@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00233_PDE4B_: (2014-09-02 )
MKKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
Atome Classification :
(54 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.---......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......---300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420..-.....430.....-..440.......450.......460..-.....470.......480.......490.......500.......510.......520.......530.......540.......550.......560...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKKEHGGTFSSTGISGGSGD
S
A
M
DSLQPLQPNY
M
P
V
C
L
F
A
E
E
S
Y
Q
K
L
A
M
E
T
L
E
E
L
D
W
C
L
D
Q
L
E
T
I
Q
T
Y
R
S
V
S
E
M
A
S
N
K
F
K
R
M
L
N
R
E
L
T
H
L
S
E
M
S
RSG
N
Q
V
S
E
Y
I
S
N
TFLDKQNDVEIPSP
T
Q
K
D
R
E
K
K
K
K
Q
Q
L
M
T
Q
I
S
G
V
K
K
L
M
H
SSSLNNT
S
I
S
RFGVNTE
N
E
D
H
L
A
K
E
L
E
D
L
N
K
WG
L
N
I
F
N
VAGYSHNR
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
FRISSD
T
F
I
T
Y
M
M
T
L
E
DHYHSD
V
A
YHNSL
H
A
A
D
V
AQS
T
H
V
L
L
STP
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
HDVDHPGVS
N
Q
F
L
I
NTNS
E
L
A
L
M
YN---
D
E
S
V
L
ENH
H
L
A
V
G
F
K
L
L
Q
E
EH
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
KVTSS
G
V
L
L
LDN
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
ADLSNP
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
QQG
D
K
E
R
E-RGMEISPMCDKHT-ASV
E
K
SQV
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
LVQ-P
D
A
Q
D
I
L
D
T
L
ED
N
R
N
W
Y
Q
S
MIPQSPSPPLDEQN
R
D
C
Q
G
L
M
E
KF
Q
F
E
L
T
LDEEDSEGPEKEGEGH
S
Y
FSST
K
T
L
C
V
IDPENRDSLGETD
I
D
I
ATEDKSPVDT
21
PsiBlast_CBE
98.99
96%
-116
- C9 -
3G45
1
PDE4B_HUMAN
B:
[8-414]
---------------------------------------------------------------------------
S
N
K
F
K
R
M
L
N
R
E
L
T
H
L
S
E
M
S
R
S
G
N
Q
V
S
E
Y
I
S
N
T
F
L
D
------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
------------------------------------------------------------------------------
1
PsiBlast_PDB
98.41
96%
-116
- C9 -
3G45
1
PDE4B_HUMAN
A:
[8-414]
---------------------------------------------------------------------------
S
N
K
F
K
R
M
L
N
R
E
L
T
H
L
S
E
M
S
R
S
G
N
Q
V
S
E
Y
I
S
N
T
F
L
D
-----------------------------------------
T
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
------------------------------------------------------------------------------
2
PsiBlast_PDB
92.45
100%
-118
- C9 -
3W5E
1
PDE4B_HUMAN
A:
[3-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------
C
Q
G
L
M
E
K
F
Q
F
E
L
T
-----------------------------------------------------
67
Fugue
92.31
99%
-113
- C9 -
1F0J
3
PDE4B_HUMAN
A:
[1-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
A
P
A
------
N
R
D
C
Q
G
L
M
E
K
F
Q
F
--------------------------------------------------------
29
PsiBlast_CBE
92.28
99%
-113
- C9 -
3HMV
2
PDE4B_HUMAN
B:
[2-361]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
A
M
I
P
---------
Q
N
R
D
C
Q
G
L
M
E
K
F
Q
F
E
L
T
-----------------------------------------------------
9
PsiBlast_PDB
92.14
99%
-114
- C9 -
3HMV
2
PDE4B_HUMAN
A:
[2-361]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
A
M
I
P
---------
Q
N
R
D
C
Q
G
L
M
E
K
F
Q
F
E
L
T
-----------------------------------------------------
30
PsiBlast_CBE
91.86
100%
-119
- C9 -
3KKT
2
PDE4B_HUMAN
B:
[24-380]
----------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
-----
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
---------------
C
Q
G
L
M
E
K
F
Q
F
E
L
------------------------------------------------------
22
PsiBlast_CBE
91.65
100%
-118
- C9 -
3WD9
1
PDE4B_HUMAN
B:
[3-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------
C
Q
G
L
M
E
K
F
Q
F
E
L
T
-----------------------------------------------------
10
PsiBlast_PDB
91.56
100%
-118
- C9 -
4MYQ
4
PDE4B_HUMAN
A:
[5-361]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
------------
C
Q
G
L
M
E
K
F
Q
F
--------------------------------------------------------
3
PsiBlast_PDB
91.34
100%
-119
- C9 -
3WD9
1
PDE4B_HUMAN
