@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00102_PTPRG_: (2014-08-25 )
MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGALHENRHGSAVQIRRRKASGDPYWAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSINGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFVLRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKATISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTWTSSGIPFSFVSMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSFPSTVWPTRLPTAASASKQAARPVLATTEALASPGPDGDSSPTKDGEGTEEGEKDEKSESEDGEREHEEDGEKDSEKKEKSGVTHAAEERNQTEPSPTPSSPNRTAEGGHQTIPGHEQDHTAVPTDQTGGRRDAGPGLDPDMVTSTQVPPTATEEQYAGSDPKRPEMPSKKPMSRGDRFSEDSRFITVNPAEKNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESDPAESMESLV
Atome Classification :
(14 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860--.........870.......880.......890.......900.......910....-...920.......930.......940.......950.......960.....--.--.970.........980.......990.......1000......1010......1020......1030......1040......---1050------.........1060......1070......1080---......1090......1100......1110......1120......1130......1140.-.....1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250.....-.1260......1270......1280......1290......1300......1310......1320......1330.....---.1340-.........1350......1360......1370......1380......1390......1400......1410......1420......1430......1440..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
R
L
L
E
P
C
W
W
I
L
F
L
K
I
T
S
S
V
L
H
Y
V
V
C
F
P
A
LT
E
G
Y
V
G
A
LHENRHG
S
A
V
Q
I
R
R
RKASGDP
Y
W
A
YSGAYGPEHWVTSSVSCGGRHQ
S
P
I
D
I
L
D
Q
Y
A
R
V
G
E
E
Y
Q
E
L
QLDGFDNESSNK
T
W
MKNTG
K
T
V
A
I
L
L
KD
D
Y
F
VSGAGLPGRFKA
E
K
V
E
F
HWGHSNGSAGSEHSINGRRF
P
V
E
M
Q
I
F
F
YNP
D
D
F
D
S
F
Q
T
A
I
SEN
R
I
I
G
A
M
A
I
F
F
Q
VSPRDNS
A
L
D
P
I
I
H
G
L
K
G
V
V
HH
E
K
E
TFL
D
P
F
V
L
R
D
L
L
P
A
S
LGS
Y
Y
R
YTGSLTTP
P
C
S
E
I
V
E
W
I
V
FRRPVP
I
