@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00106_DHI1_R: (2014-08-27 )
MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQTTMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYSASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALEIIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
Atome Classification :
(55 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280......-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKK
Y
L
L
P
V
L
V
L
C
L
G
Y
YYSTNEEF
R
P
E
M
LQG
K
K
V
I
V
TGASKGI
G
R
E
M
A
Y
H
L
S
KMG
A
H
V
V
L
T
AR
S
E
E
G
L
Q
K
V
V
S
R
C
L
ELGAAS
A
H
Y
IA
G
T
M
E
D
M
A
F
A
E
R
F
V
V
E
A
G
K
L
LG
G
L
D
M
L
I
L
N
H
I
T
Q
T
T
M
S
L
F
H
D
D
I
H
S
V
R
R
S
M
E
V
N
F
L
S
Y
V
V
L
S
T
A
ALP
M
L
KQSNG
S
I
A
I
I
S
S
M
AG
K
M
T
Q
P
L
I
A
SYSA
S
K
F
A
L
D
G
F
F
S
T
I
R
K
E
H
L
M
T
K
V
N
V
S
I
T
L
C
V
L
GFID
T
E
T
A
L
KETS
G
I
I
L
SQAA
P
K
E
E
C
A
L
E
I
I
K
G
TVLRKD
E
V
Y
YDKSSW
T
P
L
L
LGNP
G
R
R
I
M
E
F
L
S
L
R
SYNRDLFVSN-----
2
PsiBlast_PDB
97.47
87%
-125
- C2 -
1Y5R
2
DHI1_MOUSE
A:
[9-273]
--------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
S
K
M
G
A
H
V
V
L
T
A
R
S
E
E
G
L
Q
K
V
V
S
R
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
I
V
K
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
Q
T
S
L
S
L
F
H
D
D
I
H
S
V
R
R
V
M
E
V
N
F
L
S
Y
V
V
M
S
T
A
A
L
P
M
L
K
Q
S
N
G
S
I
A
V
I
S
S
L
A
G
K
M
T
Q
P
M
I
A
P
Y
S
A
S
K
F
A
L
D
G
F
F
S
T
I
R
T
E
L
Y
I
T
K
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
E
I
S
G
I
I
N
A
Q
A
S
P
K
E
E
C
A
L
E
I
I
K
G
T
A
L
R
K
S
E
V
Y
Y
D
K
S
P
L
T
P
I
L
L
G
N
P
G
R
K
I
M
E
F
F
S
L
R
Y
Y
N
K
D
M
F
--------
22
PsiBlast_CBE
95.30
87%
-123
- C2 -
1Y5M
3
DHI1_MOUSE
B:
[9-273]
--------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
S
K
M
G
A
H
V
V
L
T
A
R
S
E
E
G
L
Q
K
V
V
S
R
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
I
V
K
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
Q
T
S
L
S
L
F
H
D
D
I
H
S
V
R
R
V
M
E
V
N
F
L
S
Y
V
V
M
S
T
A
A
L
P
M
L
K
Q
S
N
G
S
I
A
V
I
S
S
L
A
G
K
M
T
Q
P
M
I
A
P
Y
S
A
S
K
F
A
L
D
G
F
F
S
T
I
R
T
E
L
Y
I
T
K
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
E
I
S
G
I
I
N
A
Q
A
S
P
K
E
E
C
A
L
E
I
I
K
G
T
A
L
R
K
S
E
V
Y
Y
D
K
S
P
L
T
P
I
L
L
G
N
P
G
R
K
I
M
E
F
F
S
L
R
Y
Y
N
K
D
M
F
--------
1
PsiBlast_PDB
94.93
87%
-121
- C2 -
1Y5M
3
DHI1_MOUSE
A:
[9-273]
--------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
S
K
M
G
A
H
V
V
L
T
A
R
S
E
E
G
L
Q
K
V
V
S
R
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
I
V
K
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
Q
T
S
L
S
L
F
H
D
D
I
H
S
V
R
R
V
M
E
V
N
F
L
S
Y
V
V
M
S
T
A
A
L
P
M
L
K
Q
S
N
G
S
I
A
V
I
S
S
L
A
G
K
M
T
Q
P
M
I
A
P
Y
S
A
S
K
F
A
L
D
G
F
F
S
T
I
R
T
E
L
Y
I
T
K
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
E
I
S
G
I
I
N
A
Q
A
S
P
K
E
E
C
A
L
E
I
I
K
G
T
A
L
R
K
S
E
V
Y
Y
D
K
S
P
L
T
P
I
L
L
G
N
P
G
R
K
I
M
E
F
F
S
L
R
Y
Y
N
K
D
M
F
--------
21
PsiBlast_CBE
94.29
87%
-115
- C2 -
1Y5R
2
DHI1_MOUSE
B:
[9-273]
--------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
S
K
M
G
A
H
V
V
L
T
A
R
S
E
E
G
L
Q
K
V
V
S
R
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
I
V
K
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
Q
T
S
L
S
L
F
H
D
D
I
H
S
V
R
R
V
M
E
V
N
F
L
S
Y
V
V
M
S
T
A
A
L
P
M
L
K
Q
S
N
G
S
I
A
V
I
S
S
L
A
G
K
M
T
Q
P
M
I
A
