@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00233_PDE3B_: (2014-09-02 )
MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELRPPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSLSPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGDAGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSLPSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVSLGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEARNMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCKADGNKLQVENSSLPQADEIQVIEEADEEE
Atome Classification :
(7 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670-.........680.......690.......700.......710.......720.......730-.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.....--..910-.---....-...-920.......930.......940.......950.......960.......970.......980.......990.......1000...-----...1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRR
D
E
R
D
A
K
A
M
RSLQPPDGAGS
P
P
E
S
L
R
N
G
Y
V
K
S
C
V
S
P
L
RQDPP
R
G
F
F
F
H
L
C
R
FCN
V
E
LRPPPASPQQPRRC
S
P
F
C
R
A
R
L
S
L
G
A
L
A
A
F
V
L
A
L
L
LGAEPESWA
A
G
A
A
W
L
R
T
L
L
S
V
C
S
H
S
L
S
P
L
F
S
I
A
C
A
F
F
F
L
T
C
F
L
T
RTKRGPGPGRS
C
G
S
W
W
L
L
A
L
P
A
C
C
Y
L
G
D
F
L
V
W
QWWSWPWGDGDAGSAAPHTP
P
E
A
AAG
R
L
L
L
V
L
S
C
V
G
L
L
L
T
L
A
H
P
L
R
L
R
H
C
V
L
V
L
L
L
A
S
F
V
W
W
V
S
F
T
S
LGS
L
P
S
A
L
R
P
L
L
S
G
L
VG
G
A
G
C
L
L
A
L
G
L
D
H
F
F
Q
I
R
EAPLHPR
L
S
S
A
A
EEKVPVIRPRR
R
S
S
C
V
S
L
G
E
T
A
A
S
Y
YGS
C
K
I
F
RRPSLPCISRE
Q
M
I
L
W
DW
D
L
K
Q
W
YKPHYQNSGGGNG
V
D
L
S
V
L
N
E
A
R
N
M
V
S
D
L
LTDPSL
P
P
Q
V
I
S
S
L
R
S
I
S
S
L
M
G
A
FSGSCRPKINPLTPFPGFYPCSEIE
D
P
A
E
K
G
D
R
K
L
N
KGLNRNSLP
T
P
Q
L
RRSSGTSG
L
L
PVEQSSRWDRNNGKR
P
H
Q
EFGISSQ
G
C
Y
LNGPFNSN
L
L
TIPKQRSSS
V
S
L
T
H
HVG
L
R
R
A
G
V
LSSLSPVNSSNHGPVSTGSLTNRSPIEFPD
T
A
D
FLNK
P
S
V
I
L
Q
R
S
LGNAPNT
P
D
F
Y
Q
Q
L
RNSD
S
N
L
C
N
S
C
G
H
Q
M
L
K
Y
V
STSESDGTDCCSGKSGEEENIF
S
K
E
S
F
K
L
M
E
T
Q
Q
E
E
E
T
E
K
K
D
S
R
K
L
F
Q
EG
D
K
W
L
T
E
E
AQ
S
E
Q
QTNI
E
Q
EV
S
L
D
L
I
L
V
E
E
Y
D
S
L
---
I
E
K
MSNWNF
P
I
F
E
L
V
E
K
M
G
E
KS
G
R
I
L
S
Q
V
M
Y
T
L
F
QDTG
L
L
E
I
FKI
P
T
Q
Q
F
M
N
Y
F
R
A
L
ENGYR-DIPYHNRI
H
A
T
D
V
L
H
A
V
W
Y
L
TTRPVP
G
L
Q
Q
I
H
NGCGTGNETDSDGRINH
G
R
I
A
Y
I
SSKSCSNP
D
E
SYGCLSSNI
P
A
L
E
L
M
A
L
Y
V
A
A
A
M
HDYDHPGRT
N
A
F
L
V
ATNAP
Q
A
V
L
YN
D
R
S
V
L
E
NHHAA
S
A
W
N
L
Y
LSRPE
Y
N
F
L
L
H
LDH
V
E
F
K
R
F
R
F
L
V
I
E
A
I
L
A
T
D
L
K
K
H
F
D
F
L
A
E
FNA--KAND--V---NSNG-
I
E
W-SNEN
D
R
L
L
V
C
Q
V
C
I
K
L
ADINGP
A
K
V
R
D
L
H
L
K
W
T
E
G
I
V
N
E
F
Y
E
QGDEEANLGLPISPFMDRSS
P
Q
L
A
K
L
Q
E
S
F
I
T
H
I
V
G
P
L
CNSY
D
A
A-----GLLPGQWLEAEEDNDTESGDDEDGEELDT
E
D
E
E
M
ENNLNPKPP
R
R
K
S
R
R
R
I
F
C
Q
L
M
H
H
LTE
N
H
K
I
W
K
E
I
V
E
E
E
E
K
CKADG
N
K
L
Q
VENSSLPQA
D
E
I
Q
V
I
E
EADEEE
33
Fugue
72.31
30%
-76
- C3 -
1F0J
3
PDE4B_HUMAN
A:
[1-357]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
---
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
---
N
R
P
L
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
--------------------------------------------
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
-
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
--
M
V
E
T
--
K
K
V
T
S
S
G
V
-
L
L
L
-
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
R
G
M
E
I
S
P
M
C
D
K