S
Y
H
Q
L
E
A
F
Y
S
I
FTT
E
Q
Q
D
H
V
K
S
V
E
Y
L
R
NNF
R
P
Q
Q
R
L
H
D
R
V
V
S
K
S
A
VRDSWNH
D
M
T
D
F
L
ENPLG
T
E
A
S
K
VCSSP
P
I
H
M
K
V
QPLNQ
T
A
L
Q
V
SWSQPETIYHP
P
I
M
N
Y
M
I
S
Y
S
WTKNE
D
E
K
EKTFTKDSD
K
D
L
K
A
T
I
SHVSPD
S
L
Y
L
F
R
V
Q
A
V
C
R
N
D
M
R
S
D
F
S
Q
T
M
L
FQAN
T
T
R
I
FQG
T
R
I
V
KTGVPTASPASSADMAPISSGSSTWTSSGI
P
F
S
F
V
S
M
ATGMGPSSSGS
Q
A
T
V
A
S
V
V
T
S
T
L
L
A
G
LGFGGGGISSFPSTVWPTRLPTAASASKQAAR
P
V
L
A
T
T
E
A
LASPGPDGDSSPTKDGEGTEEGEKDEKSESEDGEREHEEDGEK
D
S
E
K
K
E
KSGVT
H
A
A
EERNQTEPSPTPSSPNRTAEGGHQTIPGHEQDHTAVPTDQTGGRRDAGPGLDPDMVTSTQVPPTATEEQYAGSDPKRPEMPSKKPMSRGDRFSEDS
R
F
I
T
VNPAEKNTSGMISRPAPGR
M
E
W
I
I
P
L
I
V
V
S
A
L
T
F
V
C
L
I
L
L
I
A
V
L
V
Y
WRG
C
N
K
IKSKGF
P
R
R
F
R
EVPSSGERGEKG
S
R
K
C
F
Q
T
A
H
F
Y
V
EDSSS
P
R
VVPNESI
P
I
I
PIPDDMEAI
P
V
K
Q
F
V
K
H
I
G
E
L
YSNNQHG
F
S
E
D
F
E
E
V
Q
R
C
TA----D
M
N
I
T
AEHSNHPENKHK
N
R
Y
I
N
I
L
A
YDHS
R
V
K
L
RPLPGKDSKHSDYINANYVDGYN-K
A
K
A
Y
I
ATQG
P
L
K
S
T
F
E
D
F
W
R
M
I
W
EQNT
G
I
I
V
M
I
T
N
L
V
E
K
G
R
R
K
C
D
QYWPT--E--NS--EEY
G
N
I
I
V
T
L
KS
T
K
I
H
A
C
Y
T
V
R
R
F
S
IRN
T
K
VKKGQKGNPKGRQN
E
R
V
V
I
Q
Y
HYTQWPDMGV
P
E
Y
A
L
P
V
L
T
F
V
R
R
S
S
AAR---M---------PETG
P
V
L
V
H
CSAGVGRT
G
T
Y
I
V
I
D
S
M
L
Q
Q
I
KDK---S
T
V
N
V
L
G
F
L
K
H
I
R
T
QRN
Y
L
V
QTEE
Q
Y
I
F
I
H
D
A
L
L
E
A
I
LGKETEV
S
S
N
Q
L
H
S
Y
V
N
S
ILIPGV-GG
K
T
R
L
E
K
Q
F
K
L
V
T
QCN
A
K
Y
V
E
C
F
S
A
Q
K
E
C
NKEKNRNSSVVP
S
E
RARVGLAPLPGMKGT
D
Y
I
N
A
S
Y
I
M
G
Y
YRSN
E
F
I
I
TQHPLPHT
T
K
D
F
W
R
M
I
W
DHN
A
Q
I
I
V
M
LPDNQSLAED-
E
F
V
YWPSREESMNC
E
A
F
T
V
T
L
I
SKDRLCLSNE
E
Q
I
I
I
H
D
F
I
L
EATQD
D
Y
V
L
E
V
R
HFQCPKWPNPDA
P
I
S
S
T
F
E
L
I
N
V
I
K
E
---
E
A----LTRDG
P
T
I
V
HDEYG
A
V
S
A
G
M
L
C
A
L
T
T
L
S
Q
Q
LENENA
V
D
V
F
Q
V
A
K
M
I
N
L
MRPGVFT
D
I
E
Q
Y
Q
F
I
Y
K
A
M
L
S
L
V
STKENGNG
P
M
T
VDKN
G
A
V
L
I
ADES
D
P
A
E
S
M
E
SLV
40
HHSearch
72.67
35%
-89
- C2 -
1YGR
1
PTPRC_HUMAN
