@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00194_CAH9_H: (2014-08-31 )
MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.---.---.---.---...150..---...-..160.......170.......180.......190.-......200......-.---210...-.-..----.----220.......230..-.-.-...240.......250...-.-.-..260.......270.......280.......290.......300.......310.......320-........330.......340.......350...---....360..-----.----.-----.---.---.---370.---......380.......390.......400.......410.......420.......430.......440.......450.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAPLCPSPW
L
P
L
LIPAPAP
G
L
T
V
Q
L
L
L
S
L
L
L
LVPV
H
P
Q
RLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEG
S
L
KLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRY---G---G---D---PPWPRVS
P
---
A
CA-GRFQSPVDIR
P
Q
L
A
A
F
CPAL
R
P
L
E
L
LGFQLPPLP
E
L
-
R
LRNNG
H
S
V
Q
L
TLPP-G---L
E
M
ALG-P-GR----
E
----
Y
R
A
L
Q
L
H
L
H
WGAAGR-P-G-SEHTVEGHRF
P
A
E
I
H
V
V
H
L
-
S
-
T
-
A
F
A
R
V
D
E
A
LGRP
G
G
L
A
V
L
A
A
F
L
EEGPEE
N
S
A
Y
E
Q
L
L
S
R
L
E
E
I
A
EEGSETQVPGL
D
I
S
A
LL
P
S
D
F
--
S
R
Y
F
QYEGSLTTPPCAQ
G
V
I
W
T
V
FN
Q
T
V
M
L
S
A
K
Q
---
L
H
T
L
S
D
TLW-----G----P-----G---D---
S
---
R
L
Q
L
---
N
F
R
ATQPLN
G
R
V
I
EASFPAGVDSSPRAAEP
V
Q
L
N
S
C
L
A
A
G
D
I
L
A
L
V
F
G
L
L
F
A
V
T
S
V
A
F
L
V
Q
M
R
R
Q
HRRGTKGGVSYRP
A
E
VAETGA
34
HHSearch
99.78
99%
-115
- C2 -
3IAI
11
CAH9_HUMAN
A:
[1-257]
--------------------------------------------------------------------------------------------------------------------------------------
G
P
D
Q
S
H
W
R
Y
---
G
---
G
---
D
---
P
P
W
P
R
V
S
P
---
A
C
A
-
G
R
F
Q
S
P
V
D
I
R
P
Q
L
A
A
F
S
P
A
L
R
P
L
E
L
L
G
F
Q
L
P
P
L
P
E
L
-
R
L
R
N
N
G
H
S
V
Q
L
T
L
P
P
-
G
---
L
E
M
A
L
G
-
P
-
G
R
----
E
----
Y
R
A
L
Q
L
H
L
H
W
G
A
A
G
R
-
P
-
G
-
S
E
H
T
V
E
G
H
R
F
P
A
E
I
H
V
V
H
L
-
S
-
T
-
A
F
A
R
V
D
E
A
L
G
R
P
G
G
L
A
V
L
A
A
F
L
E
E
G
P
E
E
N
S
A
Y
E
Q
L
L
S
R
L
E
E
I
A
E
E
G
S
E
T
Q
V
P
G
L
D
I
S
A
L
L
P
S
D
F
--
S
R
Y
F
Q
Y
E
G
S
L
T
T
P
P
C
A
Q
G
V
I
W
T
V
F
N
Q
T
V
M
L
S
A
K
Q
---
L
H
T
L
S
D
T
L
W
-----
G
----
P
-----
G
---
D
---
S
---
R
L
Q
L
---
N
F
R
A
T
Q
P
L
N
G
R
V
I
E
A
S
F
P
--------------------------------------------------------------------
23
PsiBlast_CBE
97.22
99%
-116
- C2 -
3IAI
10
CAH9_HUMAN
B:
[6-257]
-------------------------------------------------------------------------------------------------------------------------------------------
H
W
R
Y
---
G
---
G
---
D
---
P
P
W
P
R
V
S
P
---
A
C
A
-
G
R
F
Q
S
P
V
D
I
R
P
Q
L
A
A
F
S
P
A
L
R
P
L
E
L
L
G
F
Q
L
P
P
L
P
E
L
-
R
L
R
N
N
G
H
S
V
Q
L
T
L
P
P
-
G
---
L
E
M
A
L
G
-
P
-
G
R
----
E
----
Y
R
A
L
Q
L
H
L
H
W
G
A
A
G
R
-
P
-
G
-
S
E
H
T
V
E
G
H
R
F
P
A
E
I
H
V
V
H
L
-
S
-
T
-
A
F
A
R
V
D
E
A
L
G
R
P
G
G
L
A
V
L
A
A
F
L
E
E
G
P
E
E
N
S
A
Y
E
Q
L
L
S
R
L
E
E
I
A
E
E
G
S
E
T
Q
V
P
G
L
D
I
S
A
L
L
P
S
D
F
--
S
R
Y
F
Q
Y
E
G
S
L
T
T
P
P
C
A
