@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00144_BLC1_E: (2014-08-29 )
MVKKSLRQFTLMATATVTLLLGSVPLYAQTADVQQKLAELERQSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAVAAVLKKSESEPNLLNQRVEIKKSDLVNYNPIAEKHVDGTMSLAELSAAALQYSDNVAMNKLISHVGGPASVTAFARQLGDETFRLDRTEPTLNTAIPGDPRDTTSPRAMAQTLRNLTLGKALGDSQRAQLVTWMKGNTTGAASIQAGLPASWVVGDKTGSGDYGTTNDIAVIWPKDRAPLILVTYFTQPQPKAESRRDVLASAAKIVTNGL
Atome Classification :
(53 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......-120.......130.......140......----.150.......160.......170.......180.......190.......200.......210.......220.......230.......240........250...-....260.......270-........280.......290
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
K
K
S
L
R
Q
F
T
L
M
A
T
A
T
V
T
L
L
LGSVPLYA
Q
T
A
D
V
Q
Q
K
L
A
E
L
E
R
QSGG
R
L
G
V
A
L
I
NTADN
S
Q
I
L
Y
RADE
R
F
AMCST
S
K
V
M
A
V
A
A
V
L
K
KSESE
P
N
L
L
N
Q
R
V
E
IKKSDLVNYNPI
A
E
K
HVDG
T
-
M
S
L
A
E
L
S
A
A
A
L
QYSD
N
V
A
M
N
K
L
I
S
HVGG
P
----
A
S
V
T
A
F
A
R
Q
LGDE
T
F
R
LDRTEPTLNTAIPGDPRDTT
S
P
R
A
M
A
Q
T
L
R
N
L
T
LGKALG
D
S
Q
R
A
Q
L
V
T
W
MKGNTTGAA
S
I
QAGLPA
S
W
V
VGDKTGS-GDYGTTN
D
I
A
V
I
WPK-DRA
P
L
I
L
V
T
YFTQPQP--K
A
E
S
R
R
D
V
L
A
S
A
A
K
I
V
TNGL
2
PsiBlast_PDB
98.78
98%
-77
- C2 -
4HBU
11
?
A:
[3-263]
------------------------------
A
D
V
Q
Q
K
L
A
E
L
E
R
Q
S
G
G
R
L
G
V
A
L
I
N
T
A
D
N
S
Q
I
L
Y
R
A
D
E
R
F
A
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
K
S
E
S
E
P
N
L
L
N
Q
R
V
E
I
K
K
S
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
S
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
V
A
M
N
K
L
I
A
H
V
G
G
P
----
A
S
V
T
A
F
A
R
Q
L
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
S
P
R
A
M
A
Q
T
L
R
N
L
T
L
G
K
A
L
G
D
S
Q
R
A
Q
L
V
T
W
M
K
G
N
T
T
G
A
A
S
I
Q
A
G
L
P
A
S
W
V
V
G
D
K
T
G
S
-
G
G
Y
G
T
T
N
D
I
A
V
I
W
P
K
-
D
R
A
P
L
I
L
V
T
Y
F
T
Q
P
Q
P
--
K
A
E
S
R
R
D
V
L
A
S
A
A
K
I
V
T
D
G
L
29
PsiBlast_CBE
92.42
81%
-74
- C2 -
3G31
5
?
A:
[2-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
31
PsiBlast_CBE
92.40
81%
-74
- C2 -
3G2Z
5
?
B:
[3-263]
------------------------------
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
21
PsiBlast_CBE
92.33
82%
-74
- C2 -
1YLZ
1
?
B:
[4-263]
-------------------------------
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
V
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
20
PsiBlast_PDB
92.30
82%
-73
- C2 -
1YLZ
1
?
A:
[1-263]
----------------------------
Q
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
V
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
28
PsiBlast_CBE
92.24
81%
-76
- C2 -
3G31
3
?
B:
[3-263]
------------------------------
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
35
PsiBlast_CBE
92.16
81%
-74
- C2 -
1YMS
1
?
B:
[3-263]
------------------------------
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
38
PsiBlast_CBE
92.07
81%
-74
- C2 -
1YM1
1
?
