@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00183_HS90A_: (2014-08-30 )
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEEKEEEKEKEEKESDDKPEIEDVGSDEEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMPPLEGDDDTSRMEEVD
Atome Classification :
(27 SA)
.........10........20........30........40........50........60........-----70........80........90........100.......110.......120.-.----.-.-...130.......140.......150.......160.......170....------...180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPEETQTQDQPM
E
E
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
FYS
N
K
E
I
F
L
R
E
L
ISNSS
D
A
L
D
K
I
R
YESLT
D
P
S
K-----LDSG
K
E
L
H
I
N
L
IPSKQD
R
T
L
T
I
V
DTGIG
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-A----G-A-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
KHNDDE
Q
Y
A
WESSAG
G
S
F
T
V
RTDT------GEPMGRG
T
K
V
I
L
H
LKED
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
FIG
Y
P
I
T
L
F
V
EKERDKEVSDD
E
A
E
E
K
E
E
K
E
E
E
K
E
K
EEKESDDKP
E
I
EDVGS
D
E
E
E
E
E
KKDG
D
K
K
K
K
K
K
I
K
E
KYI
D
Q
E
E
LNKTKPIWTRNPDDI
T
N
E
E
Y
G
E
F
Y
K
S
L
T
N
D
W
E
E
H
L
A
V
K
H
F
S
VE
G
Q
L
E
F
R
A
L
L
F
VPRRA
P
F
D
L
F
E
NRKKKN
N
I
K
L
Y
V
R
R
V
F
I
MD
N
C
E
E
L
I
P
E
Y
L
N
F
I
R
G
VVDSEDLP
L
N
I
S
R
E
M
L
Q
Q
S
K
I
L
K
V
I
R
K
N
L
V
K
K
C
L
E
L
F
T
E
L
A
E
D
K
E
N
Y
K
K
F
Y
E
Q
F
SKN
I
K
L
G
IHEDS
Q
N
R
K
K
L
S
E
L
L
R
Y
Y
TSASGD
E
M
V
S
L
K
D
Y
C
T
R
M
KENQ
K
H
I
Y
F
I
TGE
T
K
D
Q
VA
N
S
A
F
V
E
R
L
R
KHG
L
E
V
I
Y
M
IE
P
I
D
E
Y
C
V
Q
Q
L
K
E
FEG
K
T
L
V
S
V
T
K
EGLELPE
D
E
E
E
K
K
K
Q
E
E
K
K
T
K
F
E
N
L
C
K
I
M
K
D
I
L
E
K
K
V
E
K
V
V
VSNRLVTSP
C
C
I
V
TSTYGWT
A
N
M
E
R
I
M
K
A
Q
ALRDNST
M
G
Y
M
A
AK
K
H
L
EINP
D
H
S
I
I
E
T
L
R
Q
K
AEADKND
K
S
V
K
D
L
V
I
L
L
Y
E
T
A
L
LSSGFSLED
P
Q
T
H
A
N
R
I
Y
R
M
I
K
LGLGIDEDDPTVDDTSAAVTEEMPPLEGDDDT
S
R
MEEVD
50
PsiBlast_CBE
53.34
99%
-89
- C1 -
2BYI
1
HS90A_HUMAN
A:
[10-224]
----------
P
M
E
E
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
52.82
99%
-88
- C1 -
2BYH
1
HS90A_HUMAN
A:
[10-224]
----------
P
M
E
E
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
52.70
99%
-89
- C1 -
2YEF
1
HS90A_HUMAN
A:
[27-242]
----------
P
M
E
E
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
51.53
99%
-87
* C1 *
1YC1
1
HS90A_HUMAN
A:
[43-252]
--------------
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
T
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
51.45
99%
-86
- C1 -
2FWZ
1
HS90A_HUMAN
A:
[36-243]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
51.41
99%
-87
- C1 -
2H55
1
HS90A_HUMAN
A:
[36-244]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
51.25
99%
-85
- C1 -
3QDD
1
HS90A_HUMAN
A:
[18-226]
----------------
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
51.13
99%
-88
- C1 -
4FCR
1
HS90A_HUMAN
A:
[16-223]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
-
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
51.05
99%
-85
- C1 -
2BZ5
1
HS90A_HUMAN
A:
[15-224]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
HHSearch
51.04
100%
-84
- C1 -
3O0I
1
HS90A_HUMAN
A:
[36-243]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
51.04
99%
-86
- C1 -
2YI7
1
HS90A_HUMAN
A:
[16-224]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
51.00
99%
-85
- C1 -
1UYF
1
HS90A_HUMAN
A:
[16-224]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
50.99
99%
-87
- C1 -
2BZ5
1
HS90A_HUMAN
B:
[15-224]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
50.98
99%
-83
- C1 -
