@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00102_PTN3_H: (2014-08-24 )
MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS
Atome Classification :
(12 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640----......-.650....------...660--.......670.......680.......-690--.-----........700.......710.......720.......730.......740.......750.......760.--.---......770.......780.......790.......-800.......810.......820.......---830--..-----------......840.......850.......860....---...870...---....880.......890.......900.......910.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
S
R
L
R
A
L
GGRINNIRTSELPKEKTRS
E
V
I
C
S
I
H
F
L
D
G
V
V
Q
T
F
K
VTKQD
T
G
Q
V
L
L
D
M
V
H
N
HLGV
T
E
K
E
YFGLQHDDDSVDS
P
R
W
L
E
A
S
K
A
I
R
K
Q
LKGGF
P
C
T
L
H
F
R
V
R
F
F
IPDPN
T
L
Q
Q
E
QT
R
H
L
Y
F
L
Q
L
K
M
DICE
G
R
LTCPLN
S
A
V
V
L
A
S
Y
A
V
Q
S
HFGDYNSSIHHPGYLSDSHFIPDQN
E
D
F
L
T
K
V
E
S
L
H
E
Q
HSGLKQSEAE
S
C
Y
I
N
I
A
R
T
L
D
F
Y
G
V
E
LHSGRDLHN
L
D
L
M
I
G
I
A
S
A
G
V
A
V
Y
R
K
Y
I
C
T
S
F
Y
P
W
V
N
I
L
K
I
SFK
R
K
K
F
F
I
H
Q
R
Q
K
Q
AESR
E
H
I
V
A
F
NML
N
Y
R
S
C
K
N
L
W
K
S
C
V
E
H
H
T
F
F
Q
A
K
K
LLP
Q
E
K
N
V
L
S
Q
Y
WTMGSRNTKKSV
N
N
Q
Y
C
K
K
V
IGGMVW
N
P
A
M
R
RSLSVEHLETKSLPSRSPPITPNWRSP
R
L
R
H
E
I
RKPRHS
S
A
D
N
L
A
NE
M
T
Y
I
TET
E
D
V
F
Y
T
YKGSLAPQDSDS
E
V
SQNRSP
H
Q
E
SLSENN
P
A
Q
S
Y
L
TQKSSSSVSPSSNAPGSCSPDG
V
D
Q
Q
L
L
D
D
F
H
R
VTKGGSTE
D
A
S
QYYCDKNDNGD
S
Y
L
V
L
I
R
ITPDEDG
K
F
G
F
NLKGGVDQKM
P
L
V
V
S
RINPESPADTCIPKLNEG
D
Q
I
V
L
I
NGRDISEHTH
D
Q
V
V
M
F
I
KASRES
H
S
R
E
L
A
L
V
I
R
R
R
A
V
R
S
F
ADFKSE
D
E
L
N
Q
L
F
P
E
A
IFPMCPEGGDTLE
G
S
M
A
Q
L
K
K
GLE----SG
T
V
L
I
-
Q
F
E
Q
L
YRK------KP
G
L
A
I
--
T
F
A
KLPQNL
D
K
N
RYKDVLPYD
T
T
R
V
L
L
-Q----G-----NED
Y
I
N
A
S
Y
V
N
M
EI
P
A
A
N
L
V
N
K
Y
IATQGPL
P
H
T
C
A
Q
F
W
Q
V
V
W
DQK
L
S
L
I
V
M
L
T
T
L
T
ERGR
T
K
C
HQYWPD-P
P
--
D
---
V
MNHG
G
F
H
I
Q
CQSED
C
T
I
A
Y
V
S
R
E
M
L
V
TNTQTGEEH-
T
V
T
H
L
Q
Y
V
AWPDHGVPDD
S
S
D
F
L
E
F
V
N
Y
V
R
---
S
L---RV-----------DSE
P
V
L
V
H
CSAGIGR
T
G
V
L
V
T
M
E
T
A
M
C
L
TERNL---PIY
P
L
D
I
V
R
---
K
M
R
D
Q
R
A
M
M
V
QTSS
Q
Y
K
F
V
C
E
A
I
L
R
V
Y
E
E
G
L
V
Q
MLDPS
33
HHSearch
79.31
39%
-88
- C2 -
2BZL
2
A:
[33-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
F
R
T
L
K
K
K
L
-------
M
V
F
T
-
E
Y
E
Q
I
P
K
K
------
K
A
N
G
I
F
--
S
T
A
A
L
P
E
N
A
E
R
S
R
I
R
E
V
V
P
Y
E
E
N
R
V
E
L
-
I
----
P
TKEN-
N
T
G
Y
I
N
A
S
H
I
K
V
V
V
G
--
G
A
E
W
H
Y
I
A
T
Q
G
P
L
P
H
T
C
H
D
F
W
Q
M
V
W
E
Q
G
V
N
V
I
A
M
V
T
A
E
E
E
G
G
R
T
K
S
H
R
Y
W
P
K
---KH
S
---
S
A
T
Y
G
K
F
K
V
T
T
K
F
R
T
D
S
V
C
Y
A
T
T
G
L
