@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00106_DHI1_M: (2014-08-27 )
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
Atome Classification :
(55 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
V
M
K
N
Y
L
L
P
I
L
V
L
F
L
A
Y
Y
Y
YSTNEEF
R
P
E
M
LQG
K
K
V
I
V
TGASKGI
G
R
E
M
A
Y
H
L
S
KMG
A
H
V
V
L
T
AR
S
E
E
G
L
Q
K
V
V
S
R
C
L
ELGAAS
A
H
Y
I
AG
T
M
E
D
M
T
F
A
E
Q
F
I
V
K
A
G
K
L
MG
G
L
D
M
L
I
L
N
H
I
T
Q
T
S
L
S
L
F
H
D
D
I
H
S
V
R
R
V
M
E
V
N
F
L
S
Y
V
V
M
S
T
A
AL
P
M
L
KQSNG
S
I
A
V
I
S
S
L
A
G
KMTQ
P
M
IAPYSA
S
K
F
A
L
D
G
F
F
S
T
I
R
T
E
L
Y
I
T
K
V
N
V
S
I
T
L
C
V
LGLID
T
E
T
A
M
K
E
I
S
G
I
INAQAS
P
K
E
E
C
A
L
E
I
I
KGTALRKS
E
V
Y
YDKSPL
T
P
I
L
LGNP
G
R
K
I
M
E
F
F
S
L
R
Y
YNKDMFVSN-----
2
PsiBlast_PDB
96.40
100%
-129
- C4 -
1Y5R
2
DHI1_MOUSE
A:
[9-273]
------------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
S
K
M
G
A
H
V
V
L
T
A
R
S
E
E
G
L
Q
K
V
V
S
R
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
I
V
K
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
Q
T
S
L
S
L
F
H
D
D
I
H
S
V
R
R
V
M
E
V
N
F
L
S
Y
V
V
M
S
T
A
A
L
P
M
L
K
Q
S
N
G
S
I
A
V
I
S
S
L
A
G
K
M
T
Q
P
M
I
A
P
Y
S
A
S
K
F
A
L
D
G
F
F
S
T
I
R
T
E
L
Y
I
T
K
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
E
I
S
G
I
I
N
A
Q
A
S
P
K
E
E
C
A
L
E
I
I
K
G
T
A
L
R
K
S
E
V
Y
Y
D
K
S
P
L
T
P
I
L
L
G
N
P
G
R
K
I
M
E
F
F
S
L
R
Y
Y
N
K
D
M
F
--------
1
PsiBlast_PDB
95.54
100%
-125
- C4 -
1Y5M
3
DHI1_MOUSE
A:
[9-273]
------------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
S
K
M
G
A
H
V
V
L
T
A
R
S
E
E
G
L
Q
K
V
V
S
R
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
I
V
K
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
Q
T
S
L
S
L
F
H
D
D
I
H
S
V
R
R
V
M
E
V
N
F
L
S
Y
V
V
M
S
T
A
A
L
P
M
L
K
Q
S
N
G
S
I
A
V
I
S
S
L
A
G
K
M
T
Q
P
M
I
A
P
Y
S
A
S
K
F
A
L
D
G
F
F
S
T
I
R
T
E
L
Y
I
T
K
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
E
I
S
G
I
I
N
A
Q
A
S
P
K
E
E
C
A
L
E
I
I
K
G
T
A
L
R
K
S
E
V
Y
Y
D
K
S
P
L
T
P
I
L
L
G
N
P
G
R
K
I
M
E
F
F
S
L
R
Y
Y
N
K
D
M
F
--------
22
PsiBlast_CBE
93.67
100%
-128
- C4 -
1Y5M
3
DHI1_MOUSE
B:
[9-273]
------------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
S
K
M
G
A
H
V
V
L
T
A
R
S
E
E
G
L
Q
K
V
V
S
R
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
I
V
K
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
Q
T
S
L
S
L
F
H
D
D
I
H
S
V
R
R
V
M
E
V
N
F
L
S
Y
V
V
M
S
T
A
A
L
P
M
L
K
Q
S
N
G
S
I
A
V
I
S
S
L
A
G
K
M
T
Q
P
M
I
A
P
Y
S
A
S
K
F
A
L
D
G
F
F
S
T
I
R
T
E
L
Y
I
T
K
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
E
I
S
G
I
I
N
A
Q
A
S
P
K
E
E
C
A
L
E
I
I
K
G
T
A
L
R
K
S
E
V
Y
Y
D
K
S
P
L
T
P
I
L
L
G
N
P
G
R
K
I
M
E
F
F
S
L
R
Y
Y
N
K
D
M
F
--------
21
PsiBlast_CBE
93.59
100%
-120
- C4 -
1Y5R
2
DHI1_MOUSE
B:
[9-273]
------------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
S
K
M
G
A
H
V
V
L
T
A
R
S
E
E
G
L
Q
K
V
V
S
R
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
I
V
K
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
Q
T
S
L
S
L
F
H
D
D
I
H
S
V
R
R
V
M
E
V
N
F
L
S
Y
V
V
M
S
T
A
A
L
P
M
L
K
Q
S
N
G
S
I
A
V
I
S
S
L
A
G
K
M
T
Q
P
M
I
A
P
Y
S
A
S
K
F
A
L
D
G
F
F
S
T
I
R
T
E
L
Y
I
T
K
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
E
I
S
G
I
I
N
A
Q
A
S
P
K
E
E
C
A
L
E
I
I
K
G
T
A
L
R
K
S
E
V
Y
Y
D
K
S
P
L
T
P
I
L
L
G
N
P
G
R
K
I
M
E
F
F
S
L
R
Y
Y
N
K
D
M
F
--------
63
Fugue
88.02
74%
-124
- C4 -
1XSE
1
DHI1_CAVPO
A:
[22-295]
-----------------------
N
E
K
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
I
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
A
L
Q
K
V
V
A
R
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
S
M
E
D
M
T
F
A
E
E
F
V
A
E
A
G
N
L
M
G
G
L
D
M
L
I
L
N
H
V
L
Y
N
R
L
T
F
F
H
G
E
I
D
N
V
R
K
S
M
E
V
N
F
H
S
F
V
V
L
S
V
A
A
M
P
M
L
M
Q
S
Q
G
S
I
A
V
V
S
S
V
A
G
K
I
T
Y
P
L
I
A
P
Y
S
A
S
K
F
A
L
D
G
F
F
S
T
L
R
S
E
F
L
V
N
K
V
N
V
S
I
T
L
C
I
L
G
L
I
D
T
E
T
A
I
K
A
T
S
G
I
Y
L
G
P
A
S
P
K
E
E
C
A
L
E
I
I
K
G
T
A
L
R
Q
D
E
M
Y
Y
V
G
S
R
W
V
P
Y
L
L
G
N
P
G
R
K
I
M
E
F
L
S
A
A
E
Y
N
W
D
N
V
L
S
N
E
K
L
YG
39
PsiBlast_CBE
85.54
78%
-120
- C4 -
4HX5
3
DHI1_HUMAN
C:
[18-278]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
-------------
20
PsiBlast_PDB
85.36