Q
G
V
I
W
T
V
F
N
Q
T
V
M
L
S
A
K
Q
---
L
H
T
L
S
D
T
L
W
-----
G
----
P
-----
G
---
D
---
S
---
R
L
Q
L
---
N
F
R
A
T
Q
P
L
N
G
R
V
I
E
A
S
F
P
--------------------------------------------------------------------
3
PsiBlast_PDB
81.47
43%
-101
- C2 -
4LU3
6
CAH14_HUMAN
A:
[21-278]
-------------------------------------------------------------------------------------------------------------------------------------------
H
W
T
Y
EGP
H
---
G
---
Q
---
D
H
W
P
A
S
Y
P
---
E
C
G
-
N
N
A
Q
S
P
I
D
I
Q
T
D
S
V
T
F
D
P
D
L
P
A
L
Q
P
H
G
Y
D
Q
P
G
T
E
P
L
-
D
L
H
N
N
G
H
T
V
Q
L
S
L
P
S
-
T
---
L
Y
L
G
-
G
-
L
-
P
R
----
K
----
Y
V
A
A
Q
L
H
L
H
W
G
Q
K
G
S
-
P
-
G
G
S
E
H
Q
I
N
S
E
A
T
F
A
E
L
H
I
V
H
Y
D
S
-
D
-
S
Y
D
S
L
S
E
A
A
E
R
P
Q
G
L
A
V
L
G
I
L
I
E
V
G
E
T
K
N
I
A
Y
E
H
I
L
S
H
L
H
E
V
R
H
K
D
Q
K
T
S
V
P
P
F
N
L
R
E
L
L
P
K
Q
L
--
G
Q
Y
F
R
Y
N
G
S
L
T
T
P
P
C
Y
Q
S
V
L
W
T
V
F
Y
R
R
S
Q
I
S
M
E
Q
---
L
E
K
L
Q
G
T
L
F
-----
S
----
T
-----
E
---
E
---
E
---
P
S
K
L
LVQ
N
Y
R
A
L
Q
P
L
N
Q
R
M
V
F
A
S
F
---------------------------------------------------------------------
5
PsiBlast_PDB
79.05
43%
-98
- C2 -
1RJ6
2
CAH14_MOUSE
A:
[4-261]
-------------------------------------------------------------------------------------------------------------------------------------------
H
W
T
Y
EGP
H
---
G
---
Q
---
D
H
W
P
T
S
Y
P
---
E
C
G
-
G
D
A
Q
S
P
I
N
I
Q
T
D
S
V
I
F
D
P
D
L
P
A
V
Q
P
H
G
Y
D
Q
L
G
T
E
P
L
-
D
L
H
N
N
G
H
T
V
Q
L
S
L
P
P
-
T
---
L
H
L
G
-
G
-
L
-
P
R
----
K
----
Y
T
A
A
Q
L
H
L
H
W
G
Q
R
G
S
L
E
-
G
-
S
E
H
H
I
N
S
E
A
T
A
A
E
L
H
V
V
H
Y
D
S
-
Q
-
S
Y
S
S
L
S
E
A
A
Q
K
P
Q
G
L
A
V
L
G
I
L
I
E
V
G
E
T
E
N
P
A
Y
D
H
I
L
S
R
L
H
E
I
R
Y
K
D
Q
K
T
S
V
P
P
F
S
V
R
E
L
F
P
Q
Q
L
--
E
Q
F
F
R
Y
N
G
S
L
T
T
P
P
C
Y
Q
S
V
L
W
T
V
F
N
R
R
A
Q
I
S
M
G
Q
---
L
E
K
L
Q
E
T
L
S
-----
S
TEED
P
-----
S
---
E
---
P
---
L
V
Q
----
N
Y
R
V
P
Q
P
L
N
Q
R
T
I
F
A
S
F
---------------------------------------------------------------------
4
PsiBlast_PDB
78.78
43%
-98
- C2 -
1RJ5
2
CAH14_MOUSE
A:
[4-261]
-------------------------------------------------------------------------------------------------------------------------------------------
H
W
T
Y
EGP
H
---
G
---
Q
---
D
H
W
P
T
S
Y
P
---
E
C
G
-
G
D
A
Q
S
P
I
N
I
Q
T
D
S
V
I
F
D
P
D
L
P
A
V
Q
P
H
G
Y
D
Q
L
G
T
E
P
L
-
D
L
H
N
N
G
H
T
V
Q
L
S
L
P
P
-
T
---
L
H
L
G
-
G
-
L
-
P
R
----
K
----
Y
T
A
A
Q
L
H
L
H
W
G
Q
R
G
S
L
E
-
G
-
S
E
H
H
I
N
S
E
A
T
A
A
E
L
H
V
V
H
Y
D
S
-
Q
-
S
Y
S
S
L
S
E
A
A
Q
K
P
Q
G
L
A
V
L
G
I
L
I
E
V
G
E
T
E
N
P
A
Y
D
H
I
L
S
R
L
H
E
I
R
Y
K
D
Q
K
T
S
V
P
P
F
S
V
R
E
L
F
P
Q
Q
L
--
E
Q
F
F
R
Y
N
G
S
L
T
T
P
P
C
Y
Q
S
V
L
W
T
V
F
N
R
R
A
Q
I
S
M
G
Q
---
L
E
K
L
Q
E
T
L
S
-----
S
TEED
P
-----
S
---
E
---
P
---
L
V
Q
----
N
Y
R
V
P
Q
P
L
N
Q
R
T
I
F
A
S
F
---------------------------------------------------------------------
35
HHSearch
78.53
40%
