@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00144_BLAC_B: (2014-08-29 )
MKLWFSTLKLKKAAAVLLFSCVALAGCANNQTNASQPAEKNEKTEMKDDFAKLEEQFDAKLGIFALDTGTNRTVAYRPDERFAFASTIKALTVGVLLQQKSIEDLNQRITYTRDDLVNYNPITEKHVDTGMTLKELADASLRYSDNAAQNLILKQIGGPESLKKELRKIGDEVTNPERFEPELNEVNPGETQDTSTARALVTSLRAFALEDKLPSEKRELLIDWMKRNTTGDALIRAGVPDGWEVADKTGAASYGTRNDIAIIWPPKGDPVVLAVLSSRDKKDAKYDDKLIAEATKVVMKALNMNGK
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........--100.......110.......120.......130........140.......150.......----160.......170.......180.......190.......200.......210.......220.......230.......240.......250.-.......260....-..-.270.......280--.......290.......300.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKL
W
F
S
T
L
K
L
K
K
A
A
A
V
L
L
F
S
C
V
A
L
AGCANNQTNASQPAEKN
E
K
T
E
M
K
D
D
F
A
K
L
E
E
Q
FDAKL
G
I
F
A
LDTGTN
R
T
V
A
YRPDE
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
RITYTRDDLVNYNPI
T
E
K
HVDTG-
M
T
L
K
E
L
A
D
A
SLRYSD
N
A
A
Q
N
L
I
L
K
QIG
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
EVT
N
P
E
RFEPELNEVNPGETQD
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
EDKL
P
S
E
K
R
E
L
L
I
D
W
M
KRNTTGD
A
L
I
RAGVPDGWEVADKTGA-A-SYGTRN
D
I
A
I
I
WPP-KG-D
P
V
V
L
A
VLSSRDKK--DAKY
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
LNMNGK
12
PsiBlast_PDB
96.30
99%
-72
- C2 -
3M2J
1
BLAC_BACLI
A:
[2-257]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
A
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
A
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
C
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
W
E
V
A
D
K
T
G
A
-
A
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
L
N
----
28
PsiBlast_CBE
96.29
99%
-79
- C2 -
3M2K
1
BLAC_BACLI
B:
[1-257]
----------------------------------------------
K
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
A
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
A
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
------
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
W
E
V
A
D
K
T
G
A
-
A
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
L
N
----
31
PsiBlast_CBE
96.13
97%
-72
- C2 -
4A5R
2
?
B:
[5-261]
----------------------------------------------
K
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
V
K
A
L
N
----
24
PsiBlast_CBE
96.10
99%
-72
- C2 -
3SH9
2
BLAC_BACLI
B:
[7-262]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
A
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
A
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
C
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
W
E
V
A
D
K
T
G
A
-
A
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
L
N
----
11
PsiBlast_PDB
96.06
99%
-71
- C2 -
3LY4
1
BLAC_BACLI
A:
[1-257]
----------------------------------------------
K
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
A
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
A
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
C
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
W
E
V
A
D
K
T
G
A
-
A
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
L
N
----
25
PsiBlast_CBE
95.99
99%
-71
- C2 -
3SH8
1
BLAC_BACLI
B:
[7-262]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
A
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
A
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
C
P
E
----
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
W
E
V
A
D
K
T
G
A
-
A
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
L
N
----
7
PsiBlast_PDB
95.97
99%
-70
- C2 -
3SH8
1
BLAC_BACLI
A:
[6-262]
----------------------------------------------
K
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
A
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
A
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
C
P
E
----
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
W
E
V
A
D
K
T
G
A
-
A
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
L
N
----
35
PsiBlast_CBE
95.72
96%
-73
- C2 -
2Y91
2
BLAC_BACLI
B:
[5-261]
----------------------------------------------
K
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
-
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
V
K
A
L
N
----
8
PsiBlast_PDB
95.63
99%
-71
- C2 -
3SH9
2
BLAC_BACLI
A:
[7-262]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
A
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
A
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
C
P
--
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
W
E
V
A
D
K
T
G
A
-
A
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
L
N
----
26
PsiBlast_CBE
95.46
99%
-70
- C2 -
3SH7
1
BLAC_BACLI
B:
[8-262]
------------------------------------------------
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
A
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
A
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
C
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
W
E
V
A
D
K
T
G
A
-
A
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
L
N
----
6
PsiBlast_PDB
95.34
99%
-66
- C2 -
3SH7
1
BLAC_BACLI
A:
[6-262]
----------------------------------------------
K
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
A
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
A
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
C
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
W
E
V
A
D
K
T
G
A
-
A
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
L
N
----
27
PsiBlast_CBE
95.23
98%
-65
- C2 -
3SOI
1
BLAC_BACLI
B:
[3-258]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
A
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
A
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
F
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
F
E
V
A
D
K
T
G
A
-
A
-
S
Y
G
T
R
N
D
I
A
I
I
F
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
L
N
----
18
PsiBlast_PDB
95.14
97%
-70
- C2 -
4A5R
4
?