A:
[1-263]
----------------------------
Q
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
49
PsiBlast_CBE
91.84
81%
-73
- C2 -
3HUO
2
?
B:
[4-263]
-------------------------------
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
G
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
39
PsiBlast_CBE
91.84
81%
-76
- C2 -
1YLY
1
?
B:
[4-263]
-------------------------------
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
59
PsiBlast_CBE
91.82
81%
-75
- C2 -
4DE1
3
?
B:
[3-263]
------------------------------
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
57
PsiBlast_CBE
91.82
81%
-74
- C2 -
4DE2
4
?
B:
[3-263]
------------------------------
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
24
PsiBlast_CBE
91.82
81%
-73
- C2 -
3G34
5
?
B:
[3-263]
------------------------------
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
54
PsiBlast_CBE
91.81
81%
-71
- C2 -
3HLW
2
?
A:
[1-263]
----------------------------
Q
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
G
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
33
PsiBlast_CBE
91.77
81%
-73
- C2 -
1YMX
1
?
B:
[3-263]
------------------------------
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
30
PsiBlast_CBE
91.67
81%
-75
- C2 -
3G30
3
?
A:
[2-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
32
PsiBlast_CBE
91.66
81%
-74
- C2 -
3G2Z
4
?
A:
[2-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
56
PsiBlast_CBE
91.61
81%
-73
- C2 -
4DE3
7
?
A:
[4-263]
-------------------------------
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
27
PsiBlast_CBE
91.58
81%
-73
- C2 -
3G32
2
?
A:
[2-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
53
PsiBlast_CBE
91.57
81%
-73
- C2 -
3HLW
2
?
B:
[2-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
G
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
58
PsiBlast_CBE
91.50
81%
-72
- C2 -
4DE2
2
?
A:
[4-263]
-------------------------------
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
47
PsiBlast_CBE
91.49
81%
-73
- C2 -
3HVF
1
?
B:
[2-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
G
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
22
PsiBlast_CBE
91.46
81%
-73
- C2 -
3G35
6
?
B:
[3-263]
------------------------------
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
8
PsiBlast_PDB
91.46
84%
-73
- C2 -
1IYP
1
BLT1_ECOLX
A:
[4-262]
--------------------------------
V
Q
Q
Q
L
E
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
N
T
A
D
N
S
Q
I
L
Y
R
A
D
E
R
F
A
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
S
D
K
H
L
L
N
Q
R
V
E
I
K
K
S
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
G
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
H
L
G
G
P
----
D
K
V
T
A
F
A
R
S
L
G
D
E
T
F
R
L
D
R
T
A
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
L
A
M
A
Q
T
L
K
N
L
T
L
G
K
A
L
A
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
S
A
S
I
R
A
G
L
P
K
S
W
V
V
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
E
-
N
H
A
P
L
V
L
V
T
Y
F
T
Q
P
E
Q
--
K
A
E
R
R
R
D
I
L
A
A
A
A
K
I
V
T
H
G
F
15
PsiBlast_PDB
91.42
83%
-76
- C2 -
2ZQA
1
BLT1_ECOLX
A:
[4-262]
--------------------------------
V
Q
Q
Q
L
E
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
N
T
A
D
N
S
Q
I
L
Y
R
A
D
E
R
F
A
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
S
D
K
H
L
L
N
Q
R
V
E
I
K
K
S
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
G
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
H
L
G
G
P
----
D
K
V
T
A
F
A
R
S
L
G
D
E
T
F
R
L
D
R
T
A
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
L
A
M
A
Q
T
L
K
N
L
T
L
G
K
A
L
A
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
S
A
S
I
R
A
G
L
P
K
S
W
V
V
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
E
-
N
H
A
P
L
V
L
V
T
Y
F
T
Q
P
E
Q
--
K
A
E
N
R
N
D
I
L
A
A
A
A
K
I
V
T
H
G
F
40
PsiBlast_CBE
91.40
81%
-74
- C2 -
1YLY
1
?