-101
- C2 -
4HT2
4
CAH12_HUMAN
A:
[3-262]
-------------------------------------------------------------------------------------------------------------------------------------------
K
W
T
Y
---
F
GPD
G
---
E
---
N
S
W
S
K
K
Y
P
---
S
C
G
-
G
L
L
Q
S
P
I
D
L
H
S
D
I
L
Q
Y
D
A
S
L
T
P
L
E
F
Q
G
Y
N
L
S
A
N
K
Q
F
-
L
L
T
N
N
G
H
S
V
K
L
N
L
P
S
-
D
---
M
H
I
Q
-
G
-
L
-
Q
S
----
R
----
Y
S
A
T
Q
L
H
L
H
W
G
N
P
N
D
P
H
-
G
-
S
E
H
T
V
S
G
Q
H
F
A
A
E
L
H
I
V
H
Y
-
N
S
D
-
L
Y
P
D
A
S
T
A
S
N
K
S
E
G
L
A
V
L
A
V
L
I
E
M
G
S
-
F
N
P
S
Y
D
K
I
F
S
H
L
Q
H
V
K
Y
K
G
Q
E
A
F
V
P
G
F
N
I
E
E
L
L
P
E
R
T
--
A
E
Y
Y
R
Y
R
G
S
L
T
T
P
P
C
N
P
T
V
L
W
T
V
F
R
N
P
V
Q
I
S
Q
E
Q
---
L
L
A
L
E
T
A
L
Y
-----
C
----
T
HMDDP
S
---
P
---
R
---
E
M
I
N
---
N
F
R
Q
V
Q
K
F
D
E
R
L
V
Y
T
S
F
S
--------------------------------------------------------------------
8
PsiBlast_PDB
78.27
39%
-107
- C2 -
4KP8
2
CAH12_HUMAN
A:
[3-261]
-------------------------------------------------------------------------------------------------------------------------------------------
K
W
T
Y
FGP
D
---
G
---
E
---
N
S
W
S
K
K
Y
P
---
S
C
G
-
G
L
L
Q
S
P
I
D
L
H
S
D
I
L
Q
Y
D
A
S
L
T
P
L
E
F
Q
G
Y
N
L
S
A
N
K
Q
F
-
L
L
T
N
N
G
H
S
V
K
L
N
L
P
S
-
D
---
M
H
I
Q
-
G
-
L
-
Q
S
----
R
----
Y
S
A
T
Q
L
H
L
H
W
G
N
P
N
D
-
P
H
G
-
S
E
H
T
V
S
G
Q
H
F
A
A
E
L
H
I
V
H
Y
N
S
-
D
-
L
Y
P
D
A
S
T
A
S
N
K
S
E
G
L
A
V
L
A
V
L
I
E
M
G
-
S
F
N
P
S
Y
D
K
I
F
S
H
L
Q
H
V
K
Y
K
G
Q
E
A
F
V
P
G
F
N
I
E
E
L
L
P
E
R
T
--
A
E
Y
Y
R
Y
R
G
S
L
T
T
P
P
C
N
P
T
V
L
W
T
V
F
R
N
P
V
Q
I
S
Q
E
Q
---
L
L
A
L
E
T
A
L
Y
CTHMD
D
----
P
-----
S
---
P
---
R
---
E
M
I
N
---
N
F
R
Q
V
Q
K
F
D
E
R
L
V
Y
T
S
F
---------------------------------------------------------------------
12
PsiBlast_PDB
77.60
36%
-95
- C2 -
3MDZ
4
CAH7_HUMAN
A:
[26-281]
--------------------------------------------------------------------------------------------------------------------------------------------
W
G
Y
---
G
---
Q
---
D
DGP
S
H
W
H
K
L
Y
P
---
I
A
Q
-
G
D
R
Q
S
P
I
N
I
I
S
S
Q
A
V
Y
S
P
S
L
Q
P
L
E
L
---
S
Y
E
A
C
M
S
L
-
S
I
T
N
N
G
H
S
V
Q
V
D
F
N
D
-
S
---
D
D
R
T
V
V
-
T
-
G
G
----
P
LE
G
P
Y
R
L
K
Q
F
H
F
H
W
G
K
K
H
D
-
V
-
G
-
S
E
H
T
V
D
G
K
S
F
P
S
E
L
H
L
V
H
W
-
N
-
A
K
K
Y
S
T
F
G
E
A
A
S
A
P
D
G
L
A
V
V
G
V
F
L
E
T
G
-
D
E
H
P
S
M
N
R
L
T
D
A
L
Y
M
V
R
F
K
G
T
K
A
Q
F
S
C
F
N
P
K
C
L
L
P
A
S
---
R
H
Y
W
T
Y
P
G
S
L
T
T
P
P
L
S
E
S
V
T
W
I
V
L
R
E
P
I
C
I
S
E
R
Q
---
M
G
K
F
R
S
L
L
F
T----
S
----
E
-----
D
---
D
---
E
---
R
I
H
M
V
N-
N
F
R
P
P
Q
P
L
K
G
R
V
V
K
A
S
F
---------------------------------------------------------------------
9
PsiBlast_PDB
77.33
39%
-101
- C2 -
1JCZ
1
CAH12_HUMAN
A:
[3-261]
-------------------------------------------------------------------------------------------------------------------------------------------
K
W
T
Y
FGP
D
---
G
---
E
---
N
S
W
S
K
K
Y
P
---
S
