@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00107_ADH1B_: (2014-08-27 )
MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF
Atome Classification :
(53 SA)
.........10........20........30........40........50.....-...60.........70........80........90........100.......110.......----120..-.....130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310........320.......330.......340.......350.......360.......370...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTAG
K
V
I
K
C
K
A
A
V
L
W
EVKKPFSIEDVEVAPP
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
CRTDDHVVSG-NLVT-P
L
P
V
ILGH
E
A
A
G
I
V
E
S
VGEG
V
T
TVKPG
D
K
V
I
P
L
FTPQCGKCRVCKNPESN
Y
C
LKNDLGN----PRGTL-QDG
T
R
R
F
T
CRGK
P
I
H
H
F
LGTSTF
S
Q
Y
T
V
VDEN
A
V
A
KIDAAS
P
L
E
K
V
C
L
I
GCGFSTGYGS
A
V
N
V
A
KVTPG
S
T
C
A
V
F
GLG
G
V
G
L
S
A
V
MGCKAAG
A
A
R
I
I
A
V
DIN
K
D
K
F
A
K
A
K
ELGATECI
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
MTDGGVD
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
ACG
T
S
V
I
V
GVPPASQNLSIN
P
M
L
L
L
T-GRTWK
G
A
V
YGGFKSKEG
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
VL
P
F
E
K
I
N
E
G
F
D
L
L
HSGK
S
I
R
T
V
LTF
5
PsiBlast_PDB
96.04
100%
-115
- C1 -
1U3U
4
ADH1B_HUMAN
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
6
PsiBlast_PDB
95.97
100%
-115
- C1 -
1U3V
4
ADH1B_HUMAN
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
23
PsiBlast_CBE
95.96
100%
-115
- C1 -
1U3U
3
ADH1B_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
29
PsiBlast_CBE
95.95
99%
-117
- C1 -
1HTB
2
ADH1B_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
C
T
V
L
T
F
24
PsiBlast_CBE
95.90
100%
-115
- C1 -
1HSZ
1
ADH1B_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
25
PsiBlast_CBE
95.84
100%
-117
- C1 -
1HDX
2
ADH1B_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
27
PsiBlast_CBE
95.52
99%
-119
- C1 -
1HDY
3
ADH1B_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
H
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
26
PsiBlast_CBE
95.45
100%
-116
- C1 -
1DEH
2
ADH1B_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
1
PsiBlast_PDB
95.44
100%
-116
- C1 -
1HDX
4
ADH1B_HUMAN
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
62
Fugue
95.29
100%
-118
- C1 -
3HUD
1
ADH1B_HUMAN
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
N-
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
4
PsiBlast_PDB
95.29
100%
-114
- C1 -
1HSZ
1
ADH1B_HUMAN
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
22
PsiBlast_CBE
95.23
100%
-115
- C1 -
1U3V
4
ADH1B_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
3
PsiBlast_PDB
95.15
100%
-116
- C1 -
1DEH
2
ADH1B_HUMAN
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
28
PsiBlast_CBE
95.11
99%
-115
- C1 -
1HDZ
2
ADH1B_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
7
PsiBlast_PDB
94.71
99%
-118
- C1 -
1HDY
2
ADH1B_HUMAN
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
H
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
31
PsiBlast_CBE
94.23
94%
-115
- C1 -
1HT0
2
ADH1G_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
L
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
A
G
I
C
R
S
D
E
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