A:
[7-607]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
P
I
H
A
D
I
L
L
E
T
Y
K
R
K
I
A
D
E
G
R
P
F
L
A
E
F
Q
S
I
P
R
V
F
S
----
K
F
--
P
I
K
E
A
R
K
P
F
N
Q
N
K
N
R
Y
V
D
I
L
P
Y
D
Y
N
R
V
E
L
S
E
I
N
G
D
A
--
G
S
N
Y
I
N
A
S
Y
I
D
G
F
K
-
E
P
R
K
Y
I
A
A
Q
G
P
R
D
E
T
V
D
D
F
W
R
M
I
W
E
Q
K
A
T
V
I
V
M
V
T
R
C
E
E
G
N
R
N
K
C
A
E
Y
W
P
S
ME
E
--
G
T
--
R
A
F
G
D
V
V
V
K
I
N
Q
H
K
R
C
P
D
Y
I
I
Q
K
L
N
I
V
N
K
K
E
----------
K
A
T
G
R
E
V
T
H
I
Q
F
T
S
W
P
D
H
G
V
P
E
D
P
H
L
L
L
K
L
R
R
R
V
N
A
F
S
---
N
---------
F
F
S
G
P
I
V
V
H
S
S
A
G
V
G
R
T
G
T
Y
I
G
I
D
A
M
L
E
G
L
E
A
E
---
N
K
V
D
V
Y
G
Y
V
V
K
L
R
R
Q
R
C
L
M
V
Q
V
E
A
Q
Y
I
L
I
H
Q
A
L
V
E
Y
N
Q
F
G
E
T
E
V
N
L
S
E
L
H
P
Y
L
H
N
M
K
K
R
D
P
P
S
E
P
S
P
L
E
A
E
F
Q
R
L
P
S
Y
R
S
-
W
R
T
Q
H
I
G
N
Q
E
E
N
K
S
K
N
R
N
S
N
V
I
P
Y
D
Y
N
R
V
P
L
K
-------
S
K
Y
I
N
A
S
F
I
M
S
Y
W
K
P
E
V
M
I
A
A
Q
G
P
L
K
E
T
I
G
D
F
W
Q
M
I
F
Q
R
K
V
K
V
I
V
M
L
T
E
L
K
H
G
D
Q
E
I
C
A
Q
Y
W
G
E
--
G
K
Q
T
Y
G
D
I
E
V
D
L
K
D
T
D
K
-----
S
S
T
Y
T
L
R
V
F
E
L
R
H
S
K
R
K
D
S
R
T
V
Y
Q
Y
Q
Y
T
N
W
S
V
E
Q
L
P
A
-
E
P
K
E
L
I
S
M
I
Q
V
V
K
Q
K
L
PQKN-
H
K
S
T
P
L
L
I
H
C
R
D
G
S
Q
Q
T
G
I
F
C
A
L
L
N
L
L
E
S
A
E
T
E
E
V
V
D
I
F
Q
V
V
K
A
L
R
K
A
R
L
G
M
V
S
T
F
E
Q
Y
Q
F
L
Y
D
V
I
A
S
T
Y
P
---------------------------------
22
PsiBlast_CBE
58.52
100%
-86
- C2 -
3QCE
1
B:
[7-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
A
I
P
V
K
Q
F
V
K
H
I
G
E
L
Y
S
N
N
Q
H
G
F
S
E
D
F
E
E
V
Q
R
C
T
A
----
D
M
N
I
T
A
E
H
S
N
H
P
E
N
K
H
K
N
R
Y
I
N
I
L
A
Y
D
H
S
R
V
K
L
R
P
L
P
G
K
-
S
K
H
S
D
Y
I
N
A
N
Y
V
D
G
Y
N
-
K
A
K
A
Y
I
A
T
Q
G
P
L
K
S
T
F
E
D
F
W
R
M
I
W
E
Q
N
T
G
I
I
V
M
I
T
N
L
V
E
K
G
R
R
K
C
D
Q
Y
W
P
T
--
E
--
N
S
--
E
E
Y
G
N
I
I
V
T
L
K
S
T
K
I
H
A
C
Y
T
V
R
R
F
S
I
R
N
T
K
-------------
N
E
R
V
V
I
Q
Y
H
Y
T
Q
W
P
D
M
G
V
P
E
Y
A
L
P
V
L
T
F
V
R
R
S
S
A
A
R
---
M
