@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00233_PDE2A_: (2014-09-02 )
MRRQPAASRDLFAQEPVPPGSGDGALQDALLSLGSVIDVAGLQQAVKEALSAVLPKVETVYTYLLDGESRLVCEEPPHELPQEGKVREAVISRKRLGCNGLGPSDLPGKPLARLVAPLAPDTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALKRVQALQQRESSVAPEATQNPPEEAAGDQKGGVAYTNQDRKILQLCGELYDLDASSLQLKVLQYLQQETQASRCCLLLVSEDNLQLSCKVIGDKVLEEEISFPLTTGRLGQVVEDKKSIQLKDLTSEDMQQLQSMLGCEVQAMLCVPVISRATDQVVALACAFNKLGGDLFTDQDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVEDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDMEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRTNKQHHSLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGARAPINGCCSLDAE
Atome Classification :
(15 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.....---.---.570.......580.......590.......600.......610.......620.......630........640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.....-..770.......780.......790.......800.......810......-.820.......830.-.-......840.......850.......860.......870.......880.......890.......900.......910.......920
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRRQPAASRDLFAQEPVPPGSG
D
G
A
L
Q
D
A
L
L
S
L
G
S
V
I
D
V
A
G
L
Q
Q
A
V
K
E
A
L
S
A
V
LP
K
V
E
T
V
Y
T
Y
L
LDGES
R
L
V
CEEPPHELPQEG
K
V
R
E
A
V
I
S
R
K
RLGCNGLGPSDLPG
K
P
L
A
R
L
VAPLAPD
T
Q
V
L
V
I
P
LVDKEA
G
A
V
A
A
V
I
L
V
HCGQLSDNEE
W
S
L
Q
A
V
E
K
H
T
L
V
A
L
K
R
V
Q
A
L
Q
Q
R
E
SSVAPEATQNP
P
E
EAAGDQKGG
V
A
YTNQ
D
R
K
I
L
Q
L
C
G
E
L
YDLD
A
S
S
L
Q
L
K
V
L
Q
Y
L
Q
Q
E
TQAS
R
C
C
L
L
L
V
SEDN
L
Q
L
S
C
K
VIG
D
K
V
L
E
E
EISFPLTTGR
L
G
Q
V
V
EDKKS
I
Q
LKDL
T
S
E
D
M
Q
Q
L
Q
S
M
LGC
E
V
Q
A
M
L
C
V
P
V
I
SRAT
D
Q
V
V
A
L
A
C
A
F
N
KLGGDLFTDQ
D
E
H
V
I
Q
H
C
F
H
Y
T
S
T
V
L
T
S
T
L
A
F
Q
K
E
Q
K
L
K
C
E
C
Q
A
L
L
Q
V
A
K
N
L
F
T
H
L
D
D
V
S
V
L
L
Q
E
I
I
T
E
A
RNLSNA
E
I
C
S
V
F
L
LDQ
N
E
L
V
A
K
VFDGGVVEDE
S
Y
E
I
R
IPADQGIAGHVATTG
Q
I
LNI
P
D
A
YAH
P
L
F
YRGVDDSTG
F
R
T
R
N
I
L
C
F
PIKNEN
Q
E
V
I
G
V
A
E
L
V
N
KIN
G
P
W
F
S
K
F
D
E
D
L
A
T
A
F
S
I
Y
C
G
I
S
I
A
H
S
L
L
Y
K
K
V
N
E
A
Q
Y
R
S
H
L
A
N
E
M
M
M
Y
H
M
KVS
D
D
E
Y
T
K
L
L
H
---D---GIQ
P
V
A
A
IDSNFA
S
F
TYTPRSLPED
D
T
S
M
A
I
L
S
M
L
Q
D
M
N
F
I
NNYKID
C
P
T
L
A
R
F
C
L
M
V
K
KGYR-DP
P
Y
H
N
W
M
H
A
F
S
V
S
H
F
C
Y
L
L
Y
KNL
E
L
T
N
Y
L
E
D
M
E
I
F
A
L
F
I
S
C
M
C
H
D
LDHRGTNNSF
Q
V
A
S
K
S
V
L
A
A
L
Y
SSEG
S
V
M
E
R
H
H
F
A
Q
A
I
A
I
LNTHGC
N
I
F
D
H
F
S
R
K
D
Y
Q
R
M
L
D
L
M
R
D
I
I
L
A
T
D
L
A
H
H
L
R
I
F
K
D
L
Q
K
M
A
E
VG-YDRTN
K
Q
H
H
S
L
L
L
C
L
L
M
TSCDLSDQTK
G
W
K
T
T
R
K
I
A
E
L
I
Y
K
E
F
FSQG
D
L
E
K
-
A
MGNR
P
M
E
M
M
D
R
E-K-A-YI
P
E
L
Q
I
S
F
M
E
H
I
A
M
P
I
Y
K
L
L
Q
D
L
F
P
K
A
A
E
L
Y
E
R
V
ASN
R
E
H
W
T
KVS
H
K
F
T
I
R
GLPSNNSLDFLDEEYEVPDLDGARAPINGCCSLDAE
47
HHSearch
45.75
32%
-112
- C1 -
1TBF
2
A:
[22-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
T
R
E
L
Q
S
---
L
A
AA
V
V
P
S
A
Q
T
--
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
-
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
-
K
K
N
-
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------------------------------
45
HHSearch
45.43
30%
-117
- C1 -
3BJC
1
PDE5A_HUMAN
A:
[538-863]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
---
V
V
P
S
A
Q
T
--
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
S
E
H
P
L
A
Q
L
Y
C
H
--
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
----------------
K
K
N
-
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------------------------------
49
HHSearch
42.70
34%
-109
- C1 -
2OUR
1
PDE10_HUMAN
A:
[2-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
Q
---
F
---
T
L
P
V
R
L
--
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
M
W
P
G
I
F
-
V
Y
M
V
H
R
--
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
T
--
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
A
