@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00156_UMPS_H: (2014-08-29 )
MGSSHHHHHHSSGLVPRGSHMKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
Atome Classification :
(49 SA)
.........10........20--........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGSSHHHHHHSSGLVPRGS
H
M
--
K
E
LSFGARAELPRI
H
P
V
A
S
K
L
L
R
L
M
Q
K
KETN
L
C
LSA
D
V
S
L
A
R
E
L
L
Q
L
A
D
ALGP
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
FEDR
K
F
A
D
I
G
N
T
V
K
K
Q
YEGG
I
F
K
IA
S
W
A
D
L
V
N
AHVVP
G
S
G
V
V
K
G
L
Q
E
VGLPLHR
G
C
L
L
I
A
EMSSTGSLATG
D
Y
T
R
A
A
V
R
M
A
E
EHS
E
F
V
V
G
F
ISG
S
R
V
SMKP
E
F
L
H
LTPG
V
Q
L
EAGGDNL
G
Q
QYN
S
P
Q
E
V
IGKRG
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
RLGV
17
PsiBlast_PDB
94.41
100%
-132
- C3 -
3EWZ
1
UMPS_HUMAN
A:
[4-260]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
V
2
PsiBlast_PDB
94.18
100%
-130
- C3 -
3DBP
2
UMPS_HUMAN
A:
[22-278]
-----------------------
K
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
33
PsiBlast_CBE
94.17
100%
-132
- C3 -
3EX4
1
UMPS_HUMAN
A:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
45
PsiBlast_CBE
93.96
100%
-130
- C3 -
2V30
2
UMPS_HUMAN
A:
[24-279]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
19
PsiBlast_PDB
93.84
100%
-131
- C3 -
3EX2
3
UMPS_HUMAN
A:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
31
PsiBlast_CBE
93.75
100%
-132
- C3 -
3L0K
2
UMPS_HUMAN
B:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
18
PsiBlast_PDB
93.74
100%
-132
- C3 -
3EX1
3
UMPS_HUMAN
A:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
32
PsiBlast_CBE
93.67
100%
-131
- C3 -
3L0K
3
UMPS_HUMAN
A:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
41
PsiBlast_CBE
93.65
100%
-135
- C3 -
2QCH
4
UMPS_HUMAN
B:
[4-258]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
--
21
PsiBlast_CBE
93.64
100%
-131
- C3 -
3DBP
2
UMPS_HUMAN
B:
[22-278]
-----------------------
K
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
30
PsiBlast_CBE
93.59
100%
-134
- C3 -
3L0N
2
UMPS_HUMAN
A:
[4-258]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
--
40
PsiBlast_CBE
93.51
100%
-131
- C3 -
2QCN
3
UMPS_HUMAN
B:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
11
PsiBlast_PDB
93.51
100%
-130
- C3 -
3BGJ
2
UMPS_HUMAN
A:
[34-290]
-----------------------
K
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
1
PsiBlast_PDB
93.46
100%
-131
- C3 -
3BK0
4
UMPS_HUMAN
A:
[22-278]
-----------------------
K
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
39
PsiBlast_CBE
93.31
100%
-131
- C3 -
3EWZ
1
UMPS_HUMAN
B:
[4-260]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
V
67
HHSearch
93.23
99%
-131
* C3 *
3EWW
3
UMPS_HUMAN
A:
[3-259]
-----------------------
M
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
N
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
47
PsiBlast_CBE
93.10
99%
-130
- C3 -
3EX6
2
UMPS_HUMAN
A:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
N
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
22
PsiBlast_CBE
93.10
100%
-133
- C3 -
3BK0
2
UMPS_HUMAN
B:
[22-278]
-----------------------
K
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
36
PsiBlast_CBE
93.04
100%
-131
- C3 -
3EX1
2
UMPS_HUMAN
B:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
20
PsiBlast_PDB
92.99
100%
-129
- C3 -
3EX3
3
UMPS_HUMAN
A:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
38
PsiBlast_CBE
92.95
100%
-131
- C3 -
3EWZ
1
UMPS_HUMAN
C:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
16
PsiBlast_PDB
92.83
100%
-131
- C3 -
2QCN
3
UMPS_HUMAN
A:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
35
PsiBlast_CBE
92.82
100%
-132
- C3 -
3EX2
2
UMPS_HUMAN
B:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
28
PsiBlast_CBE
92.60
100%
-131
- C3 -
3BGJ
3
UMPS_HUMAN
B:
[34-290]
-----------------------
K
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
15
PsiBlast_PDB
92.59
100%
-133
- C3 -
2QCH
4
UMPS_HUMAN
A:
[4-258]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
