@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00098_POL_HV: (2014-08-24 )
MGARASVLSGGELDKWEKIRLRPGGKKQYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQTGSEELRSLYNTIAVLYCVHQRIDVKDTKEALDKIEEEQNKSKKKAQQAAADTGNNSQVSQNYPIVQNLQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPGATLEEMMTACQGVGGPGHKARVLAEAMSQVTNPATIMIQKGNFRNQRKTVKCFNCGKEGHIAKNCRAPRKKGCWKCGKEGHQMKDCTERQANFLREDLAFPQGKAREFSSEQTRANSPTRRELQVWGRDNNSLSEAGADRQGTVSFSFPQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGAHTNDVKQLTEAVQKIATESI
Atome Classification :
(56 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......----690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGARASVLSGGELDK
W
E
K
I
R
LRPGGK
K
Q
Y
K
L
K
H
I
V
W
A
S
R
E
L
E
R
FAVNPGLLE
T
S
E
G
C
R
Q
I
L
G
Q
LQPSLQT
G
S
E
E
L
R
S
L
Y
N
T
I
A
V
L
Y
C
V
H
QRID
V
K
D
T
K
E
A
L
D
K
I
E
E
E
Q
N
K
S
K
K
K
A
Q
Q
AAADTGNNSQVSQNYP
I
V
Q
N
L
Q
G
Q
M
V
H
Q
AISP
R
T
L
N
A
W
V
K
V
V
E
EKAFSP
E
V
I
P
M
F
S
A
L
SEGA
T
P
Q
D
L
N
T
M
L
N
TVG
G
H
Q
A
A
M
Q
M
L
K
E
T
I
N
E
E
A
A
E
WDRLHPVHAGPIAPGQMREPRGSDIAG
T
T
S
T
L
Q
E
Q
IGWMTHNPPI
P
V
G
E
I
Y
K
R
W
I
I
L
G
L
N
K
I
V
R
MYSPT
S
I
L
DIRQG
P
K
E
P
F
R
D
Y
V
D
R
F
Y
K
T
L
R
A
E
Q
A
S
Q
E
V
K
N
W
M
T
E
T
L
L
VQNANP
D
C
K
T
I
L
K
ALGPG
A
T
L
E
E
M
M
T
A
C
QGVGGP
G
H
K
A
R
V
L
A
E
A
M
S
QVTN
P
A
T
I
M
I
QKGNFRNQ
R
K
T
V
K
C
FNCGKEGHI
A
K
NCRAP
R
K
K
G
C
W
K
CGKEGH
Q
M
K
D
C
T
E
R
Q
A
N
F
L
R
E
D
LAFPQG
K
A
REFSSEQTRANSPT
R
R
E
L
Q
V
WGRDNNS
L
S
EAGADRQ
G
T
V
S
FSFP
Q
I
T
L
WQR
P
L
V
T
I
K
IG
G
Q
L
K
E
A
L
LDTGAD
D
T
V
L
E
EMNLPGRWKPKMIGGIG
G
F
I
K
V
R
Q
Y
D
Q
I
L
I
E
ICGHK
A
I
G
T
V
L
VGP
T
P
V
N
I
I
G
R
N
L
L
T
QIG
C
T
LNFPISPI
E
T
V
P
V
K
L
KPGMDGPKVKQWPL
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
KEGKISKIGPENPYNT
P
V
F
A
I
KKKDS
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
LGIPHPAGLKQ----K
K
S
V
T
V
L
DVGD
A
Y
F
SVPLDKD
F
R
KYT
A
F
TIPSINNETPG
I
R
Y
Q
YNVLPQGWKGS
P
A
I
F
Q
C
S
M
T
K
I
L
E
P
F
RKQNP
D
I
V
I
Y
Q
Y
M
D
D
LYVGSDLEI
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
RWGFTTPDKKHQKEPP
F
L
W
M
G
Y
E
LHPDK
W
T
V
Q
P
I
VLPEKDSW
T
V
N
D
I
Q
K
L
V
G
KL
N
W
A
S
Q
I
Y
A
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
VVPLT
E
E
A
E
L
E
L
AE
N
R
E
I
L
K
EPVH
G
V
YYDP
S
K
D
L
I
A
E
I
Q
K
QGQG
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
NLKTGK
Y
A
RMKGAHT
N
D
V
K
Q
L
T
E
A
V
Q
K
I
ATESI
36
PsiBlast_CBE
99.19
97%
-78
- C5 -
1RTI
2
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
59
PsiBlast_CBE
97.88
97%
-75
- C5 -
2VG5
1
?