C
G
-
G
L
L
Q
S
P
I
D
L
H
S
D
I
L
Q
Y
D
A
S
L
T
P
L
E
F
Q
G
Y
N
L
S
A
N
K
Q
F
-
L
L
T
N
N
G
H
S
V
K
L
N
L
P
S
-
D
---
M
H
I
Q
-
G
-
L
-
Q
S
----
R
----
Y
S
A
T
Q
L
H
L
H
W
G
N
P
N
D
-
P
H
G
-
S
E
H
T
V
S
G
Q
H
F
A
A
E
L
H
I
V
H
Y
N
S
-
D
-
L
Y
P
D
A
S
T
A
S
N
K
S
E
G
L
A
V
L
A
V
L
I
E
M
G
-
S
F
N
P
S
Y
D
K
I
F
S
H
L
Q
H
V
K
Y
K
G
Q
E
A
F
V
P
G
F
N
I
E
E
L
L
P
E
R
T
--
A
E
Y
Y
R
Y
R
G
S
L
T
T
P
P
C
N
P
T
V
L
W
T
V
F
R
N
P
V
Q
I
S
Q
E
Q
---
L
L
A
L
E
T
A
L
Y
CTHMD
D
----
P
-----
S
---
P
---
R
---
E
M
I
N
---
N
F
R
Q
V
Q
K
F
D
E
R
L
V
Y
T
S
F
---------------------------------------------------------------------
11
PsiBlast_PDB
77.30
36%
-89
- C2 -
3ML5
1
CAH7_HUMAN
A:
[12-269]
--------------------------------------------------------------------------------------------------------------------------------------------
W
G
Y
---
G
---
Q
---
D
DGP
S
H
W
H
K
L
Y
P
---
I
A
Q
-
G
D
R
Q
S
P
I
N
I
I
S
S
Q
A
V
Y
S
P
S
L
Q
P
L
E
L
---
S
Y
E
A
C
M
S
L
-
S
I
T
N
N
G
H
S
V
Q
V
D
F
N
D
-
S
---
D
D
R
T
V
V
-
T
-
G
G
----
P
LE
G
P
Y
R
L
K
Q
F
H
F
H
W
G
K
K
H
D
-
V
-
G
-
S
E
H
T
V
D
G
K
S
F
P
S
E
L
H
L
V
H
W
-
N
-
A
K
K
Y
S
T
F
G
E
A
A
S
A
P
D
G
L
A
V
V
G
V
F
L
E
T
G
-
D
E
H
P
S
M
N
R
L
T
D
A
L
Y
M
V
R
F
K
G
T
K
A
Q
F
S
C
F
N
P
K
S
L
L
P
A
S
---
R
H
Y
W
T
Y
P
G
S
L
T
T
P
P
L
S
E
S
V
T
W
I
V
L
R
E
P
I
S
I
S
E
R
Q
---
M
G
K
F
R
S
L
L
F
T----
S
----
E
-----
D
---
D
---
E
---
R
I
H
M
VN-
N
F
R
P
P
Q
P
L
K
G
R
V
V
K
A
S
F
R
A
-------------------------------------------------------------------
10
PsiBlast_PDB
77.26
39%
-104
- C2 -
1JD0
1
CAH12_HUMAN
A:
[3-261]
-------------------------------------------------------------------------------------------------------------------------------------------
K
W
T
Y
FGP
D
---
G
---
E
---
N
S
W
S
K
K
Y
P
---
S
C
G
-
G
L
L
Q
S
P
I
D
L
H
S
D
I
L
Q
Y
D
A
S
L
T
P
L
E
F
Q
G
Y
N
L
S
A
N
K
Q
F
-
L
L
T
N
N
G
H
S
V
K
L
N
L
P
S
-
D
---
M
H
I
Q
-
G
-
L
-
Q
S
----
R
----
Y
S
A
T
Q
L
H
L
H
W
G
N
P
N
D
-
P
H
G
-
S
E
H
T
V
S
G
Q
H
F
A
A
E
L
H
I
V
H
Y
N
S
-
D
-
L
Y
P
D
A
S
T
A
S
N
K
S
E
G
L
A
V
L
A
V
L
I
E
M
G
-
S
F
N
P
S
Y
D
K
I
F
S
H
L
Q
H
V
K
Y
K
G
Q
E
A
F
V
P
G
F
N
I
E
E
L
L
P
E
R
T
--
A
E
Y
Y
R
Y
R
G
S
L
T
T
P
P
C
N
P
T
V
L
W
T
V
F
R
N
P
V
Q
I
S
Q
E
Q
---
L
L
A
L
E
T
A
L
Y
CTHMD
D
----
P
-----
S
---
P
---
R
---
E
M
I
N
---
N
F
R
Q
V
Q
K
F
D
E
R
L
V
Y
T
S
F
---------------------------------------------------------------------
7
PsiBlast_PDB
77.11
39%
-105
- C2 -
4KP5
3
CAH12_HUMAN
A:
[3-261]
-------------------------------------------------------------------------------------------------------------------------------------------
K
W
T
Y
FGP
D
---
G
---
E
---
N
S
W
S
K
K
Y
P
---
S
C
G
-
G
L
L
Q
S
P
I
D
L
H
S
D
I
L
Q
Y
D
A
S
L
T
P
L
E
F
Q
G
Y
N
L
S
A
N
K
Q
F
-
L
L
T
N
N
G
H
S
V
K
L
N
L
P
S
-
D
---
M
H
I
Q
-
G
-
L
-
Q
S
----
R
----
Y
S
A
T
Q
L
H
L
H
W
G
N
P
N
D
-
P
H
G
-
S
E
H
T
V
S
G
Q
H
F
A
A
E
L
H
I
V
H
Y
N