A:
[1-263]
----------------------------
Q
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
17
PsiBlast_PDB
91.35
83%
-76
- C2 -
2ZQD
1
BLT1_ECOLX
A:
[4-262]
--------------------------------
V
Q
Q
Q
L
E
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
N
T
A
D
N
S
Q
I
L
Y
R
A
D
E
R
F
A
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
S
D
K
H
L
L
N
Q
R
V
E
I
K
K
S
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
G
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
H
L
G
G
P
----
D
K
V
T
A
F
A
R
S
L
G
D
E
T
F
R
L
D
R
T
A
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
L
A
M
A
Q
T
L
K
N
L
T
L
G
K
A
L
A
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
S
A
S
I
R
A
G
L
P
K
S
W
V
V
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
E
-
N
H
A
P
L
V
L
V
T
Y
F
T
Q
P
E
Q
--
K
A
E
N
R
N
D
I
L
A
A
A
A
K
I
V
T
H
G
F
44
PsiBlast_CBE
91.33
81%
-72
- C2 -
3Q1F
2
?
A:
[2-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
G
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
37
PsiBlast_CBE
91.31
81%
-73
- C2 -
1YM1
1
?
B:
[4-263]
-------------------------------
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
61
PsiBlast_CBE
91.25
81%
-75
- C2 -
4DE0
1
?
B:
[3-263]
------------------------------
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
36
PsiBlast_CBE
91.22
81%
-71
- C2 -
1YMS
1
?
A:
[1-263]
----------------------------
Q
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
34
PsiBlast_CBE
91.15
81%
-73
- C2 -
1YMX
1
?
A:
[2-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
55
PsiBlast_CBE
91.10
81%
-75
- C2 -
4DE3
6
?
B:
[3-263]
------------------------------
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
50
PsiBlast_CBE
91.07
81%
-72
- C2 -
3HUO
4
?
A:
[2-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
G
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
25
PsiBlast_CBE
90.92
81%
-72
- C2 -
3G34
2
?
A:
[2-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
7
PsiBlast_PDB
90.79
84%
-74
- C2 -
1IYO
1
BLT1_ECOLX
A:
[4-262]
--------------------------------
V
Q
Q
Q
L
E
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
N
T
A
D
N
S
Q
I
L
Y
R
A
D
E
R
F
A
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
S
D
K
H
L
L
N
Q
R
V
E
I
K
K
S
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
G
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
H
L
G
G
P
----
D
K
V
T
A
F
A
R
S
L
G
D
E
T
F
R
L
D
R
T
A
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
L
A
M
A
Q
T
L
K
N
L
T
L
G
K
A
L
A
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
S
A
S
I
R
A
G
L
P
K
S
W
V
V
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
E
-
N
H
A
P
L
V
L
V
T
Y
F
T
Q
P
E
Q
--
K
A
E
R
R
R
D
I
L
A
A
A
A
K
I
V
T
H
G
F
23
PsiBlast_CBE
90.77
81%
-73
- C2 -
3G35
2
?
A:
[4-263]
-------------------------------
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
--
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
45
PsiBlast_CBE
90.76
81%
-74
- C2 -
3Q07
2
?
B:
[4-263]
-------------------------------
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
G
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
48
PsiBlast_CBE
90.64
81%
-72
- C2 -
3HVF
1
?
A:
[1-263]
----------------------------
Q
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
G
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
43
PsiBlast_CBE
90.58
81%
-73
- C2 -
3Q1F
2
?
B:
[4-263]
-------------------------------
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
G
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
46
PsiBlast_CBE
90.40
81%
-70
- C2 -
3Q07
1
?
