@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00106_DHB1_H: (2014-08-26 )
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
R
T
V
V
L
I
TGCSSG
I
G
L
H
L
A
V
R
LASDPSQ
S
F
K
V
Y
A
T
L
R
D
L
K
TQG
R
L
W
E
A
A
R
A
LACPPGS
L
E
T
L
Q
L
DVRDS
K
S
V
A
A
A
R
E
R
VTEG
R
V
D
V
L
V
CNAGLG
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
RRGS
G
R
V
L
V
TGSVGGLMGLPFN
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
PFG
V
H
L
S
L
I
ECGP
V
H
T
A
F
M
E
K
VLG
S
P
E
E
V
L
D
RTD
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
AAQ
N
P
E
E
V
A
E
V
F
L
T
A
LRAPKP
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
RLDDPSGS
N
Y
V
T
A
M
H
R
E
V
FGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
11
PsiBlast_PDB
98.03
99%
-149
- C2 -
3HB4
1
DHB1_HUMAN
X:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
41
HHSearch
97.52
100%
-144
- C2 -
1JTV
2
DHB1_HUMAN
A:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
-------
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
20
PsiBlast_PDB
97.20
99%
-149
- C2 -
1FDU
2
DHB1_HUMAN
A:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
----
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
18
PsiBlast_PDB
97.11
99%
-147
- C2 -
3KLM
2
DHB1_HUMAN
X:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
-------
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
12
PsiBlast_PDB
97.11
99%
-147
- C2 -
3HB5
2
DHB1_HUMAN
X:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
10
PsiBlast_PDB
97.11
99%
-147
- C2 -
3DEY
2
DHB1_HUMAN
X:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
-------
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
30
PsiBlast_CBE
97.02
100%
-144
- C2 -
1A27
2
DHB1_HUMAN
A:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
16
PsiBlast_PDB
96.98
99%
-145
- C2 -
1FDS
1
DHB1_HUMAN
A:
[1-287]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
-----
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
D
V
----------------------------------------
2
PsiBlast_PDB
96.61
99%
-144
- C2 -
1DHT
1
DHB1_HUMAN
A:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
3
PsiBlast_PDB
96.54
99%
-145
- C2 -
3DHE
1
DHB1_HUMAN
A:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
6
PsiBlast_PDB
96.19
99%
-145
- C2 -
1QYV
2
DHB1_HUMAN
A:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
--------
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
8
PsiBlast_PDB
96.14
99%
-145
- C2 -
1QYX
2
DHB1_HUMAN
A:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
--------
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
28
PsiBlast_CBE
96.07
99%
-142
- C2 -
1FDU
2
DHB1_HUMAN
C:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
7
PsiBlast_PDB
95.76
99%
-145
- C2 -
1QYW
2
DHB1_HUMAN
A:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
--------
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
15
PsiBlast_PDB
95.75
99%
-144
- C2 -
1IOL
1
DHB1_HUMAN
A:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
E
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
26
PsiBlast_CBE
95.69
99%
-140
- C2 -
1FDV
1
DHB1_HUMAN
A:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
13
PsiBlast_PDB
95.53
99%
-143
- C2 -
3KLP
1
DHB1_HUMAN
X:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
---------
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
19
PsiBlast_PDB
95.47
99%
-144
- C2 -
1FDW
1
DHB1_HUMAN
A:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
------
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
Q
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
27
PsiBlast_CBE
95.46
99%
-145
- C2 -
1FDU
2
DHB1_HUMAN
D:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
----
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
4
PsiBlast_PDB
95.44
99%
-137
- C2 -
1I5R
4
DHB1_HUMAN
A:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
17
PsiBlast_PDB
95.35
99%
-142
- C2 -
1FDT
2
DHB1_HUMAN
A:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
14
PsiBlast_PDB
94.95
99%
-143
- C2 -
3KM0
2
DHB1_HUMAN
A:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
------
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
24
PsiBlast_CBE
94.45
99%
-139
- C2 -
1FDV
1
DHB1_HUMAN
C:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
21
PsiBlast_CBE
94.24
99%
-146
- C2 -
3KM0
2
DHB1_HUMAN
B:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
------------
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
22
PsiBlast_CBE
94.22
99%
-144
- C2 -
1EQU
1
DHB1_HUMAN
B:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
29
PsiBlast_CBE
93.97
99%
-142
- C2 -
1FDU
2
DHB1_HUMAN
B:
[1-285]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
-----
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
------------------------------------------
1
PsiBlast_PDB
93.70
99%
-141
- C2 -
1EQU
2
DHB1_HUMAN
A:
[1-284]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
A
F
M
E
K
V
L
G
S
P
E
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
H
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
-------------------------------------------
23
PsiBlast_CBE
93.53
99%
-143
- C2 -
1FDV
1
DHB1_HUMAN
D:
[1-286]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
-----------
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
D
-----------------------------------------
25
PsiBlast_CBE
92.86
99%
-141
- C2 -
1FDV
1
DHB1_HUMAN
B:
[1-286]
-
A
R
T
V
V
L
I
T
G
C
S
S
G
I
G
L
H
L
A
V
R
L
A
S
D
P
S
Q
S
F
K
V
Y
A
T
L
R
D
L
K
T
Q
G
R
L
W
E
A
A
R
A
L
A
C
P
P
G
S
L
E
T
L
Q
L
D
V
R
D
S
K
S
V
A
A
A
R
E
R
V
T
E
G
R
V
D
V
L
V
C
N
A
G
L
G
L
L
G
P
L
E
A
L
G
E
D
A
V
A
S
V
L
D
V
N
V
V
G
T
V
R
M
L
Q
A
F
L
P
D
M
K
R
R
G
S
G
R
V
L
V
T
G
S
V
G
G
L
M
G
L
P
F
N
D
V
Y
C
A
S
K
F
A
L
E
G
L
C
E
S
L
A
V
L
L
L
P
F
G
V
H
L
S
L
I
E
C
G
P
V
H
T
-----------
E
V
L
D
R
T
D
I
H
T
F
H
R
F
Y
Q
Y
L
A
L
S
K
Q
V
F
R
E
A
A
Q
N
P
E
E
V
A
E
V
F
L
T
A
L
R
A
P
K
P
T
L
R
Y
F
T
T
E
R
F
L
P
L
L
R
M
R
L
D
D
P
S
G
S
N
Y
V
T
A
M
H
R
E
V
F
G
D
-----------------------------------------