A:
[5-261]
----------------------------------------------
K
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
V
K
A
L
N
----
15
PsiBlast_PDB
95.06
97%
-74
- C2 -
3B3X
1
BLAC_BACLI
A:
[6-260]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
V
K
A
L
-----
17
PsiBlast_PDB
95.01
97%
-70
- C2 -
2X71
3
?
A:
[6-260]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
V
K
A
L
-----
10
PsiBlast_PDB
94.95
98%
-64
- C2 -
3SOI
1
BLAC_BACLI
A:
[3-258]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
A
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
A
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
F
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
F
E
V
A
D
K
T
G
A
-
A
-
S
Y
G
T
R
N
D
I
A
I
I
F
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
L
N
----
33
PsiBlast_CBE
94.94
97%
-68
- C2 -
2X71
2
?
B:
[6-260]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
V
K
A
L
-----
3
PsiBlast_PDB
94.66
97%
-70
- C2 -
1I2W
1
BLAC_BACLI
A:
[23-277]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
L
K
A
L
-----
32
PsiBlast_CBE
94.62
97%
-71
- C2 -
3B3X
1
BLAC_BACLI
B:
[6-260]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
V
K
A
L
-----
2
PsiBlast_PDB
94.23
97%
-68
- C2 -
1I2S
1
BLAC_BACLI
A:
[23-277]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
L
K
A
L
-----
13
PsiBlast_PDB
94.14
99%
-80
- C2 -
3M2K
1
BLAC_BACLI
A:
[2-257]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
A
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
A
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
-----------
G
E
T
Q
D
T
S
T
A
R
A
L
V
T
S
L
R
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
W
E
V
A
D
K
T
G
A
-
A
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
M
K
A
L
N
----
21
PsiBlast_CBE
94.11
97%
-70
- C2 -
1I2W
2
BLAC_BACLI
B:
[22-277]
----------------------------------------------
K
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
L
K
A
L
-----
22
PsiBlast_CBE
93.99
97%
-69
- C2 -
1I2S
1
BLAC_BACLI
B:
[23-277]
-----------------------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
L
K
A
L
-----
50
HHSearch
83.79
57%
-63
- C2 -
3LEZ
1
?