1UYE
1
HS90A_HUMAN
A:
[16-224]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
50.96
99%
-86
- C1 -
3MNR
1
HS90A_HUMAN
P:
[16-224]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
50.91
99%
-84
- C1 -
2YI0
1
HS90A_HUMAN
A:
[16-224]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
50.89
99%
-82
- C1 -
2YI6
1
HS90A_HUMAN
A:
[16-224]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
50.81
99%
-84
- C1 -
1UYD
1
HS90A_HUMAN
A:
[16-224]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
50.79
99%
-87
- C1 -
2FWY
1
HS90A_HUMAN
A:
[37-243]
----------------
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
50.60
99%
-83
- C1 -
3D0B
1
HS90A_HUMAN
A:
[16-223]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
50.59
99%
-85
- C1 -
4FCP
1
HS90A_HUMAN
B:
[16-223]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
50.49
91%
-83
- C1 -
3NMQ
1
HS90B_HUMAN
A:
[14-225]
--------------
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
K
I
D
I
I
P
N
P
Q
E
R
T
L
T
L
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
V
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
A
D
H
------
G
E
P
I
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
V
K
E
V
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
Y
L
E
K
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
50.46
99%
-85
- C1 -
4FCQ
1
HS90A_HUMAN
A:
[16-223]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
49.90
99%
-84
- C1 -
4FCP
1
HS90A_HUMAN
A:
[16-223]
---------------
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
-
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
HHSearch
45.76
50%
-74
- C1 -
1QY5
2
ENPL_CANFA
A:
[4-269]
---------------
K
S
E
K
F
A
F
Q
A
E
V
N
R
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
-----
L
A
G
N
E
E
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
I
A
K
S
G
T
S
E
F
L
N
K
M
T
-
E
A
Q
E
D
G
-
Q
S
T
S
E
L
I
G
Q
F
G
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
N
D
T
Q
H
I
W
E
S
D
-
S
N
E
F
S
V
I
A
D
P
R-----
G
N
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
S
S
K
T
---------------------------------------------------------
K
T
V
W
D
W
E
L
M
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
45.65
49%
-46
- C1 -
3PEH
1
?
A:
[21-281]
--------------
E
S
M
E
S
H
Q
Y
Q
T
E
V
T
R
L
M
D
I
I
V
N
S
L
Y
T
Q
K
E
V
F
L
R
E
L
I
S
N
A
A
D
A
L
E
K
I
R
F
L
S
L
S
D
E
S
V
-----
L
G
E
E
K
K
L
E
I
R
I
S
A
N
K
E
K
N
I
L
S
I
T
D
T
G
I
G
M
T
K
V
D
L
I
N
N
L
G
T
I
A
K
S
G
T
S
N
F
L
E
A
I
S
K
S
----
G
-
G
-
D
M
S
L
I
G
Q
F
G
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
Y
T
K
N
N
D
D
E
Q
Y
I
W
E
S
T
A
D
A
K
F
T
I
Y
K
D
P
R-----
G
A
T
L
K
R
G
T
R
I
S
L
H
L
K
E
D
A
T
N
L
L
N
D
K
K
L
M
D
L
I
S
K
Y
S
Q
F
I
Q
F
P
I
Y
L
L
H
E
N
V
Y
T
E
E
V
L
A
D
I
A
K
D
M
V
N
-----
D
----
P
N
Y
D
S
V
K
V
E
E
T
D
D
P
----------
N
K
K
T
R
T
V
E
K
K
V
K
K
W
T
L
M
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
44.75
49%
-82
- C1 -
3IED
1
?
A:
[20-271]
------------
Q
G
S
P
V
E
K
Y
N
F
K
A
E
V
N
K
V
M
D
I
I
V
N
S
L
Y
T
D
K
D
V
F
L
R
E
L
I
S
N
A
S
D
A
C
D
K
K
R
I
I
L
E
N
N
K
L
I
K
D
A
EV-
N
D
I
K
K
L
I
I
K
I
K
P
D
K
E
K
K
T
L
T
I
T
D
N
G
I
G
M
D
K
S
E
L
I
N
N
L
G
T
I
A
Q
S
G
T
A
K
F
L
K
Q
I
E
-
E
----
G
K
A
-
D
S
N
L
I
G
Q
F
G
V
G
F
Y
S
S
F
L
V
S
N
R
V
E
V
Y
T
K
K
-
E
D
Q
I
Y
R
W
S
S
D
L
K
G
S
F
S
V
N
E
I
K
KYDQEY--
I
K
G
S
G
T
K
I
I
L
H
L
K
E
E
C
D
E
Y
L
E
D
Y
K
L
K
E
L
I
K
K
Y
S
E
F
I
K
F
P
I
E
I
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------