---------
P
E
T
G
P
V
L
V
H
C
S
A
G
V
G
R
T
G
T
Y
I
V
I
D
S
M
L
Q
Q
I
K
D
K
---
S
T
V
N
V
L
G
F
L
K
H
I
R
T
Q
R
N
Y
L
V
Q
T
E
E
Q
Y
I
F
I
H
D
A
L
L
E
A
I
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
58.41
99%
-83
- C2 -
3QCM
2
B:
[7-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
A
I
P
V
K
Q
F
V
K
H
I
G
E
L
Y
S
N
N
Q
H
G
F
S
E
D
F
E
E
V
Q
R
C
T
A
----
D
M
N
I
T
A
E
H
S
N
H
P
E
N
K
H
K
N
R
Y
I
N
I
L
A
Y
D
H
S
R
V
K
L
R
P
L
P
G
--
S
K
H
S
D
Y
I
N
A
N
Y
V
D
G
Y
N
-
K
A
K
A
Y
I
A
T
Q
G
P
L
K
S
T
F
E
D
F
W
R
M
I
W
E
Q
N
T
G
I
I
I
M
I
T
N
L
V
E
K
G
R
R
K
C
D
Q
Y
W
P
T
--
E
--
N
T
--
E
E
Y
G
N
I
I
V
T
L
K
S
T
K
I
H
A
C
Y
T
V
R
R
F
S
I
R
N
T
K
V
K
----------
Q
N
E
R
V
V
I
Q
Y
H
Y
T
Q
W
P
D
M
G
V
P
E
Y
A
L
P
V
L
T
F
V
R
R
S
S
A
A
R
---
M
---------
P
E
T
G
P
V
L
V
H
C
S
A
G
V
G
R
T
G
T
Y
I
V
I
D
S
M
L
Q
Q
I
K
D
K
---
S
T
V
N
V
L
G
F
L
K
H
I
R
T
Q
R
N
Y
L
V
Q
T
E
E
Q
Y
I
F
I
H
D
A
L
L
E
A
I
L
G
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
58.27
99%
-81
- C2 -
3QCL
1
A:
[7-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
A
I
P
V
K
Q
F
V
K
H
I
G
E
L
Y
S
N
N
Q
H
G
F
S
E
D
F
E
E
V
Q
R
S
T
A
----
D
M
N
I
T
A
E
H
S
N
H
P
E
N
K
H
K
N
R
Y
I
N
I
L
A
Y
D
H
S
R
V
K
L
R
P
L
P
G
--
S
K
H
S
D
Y
I
N
A
N
Y
V
D
G
Y
N
-
K
A
K
A
Y
I
A
T
Q
G
P
L
K
S
T
F
E
D
F
W
R
M
I
W
E
Q
N
T
G
I
I
V
M
I
T
N
L
V
E
K
G
R
R
K
C
D
Q
Y
W
P
T
--
E
--
N
T
--
E
E
Y
G
N
I
I
V
T
L
K
S
T
K
I
H
A
C
Y
T
V
R
R
F
S
I
R
N
T
K
V
K
----------
Q
N
E
R
V
V
I
Q
Y
H
Y
T
Q
W
P
D
M
G
V
P
E
Y
A
L
P
V
L
T
F
V
R
R
S
S
A
A
R
---
M
---------
P
E
T
G
P
V
L
V
H
C
S
A
G
V
G
R
T
G
T
Y
I
V
I
D
S
M
L
Q
Q
I
K
D
K
---
S
T
V
N
V
L
G
F
L
K
H
I
R
T
Q
R
N
Y
L
V
Q
T
E
E
Q
Y
I
F
I
H
D
A
L
L
E
A
I
L
G
K
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
58.22
100%
-85
- C2 -
3QCF
1
B:
[7-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
A
I
P
V
K
Q
F
V
K
H
I
G
E
L
Y
S
N
N
Q
H
G
F
S
E
D
F
