@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00233_PDE10_: (2014-09-02 )
MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKAEDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFLGECNNSLCVFTPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMHFNLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPATSKSTSEKPTRKVDD
Atome Classification :
(55 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460---.......470.......480..---.....490.......500.......510.......520........530.......540..--.....550.......560.......570.......580.....-..590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700..-.....710.......720.......730.......740.......750.......760.......770.......780.......790..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEDGPSN
N
A
S
C
F
R
R
L
T
E
C
FLSPSL
T
D
E
K
V
K
A
Y
L
SL
H
P
Q
V
L
D
E
F
V
S
ESV
S
A
E
T
V
E
K
W
L
K
RKNNKAEDEP
S
P
K
E
V
S
R
YQDTNM
Q
G
V
V
Y
E
L
N
S
Y
I
E
Q
R
LDTGGDN
H
L
L
L
Y
E
L
S
S
I
I
R
I
ATKAD
G
F
A
L
Y
F
L
GECNN
S
L
C
V
FTPPGMKEGQ
P
R
L
IPAGPITQG
T
T
I
S
A
Y
VAKSR
K
T
L
L
V
E
D
ILGDERFPRGTGLESGT
R
I
Q
S
V
L
C
L
P
I
V
T
A
I
G
D
L
I
G
I
L
E
L
Y
R
H
WGK
E
A
F
C
LS
H
Q
E
VATAN
L
A
W
A
S
V
A
I
H
Q
V
Q
V
C
R
G
L
A
K
Q
T
E
L
N
D
F
L
L
D
V
S
K
T
Y
F
D
N
I
V
A
I
D
S
L
L
E
H
I
M
I
Y
A
K
N
LVNAD
R
C
A
L
F
Q
VDHK
N
K
E
L
Y
S
D
L
F
DIGEEKEGK
P
V
F
K
K
T
K
E
I
R
F
S
IEKGIAGQVARTGEVLNIPDAYADPRFN
R
E
V
D
L
Y
TGYTTR
N
I
L
C
M
P
IVSRGS
V
I
G
V
V
Q
M
V
N
K
ISGSAFSKTDENNF
K
M
F
A
V
F
C
A
L
A
L
H
C
A
N
M
Y
H
R
I
R
H
S
E
C
I
Y
R
V
T
M
E
KL
S
Y
HSIC
T
S
E
E
W
Q
G
LMHF---N
L
P
A
R
I
C
RD
I
E
L
F
H
FDIG
P
F
EN---MWP
G
I
F
V
Y
M
I
H
R
S
CGT
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
NYR-RVPYHNW
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
QNN--NGL
F
T
D
L
ERK
G
L
L
I
A
C
L
C
H
DLDHRGF
S
N
S
Y
L
Q
K
FD
H
P
L
A
A
L
Y
S-TS
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
LEG
H
N
I
F
S
TL
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
YFG
N
R
K
Q
L
E
E
M
Y
Q
TGS
L
N
LHNQS
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
TKLWPVTKL
T
A
N
D
I
Y
A
E
F
WAEG
D
E
M
K
-KLGIQPIPMMDRDKRDEVPQGQLG
F
Y
N
A
VA
I
P
C
Y
T
T
L
T
Q
ILPP
T
E
P
L
L
K
A
C
R
D
N
L
N
Q
W
E
K
V
IRGEE
T
A
M
W
ISGPATSKSTSEKPTRKVDD
83
Fugue
79.41
95%
-127
- C3 -
2OUR
1
PDE10_HUMAN
A:
[2-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
A
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
------------------------
63
PsiBlast_CBE
78.75
95%
-125
- C3 -
2OUY
1
PDE10_HUMAN
A:
[2-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
N
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
T
A
T
W
I
S
------------------
51
PsiBlast_CBE
78.68
95%
-123
- C3 -
2OUQ
1
PDE10_HUMAN
A:
[2-327]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
T
A
----------------------
67
PsiBlast_CBE
78.66
95%
-123
- C3 -
2OUU
2
PDE10_HUMAN
A:
[1-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
A
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
T
A
T
W
--------------------
15
PsiBlast_PDB
78.61
93%
-127
- C3 -
4FCB
1
PDE10_HUMAN
A:
[4-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
25
PsiBlast_CBE
78.51
93%
-127
- C3 -
3WI2
1
B:
[3-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
------------------------
46
PsiBlast_CBE
78.44
93%
-126
- C3 -
4LLK
1
?