S
G
K
P
I
H
H
F
V
G
V
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
Q
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
E
S
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
N
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
K
S
I
R
T
V
L
T
F
13
PsiBlast_PDB
94.17
93%
-115
- C1 -
1U3T
3
ADH1A_HUMAN
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
L
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
V
V
S
G
-
T
M
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
A
I
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
V
S
N
----
P
Q
G
T
L
-
Q
D
G
T
S
R
F
T
C
R
R
K
P
I
H
H
F
L
G
I
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
L
G
G
F
K
S
K
E
C
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
I
L
M
F
39
PsiBlast_CBE
94.09
87%
-114
- C1 -
4DXH
3
ADH1E_HORSE
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
17
PsiBlast_PDB
93.94
87%
-113
- C1 -
2OXI
3
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
9
PsiBlast_PDB
93.82
99%
-116
- C1 -
1HTB
2
ADH1B_HUMAN
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
C
T
V
L
T
F
32
PsiBlast_CBE
93.79
93%
-115
- C1 -
1U3T
2
ADH1A_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
L
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
V
V
S
G
-
T
M
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
A
I
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
V
S
N
----
P
Q
G
T
L
-
Q
D
G
T
S
R
F
T
C
R
R
K
P
I
H
H
F
L
G
I
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
L
G
G
F
K
S
K
E
C
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
I
L
M
F
34
PsiBlast_CBE
93.75
87%
-114
- C1 -
4NFH
5
ADH1E_HORSE
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
49
PsiBlast_CBE
93.61
87%
-114
- C1 -
2JHG
2
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
46
PsiBlast_CBE
93.61
87%
-114
- C1 -
2OXI
3
ADH1E_HORSE
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
58
PsiBlast_CBE
93.47
87%
-114
- C1 -
1N92
3
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
18
PsiBlast_PDB
93.35
87%
-112
- C1 -
1HLD
3
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
41
PsiBlast_CBE
93.19
87%
-112
- C1 -
4DWV
5
ADH1E_HORSE
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
30
PsiBlast_CBE
93.19
94%
-114
- C1 -
1U3W
4
ADH1G_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
L
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
A
G
I
C
R
S
D
E
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
S
G
K
P
I
H
H
F
V
G
V
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
Q
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
E
S
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
N
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
K
S
I
R
T
V
L
T
F
71
HHSearch
93.17
87%
-113
- C1 -
2JHF
2
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
50
PsiBlast_CBE
93.15
87%
-114
- C1 -
2JHF
3
ADH1E_HORSE
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
48
PsiBlast_CBE
93.13
87%
-114
- C1 -
2JHG
3
ADH1E_HORSE
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
16
PsiBlast_PDB
93.13
87%
-115
- C1 -
2OHX
3
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
42
PsiBlast_CBE
93.12
87%
-114
- C1 -
4DWV
7