E
E
V
Q
R
C
T
A
----
D
M
N
I
T
A
E
H
S
N
H
P
E
N
K
H
K
N
R
Y
I
N
I
L
A
Y
D
H
S
R
V
K
L
R
P
L
P
G
K
-
S
K
H
S
D
Y
I
N
A
N
Y
V
D
G
Y
N
-
K
A
K
A
Y
I
A
T
Q
G
P
L
K
S
T
F
E
D
F
W
R
M
I
W
E
Q
N
T
G
I
I
V
M
I
T
N
L
V
E
K
G
R
R
K
C
D
Q
Y
W
P
T
--
E
--
N
S
--
E
E
Y
G
N
I
I
V
T
L
K
S
T
K
I
H
A
C
Y
T
V
R
R
F
S
I
R
N
T
K
-------------
N
E
R
V
V
I
Q
Y
H
Y
T
Q
W
P
D
M
G
V
P
E
Y
A
L
P
V
L
T
F
V
R
R
S
S
A
A
R
---
M
---------
P
E
T
G
P
V
L
V
H
C
S
A
G
V
G
R
T
G
T
Y
I
V
I
D
S
M
L
Q
Q
I
K
D
K
---
S
T
V
N
V
L
G
F
L
K
H
I
R
T
Q
R
N
Y
L
V
Q
T
E
E
Q
Y
I
F
I
H
D
A
L
L
E
A
I
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
58.21
100%
-82
- C2 -
3QCJ
1
A:
[7-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
A
I
P
V
K
Q
F
V
K
H
I
G
E
L
Y
S
N
N
Q
H
G
F
S
E
D
F
E
E
V
Q
R
C
T
A
----
D
M
N
I
T
A
E
H
S
N
H
P
E
N
K
H
K
N
R
Y
I
N
I
L
A
Y
D
H
S
R
V
K
L
R
P
L
P
G
--
S
K
H
S
D
Y
I
N
A
N
Y
V
D
G
Y
N
-
K
A
K
A
Y
I
A
T
Q
G
P
L
K
S
T
F
E
D
F
W
R
M
I
W
E
Q
N
T
G
I
I
V
M
I
T
N
L
V
E
K
G
R
R
K
C
D
Q
Y
W
P
T
--
E
--
N
S
--
E
E
Y
G
N
I
I
V
T
L
K
S
T
K
I
H
A
C
Y
T
V
R
R
F
S
I
R
N
T
K
------------
Q
N
E
R
V
V
I
Q
Y
H
Y
T
Q
W
P
D
M
G
V
P
E
Y
A
L
P
V
L
T
F
V
R
R
S
S
A
A
R
---
M
---------
P
E
T
G
P
V
L
V
H
C
S
A
G
V
G
R
T
G
T
Y
I
V
I
D
S
M
L
Q
Q
I
K
D
K
---
S
T
V
N
V
L
G
F
L
K
H
I
R
T
Q
R
N
Y
L
V
Q
T
E
E
Q
Y
I
F
I
H
D
A
L
L
E
A
I
L
G
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
57.91
100%
-80
- C2 -
3QCK
1
A:
[7-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
A
I
P
V
K
Q
F
V
K
H
I
G
E
L
Y
S
N
N
Q
H
G
F
S
E
D
F
E
E
V
Q
R
C
T
A
----
D
M
N
I
T
A
E
H
S
N
H
P
E
N
K
H
K
N
R
Y
I
N
I
L
A
Y
D
H
S
R
V
K
L
R
P
L
P
---
S
K
H
S
D
Y
I
N
A
N
Y
V
D
G
Y
N
-
K
A
K
A
Y
I
A
T
Q
G
P
L
K
S
T
F
E
D
F
W
R
M
I
W
E
Q
N
T
G
I
I
V
M
I
T
N
L
V
E
K
G
R
R
K
C
D
Q
Y
W
P
T
--
E
--
N
S
--
E
E
Y
G
N
I
I
V
T
L
K
S
T
K
I
H
A
C
Y
T
V
R
R
F
S
I
R
N
T
K
V
K
----------
Q
N
E
R
V
V
I
Q
Y
H
Y
T
Q
W
P