P
Y
S
A
S
K
F
A
L
D
G
F
F
S
T
I
R
T
E
L
Y
I
T
K
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
E
I
S
G
I
I
N
A
Q
A
S
P
K
E
E
C
A
L
E
I
I
K
G
T
A
L
R
K
S
E
V
Y
Y
D
K
S
P
L
T
P
I
L
L
G
N
P
G
R
K
I
M
E
F
F
S
L
R
Y
Y
N
K
D
M
F
--------
63
Fugue
92.54
75%
-122
- C2 -
1XSE
1
DHI1_CAVPO
A:
[22-295]
-------------------
N
E
K
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
I
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
A
L
Q
K
V
V
A
R
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
S
M
E
D
M
T
F
A
E
E
F
V
A
E
A
G
N
L
M
G
G
L
D
M
L
I
L
N
H
V
L
Y
N
R
L
T
F
F
H
G
E
I
D
N
V
R
K
S
M
E
V
N
F
H
S
F
V
V
L
S
V
A
A
M
P
M
L
M
Q
S
Q
G
S
I
A
V
V
S
S
V
A
G
K
I
T
Y
P
L
I
A
P
Y
S
A
S
K
F
A
L
D
G
F
F
S
T
L
R
S
E
F
L
V
N
K
V
N
V
S
I
T
L
C
I
L
G
L
I
D
T
E
T
A
I
K
A
T
S
G
I
Y
L
G
P
A
S
P
K
E
E
C
A
L
E
I
I
K
G
T
A
L
R
Q
D
E
M
Y
Y
V
G
S
R
W
V
P
Y
L
L
G
N
P
G
R
K
I
M
E
F
L
S
A
A
E
Y
N
W
D
N
V
L
S
N
E
K
L
YG
18
PsiBlast_PDB
92.31
77%
-119
- C2 -
4HX5
3
DHI1_HUMAN
A:
[19-279]
--------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
------------
73
HHSearch
91.28
77%
-116
* C2 *
1XU9
5
DHI1_HUMAN
A:
[17-283]
------------------
L
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
40
PsiBlast_CBE
90.84
77%
-121
- C2 -
3OQ1
3
DHI1_HUMAN
D:
[18-275]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
8
PsiBlast_PDB
90.47
77%
-114
- C2 -
3BZU
2
DHI1_HUMAN
A:
[19-281]
--------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
----------
61
PsiBlast_CBE
89.61
77%
-117
- C2 -
1XU9
5
DHI1_HUMAN
B:
[18-283]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
39
PsiBlast_CBE
89.51
77%
-118
- C2 -
3QQP
2
DHI1_HUMAN
B:
[18-279]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
------------
36
PsiBlast_CBE
89.30
77%
-119
- C2 -
4HX5
3
DHI1_HUMAN
B:
[18-277]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
--------------
37
PsiBlast_CBE
89.20
77%
-118
- C2 -
3QQP
2
DHI1_HUMAN
D:
[18-271]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
--------------------
14
PsiBlast_PDB
89.19
77%
-113
- C2 -
3FCO
3
DHI1_HUMAN
A:
[18-283]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
--
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
35
PsiBlast_CBE
89.05
77%
-117
- C2 -
4HX5
3
DHI1_HUMAN
C:
[18-278]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
-------------
17
PsiBlast_PDB
89.05
77%
-117
- C2 -
3QQP
2
DHI1_HUMAN
A:
[18-283]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
11
PsiBlast_PDB
88.82
77%
-114
- C2 -
3D4N
2
DHI1_HUMAN
A:
[18-276]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
-
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
---------------
62
PsiBlast_CBE
88.78
77%
-115
- C2 -
1XU7
5
DHI1_HUMAN
D:
[18-275]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
20
PsiBlast_PDB
88.73
77%
-114
- C2 -
3D5Q
3
DHI1_HUMAN
A:
[4-269]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
-----
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
19
PsiBlast_PDB
88.64
77%
-117
- C2 -
3PDJ
3
DHI1_HUMAN
A:
[5-272]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
I
N
------
42
PsiBlast_CBE
88.52
77%
-115
- C2 -
3OQ1
3
DHI1_HUMAN
B:
[18-281]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
----------
41
PsiBlast_CBE
88.44
77%
-112
- C2 -
3OQ1
3
DHI1_HUMAN
C:
[18-283]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
47