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
10
PsiBlast_PDB
93.02
94%
-114
- C1 -
1HT0
2
ADH1G_HUMAN
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
L
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
A
G
I
C
R
S
D
E
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
S
G
K
P
I
H
H
F
V
G
V
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
Q
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
E
S
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
N
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
K
S
I
R
T
V
L
T
F
14
PsiBlast_PDB
92.96
87%
-114
- C1 -
4NFH
7
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
40
PsiBlast_CBE
92.91
87%
-114
- C1 -
4DXH
6
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
52
PsiBlast_CBE
92.90
87%
-114
- C1 -
1YE3
1
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
47
PsiBlast_CBE
92.84
87%
-115
- C1 -
2OHX
3
ADH1E_HORSE
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
21
PsiBlast_CBE
92.76
100%
-114
- C1 -
3HUD
1
ADH1B_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
V
K
K
P
F
S
I
E
D
V
E
V
A
P
P
K
A
Y
E
V
R
I
K
M
V
A
V
G
I
C
R
T
D
D
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
A
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
V
Y
G
G
F
K
S
K
E
G
I
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
V
L
T
F
57
PsiBlast_CBE
92.38
87%
-113
- C1 -
1N92
3
ADH1E_HORSE
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
12
PsiBlast_PDB
92.06
93%
-111
- C1 -
1HSO
3
ADH1A_HUMAN
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
L
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
V
V
S
G
-
T
M
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
A
I
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
V
S
N
----
P
Q
G
T
L
-
Q
D
G
T
S
R
F
T
C
R
R
K
P
I
H
H
F
L
G
I
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
L
G
G
F
K
S
K
E
C
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
I
L
M
F
11
PsiBlast_PDB
91.78
94%
-114
- C1 -
1U3W
4
ADH1G_HUMAN
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
L
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
A
G
I
C
R
S
D
E
H
V
V
S
G
-
N
L
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
L
G
N
----
P
R
G
T
L
-
Q
D
G
T
R
R
F
T
C
S
G
K
P
I
H
H
F
V
G
V
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
V
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
Q
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
I
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
E
S
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
N
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
K
S
I
R
T
V
L
T
F
33
PsiBlast_CBE
91.05
93%
-109
- C1 -
1HSO
4
ADH1A_HUMAN
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
L
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
V
G
I
C
G
T
D
D
H
V
V
S
G
-
T
M
V
T
-
P
L
P
V
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
T
V
K
P
G
D
K
V
I
P
L
A
I
P
Q
C
G
K
C
R
I
C
K
N
P
E
S
N
Y
C
L
K
N
D
V
S
N
----
P
Q
G
T
L
-
Q
D
G
T
S
R
F
T
C
R
R
K
P
I
H
H
F
L
G
I
S
T
F
S
Q
Y
T
V
V
D
E
N
A
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
N
V
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
A
I
M
G
C
K
A
A
G
A
A
R
I
I
A
V
D
I
N
K
D
K
F
A
K
A
K
