@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_ANDR_H: (2014-08-25 )
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
Atome Classification :
(65 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760-.........770.....-..780.......790..-.....800.......810....--...820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
V
QLGLGRVYPRPP
S
K
T
Y
R
G
A
F
Q
N
L
F
Q
S
V
R
E
V
I
QNPGPRHPEAASAAPPG
A
S
L
L
L
L
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
QETS
P
R
Q
Q
Q
Q
QQGEDGSP
Q
A
HRRGP
T
G
Y
L
V
LDEEQQPSQP
Q
S
A
L
ECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPS
T
L
S
LLGPTFP
G
L
S
S
C
S
A
D
L
K
D
I
L
S
E
A
S
T
M
Q
L
L
Q
Q
Q
Q
Q
E
A
V
SEGSSSGRAREASGAPTSSKDNYLGGTSTISD
N
A
K
E
L
C
K
A
V
S
V
SMG
L
G
V
E
A
L
E
HLS
P
G
E
Q
LRGD
C
M
YAPLLGVPPAVRPTPCA
P
L
A
E
CKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSG
T
L
ELP
S
T
L
S
L
Y
KSGAL
D
E
A
A
A
YQSRDYYNF
P
L
ALAGPPPPPPPPHP
H
A
R
I
K
LENPLDYG
S
A
W
A
A
A
A
A
QCRYGD
L
A
S
LHGAGAAGPGSGSPSAAASSS
W
H
T
L
F
TAEE
G
Q
L
YGPCGGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSP
T
C
V
K
SEMGPWMDSYSGPYGD
M
R
L
ETARD
H
V
L
P
I
D
Y
YFPPQ
K
T
C
L
I
CGDEASG
C
H
Y
G
A
LTCG
S
C
K
V
F
F
K
R
AAEGKQ
K
Y
L
CASRNDC
T
I
D
K
F
R
RKNC
P
S
C
R
L
R
K
C
Y
E
AGM
T
L
G
A
R
K
L
K
K
LGN
L
K
L
QEEGEASSTTSP
T
E
E
T
T
Q
K
L
T
V
S
HIEGYEC
Q
P
I
F
L
N
V
L
E
AIEP
G
V
V
C
AGHDNNQ
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
ALPGFRNLHVDD
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
FTNVNS
R
---
M
L
Y
FA
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
EF-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
II--PVDGLKN
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
CKRKNP
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
HMVSVD
F
P
E
M
M
A
E
I
I
S
VQ
V
P
K
I
LSGK
V
K
P
I
Y
F
HTQ
7
PsiBlast_PDB
93.36
100%
-132
- C2 -
1XJ7
2
A:
[1-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
E
G
Y
E
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
18
PsiBlast_PDB
92.97
100%
-130
- C2 -
2YLQ
2
A:
[8-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
16
PsiBlast_PDB
92.96
100%
-134
- C2 -
2YLO
2
?
A:
[7-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
6
PsiBlast_PDB
92.96
100%
-135
- C2 -
1E3G
1
A:
[13-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
8
PsiBlast_PDB
92.93
100%
-126
- C2 -
2Q7J
3
A:
[9-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
47
PsiBlast_CBE
92.91
100%
-130
- C2 -
1T5Z
2
A:
[1-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
48
PsiBlast_CBE
92.80
100%
-132
- C2 -
2HVC
1
A:
[1-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
33
PsiBlast_CBE
92.67
100%
-129
- C2 -
1T73
2
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
34
PsiBlast_CBE
92.66
100%
-134
- C2 -
2QPY
3
A:
[3-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
5
PsiBlast_PDB
92.63
100%
-132
- C2 -
3V49
2
A:
[18-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
-----
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
17
PsiBlast_PDB
92.60
100%
-130
- C2 -
2YLP
3
A:
[8-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
42
PsiBlast_CBE
92.57
100%
-132
- C2 -
2PIQ
2
?
A:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
35
PsiBlast_CBE
92.57
100%
-125
- C2 -
2PKL
3
A:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
49
PsiBlast_CBE
92.55
100%
-128
- C2 -
3V4A
2
A:
[1-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
-----
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
30
PsiBlast_CBE
92.54
100%
-128
- C2 -
1T79
2
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
19
PsiBlast_PDB
92.53
100%
-131
- C2 -
3ZQT
2
A:
[7-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
46
PsiBlast_CBE
92.50
100%
-133
- C2 -
1T63
2
A:
[1-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
4
PsiBlast_PDB
92.47
100%
-134
- C2 -
2PNU
3
A:
[17-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
-----
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
27
PsiBlast_CBE
92.43
100%
-132
- C2 -
1T7R
2
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
9
PsiBlast_PDB
92.36
99%
-127
- C2 -
2Q7L
3
A:
[9-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
Y
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
1
PsiBlast_PDB
92.36
100%
-130
- C2 -
2AM9
3
A:
[17-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
26
PsiBlast_CBE
92.35
100%
-130
- C2 -
1T7T
1
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
40
PsiBlast_CBE
92.19
100%
-129
- C2 -
2PIT
2
A:
[1-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
28
PsiBlast_CBE
92.17
100%
-129
- C2 -
1T7M
4
A:
[20-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
29
PsiBlast_CBE
92.13
100%
-129
- C2 -
1T7F
2
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
44
PsiBlast_CBE
92.06
100%
-126
- C2 -
2PIO
3
A:
[3-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
58
PsiBlast_CBE
92.04
100%
-134
- C2 -
2AO6
2
A:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
------
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
60
PsiBlast_CBE
92.00
100%
-135
- C2 -
1XOW
2
A:
[1-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
------
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
51
PsiBlast_CBE
91.99
100%
-128
- C2 -
3L3X
2
A:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
20
PsiBlast_PDB
91.97
100%
-133
- C2 -
4HLW
3
A:
[7-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
------
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
37
PsiBlast_CBE
91.93
100%
-132
- C2 -
2PIW
3
A:
[3-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
45
PsiBlast_CBE
91.86
100%
-129
- C2 -
1T65
2
A:
[1-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
2
PsiBlast_PDB
91.83
100%
-132
- C2 -
2AMA
1
A:
[18-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
------
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
32
PsiBlast_CBE
91.75
100%
-127
- C2 -
1T74
3
A:
[20-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
41
PsiBlast_CBE
91.69
100%
-131
- C2 -
2PIR
2
A:
[1-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
36
PsiBlast_CBE
91.69
100%
-137
- C2 -
2PIX
2
A:
[3-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
38
PsiBlast_CBE
91.68
100%
-130
- C2 -
2PIV
2
A:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
54
PsiBlast_CBE
91.67
100%
-130
- C2 -
3B66
1
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
13
PsiBlast_PDB
91.62
99%
-131
- C2 -
3G0W
1
A:
[11-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
57
PsiBlast_CBE
91.57
100%
-129
- C2 -
2YHD
2
A:
[1-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
31
PsiBlast_CBE
91.49
100%
-129
- C2 -
1T76
3
A:
[20-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
52
PsiBlast_CBE
91.48
100%
-129
- C2 -
3B68
1
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
50
PsiBlast_CBE
91.46
100%
-130
- C2 -
3L3Z
2
A:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
-
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
59
PsiBlast_CBE
91.42
100%
-135
- C2 -
1XQ3
1
?
A:
[1-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
------
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
55
PsiBlast_CBE
91.33
100%
-129
- C2 -
3B65
1
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
43
PsiBlast_CBE
91.31
100%
-130
- C2 -
2PIP
3
?
L:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
61
PsiBlast_CBE
91.30
99%
-129
- C2 -
2OZ7
1
A:
[1-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
22
PsiBlast_CBE
91.29
99%
-133
- C2 -
1I38
1
A:
[13-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
53
PsiBlast_CBE
91.28
100%
-129
- C2 -
3B67
1
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
24
PsiBlast_CBE
91.24
99%
-134
- C2 -
2AX6
1
A:
[8-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-----
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
3
PsiBlast_PDB
91.21
100%
-129
- C2 -
2AMB
4
A:
[18-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
---
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
11
PsiBlast_PDB
91.19
99%
-133
- C2 -
2IHQ
1
A:
[12-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
56
PsiBlast_CBE
91.04
100%
-130
- C2 -
3B5R
1
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
39
PsiBlast_CBE
91.03
100%
-128
- C2 -
2PIU
3
A:
[3-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
25
PsiBlast_CBE
90.79
99%
-138
- C2 -
2AX8
1
A:
[9-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
L
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
--------
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
14
PsiBlast_PDB
90.78
100%
-135
- C2 -
2AX9
1
A:
[9-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
--------
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
12
PsiBlast_PDB
90.74
99%
-129
- C2 -
2NW4
1
A:
[12-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
10
PsiBlast_PDB
90.23
99%
-132
- C2 -
1I37
1
A:
[13-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
23
PsiBlast_CBE
89.69
99%
-137
- C2 -
2AX7
1
A:
[9-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
--------
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
15
PsiBlast_PDB
89.56
100%
-138
- C2 -
2AXA
1
A:
[9-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
--------
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
79
HHSearch
81.13
50%
-126
- C2 -
3VHV
4
A:
[3-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
-----
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
K
73
HHSearch
79.95
51%
-127
- C2 -
3VHU
1
A:
[40-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
------
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
76
HHSearch
78.70
53%
-123
- C2 -
1SQN
1
PRGR_HUMAN
A:
[10-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
-
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
-
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
75
HHSearch
77.78
48%
-125
- C2 -
3MNP
4
A:
[4-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
-
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
--
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
A
K
R
G
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
D
-
K
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
62
Fugue
75.44
49%
-111
- C2 -
1A28
1
PRGR_HUMAN
A:
[5-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
---------------------
V
I
Y
A
G
H
D
N
-------
T
K
P
D
T
------------
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
-QML
Y
F
A
--
P
D
L
I
L
N
E
Q
R
M
K
-E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
-
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
PL--
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-