PsiBlast_CBE
88.41
77%
-117
- C2 -
3H6K
3
DHI1_HUMAN
B:
[18-276]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
---------------
58
PsiBlast_CBE
88.38
77%
-116
- C2 -
3BZU
2
DHI1_HUMAN
B:
[18-277]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
--------------
49
PsiBlast_CBE
88.14
77%
-117
- C2 -
3FCO
3
DHI1_HUMAN
B:
[18-283]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
---
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
F
--------
10
PsiBlast_PDB
88.14
77%
-115
- C2 -
3D3E
2
DHI1_HUMAN
A:
[18-278]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
--
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
-------------
59
PsiBlast_CBE
88.06
77%
-116
- C2 -
1XU9
4
DHI1_HUMAN
D:
[18-275]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
----
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
15
PsiBlast_PDB
88.03
77%
-115
- C2 -
3H6K
3
DHI1_HUMAN
A:
[20-279]
---------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
------------
12
PsiBlast_PDB
88.01
77%
-119
- C2 -
3FRJ
2
DHI1_HUMAN
A:
[18-278]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
--
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
-------------
4
PsiBlast_PDB
88.00
76%
-116
- C2 -
4BB5
3
DHI1_HUMAN
A:
[27-289]
----------------------
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
L
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
R
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
E
L
Y
S
T
S
Y
N
M
D
R
F
--------
9
PsiBlast_PDB
87.90
77%
-116
- C2 -
3CZR
3
DHI1_HUMAN
A:
[18-279]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
-
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
N
------------
32
PsiBlast_CBE
87.88
76%
-114
- C2 -
4BB5
3
DHI1_HUMAN
B:
[26-289]
---------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
L
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
R
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
E
L
Y
S
T
S
Y
N
M
D
R
F
--------
45
PsiBlast_CBE
87.86
77%
-118
- C2 -
3H6K
3
DHI1_HUMAN
D:
[20-275]
---------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
50
PsiBlast_CBE
87.78
77%
-116
- C2 -
3D4N
2
DHI1_HUMAN
C:
[18-275]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
--
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
48
PsiBlast_CBE
87.76
77%
-117
- C2 -
3FRJ
2
DHI1_HUMAN
B:
[18-278]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
-------------
51
PsiBlast_CBE
87.63
77%
-116
- C2 -
3D4N
2
DHI1_HUMAN
B:
[18-278]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
Y
-------------
60
PsiBlast_CBE
87.62
77%
-117
- C2 -
1XU9
4
DHI1_HUMAN
C:
[18-275]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
----
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
38
PsiBlast_CBE
87.57
77%
-118
- C2 -
3QQP
2
DHI1_HUMAN
C:
[18-275]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
34
PsiBlast_CBE
87.46
77%
-118
- C2 -
4HX5
3
DHI1_HUMAN
D:
[18-273]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
------------------
30
PsiBlast_CBE
87.38
76%
-114
- C2 -
4BB5
3
DHI1_HUMAN
D:
[26-290]
---------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
L
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
---
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
R
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
E
L
Y
S
T
S
Y
N
M
D
R
F
I
-------
6
PsiBlast_PDB
87.28
77%