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
-
D
-
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
--------------------------------------
48
HHSearch
41.21
32%
-111
- C1 -
3HR1
1
A:
[49-353]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
P
A
R
I
--
C
R
D
I
E
L
F
H
F
D
I
G
P
F
E
N
M
W
P
G
I
F
-
V
Y
M
I
H
R
--
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
N
--
G
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
T
--
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
H
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
R
-
D
-
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
N
Q
W
E
K
V
I
R
-----------------------------------------
13
PsiBlast_PDB
38.04
40%
-115
- C1 -
4LLX
1
?
A:
[64-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
T
--
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
-
K
-
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
-----
I
R
G
-----------------------------------
15
PsiBlast_PDB
37.92
40%
-115
- C1 -
4LM1
1
?
A:
[64-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
T
--
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
-
K
-
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
-----
I
R
G
-----------------------------------
19
PsiBlast_PDB
37.72
40%
-117
- C1 -
4AEL
1
PDE10_HUMAN
A:
[63-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
T
--
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
-
K
-
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
-----
I
R
------------------------------------
11
PsiBlast_PDB
37.72
40%
-114
- C1 -
4LLK
1
?
A:
[64-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
T
--
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
-
K
-
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
-----
I
R
G
-----------------------------------
14
PsiBlast_PDB
37.45
40%
-115
- C1 -
4LM0
1
?
A:
[64-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
T
--
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
-
K
-
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
-----
I
R
G
-----------------------------------
18
PsiBlast_PDB
37.41
40%
-115
- C1 -
4LM4
1
?
A:
[64-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
T
--
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
-
K
-
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
-----
I
R
G
-----------------------------------
12
PsiBlast_PDB
37.34
40%
-113
- C1 -
4LLP
1
?
A:
[64-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
T
--
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
-
K
-
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
-----
I
R
G
-----------------------------------
16
PsiBlast_PDB
37.30
40%
-112
- C1 -
4LM2
1
?
A:
[64-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
T
--
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
-
K
-
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
-----
I
R
G
-----------------------------------
10
PsiBlast_PDB
37.19
40%
-113
- C1 -
4LLJ
1
?
A:
[64-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
T
--
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
-
K
-
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
-----
I
R
G
-----------------------------------
17
PsiBlast_PDB
36.99
40%
-113
- C1 -
4LM3
3
?
A:
[64-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
T
--
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
-
K
-
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
-----
I
R
G
-----------------------------------
20
PsiBlast_PDB
36.85
40%
-109
- C1 -
4MUW
2
PDE10_HUMAN
A:
[70-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
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--
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-
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-----
I
R
G
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