A:
[5-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
T
A
T
W
I
-------------------
48
PsiBlast_CBE
78.32
93%
-126
- C3 -
4LLJ
1
?
A:
[5-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
T
A
T
W
I
-------------------
42
PsiBlast_CBE
78.32
93%
-125
- C3 -
4LLX
1
?
A:
[5-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
T
A
T
W
I
-------------------
55
PsiBlast_CBE
78.26
95%
-123
- C3 -
2OUN
1
PDE10_HUMAN
A:
[2-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
------------------------
16
PsiBlast_PDB
78.26
93%
-126
- C3 -
4FCD
1
PDE10_HUMAN
A:
[4-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
40
PsiBlast_CBE
78.12
93%
-124
- C3 -
4LM0
1
?
A:
[5-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
T
A
T
W
I
-------------------
32
PsiBlast_CBE
78.08
93%
-126
- C3 -
4LM4
1
?
A:
[5-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
T
A
T
W
I
-------------------
79
PsiBlast_CBE
78.07
96%
-131
- C3 -
4AJG
1
PDE10_HUMAN
A:
[3-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
--------------------------
18
PsiBlast_PDB
78.05
93%
-127
- C3 -
4AEL
1
PDE10_HUMAN
A:
[4-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
---------------------------
13
PsiBlast_PDB
78.00
93%
-127
- C3 -
3SNI
1
PDE10_HUMAN
A:
[4-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
11
PsiBlast_PDB
77.94
96%
-130
- C3 -
2Y0J
1
PDE10_HUMAN
A:
[15-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
30
PsiBlast_CBE
77.86
93%
-124
- C3 -
2WEY
1
B:
[3-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
------------------------
44
PsiBlast_CBE
77.80
93%
-125
- C3 -
4LLP
1
?
A:
[5-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
T
A
T
W
I
-------------------
73
PsiBlast_CBE
77.78
95%
-127
- C3 -
3UI7
1
PDE10_HUMAN
A:
[19-333]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
------------------------
38
PsiBlast_CBE
77.77
93%
-125
- C3 -
4LM1
1
?
A:
[5-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
T
A
T
W
I
S
S
-----------------
29
PsiBlast_CBE
77.74
93%
-128
- C3 -
4AEL
1
B:
[4-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
12
PsiBlast_PDB
77.71
93%
-126
- C3 -
3SN7
1
PDE10_HUMAN
A:
[4-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
78
PsiBlast_CBE
77.63
96%
-122
- C3 -
4AJG
1
D:
[3-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
36
PsiBlast_CBE
77.59
93%
-123
- C3 -
4LM2
1
?
A:
[5-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
T
A
T
W
I
-------------------
23
PsiBlast_CBE
77.58
93%
-127
- C3 -
4FCD
1
B:
[3-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
--------------
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
34
PsiBlast_CBE
77.53
93%
-122
- C3 -
4LM3
3
?