78%
-120
- C4 -
4HX5
3
DHI1_HUMAN
A:
[19-279]
------------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
------------
46
PsiBlast_CBE
85.34
78%
-117
- C4 -
3OQ1
3
DHI1_HUMAN
B:
[18-281]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
----------
9
PsiBlast_PDB
84.87
78%
-115
- C4 -
1XU9
5
DHI1_HUMAN
A:
[18-283]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
45
PsiBlast_CBE
84.32
78%
-114
- C4 -
3OQ1
3
DHI1_HUMAN
C:
[18-283]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
43
PsiBlast_CBE
83.95
78%
-120
- C4 -
3QQP
2
DHI1_HUMAN
B:
[18-279]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
------------
54
PsiBlast_CBE
83.90
78%
-118
- C4 -
3D4N
2
DHI1_HUMAN
C:
[18-275]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
--
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
44
PsiBlast_CBE
83.75
78%
-122
- C4 -
3OQ1
3
DHI1_HUMAN
D:
[18-275]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
41
PsiBlast_CBE
83.69
78%
-121
- C4 -
3QQP
2
DHI1_HUMAN
D:
[18-271]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
--------------------
6
PsiBlast_PDB
83.64
78%
-119
- C4 -
3PDJ
3
DHI1_HUMAN
A:
[5-272]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
I
N
------
11
PsiBlast_PDB
83.48
78%
-117
- C4 -
3CZR
3
DHI1_HUMAN
A:
[18-279]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
-
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
------------
42
PsiBlast_CBE
83.46
78%
-117
- C4 -
3QQP
2
DHI1_HUMAN
C:
[18-275]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
14
PsiBlast_PDB
83.39
78%
-119
- C4 -
3FRJ
2
DHI1_HUMAN
A:
[18-278]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
--
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
-------------
40
PsiBlast_CBE
83.06
78%
-120
- C4 -
4HX5
3
DHI1_HUMAN
B:
[18-277]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
--------------
49
PsiBlast_CBE
82.98
78%
-121
- C4 -
3H6K
3
DHI1_HUMAN
D:
[20-275]
-------------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
19
PsiBlast_PDB
82.96
78%
-116
- C4 -
3QQP
2
DHI1_HUMAN
A:
[18-283]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
7
PsiBlast_PDB
82.85
78%
-116
- C4 -
3D5Q
3
DHI1_HUMAN
A:
[4-269]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
-----
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
51
PsiBlast_CBE
82.79
78%
-119
- C4 -
3H6K
3
DHI1_HUMAN
B:
[18-276]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
---------------
10
PsiBlast_PDB
82.79
78%
-114
- C4 -
3BZU
2
DHI1_HUMAN
A:
[19-281]
------------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
----------
16
PsiBlast_PDB
82.75
78%
-115
- C4 -
3FCO
3
DHI1_HUMAN
A:
[18-283]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
--
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
17
PsiBlast_PDB
82.62
78%
-117
- C4 -
3H6K
3
DHI1_HUMAN
A:
[20-279]
-------------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
------------
55
PsiBlast_CBE
82.57
78%
-119
- C4 -
3D4N
2
DHI1_HUMAN
B:
[18-278]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
-------------
35
PsiBlast_CBE
82.55
78%
-121
- C4 -
3D5Q
3
DHI1_HUMAN
D:
[4-261]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
----
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
37
PsiBlast_CBE
82.51
78%
-119
- C4 -
3D5Q
3
DHI1_HUMAN
B:
[4-264]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
-------------
13
PsiBlast_PDB
82.26
78%
-115
- C4 -
3D4N
2
DHI1_HUMAN
A:
[18-276]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
-
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
---------------
34
PsiBlast_CBE
82.23
78%
-121
- C4 -
3PDJ
3
DHI1_HUMAN
B:
[5-272]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
I
N
------
57
PsiBlast_CBE
82.02
78%
-119
- C4 -
3D3E
2
DHI1_HUMAN
C:
[18-275]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
--
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
53
PsiBlast_CBE
81.93
78%
-119
- C4 -
3FCO
3
DHI1_HUMAN
B:
[18-283]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
---
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
38
PsiBlast_CBE
81.92
78%
-120
- C4 -
4HX5
3
DHI1_HUMAN
D:
[18-273]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
------------------
33
PsiBlast_CBE