A:
[2-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
G
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
16
PsiBlast_PDB
90.33
83%
-76
- C2 -
2ZQC
1
BLT1_ECOLX
A:
[4-262]
--------------------------------
V
Q
Q
Q
L
E
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
N
T
A
D
N
S
Q
I
L
Y
R
A
D
E
R
F
A
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
S
D
K
H
L
L
N
Q
R
V
E
I
K
K
S
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
G
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
H
L
G
G
P
----
D
K
V
T
A
F
A
R
S
L
G
D
E
T
F
R
L
D
R
T
A
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
L
A
M
A
Q
T
L
K
N
L
T
L
G
K
A
L
A
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
S
A
S
I
R
A
G
L
P
K
S
W
V
V
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
E
-
N
H
A
P
L
V
L
V
T
Y
F
T
Q
P
E
Q
--
K
A
E
N
R
N
D
I
L
A
A
A
A
K
I
V
T
H
G
F
9
PsiBlast_PDB
90.25
84%
-74
- C2 -
1IYQ
1
BLT1_ECOLX
A:
[4-262]
--------------------------------
V
Q
Q
Q
L
E
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
N
T
A
D
N
S
Q
I
L
Y
R
A
D
E
R
F
A
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
S
D
K
H
L
L
N
Q
R
V
E
I
K
K
S
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
G
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
H
L
G
G
P
----
D
K
V
T
A
F
A
R
S
L
G
D
E
T
F
R
L
D
R
T
A
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
L
A
M
A
Q
T
L
K
N
L
T
L
G
K
A
L
A
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
S
A
S
I
R
A
G
L
P
K
S
W
V
V
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
E
-
N
H
A
P
L
V
L
V
T
Y
F
T
Q
P
E
Q
--
K
A
E
R
R
R
D
I
L
A
A
A
A
K
I
V
T
H
G
F
14
PsiBlast_PDB
89.46
83%
-75
- C2 -
2ZQ9
1
BLT1_ECOLX
A:
[4-260]
--------------------------------
V
Q
Q
Q
L
E
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
N
T
A
D
N
S
Q
I
L
Y
R
A
D
E
R
F
A
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
S
D
K
H
L
L
N
Q
R
V
E
I
K
K
S
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
G
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
H
L
G
G
P
----
D
K
V
T
A
F
A
R
S
L
G
D
E
T
F
R
L
D
R
T
A
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
L
A
M
A
Q
T
L
K
N
L
T
L
G
K
A
L
A
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
S
A
S
I
R
A
G
L
P
K
S
W
V
V
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
E
-
N
H
A
P
L
V
L
V
T
Y
F
T
Q
P
E
Q
--
K
A
E
N
R
N
D
I
L
A
A
A
A
K
I
V
T
H
--
83
HHSearch
86.47
68%
-69
* C2 *
1HZO
1
BLAB_PROVU
A:
[4-262]
------------------------------
N
T
I
E
E
Q
L
N
T
L
E
K
Y
S
Q
G
R
L
G
V
A
L
I
N
T
E
D
N
S
Q
I
T
Y
R
G
E
E
R
F
A
M
A
S
T
S
K
V
M
A
V
A
A
V
L
K
A
S
E
K
Q
A
G
L
L
D
K
N
I
T
I
K
K
S
D
L
V
A
Y
S
P
I
T
E
K
H
L
T
T
G
-
M
T
L
A
E
L
S
A
A
T
L
Q
Y
S
D
N
T
A
M
N
K
I
L
D
Y
L
G
G
P
----
A
K
V
T
Q
F
A
R
S
I
N
D
V
T
Y
R
L
D
R
K
E
P
E
L
N
T
A
I
H
G
D
P
R
D
T
T
S
P
I
A
M
A
K
S
L
Q
A
L
T
L
G
D
A
L
G
Q
S
Q
R
Q
Q
L
V
T
W
L
K
G
N
T
T
G
D
N
S
I
K
A
G
L
P
K
H
W
V
V
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
E
-
N
H
A
P
L
I
L
V
V
Y
F
T
Q
Q
E
Q
--
N
A
K
Y
R
K
D
I
I
A
K
A
A
E
I
V
T
K
--
81
HHSearch
82.09
49%
-70
- C2 -
3C5A
1
?
A:
[2-261]
------------------------------
N
L
V
A
E
P
F
A
K
L
E
Q
D
F
G
G
S
I
G
V
Y
A
M
D
T
G
S
G
A
T
V
S
Y
R
A
E
E
R
F
P
L
C
S
S
F
K
G
F
L
A
A
A
V
L
A
R
S
Q
Q
Q
A
G
L
L
D
T
P
I
R
Y
G
K
N
A
L
V
P
W
S
P
I
S
E
K
Y
L
T
T
G
-
M
T
V
A
E
L
S
A
A
A
V
Q
Y
S
D
N
A
A
A
N
L
L
L
K
E
L
G
G
P
----
A
G
L
T
A
F
M
R
S
I
G
D
T
T
F
R
L
D
R
W
E
L
E
L
N
S
A
I
P
G
D
A
R
D
T
S
S
P
R
A
V
T
E
S
L
Q
K
L
T
L
G
S
A
L
A
A
P
Q
R
Q
Q
F
V
D
W
L
K
G
N
T
T
G
N
H
R
I
R
A
A
V
P
A
D
W
A
V
G
D
K
T
G
T
C
G
V
Y
G
T
A
N
D
Y
A
V
V
W
P
T
-
G
R
A
P
I
V
L
A
V
Y
T
R
A
P
N
K
--
D
D
K
H
S
E
A
V
I
A
A
A
A
R
L
A
L
E
--
85
HHSearch
76.56
43%
-66
- C2 -
3LEZ
1
?