A:
[3-259]
-----------------------------------------------
E
D
L
K
K
L
E
E
E
F
D
V
R
L
G
V
Y
A
I
D
T
G
A
D
K
E
I
S
Y
R
E
N
E
R
F
A
Y
T
S
T
F
K
P
L
A
V
G
A
V
L
Q
T
--
K
S
D
E
E
L
E
E
T
I
T
Y
S
E
E
D
L
V
T
Y
S
P
I
T
E
Q
H
V
D
E
G
-
M
T
L
V
E
I
A
D
A
A
I
R
Y
S
D
N
T
A
G
N
L
L
L
E
A
M
G
G
P
----
D
E
L
E
T
I
L
R
D
I
G
D
E
T
I
E
M
D
R
Y
E
T
E
L
N
E
A
K
P
G
D
I
R
D
T
S
T
A
K
A
M
A
T
T
L
Q
Q
Y
V
L
E
D
V
L
D
A
D
R
R
E
V
L
T
N
M
L
I
N
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
W
T
V
G
D
K
T
G
A
-
G
-
G
Y
G
T
R
N
D
I
G
I
I
W
P
E
G
D
E
-
E
P
I
V
I
A
I
M
S
S
R
D
E
E
--
D
A
D
Y
D
D
K
L
I
E
K
A
T
E
I
V
L
Q
E
L
R
----
55
HHSearch
80.98
47%
-68
- C2 -
3NY4
5
BLAC_MYCTU
A:
[2-265]
---------------------------------------------
L
A
D
R
F
A
E
L
E
R
R
Y
D
A
R
L
G
V
Y
V
P
A
T
G
T
T
A
A
I
E
Y
R
A
D
E
R
F
A
F
C
S
T
F
A
A
P
L
V
A
A
V
L
H
Q
--
N
P
L
T
H
L
D
K
L
I
T
Y
T
S
D
D
I
R
S
I
S
P
V
A
Q
Q
H
V
Q
T
G
-
M
T
I
G
Q
L
C
D
A
A
I
R
Y
S
D
G
T
A
A
N
L
L
L
A
D
L
G
G
P
GGG
T
A
A
F
T
G
Y
L
R
S
L
G
D
T
V
S
R
L
D
A
E
E
P
E
L
N
R
D
P
P
G
D
E
R
D
T
T
T
P
H
A
I
A
L
V
L
Q
Q
L
V
L
G
N
A
L
P
P
D
K
R
A
L
L
T
D
W
M
A
R
N
T
T
G
A
K
R
I
R
A
G
F
P
A
D
W
K
V
I
D
K
T
G
T
-
G
-
D
Y
G
R
A
N
D
I
A
V
V
W
S
P
-
T
G
-
V
P
Y
V
V
A
V
M
S
D
R
A
G
G
GY
D
A
E
P
R
E
A
L
L
A
E
A
A
T
C
V
A
G
V
L
A
----
56
HHSearch
77.84
43%
-57
- C2 -
1HZO
1
BLAB_PROVU
A:
[4-266]
-------------------------------------------
N
T
I
E
E
Q
L
N
T
L
E
K
Y
S
Q
G
R
L
G
V
A
L
I
N
T
E
D
N
S
Q
I
T
Y
R
G
E
E
R
F
A
M
A
S
T
S
K
V
M
A
V
A
A
V
L
K
A
S
E
K
Q
A
G
L
L
D
K
N
I
T
I
K
K
S
D
L
V
A
Y
S
P
I
T
E
K
H
L
T
T
G
-
M
T
L
A
E
L
S
A
A
T
L
Q
Y
S
D
N
T
A
M
N
K
I
L
D
Y
L
G
G
P
----
A
K
V
T
Q
F
A
R
S
I
N
D
V
T
Y
R
L
D
R
K
E
P
E
L
N
T
A
I
H
G
D
P
R
D
T
T
S
P
I
A
M
A
K
S
L
Q
A
L
T
L
G
D
A
L
G
Q
S
Q
R
Q
Q
L
V
T
W
L
K
G
N
T
T
G
D
N
S
I
K
A
G
L
P
K
H
W
V
V
G
D
K
T
G
S
-
G
-
D
Y
G
T
T
N
D
I
A
V
I
W
P
E
-
N
H
-
A
P
L
I
L
V
V
Y
F
T
Q
Q
E
Q
--
N
A
K
Y
R
K
D
I
I
A
K
A
A
E
I
V
T
K
E
I
S
N
---
59
HHSearch
77.69
43%
-60
- C2 -
3C5A
1
?