K
V
K
H
L
L
S
G
Q
E
R
-
T
V
W
H
L
Q
Y
T
D
W
P
D
H
G
C
P
E
D
V
Q
G
F
L
S
Y
L
E
E
I
Q
---
S
V
---
R
R
H
T
N
SMLEGTKN
R
H
P
P
I
V
V
H
C
S
A
G
V
G
R
T
G
V
L
I
L
S
E
L
M
I
Y
C
L
E
H
N
E
---
K
V
E
V
P
M
M
L
R
---
L
L
R
E
Q
R
M
F
M
I
Q
T
I
A
Q
Y
K
F
V
Y
Q
V
L
I
Q
F
L
Q
N
---------
15
PsiBlast_PDB
75.88
36%
-90
- C2 -
1NO6
1
PTN1_HUMAN
A:
[3-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
E
F
E
Q
I
D
K
-------
S
G
S
W
A
A
-
I
Y
Q
D
I
R
H
E
------
A
S
D
F
P
C
--
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
Q
----
E
-----
D
N
D
Y
I
N
A
S
L
I
K
M
E
----
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
-
K
E
--
E
K
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
-
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
---
S
P
-----------
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
R
K
---
D
P
S
S
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
--------------
14
PsiBlast_PDB
75.53
36%
-88
- C2 -
1NNY
1
PTN1_HUMAN
A:
[3-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
E
F
E
Q
I
D
K
-------
S
G
S
W
A
A
-
I
Y
Q
D
I
R
H
E
------
A
S
D
F
P
C
--
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
Q
----
E
-----
D
N
D
Y
I
N
A
S
L
I
K
M
E
----
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
-
K
E
--
E
K
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
-
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
---
S
P
-----------
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
R
K
---
D
P
S
S
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
--------------
13
PsiBlast_PDB
75.41
36%
-90
- C2 -
1NL9
1
PTN1_HUMAN
A:
[3-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
E
F
E
Q
I
D
K
-------
S
G
S
W
A
A
-
I
Y
Q
D
I
R
H
E
------
A
S
D
F
P
C
--
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
Q
----
E
-----
D
N
D
Y
I
N
A
S
L
I
K
M
E
----
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
-
K
E
--
E
K
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
-
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
---
S
P
-----------
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
R
K
---
D
P
S
S
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
--------------
17
PsiBlast_PDB
74.60
36%
-87
- C2 -
1ONY
1
PTN1_HUMAN
A:
[3-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
E
F
E
Q
I
D
K
-------
S
G
S
W
A
A
-
I
Y
Q
D
I
R
H
E
------
A
S
D
F
P
C
--
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
Q
----
E
-----
D
N
D
Y
I
N
A
S
L
I
K
M
E
----
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
-
K
E
--
E
K
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