S
-
D
-
L
Y
P
D
A
S
T
A
S
N
K
S
E
G
L
A
V
L
A
V
L
I
E
M
G
-
S
F
N
P
S
Y
D
K
I
F
S
H
L
Q
H
V
K
Y
K
G
Q
E
A
F
V
P
G
F
N
I
E
E
L
L
P
E
R
T
--
A
E
Y
Y
R
Y
R
G
S
L
T
T
P
P
C
N
P
T
V
L
W
T
V
F
R
N
P
V
Q
I
S
Q
E
Q
---
L
L
A
L
E
T
A
L
Y
CTHMD
D
----
P
-----
S
---
P
---
R
---
E
M
I
N
---
N
F
R
Q
V
Q
K
F
D
E
R
L
V
Y
T
S
F
---------------------------------------------------------------------
39
HHSearch
75.30
35%
-93
* C2 *
3K34
5
CAH2_HUMAN
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------
H
W
G
Y
---
G
KHN
G
---
P
---
E
H
W
H
K
D
F
P
---
I
A
K
-
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
S
-
Y
D
Q
A
--
T
S
L
-
R
I
L
N
N
G
H
A
F
N
V
E
F
D
D
-
S
QDK
A
V
L
K
G
G
P
L
-
D
G
----
T
----
Y
R
L
I
Q
F
H
F
H
W
G
S
L
D
G
-
Q
-
G
-
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
-
N
-
T
-
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
S
-
A
K
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
S
L
---
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
---
V
L
K
F
R
K
L
N
F
-----
N
----
G
-----
E
---
G
EPE
E
---
L
M
V
D
---
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
K
--------------------------------------------------------------------
19
PsiBlast_PDB
74.51
34%
-91
- C2 -
3DCW
1
CAH2_HUMAN
A:
[4-259]
-------------------------------------------------------------------------------------------------------------------------------------------
H
W
G
Y
---
G
KHN
G
---
P
---
E
H
W
H
K
D
F
P
---
I
A
K
-
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
Y
D
Q
A
T
S
L
-
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
-
S
---
Q
D
K
A
V
L
-
K
-
G
G
PLD
G
T
----
Y
R
L
I
Q
F
H
F
H
W
G
S
L
D
G
-
Q
-
G
-
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
-
N
-
T
-
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
S
A
K
-
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
S
L
--
D
-
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
E
-----
G
----
E
-----
P
---
E
---
E
---
L
M
V
D
---
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
---------------------------------------------------------------------
18
PsiBlast_PDB
74.29
34%
-95
- C2 -
3DCS
1
CAH2_HUMAN
A:
[4-259]
-------------------------------------------------------------------------------------------------------------------------------------------
H
W
G
Y
---
G
KHN
G
---
P
---
E
H
W
H
K
D
F
P
---
I
A
K
-
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
Y
D
Q
A
T
S
L
-
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
-
S
---
Q
D
K
A
V
L
-
K
-
G
G
PLD
G
T
----
Y
R
L
I
Q
F
H
F
H
W
G
S
L
D
G
-
Q
-
G
-
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
-
N
-
T
-
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
S
A
K
-
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
S
L
--
D
-
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
E
-----
G
----
E
-----
P
---
E
---
E
---
L
M
V
D
---