D
M
G
V
P
E
Y
A
L
P
V
L
T
F
V
R
R
S
S
A
A
R
---
M
---------
P
E
T
G
P
V
L
V
H
C
S
A
G
V
G
R
T
G
T
Y
I
V
I
D
S
M
L
Q
Q
I
K
D
K
---
S
T
V
N
V
L
G
F
L
K
H
I
R
T
Q
R
N
Y
L
V
Q
T
E
E
Q
Y
I
F
I
H
D
A
L
L
E
A
I
L
G
K
E
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.79
100%
-82
- C2 -
3QCH
1
A:
[7-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
A
I
P
V
K
Q
F
V
K
H
I
G
E
L
Y
S
N
N
Q
H
G
F
S
E
D
F
E
E
V
Q
R
C
T
A
----
D
M
N
I
T
A
E
H
S
N
H
P
E
N
K
H
K
N
R
Y
I
N
I
L
A
Y
D
H
S
R
V
K
L
R
P
L
P
---
S
K
H
S
D
Y
I
N
A
N
Y
V
D
G
Y
N
-
K
A
K
A
Y
I
A
T
Q
G
P
L
K
S
T
F
E
D
F
W
R
M
I
W
E
Q
N
T
G
I
I
V
M
I
T
N
L
V
E
K
G
R
R
K
C
D
Q
Y
W
P
T
--
E
--
N
S
--
E
E
Y
G
N
I
I
V
T
L
K
S
T
K
I
H
A
C
Y
T
V
R
R
F
S
I
R
N
T
K
------------
Q
N
E
R
V
V
I
Q
Y
H
Y
T
Q
W
P
D
M
G
V
P
E
Y
A
L
P
V
L
T
F
V
R
R
S
S
A
A
R
---
M
---------
P
E
T
G
P
V
L
V
H
C
S
A
G
V
G
R
T
G
T
Y
I
V
I
D
S
M
L
Q
Q
I
K
D
K
---
S
T
V
N
V
L
G
F
L
K
H
I
R
T
Q
R
N
Y
L
V
Q
T
E
E
Q
Y
I
F
I
H
D
A
L
L
E
A
I
L
G
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
57.42
100%
-80
- C2 -
3QCI
1
A:
[7-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
A
I
P
V
K
Q
F
V
K
H
I
G
E
L
Y
S
N
N
Q
H
G
F
S
E
D
F
E
E
V
Q
R
C
T
A
----
D
M
N
I
T
A
E
H
S
N
H
P
E
N
K
H
K
N
R
Y
I
N
I
L
A
Y
D
H
S
R
V
K
L
R
P
L
P
---
S
K
H
S
D
Y
I
N
A
N
Y
V
D
G
Y
N
-
K
A
K
A
Y
I
A
T
Q
G
P
L
K
S
T
F
E
D
F
W
R
M
I
W
E
Q
N
T
G
I
I
V
M
I
T
N
L
V
E
K
G
R
R
K
C
D
Q
Y
W
P
T
--
E
--
N
S
--
E
E
Y
G
N
I
I
V
T
L
K
S
T
K
I
H
A
C
Y
T
V
R
R
F
S
I
R
N
T
K
V
K
----------
Q
N
E
R
V
V
I
Q
Y
H
Y
T
Q
W
P
D
M
G
V
P
E
Y
A
L
P
V
L
T
F
V
R
R
S
S
A
A
R
---
M
---------
P
E
T
G
P
V
L
V
H
C
S
A
G
V
G
R
T
G
T
Y
I
V
I
D
S
M
L
Q
Q
I
K
D
K
---
S
T
V
N
V
L
G
F
L
K
H
I
R
T
Q
R
N
Y
L
V
Q
T
E
E
Q
Y
I
F
I
H
D
A
L
L
E
A
I
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
57.16
98%
-83
- C2 -
2H4V
3
PTPRG_HUMAN
A:
[19-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