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
------
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
K
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
23
PsiBlast_CBE
97.69
97%
-72
- C5 -
3MEE
1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
56
PsiBlast_CBE
97.61
97%
-72
- C5 -
3MED
1
POL_HV1H2
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
N
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
34
PsiBlast_CBE
97.59
97%
-73
- C5 -
2RKI
2
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
38
PsiBlast_CBE
97.52
97%
-77
- C5 -
3NBP
1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
---
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
37
PsiBlast_CBE
97.41
97%
-73
- C5 -
1RTH
2
?
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
17
PsiBlast_PDB
97.38
97%
-76
- C5 -
3TAM
1
?
A:
[4-383]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
----
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
N
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
22
PsiBlast_CBE
97.31
97%
-74
- C5 -
3QIP
1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
--
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
57
PsiBlast_CBE
97.25
97%
-76
- C5 -
2WOM
1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
N
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
43
PsiBlast_CBE
97.25
97%
-78
- C5 -
3DI6
1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
----
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
65
PsiBlast_CBE
97.17
97%
-73
- C5 -
1IKX
1
POL_HV1B1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
N
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
K
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
10
PsiBlast_PDB
97.16
97%
-73
- C5 -
2YNI
1
A:
[2-383]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
41
PsiBlast_CBE
97.15
97%
-77
- C5 -
3E01
1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
----
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
13
PsiBlast_PDB
97.12
97%
-76
- C5 -
3LP0
1
A:
[3-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
---
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
N
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
16
PsiBlast_PDB
97.11
97%
-75
- C5 -
3T1A
1
A:
[3-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
----
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
N
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
14
PsiBlast_PDB
97.10
97%
-74
- C5 -
3LP1
1
?
A:
[3-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
----
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
N
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
7
PsiBlast_PDB
97.07
97%
-74
- C5 -
3T19
1
?
A:
[3-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
----
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
45
PsiBlast_CBE
97.06
97%
-72
- C5 -
4KV8
1
?
A:
[2-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
15
PsiBlast_PDB
97.06
97%
-74
- C5 -
3LP2
1
A:
[3-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
----
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
N
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
2
PsiBlast_PDB
97.02
97%
-73
- C5 -
3C6T
1
A:
[2-383]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
9
PsiBlast_PDB
96.95
97%
-70
- C5 -
2YNH
1
?
A:
[2-383]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
33
PsiBlast_CBE
96.94
97%
-75
- C5 -
2WON
1
?
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
39
PsiBlast_CBE
96.93
97%
-74
- C5 -
3M8Q
1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
---
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
64
PsiBlast_CBE
96.92
97%
-72
- C5 -
1IKY
1
POL_HV1B1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
N
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
K
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
66
PsiBlast_CBE
96.86
97%
-76
- C5 -
1IKV
1
?
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
-----
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
K
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
1
PsiBlast_PDB
96.86
97%
-74
- C5 -
2RF2
1
?
A:
[4-383]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
---
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
32
PsiBlast_CBE
96.80
97%
-72
- C5 -
3LAK
1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
55
PsiBlast_CBE
96.77
97%
-68
- C5 -
3MEG
1
?
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
N
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
26
PsiBlast_CBE
96.73
97%
-73
- C5 -
3LAN
1
?
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
21
PsiBlast_CBE
96.73
97%
-70
- C5 -
4I7F
1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
8
PsiBlast_PDB
96.71
97%
-74
- C5 -
2YNG
1
A:
[2-383]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
49
PsiBlast_CBE
96.66
97%
-71
- C5 -
1IKW
1
POL_HV1B1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
K
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
58
PsiBlast_CBE
96.63
97%
-73
- C5 -
2VG7
1
POL_HV1B1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
------
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
K
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
30
PsiBlast_CBE
96.39
97%
-70
- C5 -
3LAL
1
?
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
42
PsiBlast_CBE
96.37
97%
-75
- C5 -
3DYA
1
POL_HV1H2
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
----
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
18
PsiBlast_PDB
96.36
97%
-77
- C5 -
3FFI
1
?
A:
[2-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
----
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
3
PsiBlast_PDB
96.36
97%
-69
- C5 -
3C6U
1
?