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
---------------------------------------------------------------------
15
PsiBlast_PDB
74.13
34%
-94
- C2 -
3DC3
1
CAH2_HUMAN
A:
[4-259]
-------------------------------------------------------------------------------------------------------------------------------------------
H
W
G
Y
---
G
KHN
G
---
P
---
E
H
W
H
K
D
F
P
---
I
A
K
-
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
Y
D
Q
A
T
S
L
-
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
-
S
---
Q
D
K
A
V
L
-
K
-
G
G
PLD
G
T
----
Y
R
L
I
Q
F
H
F
H
W
G
S
L
D
G
-
Q
-
G
-
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
-
N
-
T
-
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
S
A
K
-
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
S
L
--
D
-
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
E
-----
G
----
E
-----
P
---
E
---
E
---
L
M
V
D
---
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
---------------------------------------------------------------------
17
PsiBlast_PDB
73.95
34%
-91
- C2 -
3DCC
1
CAH2_HUMAN
A:
[4-259]
-------------------------------------------------------------------------------------------------------------------------------------------
H
W
G
Y
---
G
KHN
G
---
P
---
E
H
W
H
K
D
F
P
---
I
A
K
-
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
Y
D
Q
A
T
S
L
-
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
-
S
---
Q
D
K
A
V
L
-
K
-
G
G
PLD
G
T
----
Y
R
L
I
Q
F
H
F
H
W
G
S
L
D
G
-
Q
-
G
-
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
-
N
-
T
-
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
S
A
K
-
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
S
L
--
D
-
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
E
-----
G
----
E
-----
P
---
E
---
E
---
L
M
V
D
---
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
---------------------------------------------------------------------
20
PsiBlast_PDB
73.82
34%
-91
- C2 -
3OIK
2
CAH2_HUMAN
A:
[4-259]
-------------------------------------------------------------------------------------------------------------------------------------------
H
W
G
Y
---
G
KHN
G
---
P
---
E
H
W
H
K
D
F
P
---
I
A
K
-
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
Y
D
Q
A
T
S
L
-
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
-
S
---
Q
D
K
A
V
L
-
K
-
G
G
PLD
G
T
----
Y
R
L
I
Q
F
H
F
H
W
G
S
L
D
G
-
Q
-
G
-
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
-
N
-
T
-
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
S
A
K
-
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
S
L
--
D
-
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
E
-----
G
----
E
-----
P
---
E
---
E
---
L
M
V
D
---
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
---------------------------------------------------------------------
14
PsiBlast_PDB
73.39
34%
-90
- C2 -
3DBU
1
CAH2_HUMAN
A:
[4-259]