Q
S
M
K
Q
F
V
K
H
I
G
E
L
Y
S
N
N
Q
H
G
F
S
E
D
F
E
E
V
Q
R
C
T
A
----
D
M
N
I
T
A
E
H
S
N
H
P
E
N
K
H
K
N
R
Y
I
N
I
L
A
Y
D
H
S
R
V
K
L
R
P
L
P
-----
H
S
D
Y
I
N
A
N
Y
V
D
G
Y
N
-
K
A
K
A
Y
I
A
T
Q
G
P
L
K
S
T
F
E
D
F
W
R
M
I
W
E
Q
N
T
G
I
I
V
M
I
T
N
L
V
E
K
G
R
R
K
C
D
Q
Y
W
P
T
--
E
--
N
S
--
E
E
Y
G
N
I
I
V
T
L
K
S
T
K
I
H
A
C
Y
T
V
R
R
F
S
I
R
N
T
K
--------------
E
R
V
V
I
Q
Y
H
Y
T
Q
W
P
D
M
G
V
P
E
Y
A
L
P
V
L
T
F
V
R
R
S
S
A
A
R
---
M
---------
P
E
T
G
P
V
L
V
H
C
S
A
G
V
G
R
T
G
T
Y
I
V
I
D
S
M
L
Q
Q
I
K
D
K
---
S
T
V
N
V
L
G
F
L
K
H
I
R
T
Q
R
N
Y
L
V
Q
T
E
E
Q
Y
I
F
I
H
D
A
L
L
E
A
I
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
48.29
44%
-70
- C2 -
3S3E
3
PTP10_DROME
A:
[23-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
P
I
L
I
K
N
F
A
E
H
Y
R
L
M
S
A
D
S
D
F
R
F
S
E
E
F
E
E
L
K
H
V
G
R
----
D
Q
--
P
C
T
F
A
D
L
P
C
N
R
P
K
N
R
F
T
N
I
L
P
Y
D
H
S
R
F
K
L
Q
P
V
D
D
D
E
G
--
S
D
Y
I
N
A
N
Y
V
P
G
H
N
-
S
P
R
E
F
I
V
T
Q
G
P
L
H
S
T
R
D
D
F
W
R
M
C
W
E
S
N
S
R
A
I
V
M
L
T
R
C
F
E
K
G
R
E
K
C
D
Q
Y
W
P
N
--
D
--
T
V
P
-
V
F
Y
G
D
I
K
V
Q
I
L
N
D
S
H
Y
A
D
W
V
M
T
E
F
M
L
C
R
-----
G
S
--------
E
Q
R
I
L
R
H
F
H
F
T
T
W
P
D
F
G
V
P
N
P
P
Q
T
L
V
R
F
V
R
A
F
R
D
R
I
---
G
---------
A
E
Q
R
P
I
V
V
H
C
S
A
G
V
G
R
S
G
T
F
I
T
L
D
R
I
L
Q
Q
I
N
T
S
---
D
Y
V
D
I
F
G
I
V
Y
A
M
R
K
E
R
V
W
M
V
Q
T
E
Q
Q
Y
I
C
I
H
Q
C
L
L
A
V
L
E
G
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
44.43
36%
-58
- C2 -
2P6X
3
PTN22_HUMAN
A:
[7-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
K
F
L
D
E
A
Q
S
K
K
-
I
T
K
E
E
F
A
N
E
F
L
K
L
K
R
Q
S
T
K
Y
K
A
D
K
T
Y
P
T
T
V
A
E
K
P
K
N
I
K
K
N
R
Y
K
D
I
L
P
Y
D
Y
S
R
V
E
L
S
L
I
T
-
D
E
--
D
S
S
Y
I
N
A
N
F
I
K
G
V
Y
-
G
P
K
A
Y
I
A
T
Q
G
P
L
S
T
T
L
L
D
F
W
R
M
I
W
E
Y
S
V
L
I
I
V
M
A
C
M
E
Y
E
M
G
K
K
K
C
E
R
Y
W
A
E
--
P
--
G
E
MQ
L
E
F
G
P
F
S
V
S
C
E
A
E
K
R
K
S
