@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00121_TPIS_T: (2014-08-28 )
MASKPQPIAAANWKCNGSESLLVPLIETLNAATFDHDVQCVVAPTFLHIPMTKARLTNPKFQIAAQNAITRSGAFTGEVSLQILKDYGISWVVLGHSERRLYYGETNEIVAEKVAQACAAGFHVIVCVGETNEEREAGRTAAVVLTQLAAVAQKLSKEAWSRVVIAYEPVWAIGTGKVATPQQAQEVHELLRRWVRSKLGTDIAAQLRILYGGSVTAKNARTLYQMRDINGFLVGGASLKPEFVEIIEATK
Atome Classification :
(24 SA)
.........10........20........30....-..-..40........50.-.......60........70.........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240-........250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASKPQP
I
A
A
A
NWKCNGSE
S
L
L
V
P
L
I
E
T
LNAATFD-HD-
V
Q
C
V
V
A
P
T
F
L
HIPM
T
-
K
ARLTNP
K
F
Q
I
A
AQNAIT-RSGAFTG
E
V
S
L
Q
I
L
K
DYG
I
S
W
V
V
LGHSE
R
R
L
YYG
E
T
N
E
I
V
A
E
K
V
A
Q
A
C
AAG
F
H
V
I
V
C
VGETN
E
E
R
EAG
R
T
A
A
V
V
L
T
Q
L
A
A
V
A
Q
K
L
S
K
E
A
W
S
R
V
V
I
A
YE
P
V
W
AIGTGKVAT
P
Q
Q
A
Q
E
V
H
E
L
L
R
R
W
V
R
S
KLGT
D
I
A
A
Q
L
R
I
L
YGGSVTAKNA
R
T
L
Y
Q
M
RDI
N
G
F
L
VGGASL
K
-
P
-
E
F
V
E
I
I
EATK
1
PsiBlast_PDB
96.81
99%
-129
- C6 -
4HHP
2
TPIS_TRYCR
A:
[3-251]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
E
S
L
L
V
P
L
I
E
T
L
N
A
A
T
F
D
-
H
D
-
V
Q
C
V
V
A
P
T
F
L
H
I
P
M
T
-
K
A
R
L
T
N
P
K
F
Q
I
A
A
Q
N
A
I
T
-
R
S
G
A
F
T
G
E
V
S
L
Q
I
L
K
D
Y
G
I
S
W
V
V
L
G
H
S
E
R
R
L
Y
Y
G
D
T
N
E
I
V
A
E
K
V
A
Q
A
C
A
A
G
F
H
V
I
V
C
V
G
E
T
N
E
E
R
E
A
G
R
T
A
A
V
V
L
T
Q
L
A
A
V
A
Q
K
L
S
K
E
A
W
S
R
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
V
H
E
L
L
R
R
W
V
R
S
K
L
G
T
D
I
A
A
Q
L
R
I
L
Y
G
G
S
V
T
A
K
N
A
R
T
L
Y
Q
M
R
D
I
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
E
I
I
E
A
T
K
49
PsiBlast_CBE
89.38
73%
-129
- C6 -
2J27
1
TPIS_TRYBB
A:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
A
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
24
PsiBlast_CBE
88.71
73%
-126
- C6 -
1TPF
2
TPIS_TRYBB
B:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
25
PsiBlast_CBE
88.60
73%
-127
- C6 -
1TPF
2
TPIS_TRYBB
A:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
48
PsiBlast_CBE
88.38
73%
-129
- C6 -
2J27
1
TPIS_TRYBB
B:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
A
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
39
PsiBlast_CBE
88.22
73%
-126
- C6 -
2V2C
1
TPIS_TRYBB
A:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
L
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
20
PsiBlast_CBE
88.19
73%
-126
- C6 -
4TIM
1
TPIS_TRYBB
B:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
17
PsiBlast_CBE
88.16
73%
-127
- C6 -
6TIM
1
TPIS_TRYBB
B:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
26
PsiBlast_CBE
87.73
73%
-126
- C6 -
1IIH
1
TPIS_TRYBB
B:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
27
PsiBlast_CBE
87.57
73%
-124
- C6 -
1IIG
1
TPIS_TRYBB
B:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
38
PsiBlast_CBE
87.33
73%
-124
- C6 -
1KV5
4
TPIS_TRYBB
A:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
S
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
23
PsiBlast_CBE
87.19
73%
-126
- C6 -
1TRD
1
TPIS_TRYBB
B:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
37
PsiBlast_CBE
87.09
73%
-124
- C6 -
1KV5
3
TPIS_TRYBB
B:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
S
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
47
PsiBlast_CBE
86.30
73%
-126
- C6 -
1TSI
1
TPIS_TRYBB
A:
[2-250]
--
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
N
-
H
D
-
V
Q
C