E
L
G
A
T
E
C
I
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
K
E
M
T
D
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
M
A
S
L
L
C
C
H
E
A
C
G
T
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
T
-
G
R
T
W
K
G
A
I
L
G
G
F
K
S
K
E
C
V
P
K
L
V
A
D
F
M
A
K
K
F
S
L
D
A
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
H
S
G
K
S
I
R
T
I
L
M
F
38
PsiBlast_CBE
90.86
87%
-113
- C1 -
5ADH
2
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
15
PsiBlast_PDB
88.86
87%
-113
- C1 -
6ADH
2
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
37
PsiBlast_CBE
87.94
87%
-110
- C1 -
6ADH
2
ADH1E_HORSE
B:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
36
PsiBlast_CBE
83.28
87%
-107
- C1 -
7ADH
23
ADH1E_HORSE
A:
[1-374]
-
S
T
A
G
K
V
I
K
C
K
A
A
V
L
W
E
E
K
K
P
F
S
I
E
E
V
E
V
A
P
P
K
A
H
E
V
R
I
K
M
V
A
T
G
I
C
R
S
D
D
H
V
V
S
G
-
T
L
V
T
-
P
L
P
V
I
A
G
H
E
A
A
G
I
V
E
S
I
G
E
G
V
T
T
V
R
P
G
D
K
V
I
P
L
F
T
P
Q
C
G
K
C
R
V
C
K
H
P
E
G
N
F
C
L
K
N
D
L
S
M
----
P
R
G
T
M
-
Q
D
G
T
S
R
F
T
C
R
G
K
P
I
H
H
F
L
G
T
S
T
F
S
Q
Y
T
V
V
D
E
I
S
V
A
K
I
D
A
A
S
P
L
E
K
V
C
L
I
G
C
G
F
S
T
G
Y
G
S
A
V
K
V
A
K
V
T
Q
G
S
T
C
A
V
F
G
L
G
G
V
G
L
S
V
I
M
G
C
K
A
A
G
A
A
R
I
I
G
V
D
I
N
K
D
K
F
A
K
A
K
E
V
G
A
T
E
C
V
N
P
Q
D
Y
K
K
P
I
Q
E
V
L
T
E
M
S
N
G
G
V
D
F
S
F
E
V
I
G
R
L
D
T
M
V
T
A
L
S
C
C
Q
E
A
Y
G
V
S
V
I
V
G
V
P
P
D
S
Q
N
L
S
M
N
P
M
L
L
L
S
-
G
R
T
W
K
G
A
I
F
G
G
F
K
S
K
D
S
V
P
K
L
V
A
D
F
M
A
K
K
F
A
L
D
P
L
I
T
H
V
L
P
F
E
K
I
N
E
G
F
D
L
L
R
S
G
E
S
I
R
T
I
L
T
F
72
HHSearch
81.18
59%
-110
* C1 *
1P0F
2
ADH8_PELPE
A:
[2-373]
-
C
T
A
G
K
D
I
T
C
K
A
A
V
A
W
E
P
H
K
P
L
S
L
E
T
I
T
V
A
P
P
K
A
H
E
V
R
I
K
I
L
A
S
G
I
C
G
S
D
S
S
V
L
K
E
-
I
I
P
S
-
K
F
P
V
I
L
G
H
E
A
V
G
V
V
E
S
I
G
A
G
V
T
C
V
K
P
G
D
K
V
I
P
L
F
V
P
Q
C
G
S
C
R
A
C
K
S
S
N
S
N
F
C
E
K
N
D
M
G
A
----
K
T
G
L
M
-
A
D
M
T
S
R
F
T
C
R
G
K
P
I
Y
N
L
M
G
T
S
T
F
T
E
Y
T
V
V
A
D
I
A
V
A
K
I
D
P
K
A
P
L
E
-
S
C
L
I
G
C
G
F
A
T
G
Y
G
A
A
V
N
T
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
G
V
G
F
S
A
I
V
G
C
K
A
A
G
A
S
R
I
I
G
V
G
T
H
K
D
K
F
P
K
A
I
E
L
G
A
T
E
C
L
N
P
K
D
Y
D
K
P
I
Y
E
V
I
C
E
K
T
N
G
G
V
D
Y
A
V
E
C
A
G
R
I
E
T
M
M
N
A
L
Q
S
T
Y
C
G
S
G
V
T
V
V
L
G
L
A
S
P
N
E
R
L
P
L
D
P
L
L
L
L
T
-
G
R
S
L
K
G
S
V
F
G
G
F
K
G
-
E
E
V
S
R
L
V
D
D
Y
M
K
K
K
I
N
V
N
F
L
V
S
T
K
L
T
L
D
Q
I
N
K
A
F
E
L
L
S
S
G
Q
G
V
R
S
I
M
I
Y
74
HHSearch
77.91
62%
-105
- C1 -
2FZW
1
ADHX_HUMAN
A:
[1-373]
---
A
N
E
V
I
K
C
K
A
A
V
A
W
E
A
G
K
P
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
T
L
S
G
-
A
D
P
E
G
C
F
P
V
I
L
G
H
L
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
----
G
K
G
L
M
-
P
D
G
T
S
R
F
T
C
K
G
K
T
I
L
H
Y
M
G
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
S
R
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
Q
D
F
S
K
P
I
Q
E
V
L
I
E
M
T
D
G
G
V
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
E
A
C
H
K
G
W
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
F
Q
L
V
T
-
G
R
T
W
K
G
T
A
F
G
G
W
K
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
S
F
D
E
I
N
K
A
F
E
L
M
H
S
G
K
S
I
R
T
V
V
K
I
73
HHSearch
75.36
55%
-107
- C1 -
1CDO
1
ADH1_GADMC
A:
[1-374]
-
A
T
V
G
K
V
I
K
C
K
A
A
V
A
W
E
A
N
K
P