A:
[3-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
28
PsiBlast_CBE
96.32
97%
-70
- C5 -
3LAM
1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
40
PsiBlast_CBE
96.30
97%
-75
- C5 -
3M8P
1
?
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
----
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
4
PsiBlast_PDB
96.17
97%
-73
- C5 -
3DRP
1
A:
[3-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
24
PsiBlast_CBE
96.09
97%
-77
- C5 -
3MEC
1
POL_HV1H2
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
--
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
44
PsiBlast_CBE
95.92
97%
-72
- C5 -
2JLE
1
?
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
19
PsiBlast_PDB
95.83
97%
-73
- C5 -
2YNF
1
?
A:
[2-383]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
---
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
L
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
11
PsiBlast_PDB
95.79
97%
-73
- C5 -
4NCG
1
?
A:
[4-383]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
---
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
6
PsiBlast_PDB
95.73
97%
-72
- C5 -
3I0S
1
?
A:
[3-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
48
PsiBlast_CBE
95.63
97%
-77
- C5 -
3ISN
1
?
C:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
K
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
5
PsiBlast_PDB
95.59
97%
-73
- C5 -
3I0R
1
A:
[3-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
20
PsiBlast_PDB
95.58
97%
-72
- C5 -
3DRR
1
?
A:
[3-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
C
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
50
PsiBlast_CBE
95.47
97%
-69
- C5 -
1TV6
1
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
K
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
----
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
12
PsiBlast_PDB
95.42
97%
-72
- C5 -
3DRS
1
?
A:
[3-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
N
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
62
PsiBlast_CBE
95.10
97%
-76
- C5 -
4B3Q
3
?
A:
[1-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
-------------
V
D
F
R
E
L
N
K
K
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
63
PsiBlast_CBE
95.06
97%
-78
- C5 -
4B3O
3
A:
[4-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
-------------
V
D
F
R
E
L
N
K
K
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
61
PsiBlast_CBE
90.49
97%
-73
- C5 -
4B3P
2
A:
[5-380]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
---------------
V
D
F
R
E
L
N
K
K
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
----------
E
D
F
R
K
Y
T
A
F
T
I
--
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
----
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
60
PsiBlast_CBE
90.13
97%
-63
- C5 -
3HVT
1
?
A:
[2-380]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
F
W
E
V
Q
L
G
I
P
H
P
A
G
L
K
K
----
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
K
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
P
D
K
W
T
V
Q
P
I
V
L
P
E
K
D
S
W
T
V
N
D
I
Q
K
L
V
G
K
L
N
W
A
S
Q
I
Y
P
G
I
K
V
R
Q
L
C
K
L
L
R
G
T
K
A
L
T
E
V
I
P
L
T
E
E
A
E
L
E
L
A
E
N
R
E
I
L
K
E
P
V
H
G
V
Y
Y
D
P
S
K
D
L
I
A
E
I
Q
K
Q
G
Q
G
Q
W
T
Y
Q
I
Y
Q
E
P
F
K
N
L
K
T
G
K
Y
A
R
M
R
G
A
H
T
N
D
V
K
Q
L
T
E
A
V
Q
K
I
T
T
E
S
I
75
Fugue
64.45
93%
-64
- C5 -
1VRT
1
A:
[4-233]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
E
T
V
P
V
K
L
K
P
G
M
D
G
P
K
V
K
Q
W
P
L
T
E
E
K
I
K
A
L
V
E
I
C
T
E
M
E
K
E
G
K
I
S
K
I
G
P
E
N
P
Y
N
T
P
V
F
A
I
K
K
K
D
S
T
K
W
R
K
L
V
D
F
R
E
L
N
K
R
T
Q
D
---
F
W
E
V
Q
L
G
-
I
P
H
P
A
G
L
K
K
K
K
S
V
T
V
L
D
V
G
D
A
Y
F
S
V
P
L
D
E
D
F
R
K
Y
T
A
F
T
I
P
S
I
N
N
E
T
P
G
I
R
Y
Q
Y
N
V
L
P
Q
G
W
K
G
S
P
A
I
F
Q
S
S
M
T
K
I
L
E
P
F
R
K
Q
N
P
D
I
V
I
Y
Q
Y
M
D
D
L
Y
V
G
S
D
L
E
I
G
Q
H
R
T
K
I
E
E
L
R
Q
H
L
L
R
W
G
L
T
T
P
D
K
K
H
Q
K
E
P
P
F
L
W
M
G
Y
E
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------