@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_RARA_H: (2014-08-26 )
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200....--...210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400...-....410.......420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASNSSSCPTPGGGHLNGYPVP
P
Y
A
FFF
P
P
M
LGGLSPP
G
A
L
T
T
L
Q
HQLPVSGYSTPS
P
A
T
I
ETQSSSSEEIVPSPPSPPPLPRIYK
P
C
F
V
CQDKSSGYHYGV
S
A
C
E
G
C
K
G
F
F
R
R
S
I
QKN
M
V
Y
T
CHRDKNC
I
I
N
K
V
T
R
N
R
C
Q
Y
C
R
L
Q
K
C
F
E
VGM
S
K
E
S
V
RNDRN
K
K
KKEVPKPECSE
S
Y
TL
T
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
LG--KYTTNNSSE
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
QLPG
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
CTRYTPEQD
T
M
TFSDG
L
T
L
N
R
T
QMHNAGF
G
P
L
T
D
L
V
F
A
F
A
N
QLLPLEMDDA
E
T
G
L
L
S
A
I
C
L
ICG
D
R
Q
DLEQP
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
KRRPSRP
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
SAKGA
E
R
V
I
T
L
K
M
EIPGS-M
P
P
L
I
Q
E
M
L
ENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
1
PsiBlast_PDB
91.71
100%
-125
- C2 -
3A9E
2
RARA_HUMAN
B:
[25-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
T
L
T
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
--
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
-
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
5
PsiBlast_PDB
90.92
100%
-132
- C2 -
1DKF
1
RARA_HUMAN
B:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
--
K
Y
T
T
---
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
-
M
P
P
L
I
Q
E
M
L
E
N
----------------------------------------------
2
PsiBlast_PDB
90.17
100%
-125
- C2 -
3KMR
2
RARA_HUMAN
A:
[27-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
--
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
-
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
6
PsiBlast_PDB
89.89
100%
-125
- C2 -
4DQM
2
RARA_HUMAN
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
--
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
-
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
23
PsiBlast_CBE
89.50
100%
-125
- C2 -
4DQM
2
RARA_HUMAN
C:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
--
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
-
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
25
PsiBlast_CBE
87.63
86%
-122
- C2 -
4DM6
2
RARB_HUMAN
B:
[24-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
-
M
P
P
L
I
Q
E
M
L
E
N
----------------------------------------------
24
PsiBlast_CBE
86.65
86%
-121
- C2 -
4DM8
2
RARB_HUMAN
B:
[24-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
-
M
P
P
L
I
Q
E
M
L
E
N
----------------------------------------------
8
PsiBlast_PDB
86.53
86%
-120
- C2 -
4DM6
2
RARB_HUMAN
A:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
-
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
22
PsiBlast_CBE
86.07
84%
-114
- C2 -
1XDK
2
RARB_MOUSE
F:
[30-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
-
M
P
P
L
I
Q
E
M
L
E
N
S
E
G
H
E
P
L
T
P
S
------------------------------------
9
PsiBlast_PDB
85.91
86%
-119
- C2 -
4DM8
2
RARB_HUMAN
A:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
--
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
-
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
4
PsiBlast_PDB
85.86
84%
-113
- C2 -
1XDK
2
RARB_MOUSE
B:
[30-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
-
M
P
P
L
I
Q
E
M
L
E
N
S
E
G
H
E
P
L
T
P
S
------------------------------------
17
PsiBlast_PDB
85.60
83%
-123
- C2 -
1FCZ
2
RARG_HUMAN
A:
[1-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
-
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
14
PsiBlast_PDB
85.60
82%
-122
- C2 -
1EXX
2
RARG_HUMAN
A:
[5-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
-
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
16
PsiBlast_PDB
85.54
83%
-123
- C2 -
1FCX
2
RARG_HUMAN
A:
[1-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
-
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
15
PsiBlast_PDB
85.45
83%
-124
- C2 -
1FCY
2
RARG_HUMAN
A:
[2-236]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
-
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
12
PsiBlast_PDB
85.44
81%
-120
- C2 -
4LBD
1
RARG_HUMAN
A:
[26-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
-
M
P
P
L
I
R
E
M
L
E
N
----------------------------------------------
18
PsiBlast_PDB
85.12
83%
-122
- C2 -
1FD0
2
RARG_HUMAN
A:
[1-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
-
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
13
PsiBlast_PDB
85.10
82%
-121
- C2 -
1EXA
2
RARG_HUMAN
A:
[5-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
-
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
11
PsiBlast_PDB
85.01
81%
-114
- C2 -
3LBD
1
RARG_HUMAN
A:
[26-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
-
M
P
P
L
I
R
E
M
L
E
N
----------------------------------------------
10
PsiBlast_PDB
84.74
81%
-116
- C2 -
2LBD
1
RARG_HUMAN
A:
[26-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
-
M
P
P
L
I
R
E
M
L
E
N
P
---------------------------------------------
7
PsiBlast_PDB
83.90
86%
-122
- C2 -
1XAP
1
RARB_HUMAN
A:
[28-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
--
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
---
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
-
M
P
P
L
I
Q
E
M
L
E
N
----------------------------------------------
3
PsiBlast_PDB
83.76
100%
-121
- C2 -
3KMZ
7
RARA_HUMAN
B:
[26-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
--
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
--------------------------------------------------------------
21
PsiBlast_CBE
83.22
100%
-120
- C2 -
3KMZ
8
RARA_HUMAN
A:
[26-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
--
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
--------------------------------------------------------------
27
Fugue
71.29
35%
-108
- C2 -
1BSX
2
THB_HUMAN
A:
[10-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
QK
R
K
F
L
P
E
D
I
G
Q
A
P
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
----------------------------------------------