D
Y
I
I
R
T
L
K
V
K
F
N
-----
S
--------
E
T
R
T
I
Y
Q
F
H
Y
K
N
W
P
D
H
D
V
P
S
S
I
D
P
I
L
E
L
I
W
D
V
R
C
Y
Q
---
E
---------
D
D
S
V
P
I
C
I
H
C
S
A
G
C
G
R
T
G
V
I
C
A
I
D
Y
T
W
M
L
L
K
D
G
IIP
E
N
F
S
V
F
S
L
I
R
E
M
R
T
Q
R
P
S
L
V
Q
T
Q
E
Q
Y
E
L
V
Y
N
A
V
L
E
L
F
K
R
Q
M
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
43.92
37%
-73
- C2 -
2CJZ
2
PTN5_HUMAN
A:
[26-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
A
E
E
L
H
E
K
A
L
-----
D
P
F
L
L
Q
A
E
F
F
E
I
P
M
N
F
V
----
D
----
P
K
E
Y
D
I
P
G
L
V
R
K
N
R
Y
K
T
I
L
P
N
P
H
S
R
V
C
L
T
S
P
D
P
D
D
-
P
L
S
S
Y
I
N
A
N
Y
I
R
G
Y
G
G
E
E
K
V
Y
I
A
T
Q
G
P
I
V
S
T
V
A
D
F
W
R
M
V
W
Q
E
H
T
P
I
I
V
M
I
T
----------
T
E
Y
W
P
E
--
E
---
Q
--
V
A
Y
D
G
V
E
I
T
V
Q
K
V
I
H
T
E
D
Y
R
L
R
L
I
S
L
K
S
---------------
E
E
R
G
L
K
H
Y
W
F
T
S
W
P
D
Q
K
T
P
D
R
A
P
P
L
L
H
L
V
R
E
V
E
E
A
A
Q
Q
E
G
---------
P
H
C
A
P
I
I
V
H
S
S
A
G
I
G
R
T
G
C
F
I
A
T
S
I
C
C
Q
Q
L
R
Q
E
---
G
V
V
D
I
L
K
T
T
C
Q
L
R
Q
D
R
G
G
M
I
Q
T
C
E
Q
Y
Q
F
V
H
H
V
M
S
L
Y
E
K
Q
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
43.75
38%
-66
- C2 -
4GE6
1
PTN9_HUMAN
A:
[9-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
M
T
I
Q
E
L
V
D
Y
V
N
A
R
Q
K
---
Q
G
I
Y
E
E
Y
E
D
I
R
R
E
N
P
----
V
G
--
T
F
H
C
S
M
S
P
G
N
L
E
K
N
R
Y
G
D
V
P
C
L
D
Q
T
R
V
K
L
T
K
R
S
G
H
--
T
Q
T
D
Y
I
N
A
S
F
M
D
G
Y
K
-
Q
K
N
A
Y
I
G
T
Q
G
P
L
E
N
T
Y
R
D
F
W
L
M
V
W
E
Q
K
V
L
V
I
V
M
T
T
R
F
E
E
G
G
R
R
K
C
G
Q
Y
W
P
L
--
E
KD
S
R
--
I
R
F
G
F
L
T
V
T
N
L
G
V
E
N
M
N
H
Y
K
K
T
T
L
E
I
H
N
T
E
---
E
--------
R
Q
K
R
Q
V
T
H
F
Q
F
L
S
W
P
D
Y
G
V
P
S
S
A
A
S
L
I
D
F
L
R
V
V
R
N
Q
Q
---
S
L
A
V
S
N
MGAR
C
P
E
P
P
I
V
V
H
C
S
A
G
I
G
R
T
G
T
F
C
S
L
D
I
C
L
A
Q
L
E
E
L
---
G
T
L
N
V
F
Q
T
V
S
R
M
R
T
Q
R
A
F
S
I
Q
T
P
E
Q
Y
Y
F
C
Y
K
A
I
L
E
F
A
E
K
E
G
M
V
S
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------