--
66
HHSearch
92.56
99%
-132
- C3 -
3G3D
3
UMPS_HUMAN
A:
[56-311]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
29
PsiBlast_CBE
92.51
100%
-131
- C3 -
3L0N
2
UMPS_HUMAN
B:
[4-258]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
--
46
PsiBlast_CBE
92.45
99%
-133
- C3 -
3EX6
1
UMPS_HUMAN
B:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
N
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
34
PsiBlast_CBE
92.43
100%
-131
- C3 -
3EX3
2
UMPS_HUMAN
B:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
51
PsiBlast_CBE
92.30
99%
-131
- C3 -
3EWU
3
UMPS_HUMAN
A:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
N
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
48
PsiBlast_CBE
92.24
99%
-133
- C3 -
3EWW
2
UMPS_HUMAN
B:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
N
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
13
PsiBlast_PDB
92.17
100%
-130
- C3 -
2QCD
2
UMPS_HUMAN
B:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
42
PsiBlast_CBE
92.09
100%
-130
- C3 -
2QCG
2
UMPS_HUMAN
B:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
53
PsiBlast_CBE
92.05
99%
-132
- C3 -
2QCL
3
UMPS_HUMAN
A:
[4-258]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
N
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
--
23
PsiBlast_CBE
91.92
89%
-132
- C3 -
4HKP
5
UMPS_HUMAN
B:
[56-311]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
52
PsiBlast_CBE
91.89
99%
-131
- C3 -
2QCL
2
UMPS_HUMAN
B:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
N
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
14
PsiBlast_PDB
91.61
100%
-129
- C3 -
2QCG
2
UMPS_HUMAN
A:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
44
PsiBlast_CBE
91.58
100%
-130
- C3 -
2V30
2
UMPS_HUMAN
B:
[24-278]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
--
50
PsiBlast_CBE
91.52
99%
-132
- C3 -
3EWU
2
UMPS_HUMAN
B:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
N
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
6
PsiBlast_PDB
91.42
89%
-133
- C3 -
3MW7
2
UMPS_HUMAN
A:
[53-311]
---------------------A
P
K
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
4
PsiBlast_PDB
91.27
89%
-131
- C3 -
3BVJ
3
UMPS_HUMAN
A:
[55-311]
-----------------------
K
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
7
PsiBlast_PDB
90.85
89%
-132
- C3 -
4HIB
3
UMPS_HUMAN
A:
[56-311]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
27
PsiBlast_CBE
90.64
89%
-131
- C3 -
3BVJ
2
UMPS_HUMAN
B:
[55-311]
-----------------------
K
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
24
PsiBlast_CBE
90.57
89%
-133
- C3 -
4HIB
2
UMPS_HUMAN
B:
[56-311]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
8
PsiBlast_PDB
90.22
89%
-131
- C3 -
4HKP
5
UMPS_HUMAN
A:
[56-311]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
26
PsiBlast_CBE
90.14
89%
-130
- C3 -
3G3D
4
UMPS_HUMAN
B:
[53-311]
---------------------A
P
K
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
25
PsiBlast_CBE
89.85
89%
-132
- C3 -
3MW7
2
UMPS_HUMAN
B:
[56-311]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
C
H
E
F
L
I
F
E
D
R
K
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
54
PsiBlast_CBE
69.47
99%
-61
- C3 -
3EWY
3
UMPS_HUMAN
A:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
-
H
E
F
L
I
F
E
D
R
A
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-
55
PsiBlast_CBE
69.07
99%
-64
- C3 -
3EWX
2
UMPS_HUMAN
A:
[4-259]
------------------------
E
L
S
F
G
A
R
A
E
L
P
R
I
H
P
V
A
S
K
L
L
R
L
M
Q
K
K
E
T
N
L
C
L
S
A
D
V
S
L
A
R
E
L
L
Q
L
A
D
A
L
G
P
S
I
C
M
L
K
T
H
V
D
I
L
N
D
F
T
L
D
V
M
K
E
L
I
T
L
A
K
-
H
E
F
L
I
F
E
D
R
A
F
A
D
I
G
N
T
V
K
K
Q
Y
E
G
G
I
F
K
I
A
S
W
A
D
L
V
N
A
H
V
V
P
G
S
G
V
V
K
G
L
Q
E
V
G
L
P
L
H
R
G
C
L
L
I
A
E
M
S
S
T
G
S
L
A
T
G
D
Y
T
R
A
A
V
R
M
A
E
E
H
S
E
F
V
V
G
F
I
S
G
S
R
V
S
M
K
P
E
F
L
H
L
T
P
G
V
Q
L
E
A
G
G
D
N
L
G
Q
Q
Y
N
S
P
Q
E
V
I
G
K
R
G
S
D
I
I
I
V
G
R
G
I
I
S
A
A
D
R
L
E
A
A
E
M
Y
R
K
A
A
W
E
A
Y
L
S
R
L
G
-