-------------------------------------------------------------------------------------------------------------------------------------------
H
W
G
Y
---
G
KHN
G
---
P
---
E
H
W
H
K
D
F
P
---
I
A
K
-
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
Y
D
Q
A
T
S
L
-
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
-
S
---
Q
D
K
A
V
L
-
K
-
G
G
PLD
G
T
----
Y
R
L
I
Q
F
H
F
H
W
G
S
L
D
G
-
Q
-
G
-
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
-
N
-
T
-
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
S
A
K
-
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
S
L
--
D
-
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
E
-----
G
----
E
-----
P
---
E
---
E
---
L
M
V
D
---
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
---------------------------------------------------------------------
42
HHSearch
73.31
36%
-92
- C2 -
4KNN
7
CAH13_HUMAN
B:
[6-263]
-------------------------------------------------------------------------------------------------------------------------------------------
S
W
G
Y
---
R
EHN
G
---
P
---
I
H
W
K
E
F
F
P
---
I
A
D
-
G
D
Q
Q
S
P
I
E
I
K
T
K
E
V
K
Y
D
S
S
L
R
P
L
S
I
K
-
Y
D
P
--
S
S
A
K
-
I
I
S
N
S
G
H
S
F
N
V
D
F
D
D
-
T
ENK
S
V
L
R
G
G
P
L
-
T
G
----
S
----
Y
R
L
R
Q
V
H
L
H
W
G
S
A
D
D
-
H
-
G
-
S
E
H
I
V
D
G
V
S
Y
A
A
E
L
H
V
V
H
W
-
N
S
D
-
K
Y
P
S
F
V
E
A
A
H
E
P
D
G
L
A
V
L
G
V
F
L
Q
I
G
-
E
P
N
S
Q
L
Q
K
I
T
D
T
L
D
S
I
K
E
K
G
K
Q
T
R
F
T
N
F
D
L
L
S
L
L
P
P
S
W
---
D
Y
W
T
Y
P
G
S
L
T
V
P
P
L
L
E
S
V
T
W
I
V
L
K
Q
P
I
N
I
S
S
Q
Q
---
L
A
K
F
R
S
L
L
C
-----
T
----
A
EGE--
A
---
A
---
A
---
F
L
V
S
---
N
H
R
P
P
Q
P
L
K
G
R
K
V
R
A
S
F
H
--------------------------------------------------------------------
45
HHSearch
72.38
33%
-91
- C2 -
2FOY
3
CAH1_HUMAN
A:
[5-260]
--------------------------------------------------------------------------------------------------------------------------------------------
W
G
Y
---
D
DKN
G
---
P
---
E
Q
W
S
K
L
Y
P
---
I
A
N
-
G
N
N
Q
S
P
V
D
I
K
T
S
E
T
K
H
D
T
S
L
K
P
I
S
V
-
S
Y
N
P
--
A
T
A
K
-
E
I
I
N
V
G
H
S
F
H
V
N
F
E
D
-
N
DNR
S
V
L
K
G
G
P
F
-
S
D
----
S
----
Y
R
L
F
Q
F
H
F
H
W
G
S
T
N
E
-
H
-
G
-
S
E
H
T
V
D
G
V
K
Y
S
A
E
L
H
V
A
H
W
-
N
-
S
A
K
Y
S
S
L
A
E
A
A
S
K
A
D
G
L
A
V
I
G
V
L
M
K
V
G
-
E
A
N
P
K
L
Q
K
V
L
D
A
L
Q
A
I
K
T
K
G
K
R
A
P
F
T
N
F
D
P
S
T
L
L
P
S
S
L
---
D
F
W
T
Y
P
G
S
L
T
H
P
P
L
Y
E
S
V
T
W
I
I
C
K
E
S
I
S
V
S
S
E
Q
---
L
A
Q
F
R
S
L
L
S
-----
N
----
V
-----
E
GDN
A
---
V
---
P
M
Q
H
---
N
N
R
P
T
Q
P
L
K
G
R
T
V
R
A
S
F
---------------------------------------------------------------------
41
HHSearch
70.43
32%
-87
- C2 -
3FW3
2
CAH4_HUMAN
A:
[20-266]
------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
P
---
V
K
W
G
---
G
---
N
C
Q
-
K
D
R
Q
S
P
I
N
I
V
T
T
K
A
K
V
D
K
K
L
G
R
F
F
F
S
G
Y
D
K
K
Q
--
T
W
-
T
V
Q
N
N
G
H
S
V
M
M
L
L
E
N
-
K
---
A
S
I
S
G
G
-
G
L
P
A
----
P
----
