@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_VDR_RA: (2014-08-26 )
MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSSSSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNEIS
Atome Classification :
(50 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEATAASTSLPDPGDFDRNV
P
R
I
C
GVCGDRAT
G
F
H
FNAM
T
C
E
G
C
K
G
F
F
R
R
S
MKR
K
A
L
F
TCPFNGD
C
R
ITKDN
R
R
H
C
Q
A
C
R
L
K
R
C
V
D
I
G
M
M
K
E
F
ILT
D
E
E
V
Q
R
K
R
E
M
I
M
K
R
K
E
E
E
A
L
K
D
S
LRPKLSE
E
Q
Q
H
I
I
A
I
L
LDAHHKTYDPT
Y
A
D
F
R
DFRPPVRMDGSTGSYSPR
P
T
L
S
FSGNSSSSSS
D
L
Y
T
T
SLDMMEPSGFSNLDLNGEDSDD
P
S
V
T
L
DL
S
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
MIPGFRDLTSDD
Q
I
V
L
L
KSS
A
I
E
V
I
M
LRSNQSFTMDDMSWDCGSQD
Y
K
Y
DVTDVSKAG
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
KLNLHEEE
H
V
L
L
M
A
I
C
I
VSPDRPGV
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
RCRHPPPG
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
RSLSFQPENSM
K
L
T
P
L
V
L
E
V
FGNEIS
74
HHSearch
90.33
99%
-115
- C5 -
2O4J
2
VDR_RAT
A:
[8-259]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
-----------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
73
HHSearch
89.24
90%
-110
- C5 -
3B0T
1
VDR_HUMAN
A:
[2-254]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
----------
G
-------------------------------------
G
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
8
PsiBlast_PDB
88.81
84%
-114
- C5 -
3VJS
2
VDR_RAT
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
6
PsiBlast_PDB
88.75
84%
-120
- C5 -
2ZL9
2
VDR_RAT
A:
[18-267]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
-----------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
9
PsiBlast_PDB
88.41
84%
-117
- C5 -
3VJT
2
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
2
PsiBlast_PDB
87.91
84%
-121
- C5 -
1RK3
2
VDR_RAT
A:
[8-258]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
-----------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
7
PsiBlast_PDB
87.56
84%
-116
- C5 -
2ZLA
2
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
5
PsiBlast_PDB
87.39
84%
-115
- C5 -
3A2H
2
VDR_RAT
A:
[12-263]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
30
PsiBlast_CBE
87.38
76%
-109
- C5 -
3A40
1
VDR_HUMAN
X:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
71
HHSearch
87.32
68%
-113
* C5 *
2HC4
2
VDRA_DANRE
A:
[3-301]
-------------------------------------------------------------------------------------------------------------------------
H
M
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
10
PsiBlast_PDB
87.19
84%
-118
- C5 -
3VRU
2
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
4
PsiBlast_PDB
87.13
84%
-113
- C5 -
2O4R
2
VDR_RAT
A:
[8-259]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
-----------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
31
PsiBlast_CBE
87.11
76%
-110
- C5 -
3A3Z
1
VDR_HUMAN
X:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
39
PsiBlast_CBE
86.94
76%
-108
- C5 -
3P8X
1
VDR_HUMAN
A:
[22-276]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
33
PsiBlast_CBE
86.78
76%
-110
- C5 -
2HB7
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
15
PsiBlast_PDB
86.78
76%
-108
- C5 -
1IE9
1
VDR_HUMAN
A:
[1-255]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
28
PsiBlast_CBE
86.66
76%
-112
- C5 -
3AUQ
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
12
PsiBlast_PDB
86.62
84%
-122
- C5 -
3VRW
2
VDR_RAT
A:
[18-267]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
-----------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
24
PsiBlast_CBE
86.60
76%
-109
- C5 -
3CS6
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
32
PsiBlast_CBE
86.47
76%
-109
- C5 -
2HB8
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
11
PsiBlast_PDB
86.47
84%
-120
- C5 -
3VRV
2
VDR_RAT
A:
[18-267]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
17
PsiBlast_PDB
86.46
76%
-111
- C5 -
3KPZ
1
VDR_HUMAN
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
27
PsiBlast_CBE
86.40
76%
-111
- C5 -
3AUR
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
1
PsiBlast_PDB
86.24
84%
-113
- C5 -
1RJK
2
VDR_RAT
A:
[8-258]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
-----------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
19
PsiBlast_PDB
86.19
76%
-114
- C5 -
4G2I
1
VDR_HUMAN
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
41
PsiBlast_CBE
86.16
76%
-110
- C5 -
3A2J
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
F
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
F
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
37
PsiBlast_CBE
86.15
76%
-112
- C5 -
1TXI
1
VDR_HUMAN
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
49
PsiBlast_CBE
86.12
76%
-110
- C5 -
3M7R
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
Q
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
25
PsiBlast_CBE
86.08
76%
-109
- C5 -
3CS4
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
44
PsiBlast_CBE
86.03
76%
-116
- C5 -
3W0C
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
43
PsiBlast_CBE
86.02
76%
-115
- C5 -
3W0Y
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
18
PsiBlast_PDB
85.99
76%
-108
- C5 -
3TKC
1
VDR_HUMAN
A:
[2-255]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
16
PsiBlast_PDB
85.88
76%
-108
- C5 -
3OGT
1
VDR_HUMAN
A:
[2-255]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
40
PsiBlast_CBE
85.78
76%
-112
- C5 -
3A2I
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
F
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
38
PsiBlast_CBE
85.78
76%
-112
- C5 -
1S19
1
VDR_HUMAN
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
29
PsiBlast_CBE
85.77
76%
-109
- C5 -
3A78
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
45
PsiBlast_CBE
85.66
76%
-116
- C5 -
3W0A
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
13
PsiBlast_PDB
85.66
76%
-114
- C5 -
1DB1
1
VDR_HUMAN
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
22
PsiBlast_CBE
85.65
76%
-113
- C5 -
4ITE
1
?
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
20
PsiBlast_PDB
85.61
76%
-112
- C5 -
1S0Z
1
VDR_HUMAN
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
26
PsiBlast_CBE
85.57
76%
-110
- C5 -
3AX8
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
47
PsiBlast_CBE
85.56
76%
-117
- C5 -
3AZ2
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
35
PsiBlast_CBE
85.52
76%
-111
- C5 -
2HAR
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
--
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
48
PsiBlast_CBE
85.47
76%
-115
- C5 -
3AZ1
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
21
PsiBlast_CBE
85.38
76%
-110
- C5 -
4ITF
1
?
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
14
PsiBlast_PDB
85.37
76%
-113
- C5 -
1IE8
1
VDR_HUMAN
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
36
PsiBlast_CBE
85.27
76%
-108
- C5 -
2HAM
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
-
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
46
PsiBlast_CBE
85.21
76%
-115
- C5 -
3AZ3
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
23
PsiBlast_CBE
84.86
76%
-107
- C5 -
3VHW
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
-
S
-----------------------------------------------
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
34
PsiBlast_CBE
84.80
76%
-109
- C5 -
2HAS
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
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Q
R
I
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D
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P
V
R
V
N
D
G
G
G
S
-----------------------------------------------
V
T
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V
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E
V
F
G
----