@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_GCR_MO: (2014-08-25 )
MDSKESLAPPGRDEVPSSLLGRGRGSVMDLYKTLRGGATVKVSASSPSVAAASQADSKQQRILLDFSKGSASNAQQQQQQQQPQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTSRPENPKSSTPAAGCATPTEKEFPQTHSDPSSEQQNRKSQPGTNGGSVKLYTTDQSTFDILQDLEFSAGSPGKETNESPWRSDLLIDENLLSPLAGEDDPFLLEGDVNEDCKPLILPDTKPKIQDTGDTILSSPSSVALPQVKTEKDDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDNLTSLGAMNFAGRSVFSNGYSSPGMRPDVSSPPSSSSTATGPPPKLCLVCSDEASVCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENANKTIVPAALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQASGNLLCFAPDLIINEQRMTLPCMYDQCKHMLFISTELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHDVVENLLSYCFQTFLDKSMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
Atome Classification :
(37 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530-.........540.......550.......560.......570.......580.......590.......600.......610.......620...---....630.......640-.......650.......-660.......670.......----680.......690.......700.......710.......720.......730.......740.....-.-.750........760.......770.......780.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDSKESLAPPG
R
D
E
V
P
S
S
L
L
GRGR
G
S
V
M
D
L
Y
K
T
LRGG
A
T
V
K
V
SASSPSVAAASQADSKQ
Q
R
I
L
L
D
FSKGSAS
N
A
Q
Q
Q
Q
Q
QQQPQP
D
L
S
K
A
V
S
LS
M
G
L
Y
MGETETKVMGNDLGYPQQGQLGLSSG
E
T
D
F
R
L
L
E
E
S
I
A
NLNRSTSRPENPKSSTPAAGCATPTEKEFPQTHSDPS
S
E
Q
QNRKSQPGTNGG
S
V
K
L
Y
TTDQ
S
T
F
D
I
L
Q
D
L
EFSAGSPGKETNESPWRSD
L
L
I
D
E
NLLSPLAGEDD
P
F
L
LEGDVNEDCK
P
L
ILPDTKPKIQDTG
D
T
ILSSPSSVALPQVKTEKD
D
F
I
E
LCTPGVIKQEKLG
P
V
Y
C
Q
ASFSGTNIIGNK
M
S
A
I
S
V
H
G
V
STSG
G
Q
M
Y
H
Y
DMNTASLSQQQDQKP
V
F
NVIPPIPVGSENWNRCQGSGEDN
L
T
SLGAMNFAG
R
S
V
F
SNGYSSPGMRPDVSSPPSSSSTATGPPP
K
L
C
L
V
CSDEAS
V
C
H
Y
G
V
LTCG
S
C
K
V
F
F
K
R
A
VEGQH
N
Y
L
CAGRN
D
C
I
I
D
K
I
RRKNC
P
A
C
R
Y
R
K
C
L
Q
AGMNL
E
A
R
K
T
K
K
K
I
K
G
I
Q
Q
A
TAGVSQDTSENAN
K
T
I
VPAA---LPQL
T
P
T
L
V
S
L
L
E
VIEP
E
V
L
Y
AGYDSSVP
D
S
A
W
R
I
M
T
T
L
N
MLG
G
R
Q
V
I
A
A
V
K
W
A
K
AIPGFRNLHLD
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
A
F
A
L
G
W
R
S
Y
R
QASG
N
---
L
L
C
FAPD
L
I
INEQRMTL-
P
C
M
Y
D
QCK
H
M
L
F
I
S
T
E
L
-
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----SVPKEGL
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
KREGNS
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
-D-KS-MSIE
F
P
E
M
L
A
E
I
I
T
N
QIPKYSNGN
I
K
K
L
L
FHQK
5
PsiBlast_PDB
89.04
98%
-140
- C4 -
3MNP
4
A:
[4-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
---
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
-
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
A
K
R
G
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
-
D
-
K
S
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
3
PsiBlast_PDB
87.45
99%
-140
- C4 -
3MNE
4
A:
[4-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
---
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
-----
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
-
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
-
D
-
K
S
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
6
PsiBlast_PDB
86.97
94%
-141
- C4 -
1M2Z
5
GCR_HUMAN
A:
[3-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
---
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
4
PsiBlast_PDB
86.84
98%
-142
- C4 -
3MNO
4
A:
[4-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
---
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
---
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
-
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
-
D
-
K
S
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
24
PsiBlast_CBE
86.67
94%
-139
- C4 -
1M2Z
2
D:
[5-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
10
PsiBlast_PDB
86.40
94%
-141
- C4 -
3K22
3
GCR_HUMAN
A:
[8-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
-
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
25
PsiBlast_CBE
86.33
94%
-146
- C4 -
3E7C
4
B:
[5-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
--
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
-----
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
7
PsiBlast_PDB
85.47
94%
-144
- C4 -
3E7C
3
GCR_HUMAN
A:
[6-256]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
---
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
12
PsiBlast_PDB
85.44
94%
-141
- C4 -
3BQD
2
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
27
PsiBlast_CBE
85.14
94%
-140
- C4 -
3K23
2
GCR_HUMAN
B:
[9-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
---
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
21
PsiBlast_CBE
85.11
92%
-146
- C4 -
1P93
2
D:
[30-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
22
PsiBlast_CBE
84.56
92%
-147
- C4 -
1P93
3
GCR_HUMAN
C:
[30-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
8
PsiBlast_PDB
84.27
94%
-142
- C4 -
3CLD
2
GCR_HUMAN
A:
[8-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
---
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
-----
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
28
PsiBlast_CBE
83.93
94%
-141
- C4 -
3CLD
2
B:
[10-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
---
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
-----
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
2
PsiBlast_PDB
83.22
92%
-141
- C4 -
1P93
3
GCR_HUMAN
A:
[30-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
26
PsiBlast_CBE
83.11
94%
-137
- C4 -
3K23
2
C:
[7-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
-
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
-
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
---
N
I
K
K
L
L
F
H
--
23
PsiBlast_CBE
83.10
92%
-141
- C4 -
1P93
2
GCR_HUMAN
B:
[32-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
9
PsiBlast_PDB
82.91
94%
-130
- C4 -
3K23
3
GCR_HUMAN
A:
[7-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
-
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
------
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
--
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
11
PsiBlast_PDB
82.06
94%
-147
- C4 -
4LSJ
3
?