V
V
A
S
T
F
V
H
L
A
M
T
-
K
E
R
L
S
H
P
K
F
V
I
A
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
R
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
V
D
I
I
K
A
T
Q
11
PsiBlast_PDB
85.75
68%
-124
- C6 -
2Y63
1
TPIS_LEIME
A:
[3-251]
--
A
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
-
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
I
P
L
V
-
Q
A
K
L
R
N
P
K
Y
V
I
S
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
R
D
I
I
D
A
T
R
7
PsiBlast_PDB
85.69
68%
-124
- C6 -
1N55
6
TPIS_LEIME
A:
[3-251]
--
A
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
-
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
I
P
L
V
-
Q
A
K
L
R
N
P
K
Y
V
I
S
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
R
D
I
I
D
A
T
R
62
HHSearch
85.35
69%
-121
- C6 -
2VXN
6
TPIS_LEIME
A:
[3-251]
--
A
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
-
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
I
P
L
V
-
Q
A
K
L
R
N
P
K
Y
V
I
S
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
R
D
I
I
D
A
T
R
5
PsiBlast_PDB
85.02
68%
-121
- C6 -
1QDS
1
TPIS_LEIME
A:
[2-251]
-
S
A
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
-
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
I
P
L
V
-
Q
A
K
L
R
N
P
K
Y
V
I
S
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
R
D
I
I
D
A
T
R
10
PsiBlast_PDB
84.87
68%
-123
- C6 -
2Y62
3
TPIS_LEIME
A:
[3-251]
--
A
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
-
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
I
P
L
V
-
Q
A
K
L
R
N
P
K
Y
V
I
S
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
R
D
I
I
D
A
T
R
9
PsiBlast_PDB
84.71
68%
-122
- C6 -
2Y61
3
TPIS_LEIME
A:
[3-251]
--
A
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
-
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
I
P
L
V
-
Q
A
K
L
R
N
P
K
Y
V
I
S
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
R
D
I
I
D
A
T
R
50
Fugue
84.48
68%
-121
- C6 -
1IF2
1
TPIS_LEIME
A:
[3-251]
--
A
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
-
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
I
P
L
V
-
Q
A
K
L
R
N
P
K
Y
V
I
S
A
Q
N
A
I
A
-
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
-
P
-
E
F
R
D
I
I
D
A
T
R
75
HHSearch
78.08
51%
-123
- C6 -
4MKN
6
?
A:
[17-264]
--
S
S
A
K
F
F
V
G
G
N
W
K
C
N
G
S
V
A
N
V
A
K
L
V
D
E
L
N
A
G
T
I
P
-
R
G
-
V
D
V
V
V
A
P
P
F
I
Y
I
D
Y
V
M
Q
H
L
D
R
-
D
K
Y
Q
L
S
A
Q
N
A
W
I
G
G
N
G
A
F
T
G
E
V
S
A
E
Q
L
T
D
F
G
V
P
W
V
I
L
G
H
S
E
R
R
S
L
F
G
E
S
N
E
V
V
A
K
K
T
S
H
A
L
A
A
G
L
G
V
I
A
C
I
G
E
T
L
E
Q
R
N
S
G
S
V
F
K
V
L
D
A
Q
M
D
A
L
V
D
E
V
K
D
--
W
T
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
V
V
A
S
P
E
Q
A
Q
E
V
H
A
Y
L
R
Q
Y
C
A
K
K
L
G
A
A
V
A
D
K
L
R
I
I
Y
G
G
S
V
S
D
T
N
C
K
D
L
S
K
Q
E
D
I
D
G
F
L
V
G
G
A
S
L
K
G
A
-
A
F
V
T
I
C
N
A
A
-
61
HHSearch
75.07
44%
-122
- C6 -
1O5X
1
TPIS_PLAFA
A:
[3-247]
----
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
N
N
L
D
F
D
-
P
S
K
L
D
V
V
V
F
P
V
S
V
H
Y
D
H
T
-
R
K
L
L
Q
-
S
K
F
S
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
D
N
--
F
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
-
S
F
V
D
I
I
K
S
A
-
67
HHSearch
72.33
43%
-111
- C6 -
2BTM
1
TPIS_GEOSE
A:
[1-249]
----
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
H
V
P
P
A
D
E
-
V
I
S
V
V
C
A
P
F
L
F
L
D
R
L
-
V
Q
A
A
D
G
T
D
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
-
P
A
S
F
L
Q
L
V
E
A
G
-