@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00102_PTN2_H: (2014-08-24 )
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
Atome Classification :
(17 SA)
.........10....-....20........30........40........50........60.---..----..--...70........80........90........100.......110.......120......-.130.-.......140.......150.......160.......170.......180.......190.......200...--------....210.......220.......230......---.240-.---........250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MP
T
T
I
E
R
E
F
E
E
L
D
T
Q-RRWQ
P
L
Y
L
E
IRNESHDY
P
H
R
V
A
KFPENRNRNRYRDVSPYDH
S
R
V
K
L
Q---NA----EN--DYIN
A
S
L
V
D
I
E
E
A
Q
R
S
Y
I
L
TQGPL
P
N
T
C
C
H
F
W
L
M
V
W
Q
QK
T
K
A
V
V
M
L
N
R
I
V
E
K
ESVKCAQYWP-TD
D
-
Q
-
E
M
L
F
K
ETG
F
S
V
K
L
L
S
E
D
V
K
S
Y
Y
T
V
H
L
L
Q
L
ENINSGE
T
R
T
I
S
H
F
HYTTWPDFGVPE
S
P
A
S
F
L
N
F
L
F
K
V
RESGSL--------NPDHG
P
A
V
I
H
CSAGIGRS
G
T
F
S
L
V
D
T
C
L
V
L
MEK---GD---D---I
N
I
K
Q
V
L
L
N
M
R
K
Y
RMGLIQT
P
D
Q
L
R
F
S
Y
M
A
I
IEGAKCIKG
D
S
S
I
Q
K
R
W
K
E
L
S
K
E
DLSPAFDHSPNK
I
M
TEKYNGNRIGLEEEKLTGDRCT
G
L
S
S
K
M
Q
D
T
M
E
E
N
S
E
S
A
L
R
K
R
I
R
E
D
RKA
T
T
A
Q
K
V
Q
Q
M
K
Q
RL
N
E
N
E
R
K
R
K
R
W
L
Y
W
Q
P
I
L
T
K
M
G
F
M
S
V
I
L
V
G
A
F
V
G
W
T
L
F
F
QQNAL
3
PsiBlast_PDB
93.47
69%
-103
- C1 -
2NT7
1
PTN1_HUMAN
A:
[3-298]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
D
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
92.99
69%
-104
- C1 -
2ZMM
1
PTN1_HUMAN
A:
[3-298]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
92.78
69%
-102
- C1 -
2QBP
1
PTN1_HUMAN
A:
[3-298]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
92.74
69%
-102
- C1 -
2QBS
1
PTN1_HUMAN
A:
[3-298]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.66
69%
-102
- C1 -
2NTA
1
PTN1_HUMAN
A:
[3-298]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
D
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
92.58
69%
-103
- C1 -
2QBQ
1
PTN1_HUMAN
A:
[3-298]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
21
Fugue
92.52
69%
-108
- C1 -
1BZH
1
PTN1_HUMAN
A:
[2-298]
---
E
M
E
K
E
F
E
Q
I
D
K
S
G-
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
------DN
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
-
Q
K
E
-
E
K
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
RKD
P
S
---
S
---
V
D
I
K
K
V
L
L
D
M
R
K
F
R
M
G
L
I
Q
T
A
E
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
92.36
69%
-102
- C1 -
2H4K
1
PTN1_HUMAN
A:
[3-298]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.36
69%
-103
- C1 -
2AZR
1
PTN1_HUMAN
A:
[3-298]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
92.22
69%
-103
- C1 -
2HB1
1
PTN1_HUMAN
A:
[3-298]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.14
69%