Y
Q
A
K
Q
L
H
L
H
W
S
D
L
P
Y
-
K
-
G
-
S
E
H
S
L
D
G
E
H
F
A
M
E
M
H
I
V
H
E
-
K
-
E
K----------
P
E
D
E
I
A
V
L
A
F
L
V
E
A
G
T
Q
V
N
E
G
F
Q
P
L
V
E
A
L
S
N
I
P
K
P
E
M
S
T
T
M
A
E
S
S
L
L
D
L
L
P
K
E
E
KL
R
H
Y
F
R
Y
L
G
S
L
T
T
P
T
C
D
E
K
V
V
W
T
V
F
R
E
P
I
Q
L
H
R
E
Q
---
I
L
A
F
S
Q
K
L
Y
-----
Y
----
D
-----
K
---
E
---
Q
TV-
S
M
K
D
---
N
V
R
P
L
Q
Q
L
G
Q
R
T
V
I
K
S
----------------------------------------------------------------------
48
HHSearch
69.62
34%
-83
- C2 -
1KEQ
5
CAH5A_MOUSE
A:
[4-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
R
Q
S
P
I
N
I
Q
W
K
D
S
V
Y
D
P
Q
L
A
P
L
R
V
S
Y
D
A
A
S
---
C
R
-
Y
L
W
N
T
G
Y
A
F
Q
V
E
F
D
D
-
S
CED
S
G
I
S
G
G
P
L
-
G
N
----
H
----
Y
R
L
K
Q
F
H
F
H
W
G
A
T
D
E
-
W
-
G
-
S
E
H
A
V
D
G
H
T
Y
P
A
E
L
H
L
V
H
W
-
N
-
S
T
K
Y
E
N
C
K
K
A
S
V
G
E
N
G
L
A
V
I
G
V
F
L
K
L
G
-
A
H
H
Q
A
L
Q
K
L
V
D
V
L
P
E
V
R
H
K
D
T
Q
V
A
M
G
P
F
D
P
S
C
L
M
P
A
C
---
R
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
A
E
S
V
T
W
I
V
Q
K
T
P
V
E
V
S
P
S
Q
---
L
S
M
F
R
T
L
L
F
-----
S
----
G
-----
R
---
G
---
E
E
E
D
V
M
V
N
---
N
Y
R
P
L
Q
P
L
R
D
R
K
L
R
S
S
F
R
L
-------------------------------------------------------------------
50
HHSearch
63.73
32%
-102
- C2 -
4G7A
1
?
A:
[25-248]
-------------------------------------------------------------------------------------------------------------------------------------------
E
W
S
Y
---
E
---
G
EKG
P
---
E
H
W
A
Q
L
K
P
EFF
W
C
K
-
L
K
N
Q
S
P
I
N
I
D
K
K
-
Y
K
V
K
A
N
L
P
K
L
N
L
-
Y
Y
K
T
A
---
K
E
S
E
V
V
N
N
G
H
T
I
Q
I
N
I
K
E
-
D
---
N
T
L
N
Y
L
---
G
E
----
K
----
Y
Q
L
K
Q
F
H
F
H
T
--------
P
-
S
E
H
T
I
E
K
K
S
Y
P
L
E
I
H
F
V
H
K
-
T
-
E
------------
D
G
K
I
L
V
V
G
V
M
A
K
L
G
-
K
T
N
K
E
L
D
K
I
L
N
V
A
P
A
E
--
E
G
E
K
I
L
D
K
N
L
N
L
N
N
L
I
P
K
D
---
K
R
Y
M
T
Y
S
G
S
L
T
T
P
P
C
T
E
G
V
R
W
I
V
L
K
K
P
I
S
I
S
K
Q
Q
---
L
E
K
L
K
S
V
M
V
-----
N
-------------------------
P
---
N
N
R
P
V
Q
E
I
N
S
R
W
I
I
E
G
F
---------------------------------------------------------------------
51
HHSearch
60.53
33%
-97
- C2 -
1KOP
1
CAH_NEIGO
A:
[1-222]
-----------------------------------------------------------------------------------------------------------------------------------------
H
T
H
W
G
Y
---
T
GHD
S
---
P
---
E
S
W
G
N
L
S
E
EFR
L
C
S
T
G
K
N
Q
S
P
V
N
I
T
E
T
---
V
S
G
K
L
P
A
I
K
V
-
N
Y
K
P
S
---
M
V
-
D
V
E
N
N
G
H
T
I
Q
V
N
Y
P
E
G
G
---
N
T
L
T
V
N
---
G
R
----
T
----
Y
T
L
K
Q
F
H
F
H
V
--------
P
-
S
E
N
Q
I
K
G
R
T
F
P
M
E
A
H
F
V
H
L
-
D
-
E
------------
N
K
Q
P
L
V
L
A
V
L
Y
E
A
G
-
K
T
N
G
R
L
S
S
I
W
N
V
M
P
M
T
A
--
G
K
V
K
L
N
Q
P
F
D
A
S
T
L
L
P
K
R
---
L
K
Y
Y
R
F
A
G
S
L
T
T
P
P
C
T
E
G
V
S
W
L
V
L
K
T
Y
D
H
I
D
Q
A
Q
---
A
E
K
F
T
R
A
V
G
-----
S
-------------------------
E
---
N
N
R
P
V
Q
P
L
N
A
R
V
V
I
------------------------------------------------------------------------