-
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
---
S
P
-----------
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
R
K
---
D
P
S
S
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
--------------
18
PsiBlast_PDB
74.54
36%
-91
- C2 -
1ONZ
1
PTN1_HUMAN
A:
[3-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
E
F
E
Q
I
D
K
-------
S
G
S
W
A
A
-
I
Y
Q
D
I
R
H
E
------
A
S
D
F
P
C
--
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
Q
----
E
-----
D
N
D
Y
I
N
A
S
L
I
K
M
E
----
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
-
K
E
--
E
K
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
-
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
---
S
P
-----------
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
R
K
---
D
P
S
S
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
--------------
16
PsiBlast_PDB
74.25
36%
-88
- C2 -
1NZ7
1
PTN1_HUMAN
A:
[3-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
E
F
E
Q
I
D
K
-------
S
G
S
W
A
A
-
I
Y
Q
D
I
R
H
E
------
A
S
D
F
P
C
--
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
Q
----
E
-----
D
N
D
Y
I
N
A
S
L
I
K
M
E
----
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
-
K
E
--
E
K
E
M
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
-
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
---
S
P
-----------
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
R
K
---
D
P
S
S
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
--------------
11
PsiBlast_PDB
71.95
35%
-84
- C2 -
4I8N
1
PTN1_HUMAN
A:
[36-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
K
E
F
E
Q
I
D
K
S
G
S
W
A
A
-
I
Y
Q
D
I
R
H
E
------
A
S
D
F
P
C
--
R
V
A
K
L
P
K
N
K
N
R
N
R
Y
R
D
V
S
P
F
D
H
S
R
I
K
L
H
Q
----
E
-----
D
N
D
Y
I
N
A
S
L
I
K
M
E
----
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
C
G
H
F
W
E
M
V
W
E
Q
K
S
R
G
V
V
M
L
N
R
V
M
E
K
G
S
L
K
C
A
Q
Y
W
P
Q
-
K
E
--
E
KEM
I
F
E
D
T
N
L
K
L
T
L
I
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
E
N
L
T
T
Q
E
T
R
-
E
I
L
H
F
H
Y
T
T
W
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
L
F
K
V
R
E
S
G
S
L
---
S
P
-----------
E
H
G
P
V
V
V
H
C
S
A
G
I
G
R
S
G
T
F
C
L
A
D
T
C
L
L
L
M
D
K
R
K
---
D
P
S
S
V
D
I
K
K
V
L
L
E
M
R
K
F
R
M
G
L
I
Q
T
A
D
Q
L
R
F
S
Y
L
A
V
I
--------------
45
HHSearch
71.62
37%
-83
- C2 -
2H4V
3
PTPRG_HUMAN
A:
[41-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
E
-
D
F
E
E
V
Q
R
C
------
T
A
D
M
N
I
T
A
E
H
S
N
H
P
E
N
K
H
K
N
R
Y
I
N
I
L
A
Y
D
H
S
R
V
K
L
-
R
----
P
LP---
H
S
D
Y
I
N
A
N
Y
V
D
G
Y
----
N
K
A
K
A
Y
I
A
T
Q
G
P
L
K
S