A:
[2-256]
---------------------------------
S
E
D
L
K
K
L
E
E
E
F
D
V
R
L
G
V
Y
A
I
D
T
G
A
D
K
E
I
S
Y
R
E
N
E
R
F
A
Y
T
S
T
F
K
P
L
A
V
G
A
V
L
Q
T
K
S
D
--
E
E
L
E
E
T
I
T
Y
S
E
E
D
L
V
T
Y
S
P
I
T
E
Q
H
V
D
E
G
-
M
T
L
V
E
I
A
D
A
A
I
R
Y
S
D
N
T
A
G
N
L
L
L
E
A
M
G
G
P
----
D
E
L
E
T
I
L
R
D
I
G
D
E
T
I
E
M
D
R
Y
E
T
E
L
N
E
A
K
P
G
D
I
R
D
T
S
T
A
K
A
M
A
T
T
L
Q
Q
Y
V
L
E
D
V
L
D
A
D
R
R
E
V
L
T
N
M
L
I
N
N
T
T
G
D
A
L
I
R
A
G
V
P
D
G
W
T
V
G
D
K
T
G
A
-
G
G
Y
G
T
R
N
D
I
G
I
I
W
P
E
G
D
E
E
P
I
V
I
A
I
M
S
S
R
D
E
E
--
D
A
D
Y
D
D
K
L
I
E
K
A
T
E
I
V
L
Q
--
78
HHSearch
76.08
45%
-70
- C2 -
3NY4
5
BLAC_MYCTU
A:
[2-262]
--------------------------------
L
A
D
R
F
A
E
L
E
R
R
Y
D
A
R
L
G
V
Y
V
P
A
T
G
T
T
A
A
I
E
Y
R
A
D
E
R
F
A
F
C
S
T
F
A
A
P
L
V
A
A
V
L
H
Q
N
P
L
T
H
--
L
D
K
L
I
T
Y
T
S
D
D
I
R
S
I
S
P
V
A
Q
Q
H
V
Q
T
G
-
M
T
I
G
Q
L
C
D
A
A
I
R
Y
S
D
G
T
A
A
N
L
L
L
A
D
L
G
G
P
GGG
T
A
A
F
T
G
Y
L
R
S
L
G
D
T
V
S
R
L
D
A
E
E
P
E
L
N
R
D
P
P
G
D
E
R
D
T
T
T
P
H
A
I
A
L
V
L
Q
Q
L
V
L
G
N
A
L
P
P
D
K
R
A
L
L
T
D
W
M
A
R
N
T
T
G
A
K
R
I
R
A
G
F
P
A
D
W
K
V
I
D
K
T
G
T
-
G
D
Y
G
R
A
N
D
I
A
V
V
W
S
P
-
T
G
V
P
Y
V
V
A
V
M
S
D
R
A
G
G
GY
D
A
E
P
R
E
A
L
L
A
E
A
A
T
C
V
A
G
--
84
HHSearch
74.57
43%
-67
- C2 -
2WK0
4
BLAC_BACLI
A:
[6-258]
----------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
K
S
I
E
--
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
V
K
--
77
HHSearch
74.53
43%
-63
- C2 -
1W7F
1
BLAC_BACLI
A:
[48-300]
----------------------------------
D
D
F
A
K
L
E
E
Q
F
D
A
K
L
G
I
F
A
L
D
T
G
T
N
R
T
V
T
Y
R
P
D
E
R
F
A
F
A
S
T
I
K
A
L
T
V
G
V
L
L
Q
Q
K
S
I
E
--
D
L
N
Q
R
I
T
Y
T
R
D
D
L
V
N
Y
N
P
I
T
E
K
H
V
D
T
G
-
M
T
L
K
E
L
A
D
A
S
L
R
Y
S
D
N
T
A
Q
N
L
I
L
K
Q
I
G
G
P
----
E
S
L
K
K
E
L
R
K
I
G
D
E
V
T
N
P
E
R
F
E
P
E
L
N
E
V
N
P
G
E
T
Q
D
T
S
T
A
R
A
L
A
T
S
L
Q
A
F
A
L
E
D
K
L
P
S
E
K
R
E
L
L
I
D
W
M
K
R
N
T
T
G
D
A
L
I
R
A
G
V
P
E
G
W
E
V
A
D
K
T
G
A
-
G
S
Y
G
T
R
N
D
I
A
I
I
W
P
P
-
K
G
D
P
V
V
L
A
V
L
S
S
R
D
K
K
--
D
A
K
Y
D
D
K
L
I
A
E
A
T
K
V
V
V
K
--
73
HHSearch
66.08
34%
-55
- C2 -
4GNU
1
?