81.90
78%
-117
- C4 -
4BB5
3
DHI1_HUMAN
B:
[26-289]
-------------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
L
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
R
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
E
L
Y
S
T
S
Y
N
M
D
R
F
--------
31
PsiBlast_CBE
81.67
78%
-115
- C4 -
4BB5
3
DHI1_HUMAN
D:
[26-290]
-------------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
L
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
---
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
R
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
E
L
Y
S
T
S
Y
N
M
D
R
F
I
-------
8
PsiBlast_PDB
81.49
78%
-114
- C4 -
1XU7
5
DHI1_HUMAN
A:
[18-277]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
--------------
32
PsiBlast_CBE
81.41
78%
-119
- C4 -
4BB5
2
DHI1_HUMAN
C:
[26-279]
-------------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
L
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
R
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
E
L
------------------
30
PsiBlast_CBE
81.32
78%
-119
- C4 -
4BB6
3
DHI1_HUMAN
B:
[26-283]
-------------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
L
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
R
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
E
L
Y
S
T
S
--------------
52
PsiBlast_CBE
81.22
78%
-118
- C4 -
3FRJ
2
DHI1_HUMAN
B:
[18-278]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
-------------
12
PsiBlast_PDB
81.10
78%
-117
- C4 -
3D3E
2
DHI1_HUMAN
A:
[18-278]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
--
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
-------------
5
PsiBlast_PDB
81.07
78%
-118
- C4 -
4BB5
3
DHI1_HUMAN
A:
[27-289]
--------------------------
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
L
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
R
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
E
L
Y
S
T
S
Y
N
M
D
R
F
--------
60
PsiBlast_CBE
80.97
78%
-123
- C4 -
3BZU
2
DHI1_HUMAN
D:
[20-275]
-------------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
--
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
61
PsiBlast_CBE
80.93
78%
-117
- C4 -
3BZU
2
DHI1_HUMAN
C:
[18-276]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
-----
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
---------------
62
PsiBlast_CBE
80.58
78%
-116
- C4 -
3BZU
2
DHI1_HUMAN
B:
[18-277]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
--------------
4
PsiBlast_PDB
80.51
78%
-113
- C4 -
4BB6
3
DHI1_HUMAN
A:
[26-291]
-------------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
L
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
R
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
E
L
Y
S
T
S
Y
N
W
D
R
F
I
N
------
56
PsiBlast_CBE
80.19
78%
-119
- C4 -
3D3E
2
DHI1_HUMAN
D:
[18-275]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
--
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
18
PsiBlast_PDB
80.16
78%
-116
- C4 -
3OQ1
3
DHI1_HUMAN
A:
[18-275]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
58
PsiBlast_CBE
79.94
78%
-118
- C4 -
3D3E
2
DHI1_HUMAN
B:
[18-275]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
--
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
15
PsiBlast_PDB
79.91
78%
-116
- C4 -
3HFG
3
DHI1_HUMAN
A:
[20-277]
-------------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
--------------
50
PsiBlast_CBE
79.87
78%
-117
- C4 -
3H6K
3
DHI1_HUMAN
C:
[18-277]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
--------------
48
PsiBlast_CBE
79.46
78%
-117
- C4 -
3HFG
2
DHI1_HUMAN
C:
[18-275]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
----
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
47
PsiBlast_CBE
79.29
78%
-118
- C4 -
3HFG
3
DHI1_HUMAN
D:
[19-275]
------------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
---
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
36
PsiBlast_CBE
78.34
78%
-115
- C4 -
3D5Q
3
DHI1_HUMAN
C:
[4-261]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
------
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
59
PsiBlast_CBE
77.91
78%
-116
- C4 -
3CZR
3
DHI1_HUMAN
B:
[18-277]
-----------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
--------------