T
F
E
D
F
W
R
M
I
W
E
Q
N
T
G
I
I
V
M
I
T
N
L
V
E
K
G
R
R
K
C
D
Q
Y
W
P
T
-
E
---
N
---
S
E
E
Y
G
N
I
I
V
T
L
K
S
T
K
I
H
A
C
Y
T
V
R
R
F
S
I
R
N
T
K
---
E
R
-
V
V
I
Q
Y
H
Y
T
Q
W
P
D
M
G
V
P
E
Y
A
L
P
V
L
T
F
V
R
R
S
S
---
A
A
---
R
M
P----------
E
T
G
P
V
L
V
H
C
S
A
G
V
G
R
T
G
T
Y
I
V
I
D
S
M
L
Q
Q
I
K
D
K
S
---
T
V
N
V
L
G
F
L
K
---
H
I
R
T
Q
R
N
Y
L
V
Q
T
E
E
Q
Y
I
F
I
H
D
A
L
L
E
A
I
L
G
---------
9
PsiBlast_PDB
71.08
36%
-86
- C2 -
2H03
1
A:
[7-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
P
I
K
I
N
Q
F
E
G
H
F
M
K
L
Q
A
--
D
----
S
N
Y
L
L
S
K
E
Y
E
E
L
K
D
V
------
G
R
N
Q
S
C
--
D
I
A
L
L
P
E
N
R
G
K
N
R
Y
N
N
I
L
P
Y
D
A
T
R
V
K
L
-
S
----
G
-----
G
S
D
Y
I
N
A
S
Y
----
I
P
G
N
N
F
R
R
E
Y
I
V
T
Q
G
P
L
P
G
T
K
D
D
F
W
K
M
V
W
E
Q
N
V
H
N
I
V
M
V
T
Q
C
V
E
K
G
R
V
K
C
D
H
Y
W
P
A
-
D
Q
--
D
---
S
L
Y
Y
G
D
L
I
L
Q
M
L
S
E
S
V
L
P
E
W
T
I
R
E
F
K
I
C
G
E
E
Q
L
D
A
H
R
L
I
R
H
F
H
Y
T
V
W
P
D
H
G
V
P
E
T
T
Q
S
L
I
Q
F
V
R
T
V
R
---
D
Y
I
N
R
S
P
-----------
G
A
G
P
T
V
V
H
C
S
A
G
V
G
R
T
G
T
F
I
A
L
D
R
I
L
Q
Q
L
D
S
K
D
---
S
V
D
I
Y
G
A
V
H
---
D
L
R
L
H
R
V
H
M
V
Q
T
E
C
Q
Y
V
Y
L
H
Q
C
V
---------------
36
HHSearch
69.76
37%
-85
- C2 -
4GE6
1
PTN9_HUMAN
A:
[28-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Y
E
-
E
Y
E
D
I
R
R
E
------
N
P
V
G
T
F
--
H
C
S
M
S
P
G
N
L
E
K
N
R
Y
G
D
V
P
C
L
D
Q
T
R
V
K
L
-
T
----
K
RSGHT
Q
T
D
Y
I
N
A
S
F
M
D
G
Y
----
K
Q
K
N
A
Y
I
G
T
Q
G
P
L
E
N
T
Y
R
D
F
W
L
M
V
W
E
Q
K
V
L
V
I
V
M
T
T
R
F
E
E
G
G
R
R
K
C
G
Q
Y
W
P
L
E
K
D
--
S
---
R
I
R
F
G
F
L
T
V
T
N
L
G
V
E
N
M
N
H
Y
K
K
T
T
L
E
I
H
N
T
E
E
R
Q
K
R
-
Q
V
T
H
F
Q
F
L
S
W
P
D
Y
G
V
P
S
S
A
A
S
L
I
D
F
L
R
V
V
R
---
N
Q
---
Q
S
L
A
V
S
N
MGARC-
P
E
P
P
I
V
V
H
C
S
A
G
I
G
R
T
G
T
F
C
S
L
D
I
C
L
A
Q
L
E
E
L
G
---
T
L
N
V
F
Q
T
V
S
---
R
M
R
T
Q
R
A
F
S
I
Q
T
P
E
Q
Y
Y
F
C
Y
K
A
I
L
E
F
A
E
K
E
G
M
V
-----
50
HHSearch
66.29
36%
-85
- C2 -
2P6X
3
PTN22_HUMAN
A:
[22-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
A
N
-
E
F
L
K
L
K
R
Q
S
T
K
Y
K
A
D
K
T
Y
P
T
--
T
V
A
E
K
P
K
N
I
K
K
N
R
Y
K
D
I
L
P
Y
D
Y
S
R
V
E
L
-
S
LITD
E
-----
D
S
S
Y
I
N
A
N
F
I
K
G
V
Y
----
G
P
K
A
Y
I
A
T
Q
G
P
L
S
T
T
L
L
D
F
W
R
M
I
W
E
Y
S
V
L
I
I
V
M
A
C
M
E
Y
E
M
G
K
K
K
C
E
R
Y
W
A
E
-
P
G
--
E
M--
Q
L
E
F
G
P
F
S
V
S
C
E
A
E
K
R
K
S
D
Y
I
I
R
T
L
K
V
K
F
N
--
S
E
T
R
-
T
I
Y
Q
F
H
Y
K
N
W
P
D
H
D
V
P
S
S
I
D
P
I
L
E
L
I
W
D
V
R
---
C
Y
---
Q
E
D----------
D
S
V
P
I
C
I
H
C
S
A
G
C
G
R
T
G
V
I
C
A
I
D
Y
T
W
M
L
L
K
D
G
I
IPE
N
F
S
V
F
S
L
I
R
---
E
M
R
T
Q
R
P
S
L
V
Q
T
Q
E
Q
Y
E
L
V
Y
N
A
V
L
E
L
F
K
R
Q
M
-------