A:
[21-280]
-----------------------------
K
L
T
F
K
T
D
L
E
K
L
E
R
E
K
A
A
Q
I
G
V
A
I
V
D
P
Q
G
E
I
V
A
G
H
R
M
A
Q
R
F
A
M
C
S
T
F
K
F
P
L
A
A
L
V
F
E
R
I
D
S
G
T
E
R
G
D
R
K
L
S
Y
G
P
D
M
I
V
E
W
S
P
A
T
E
R
F
L
A
S
G
H
M
T
V
L
E
A
A
Q
A
A
V
Q
L
S
D
N
G
A
T
N
L
L
L
R
E
I
G
G
P
----
A
A
M
T
Q
Y
F
R
K
I
G
D
S
V
S
R
L
D
R
K
E
P
E
M
S
D
N
T
P
G
D
L
R
D
T
T
T
P
I
A
M
A
R
T
V
A
K
V
L
Y
G
G
A
L
T
S
T
S
T
H
T
I
E
R
W
L
I
G
N
Q
T
G
D
A
T
L
R
A
G
F
P
K
D
W
V
V
G
E
K
T
G
T
-
C
A
N
G
G
R
N
D
I
G
F
-
F
K
A
-
Q
E
R
D
Y
A
V
A
V
Y
T
T
A
P
K
L
--
S
A
V
E
R
D
E
L
V
A
S
V
G
Q
V
I
T
Q
--
62
PsiBlast_CBE
45.14
81%
27
- C2 -
4DE0
1
?
A:
[4-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L
60
PsiBlast_CBE
45.00
81%
27
- C2 -
4DE1
2
?
A:
[4-263]
-----------------------------
T
S
A
V
Q
Q
K
L
A
A
L
E
K
S
S
G
G
R
L
G
V
A
L
I
D
T
A
D
N
T
Q
V
L
Y
R
G
D
E
R
F
P
M
C
S
T
S
K
V
M
A
A
A
A
V
L
K
Q
S
E
T
Q
K
Q
L
L
N
Q
P
V
E
I
K
P
A
D
L
V
N
Y
N
P
I
A
E
K
H
V
N
G
T
-
M
T
L
A
E
L
S
A
A
A
L
Q
Y
S
D
N
T
A
M
N
K
L
I
A
Q
L
G
G
P
----
G
G
V
T
A
F
A
R
A
I
G
D
E
T
F
R
L
D
R
T
E
P
T
L
N
T
A
I
P
G
D
P
R
D
T
T
T
P
R
A
M
A
Q
T
L
R
Q
L
T
L
G
H
A
L
G
E
T
Q
R
A
Q
L
V
T
W
L
K
G
N
T
T
G
A
A
S
I
R
A
G
L
P
T
S
W
T
A
G
D
K
T
G
S
-
G
D
Y
G
T
T
N
D
I
A
V
I
W
P
Q
-
G
R
A
P
L
V
L
V
T
Y
F
T
Q
P
Q
Q
--
N
A
E
S
R
R
D
V
L
A
S
A
A
R
I
I
A
E
G
L