A:
[4-263]
---------------------------------------------
V
A
E
P
F
A
K
L
E
Q
D
F
G
G
S
I
G
V
Y
A
M
D
T
G
S
G
A
T
V
S
Y
R
A
E
E
R
F
P
L
C
S
S
F
K
G
F
L
A
A
A
V
L
A
R
S
Q
Q
Q
A
G
L
L
D
T
P
I
R
Y
G
K
N
A
L
V
P
W
S
P
I
S
E
K
Y
L
T
T
G
-
M
T
V
A
E
L
S
A
A
A
V
Q
Y
S
D
N
A
A
A
N
L
L
L
K
E
L
G
G
P
----
A
G
L
T
A
F
M
R
S
I
G
D
T
T
F
R
L
D
R
W
E
L
E
L
N
S
A
I
P
G
D
A
R
D
T
S
S
P
R
A
V
T
E
S
L
Q
K
L
T
L
G
S
A
L
A
A
P
Q
R
Q
Q
F
V
D
W
L
K
G
N
T
T
G
N
H
R
I
R
A
A
V
P
A
D
W
A
V
G
D
K
T
G
T
C
G
-
V
Y
G
T
A
N
D
Y
A
V
V
W
P
T
-
G
R
-
A
P
I
V
L
A
V
Y
T
R
A
P
N
K
--
D
D
K
H
S
E
A
V
I
A
A
A
A
R
L
A
L
E
G
L
-----
47
HHSearch
77.40
42%
-64
- C2 -
1GHP
1
BLAC_STAAU
A:
[2-258]
-----------------------------------------------
K
E
L
N
D
L
E
K
K
Y
N
A
H
I
G
V
Y
A
L
D
T
K
S
G
K
E
V
K
F
N
S
D
K
R
F
A
Y
A
S
T
S
K
A
I
N
S
A
I
L
L
E
Q
--
V
P
Y
N
K
L
N
K
K
V
H
I
N
K
D
D
I
V
A
Y
S
P
I
L
E
K
Y
V
G
K
D
-
I
T
L
K
A
L
I
E
A
S
M
T
Y
S
D
N
T
A
N
N
K
I
I
K
E
I
G
G
I
----
K
K
V
K
Q
R
L
K
E
L
G
D
K
V
T
N
P
V
R
Y
D
I
E
L
Q
Y
Y
S
P
K
S
K
K
D
T
S
T
P
A
A
F
G
K
T
L
N
K
L
I
A
N
G
K
L
S
K
E
N
K
K
F
L
L
D
L
M
L
N
N
K
S
G
D
T
L
I
K
D
G
V
P
K
D
Y
K
V
A
D
K
S
G
Q
-
A
I
T
Y
A
S
R
N
D
V
A
F
V
Y
P
K
-
G
Q
S
E
P
I
V
L
V
I
F
T
N
K
D
N
K
--
S
D
K
P
N
D
K
L
I
S
E
T
A
K
S
V
M
K
E
F
-----
53
HHSearch
71.54
33%
-44
- C2 -
4GNU
1
?
A:
[21-285]
------------------------------------------
K
L
T
F
K
T
D
L
E
K
L
E
R
E
K
A
A
Q
I
G
V
A
I
V
D
P
Q
G
E
I
V
A
G
H
R
M
A
Q
R
F
A
M
C
S
T
F
K
F
P
L
A
A
L
V
F
E
R
I
D
S
G
T
E
R
G
D
R
K
L
S
Y
G
P
D
M
I
V
E
W
S
P
A
T
E
R
F
L
A
S
G
H
M
T
V
L
E
A
A
Q
A
A
V
Q
L
S
D
N
G
A
T
N
L
L
L
R
E
I
G
G
P
----
A
A
M
T
Q
Y
F
R
K
I
G
D
S
V
S
R
L
D
R
K
E
P
E
M
S
D
N
T
P
G
D
L
R
D
T
T
T
P
I
A
M
A
R
T
V
A
K
V
L
Y
G
G
A
L
T
S
T
S
T
H
T
I
E
R
W
L
I
G
N
Q
T
G
D
A
T
L
R
A
G
F
P
K
D
W
V
V
G
E
K
T
G
T
-
C
-
A
N
G
G
R
N
D
I
G
F
-
F
K
A
-
Q
E
-
R
D
Y
A
V
A
V
Y
T
T
A
P
K
L
--
S
A
V
E
R
D
E
L
V
A
S
V
G
Q
V
I
T
Q
L
I
L
S
T
--
19
PsiBlast_PDB
70.70
96%
14
- C2 -
2Y91
3
BLAC_BACLI
A:
[5-261]
----------------------------------------------
K
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
X
T
I
K
A
L
T
V
G
V
L
L
Q
Q
--
K
S
I
E
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
-
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
-
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
V
K
A
L
N
----