A:
[7-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
--------
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
14
PsiBlast_PDB
80.35
78%
-134
- C4 -
3GN8
2
?
A:
[2-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
-
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
----
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
N
-
K
S
-
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
31
PsiBlast_CBE
80.23
93%
-132
- C4 -
3H52
4
GCR_HUMAN
B:
[5-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
32
PsiBlast_CBE
79.85
78%
-134
- C4 -
3GN8
2
?
B:
[2-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
-
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
----
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
N
-
K
S
-
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
33
PsiBlast_CBE
79.78
78%
-131
- C4 -
4E2J
4
?
B:
[4-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
-
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
----
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
N
-
K
S
-
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
15
PsiBlast_PDB
79.77
78%
-134
- C4 -
4E2J
3
?
A:
[4-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
-
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
----
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
N
-
K
S
--
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
29
PsiBlast_CBE
79.37
93%
-143
- C4 -
3H52
1
D:
[7-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
------------
E
M
L
A
E
I
I
T
N
Q
I
----
N
G
N
I
K
K
L
L
F
H
Q
-
13
PsiBlast_PDB
79.02
93%
-131
- C4 -
3H52
2
GCR_HUMAN
A:
[5-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
----
G
N
I
K
K
L
L
F
H
Q
-
16
PsiBlast_PDB
78.68
72%
-132
- C4 -
3RY9
2
?
A:
[2-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
M
I
S
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
S
T
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
---
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
-
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
-
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
----
T
V
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
------
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
E
S
K
T
-
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
K
79
HHSearch
78.17
56%
-131
- C4 -
3VHV
4
A:
[2-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
S
T
I
---
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
----
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
-----
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
-
E
-
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
K
34
PsiBlast_CBE
78.03
72%
-134
- C4 -
3RY9
3
?
B:
[2-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
M
I
S
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
--
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
---
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
-
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
-
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
----
T
V
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
E
S
K
T
-
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
-
73
HHSearch
77.49
55%
-134
- C4 -
3VHU
1
A:
[38-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
----
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
------
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
-
E
-
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
1
PsiBlast_PDB
77.20
92%
-133
- C4 -
1NHZ
4
A:
[33-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
-
D
-
K
T
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
--------
N
I
K
K
L
L
F
H
Q
-
30
PsiBlast_CBE
77.03
93%
-137
- C4 -
3H52
1
GCR_HUMAN
C:
[5-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
-
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
----
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
----------------
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
20
PsiBlast_PDB
76.90
64%
-128
- C4 -
4FN9
6
?
A:
[5-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
---
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
-
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
-
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
----
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
Q
S
Q
A
-
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
17
PsiBlast_PDB
76.55
65%
-136
- C4 -
2Q1H
3
?
A:
[4-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
S
I
L
E
A
I
E
P
E
V
V
Y
A
G
Y
D
N
S
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
G
K
Q
M
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
H
T
N
G
Q
---
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
-
S
A
M
Y
D
L
C
Q
G
M
R
Q
I
S
Q
E
F
-
V
R
L
Q
V
T
Y
E
E
F
L
C
M
K
V
L
L
L
L
S
----
T
V
P
K
D
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
R
R
A
I
A
---
N
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
Q
S
Q
A
-
L
S
V
E
F
P
E
M
L
V
E
I
I
S
D
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
K
-
76
HHSearch
72.54
55%
-125
* C4 *
1SQN
1
PRGR_HUMAN
A:
[10-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
-
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
-
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
----
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
-
Q
-
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
72
HHSearch
72.27
47%
-123
- C4 -
1T7R
2
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
----
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
-
K
-
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
61
Fugue
68.46
49%
-121
- C4 -
1A28
1
PRGR_HUMAN
A:
[5-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
------------------------
V
I
Y
A
G
H
D
N
-------
T
K
P
D
T
-------
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
-QML
Y
F
A
--
P
D
L
I
L
N
E
Q
R
M
K
-E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
-
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
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