-115
- C2 -
1XU7
5
DHI1_HUMAN
A:
[18-277]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
--------------
56
PsiBlast_CBE
87.27
77%
-121
- C2 -
3BZU
2
DHI1_HUMAN
D:
[20-275]
---------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
--
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
31
PsiBlast_CBE
87.26
76%
-117
- C2 -
4BB5
2
DHI1_HUMAN
C:
[26-279]
---------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
L
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
R
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
E
L
------------------
57
PsiBlast_CBE
87.18
77%
-116
- C2 -
3BZU
2
DHI1_HUMAN
C:
[18-276]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
-----
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
---------------
53
PsiBlast_CBE
87.18
77%
-119
- C2 -
3D3E
2
DHI1_HUMAN
C:
[18-275]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
--
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
46
PsiBlast_CBE
87.10
77%
-116
- C2 -
3H6K
3
DHI1_HUMAN
C:
[18-277]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
--------------
13
PsiBlast_PDB
87.02
77%
-117
- C2 -
3HFG
3
DHI1_HUMAN
A:
[20-277]
---------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
--------------
16
PsiBlast_PDB
86.81
77%
-117
- C2 -
3OQ1
3
DHI1_HUMAN
A:
[18-275]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
5
PsiBlast_PDB
86.63
76%
-111
- C2 -
4BB6
3
DHI1_HUMAN
A:
[26-291]
---------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
L
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
R
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
E
L
Y
S
T
S
Y
N
W
D
R
F
I
N
------
55
PsiBlast_CBE
85.98
77%
-116
- C2 -
3CZR
3
DHI1_HUMAN
B:
[18-277]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
T
S
--------------
52
PsiBlast_CBE
85.68
77%
-116
- C2 -
3D3E
2
DHI1_HUMAN
D:
[18-275]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
--
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
44
PsiBlast_CBE
85.65
77%
-116
- C2 -
3HFG
2
DHI1_HUMAN
C:
[18-275]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
----
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
54
PsiBlast_CBE
85.62
77%
-116
- C2 -
3D3E
2
DHI1_HUMAN
B:
[18-275]
-------------------
N
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
--
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------
33
PsiBlast_CBE
85.51
76%
-120
- C2 -
4BB6
3
DHI1_HUMAN
B:
[26-283]
---------------------
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
L
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
I
V
H
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
R
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
E
L
Y
S
T
S
--------------
43
PsiBlast_CBE
85.03
77%
-116
- C2 -
3HFG
3
DHI1_HUMAN
D:
[19-275]
--------------------
E
E
F
R
P
E
M
L
Q
G
K
K
V
I
V
T
G
A
S
K
G
I
G
R
E
M
A
Y
H
L
A
K
M
G
A
H
V
V
V
T
A
R
S
K
E
T
L
Q
K
V
V
S
H
C
L
E
L
G
A
A
S
A
H
Y
I
A
G
T
M
E
D
M
T
F
A
E
Q
F
V
A
Q
A
G
K
L
M
G
G
L
D
M
L
I
L
N
H
I
T
N
T
S
L
N
L
F
H
D
D
I
H
H
V
R
K
S
M
E
V
N
F
L
S
Y
V
V
L
T
V
A
A
L
P
M
L
K
Q
S
N
G
S
I
V
V
V
S
S
L
A
G
K
V
A
Y
P
M
V
A
A
Y
S
A
S
K
F
A
L
D
G
F
F
S
S
I
R
K
E
Y
S
V
S
R
V
N
V
S
I
T
L
C
V
L
G
L
I
D
T
E
T
A
M
K
A
V
S
G
---
M
Q
A
A
P
K
E
E
C
A
L
E
I
I
K
G
G
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
T
L
L
I
R
N
P
S
R
K
I
L
E
F
L
Y
S
----------------