H
T
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
QPDA
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
A
P
A
N
R
D
C
Q
G
L
M
E
K
F
Q
F
----------------------------------------------------------------------
45
HHSearch
72.08
32%
-109
- C3 -
1ZKL
1
PDE7A_HUMAN
A:
[15-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
C
M
---
L
E
K
V
G
N
W
N
F
D
I
F
L
F
D
R
L
T
N
---
G
N
S
L
V
S
L
T
F
H
L
F
S
L
H
G
L
I
E
Y
F
H
L
D
M
M
K
L
R
R
F
L
V
M
I
Q
E
D
Y
H
S
Q
N
P
Y
H
N
A
V
H
A
A
D
V
T
Q
A
M
H
C
Y
L
K
E
P
--
K
------------------------------------------
L
A
N
S
V
T
P
W
D
I
L
L
S
L
I
A
A
A
T
H
D
L
D
H
P
G
V
N
Q
P
F
L
I
K
T
N
H
Y
L
A
T
L
Y
K
N
T
S
V
L
E
N
H
H
W
R
S
A
V
G
L
L
R
---
E
S
G
L
F
S
H
L
P
L
E
S
R
Q
Q
M
E
T
Q
I
G
A
L
I
L
A
T
D
I
S
R
Q
N
E
Y
L
S
L
F
R
S
--
H
L
D
R
--------
G
D
-
L
C
L
-
E
D
T
R
H
R
H
L
V
L
Q
M
A
L
K
C
A
D
I
C
N
P
C
R
T
W
E
L
S
K
Q
W
S
E
K
V
T
E
E
F
F
H
Q
G
D
I
E
K
K
Y
H
L
G
V
S
P
L
C
D
R
H
T
E
S
I
A
N
I
Q
I
G
F
M
T
Y
L
V
E
P
L
F
T
E
W
A
R
-------
F
S
N
T
--------------------------------------------
R
L
S
Q
T
M
L
G
H
V
G
L
N
K
A
S
W
K
G
L
Q
------------------------------------
46
HHSearch
69.30
38%
-107
- C3 -
1Y2K
13
PDE4D_HUMAN
A:
[28-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
E
---
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
---
N
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
--
A
------------------------------------------
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
--
M
V
E
T
K
K
V
---
T
S
S
G
V
L
L
L
-
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
67.48
32%
-104
- C3 -
2PW3
1
PDE4D_HUMAN
A:
[11-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
---
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
--------------------------------------------
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
N
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
K
--
V
---
T
S
S
G
-
V
L
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.04
32%
-103
- C3 -
2QYN
1
PDE4D_HUMAN
A:
[11-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
---
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
--------------------------------------------
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
K
--
V
---
T
S
S
G
-
V
L
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
67.02
32%
-105
- C3 -
1TB7
11
PDE4D_HUMAN
A:
[6-303]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
E
D
V
L
A
K
E
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
---
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
--------------------------------------------
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
K
--
V
--------
V
L
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.33
32%
-104
- C3 -
1TBB
7
PDE4D_HUMAN
A:
[7-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
D
V
L
A
K
E
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
---
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
--------------------------------------------
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
K
--
V
---
T
----
V
L
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
------------------------------------------------------------------------------------------------------------------