L
V
I
E
E
I
E
V
D
V
P
H
A
N
E
I
R
I
K
I
I
A
T
G
V
C
H
T
D
L
Y
H
L
F
E
-
G
K
H
K
D
G
F
P
V
V
L
G
H
E
G
A
G
I
V
E
S
V
G
P
G
V
T
E
F
Q
P
G
E
K
V
I
P
L
F
I
S
Q
C
G
E
C
R
F
C
Q
S
P
K
T
N
Q
C
V
K
G
W
A
N
E
----
S
P
D
V
M
-
S
P
K
E
T
R
F
T
C
K
G
R
K
V
L
Q
F
L
G
T
S
T
F
S
Q
Y
T
V
V
N
Q
I
A
V
A
K
I
D
P
S
A
P
L
D
T
V
C
L
L
G
C
G
V
S
T
G
F
G
A
A
V
N
T
A
K
V
E
P
G
S
T
C
A
V
F
G
L
G
A
V
G
L
A
A
V
M
G
C
H
S
A
G
A
K
R
I
I
A
V
D
L
N
P
D
K
F
E
K
A
K
V
F
G
A
T
D
F
V
N
P
N
D
H
S
E
P
I
S
Q
V
L
S
K
M
T
N
G
G
V
D
F
S
L
E
C
V
G
N
V
G
V
M
R
N
A
L
E
S
C
L
K
G
W
G
V
S
V
L
V
G
W
T
D
L
H
D
-
V
A
T
R
P
I
Q
L
I
A
-
G
R
T
W
K
G
S
M
F
G
G
F
K
G
K
D
G
V
P
K
M
V
K
A
Y
L
D
K
K
V
K
L
D
E
F
I
T
H
R
M
P
L
E
S
V
N
D
A
I
D
L
M
K
H
G
K
C
I
R
T
V
L
S
L
76
HHSearch
73.73
54%
-104
- C1 -
3UKO
1
ADHX_ARATH
A:
[1-376]
-
A
T
Q
G
Q
V
I
T
C
K
A
A
V
A
Y
E
P
N
K
P
L
V
I
E
D
V
Q
V
A
P
P
Q
A
G
E
V
R
I
K
I
L
Y
T
A
L
C
H
T
D
A
Y
T
W
S
G
-
K
D
P
E
G
L
F
P
C
I
L
G
H
E
A
A
G
I
V
E
S
V
G
E
G
V
T
E
V
Q
A
G
D
H
V
I
P
C
Y
Q
A
E
C
R
E
C
K
F
C
K
S
G
K
T
N
L
C
G
K
V
R
S
A
T
----
G
V
G
I
M
M
N
D
R
K
S
R
F
S
V
N
G
K
P
I
Y
H
F
M
G
T
S
T
F
S
Q
Y
T
V
V
H
D
V
S
V
A
K
I
D
P
T
A
P
L
D
K
V
C
L
L
G
C
G
V
P
T
G
L
G
A
V
W
N
T
A
K
V
E
P
G
S
N
V
A
I
F
G
L
G
T
V
G
L
A
V
A
E
G
A
K
T
A
G
A
S
R
I
I
G
I
D
I
D
S
K
K
Y
E
T
A
K
K
F
G
V
N
E
F
V
N
P
K
D
H
D
K
P
I
Q
E
V
I
V
D
L
T
D
G
G
V
D
Y
S
F
E
C
I
G
N
V
S
V
M
R
A
A
L
E
C
C
H
K
G
W
G
T
S
V
I
V
G
V
A
A
S
G
Q
E
I
S
T
R
P
F
Q
L
V
T
-
G
R
V
W
K
G
T
A
F
G
G
F
K
S
R
T
Q
V
P
W
L
V
E
K
Y
M
N
K
E
I
K
V
D
E
Y
I
T
H
N
L
T
L
G
E
I
N
K
A
F
D
L
L
H
E
G
T
C
L
R
C
V
L
D
T
75
HHSearch
73.55
54%
-106
- C1 -
1E3I
2
ADH4_MOUSE
A:
[2-376]
--
T
Q
G
K
V
I
K
C
K
A
A
I
A
W
K
T
G
S
P
L
C
I
E
E
I
E
V
S
P
P
K
A
C
E
V
R
I
Q
V
I
A
T
C
V
C
P
T
D
I
N
A
T
D
P
-
K
K
K
A
-
L
F
P
V
V
L
G
H
E
C
A
G
I
V
E
S
V
G
P
G
V
T
N
F
K
P
G
D
K
V
I
P
F
F
A
P
Q
C
K
R
C
K
L
C
L
S
P
L
T
N
L
C
G
K
L
R
N
F
K
YPTI
D
Q
E
L
M
-
E
D
R
T
S
R
F
T
C
K
G
R
S
I
Y
H
F
M
G
V
S
S
F
S
Q
Y
T
V
V
S
E
A
N
L
A
R
V
D
D
E
A
N
L
E
R
V
C
L
I
G
C
G
F
S
S
G
Y
G
A
A
I
N
T
A
K
V
T
P
G
S
T
C
A
V
F
G
L
G
C
V
G
L
S
A
I
I
G
C
K
I
A
G
A
S
R
I
I
A
I
D
I
N
G
E
K
F
P
K
A
K
A
L
G
A
T
D
C
L
N
P
R
E
L
D
K
P
V
Q
D
V
I
T
E
L
T
A
G
G
V
D
Y
S
L
D
C
A
G
T
A
Q
T
L
K
A
A
V
D
C
T
V
L
G
W
G
S
C
T
V
V
G
A
K
--
V
D
E
M
T
I
P
T
V
D
V
I
L
-
G
R
S
I
N
G
T
F
F
G
G
W
K
S
V
D
S
V
P
N
L
V
S
D
Y
K
N
K
K
F
D
L
D
L
L
V
T
H
A
L
P
F
E
S
I
N
D
A
I
D
L
M
K
E
G
K
S
I
R
T
I
L
T
F
77
HHSearch
55.87
34%
-99
- C1 -
1F8F
2
?
A:
[5-370]
-------
K
D
I
I
A
A
V
T
P
C
K
G
A
D
F
E
L
Q
A
L
K
I
R
Q
P
Q
G
D
E
V
L
V
K
V
V
A
T
G
M
C
H
T
D
L
I
V
R
D
Q
-
K
Y
P
V
-
P
L
P
A
V
L
G
H
E
G
S
G
I
I
E
A
I
G
P
N
V
T
E
L
Q
V
G
D
H
V
V
L
S
Y
G
Y
-
C
G
K
C
T
Q
C
N
T
G
N
P
A
Y
C
S
E
F
F
G
R
N
----
F
S
G
A
D
-
S
E
G
N
H
A
L
C
----
V
N
D
H
F
F
A
Q
S
S
F
A
T
Y
A
L
S
R
E
N
N
T
V
K
V
T
K
D
V
P
I
E
L
L
G
P
L
G
C
G
I
Q
T
G
A
G
A
C
I
N
A
L
K
V
T
P
A
S
S
F
V
T
W
G
A
G
A
V
G
L
S
A
L
L
A
A
K
V
C
G
A
S
I
I
I
A
V
D
I
V
E
S
R
L
E
L
A
K
Q
L
G
A
T
H
V
I
N
S
K
T
--
Q
D
P
V
A
A
I
K
E
I
T
D
G
G
V
N
F
A
L
E
S
T
G
S
P
E
I
L
K
Q
G
V
D
A
L
-
G
I
L
G
K
I
A
V
V
G
A
P
Q
L
G
T
T
A
Q
F
D
V
N
D
L
L
L
G
G
K
T
I
L
G
V
V
E
G
S
G
S
P
K
K
F
I
P
E
L
V
R
L
Y
Q
Q
G
K
F
P
F
D
Q
L
V
K
F
-
Y
A
F
D
E
I
N
Q
A
A
I
D
S
R
K
G
I
T
L
K
P
I
I
K
I