-104
- C1 -
4I8N
1
PTN1_HUMAN
A:
[37-333]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
L
----------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
92.02
69%
-103
- C1 -
2ZN7
1
PTN1_HUMAN
A:
[3-298]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.97
69%
-101
- C1 -
2H4G
1
PTN1_HUMAN
A:
[3-298]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
91.73
69%
-101
- C1 -
2QBR
1
PTN1_HUMAN
A:
[3-299]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
L
----------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
91.09
69%
-103
- C1 -
2B07
1
PTN1_HUMAN
A:
[3-298]
----
M
E
K
E
F
E
Q
I
D
K
S
-
G
S
W
A
A
I
Y
Q
D
I
R
H
E
A
S
D
F
P
C
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
---
Q
E
----
D
N
--
D
Y
I
N
A
S
L
I
K
M
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
K
E
E
-
K
-
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
--------
S
P
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
---
R
K
---
D
PSS
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
E
G
A
K
F
I
M
G
D
S
S
V
Q
D
Q
W
K
E
L
S
H
E
D
-----------------------------------------------------------------------------------------------------------------------
34
HHSearch
75.02
40%
-90
- C1 -
4GE6
1
PTN9_HUMAN
A:
[18-304]
------
D
Y
V
N
A
R
Q
K
Q
-
G
-
I
Y
E
E
Y
E
D
I
R
R
E
N
P
V
G
T
F
H
C
S
M
S
P
G
N
L
E
K
N
R
Y
G
D
V
P
C
L
D
Q
T
R
V
K
L
T
---
K
R
SGHT
Q
T
--
D
Y
I
N
A
S
F
M
D
G
Y
K
Q
K
N
A
Y
I
G
T
Q
G
P
L
E
N
T
Y
R
D
F
W
L
M
V
W
E
Q
K
V
L
V
I
V
M
T
T
R
F
E
E
G
G
R
R
K
C
G
Q
Y
W
P
-
L
E
K
D
S
-
R
I
R
F
G
--
F
L
T
V
T
N
L
G
V
E
N
M
N
H
Y
K
K
T
T
L
E
I
H
N
T
E
E
R
Q
K
R
Q
V
T
H
F
Q
F
L
S
W
P
D
Y
G
V
P
S
S
A
A
S
L
I
D
F
L
R
V
V
R
N
Q
Q
S
L
A
V
S
N
MGAR-
C
P
E
P
P
I
V
V
H
C
S
A
G
I
G
R
T
G
T
F
C
S
L
D
I
C
L
A
Q
L
E
E
---
L
G
---
T
---
L
N
V
F
Q
T
V
S
R
M
R
T
Q
R
A
F
S
I
Q
T
P
E
Q
Y
Y
F
C
Y
K
A
I
L
E
F
A
E
K
E
G
---------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
69.43
36%
-84
- C1 -
2P6X
3
PTN22_HUMAN
A:
[23-292]
---
E
F
A
N
E
F
L
K
L
K
R
Q
-
S
T
-------
K
Y
K
A
D
K
T
Y
P
T
T
V
A
E
K
P
K
N
I
K
K
N
R
Y
K
D
I
L
P
Y
D
Y
S
R
V
E
L
S
LIT
D
E
----
D
S
--
S
Y
I
N
A
N
F
I
K
G
V
Y
G
P
K
A
Y
I
A
T
Q
G
P
L
S
T
T
L
L
D
F
W
R
M
I
W
E
Y
S
V
L
I
I
V
M
A
C
M
E
Y
E
M
G
K
K
K
C
E
R
Y
W
A
-
E
P
G
E
M
-
Q
L
E
F
--
G
P
F
S
V
S
C
E
A
E
K
R
K
S
D
Y
I
I
R
T
L
K
V
K
F
--
N
S
E
T
R
T
I
Y
Q
F
H
Y
K
N
W
P
D
H
D
V
P
S
S
I
D
P
I
L
E
L
I
W
D
V
R
C
Y
Q
----------
E
D
D
S
V
P
I
C
I
H
C
S
A
G
C
G
R
T
G
V
I
C
A
I
D
Y
T
W
M
L
L
K
D
---
G
I
IPE
N
---
F
S
V
F
S
L
I
R
E
M
R
T
Q
R
P
S
L
V
Q
T
Q
E
Q
Y
E
L
V
Y
N
A
V
L
E
L
F
K
R
-----------------------------------------------------------------------------------------------------------------------------------------