast_CBE
81.91
88%
-107
- C4 -
1DM4
1
?
B:
[2-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
P
P
W
D
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
-------
G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
G
D
A
C
E
G
D
A
G
G
P
F
V
M
K
S
P
F
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
G
85
HHSearch
65.00
39%
-102
- C4 -
2WPH
3
?
S:
[1-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
N
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
T
--------
G
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
H
T
E
-
Q
K
R
N
V
I
R
I
I
P
H
H
N
F
N
A
A
I
N
T
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
N
I
F
L
K
F
G
S
-
G
Y
V
S
G
W
G
R
V
F
H
K
G
R
------
S
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
K
F
-----
T
I
T
N
N
M
F
C
A
G
F
H
E
G
G
---
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
--
94
HHSearch
60.83
35%
-97
- C4 -
4JZE
4
?
H:
[1-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
K
V
C
P
K
G
E
C
P
W
Q
V
L
L
L
V
--
N
G
A
Q
L
C
G
G
T
L
I
N
T
I
W
V
V
S
A
A
H
C
F
D
K
I
-----
K
N
W
R
N
L
I
A
V
L
G
E
H
D
L
S
E
H
D
G
D
E
-
Q
S
R
R
V
A
Q
V
I
I
P
S
T
Y
V
P
--
G
T
T
N
H
D
I
A
L
L
R
L
H
Q
P
V
V
L
T
D
H
V
V
P
L
C
L
P
E
R
T
F
S
E
R
T
L
A
F
V
R
F
S
L
V
S
G
W
G
Q
L
L
D
R
G
A
------
T
A
L
E
L
M
V
L
N
V
P
R
L
M
T
Q
D
C
L
Q
Q
S
R
K
VGDSP
N
I
T
E
Y
M
F
C
A
G
Y
S
D
G
S
---
K
D
S
C
K
G
D
S
G
G
P
H
A
T
H
Y
--
R
G
T
W
Y
L
T
G
I
V
S
W
G
Q
G
C
A
T
V
G
H
F
G
V
Y
T
R
V
S
Q
Y
I
E
W
L
Q
K
L
M
R
S
E
-