A:
[5-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
T
A
T
W
I
S
------------------
76
PsiBlast_CBE
77.41
96%
-123
- C3 -
4AJM
1
D:
[3-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
--------------------------
24
PsiBlast_CBE
77.41
93%
-125
- C3 -
4FCB
1
B:
[3-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
--------------
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
19
PsiBlast_PDB
77.36
93%
-123
- C3 -
2WEY
1
PDE10_HUMAN
A:
[3-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
------------------------
27
PsiBlast_CBE
77.32
93%
-127
- C3 -
3SNI
1
B:
[3-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
--------------
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
28
PsiBlast_CBE
77.20
93%
-127
- C3 -
3SN7
1
B:
[3-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
--------------
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
22
PsiBlast_CBE
77.09
96%
-126
- C3 -
2Y0J
1
B:
[15-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
72
PsiBlast_CBE
77.02
95%
-127
- C3 -
3UI7
1
B:
[18-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
17
PsiBlast_PDB
76.69
93%
-123
- C3 -
3WI2
1
PDE10_HUMAN
A:
[3-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
------------------------
26
PsiBlast_CBE
76.45
93%
-124
- C3 -
3SNL
1
B:
[3-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
--------------
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
8
PsiBlast_PDB
75.91
99%
-126
- C3 -
3QPN
1
A:
[31-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
P
A
R
I
C
R
D
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
I
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
N
G
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
H
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
R
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
N
Q
W
E
K
V
I
R
---------------------------
7
PsiBlast_PDB
75.61
99%
-123
- C3 -
2OVY
1
A:
[31-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
P
A
R
I
C
R
D
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
I
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
N
G
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
H
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
R
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
N
Q
W
E
K
V
I
R
---------------------------
2
PsiBlast_PDB
75.60
99%
-122
- C3 -
3HQY
1
A:
[49-353]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
P
A
R
I
C
R
D
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
I
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
N
G
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
H
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
R
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
N
Q
W
E
K
V
I
R
---------------------------
3
PsiBlast_PDB
75.55
99%
-122
- C3 -
3HQZ
1
A:
[49-353]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
P
A
R
I
C
R
D
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
I
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
N
G
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
H
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
R
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
N
Q
W
E
K
V
I
R
---------------------------
4
PsiBlast_PDB
75.27
99%
-121
- C3 -
3HR1
1
A:
[49-353]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
P
A
R
I
C
R
D
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
I
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
N
G
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
H
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
R
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
N
Q
W
E
K
V
I
R
---------------------------
10
PsiBlast_PDB
75.25
99%
-123
- C3 -
3QPP
3
A:
[31-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
P
A
R
I
C
R
D
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
I
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
N
G
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
H
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
R
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
N
Q
W
E
K
V
I
R
---------------------------
59
PsiBlast_CBE
75.07
93%
-122
- C3 -
4MUW
2
PDE10_HUMAN
A:
[14-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
6
PsiBlast_PDB
75.00
99%
-123
- C3 -
2OVV
1
A:
[32-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
R
I
C
R
D
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
I
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
N
G
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
H
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
R
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
N
Q
W
E
K
V
I
R
---------------------------
9
PsiBlast_PDB
74.92
99%
-125
- C3 -
3QPO
1
A:
[31-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
P
A
R
I
C
R
D
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
I
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
N
G
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
H
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
R
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
N
Q
W
E
K
V
I
R
---------------------------
5
PsiBlast_PDB
74.77
99%
-121
- C3 -
2O8H
1
A:
[32-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
R
I
C
R
D
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
I
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
N
G
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
H
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
R
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
N
Q
W
E
K
V
I
R
G
E
E
------------------------
57
PsiBlast_CBE
74.56
93%
-122
- C3 -
4MVH
1
PDE10_HUMAN
A:
[25-331]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
60
PsiBlast_CBE
74.54
93%
-124
- C3 -
4DDL
1
B:
[11-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
61
PsiBlast_CBE
74.49
93%
-120
- C3 -
4DDL
1
PDE10_HUMAN
A:
[1-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
E
E
W
Q
G
L
M
Q
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
1
PsiBlast_PDB
74.45
99%
-123
- C3 -
3HQW
1
A:
[47-349]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
R
I
C
R
D
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
I
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
N
G
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
H
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
R
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
N
Q
W
E
K
V
I
R
---------------------------
56
PsiBlast_CBE
74.32
93%
-124
- C3 -
4MVH
1
B:
[24-331]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
---
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
58
PsiBlast_CBE
73.55
93%
-123
- C3 -
4MUW
1
B:
[26-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
21
PsiBlast_CBE
71.68
93%
-128
- C3 -
4DFF
1
B:
[34-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
E
L
F
H
F
D
I
G
P
F
E
N
---
M
W
P
G
I
F
V
Y
M
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
--
H
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
--------------
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
---------
P
I
P
M
M
D
R
-
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
-------------------------
94
HHSearch
60.58
37%
-100
- C3 -
1TBF
2
A:
[22-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
T
R
E
L
Q
S
L
A
AA
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
KI
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
---------------------------
90
HHSearch
56.22
31%
-102
- C3 -
3BJC
1
PDE5A_HUMAN
A:
[538-863]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
KI
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
S
E
H
P
L
A
Q
L
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
---------------
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
-------------------------