A:
[3-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------
C
Q
G
L
M
E
K
F
Q
F
E
L
T
-----------------------------------------------------
23
PsiBlast_CBE
91.22
100%
-117
- C9 -
3W5E
1
PDE4B_HUMAN
B:
[3-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------
C
Q
G
L
M
E
K
F
Q
F
E
L
T
-----------------------------------------------------
27
PsiBlast_CBE
91.21
99%
-116
- C9 -
1RO6
1
PDE4B_HUMAN
B:
[2-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
A
P
A
P
P
L
D
E
Q
---------------------------------------------------------------------
5
PsiBlast_PDB
90.77
99%
-113
- C9 -
1RO6
2
PDE4B_HUMAN
A:
[2-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
A
P
A
P
P
L
D
E
Q
---------------------------------------------------------------------
25
PsiBlast_CBE
90.35
99%
-118
- C9 -
1ROR
1
PDE4B_HUMAN
B:
[2-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
A
P
----------------------------------------------------------------------------
28
PsiBlast_CBE
90.26
99%
-120
- C9 -
1F0J
2
PDE4B_HUMAN
B:
[1-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
A
P
----------------------------------------------------------------------------
26
PsiBlast_CBE
90.25
99%
-119
- C9 -
1RO9
1
PDE4B_HUMAN
B:
[2-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
A
P
----------------------------------------------------------------------------
20
PsiBlast_PDB
89.98
99%
-119
- C9 -
1XM6
1
PDE4B_HUMAN
A:
[33-383]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------
C
Q
G
L
M
E
K
F
Q
F
E
L
T
L
D
---------------------------------------------------
11
PsiBlast_PDB
89.94
100%
-111
- C9 -
3KKT
1
PDE4B_HUMAN
A:
[33-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
S
P
S
P
P
L
D
E
Q
N
R
D
C
Q
G
L
M
E
K
F
Q
F
E
-------------------------------------------------------
7
PsiBlast_PDB
89.84
99%
-118
- C9 -
1ROR
1
PDE4B_HUMAN
A:
[2-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
A
P
A
---------------------------------------------------------------------------
6
PsiBlast_PDB
89.62
99%
-118
- C9 -
1RO9
1
PDE4B_HUMAN
A:
[2-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
A
P
A
---------------------------------------------------------------------------
17
PsiBlast_PDB
88.86
99%
-120
- C9 -
1XMU
1
PDE4B_HUMAN
A:
[25-355]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
47
PsiBlast_CBE
88.61
99%
-115
- C9 -
3O57
5
PDE4B_HUMAN
A:
[2-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
A
M
I
P
Q
A
-----------------------------------------------------------------------------
51
PsiBlast_CBE
88.55
99%
-115
- C9 -
3D3P
4
PDE4B_HUMAN
A:
[2-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
A
M
I
P
Q
A
-----------------------------------------------------------------------------
53
PsiBlast_CBE
88.53
100%
-115
- C9 -
2QYL
1
PDE4B_HUMAN
A:
[2-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
48
PsiBlast_CBE
87.97
99%
-113
- C9 -
3O56
6
PDE4B_HUMAN
A:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
A
M
I
P
Q
A
-----------------------------------------------------------------------------
49
PsiBlast_CBE
87.87
99%
-115
- C9 -
3GWT
8
PDE4B_HUMAN
A:
[2-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
A
M
I
P
Q
A
-----------------------------------------------------------------------------
50
PsiBlast_CBE
87.56
99%
-113
- C9 -
3FRG
6
PDE4B_HUMAN
A:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
A
M
I
P
Q
A
-----------------------------------------------------------------------------
52
PsiBlast_CBE
87.20
100%
-117
- C9 -
4KP6
20
PDE4B_HUMAN
A:
[15-338]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
12
PsiBlast_PDB
87.04
99%
-118
- C9 -
1XLX
1
PDE4B_HUMAN
A:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
62
PsiBlast_CBE
86.98
100%
-119
- C9 -
3O0J
15
A:
[1-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
--------------------------------------------------------------------------------
19
PsiBlast_PDB
86.96
99%
-123
- C9 -
1XLZ
1
PDE4B_HUMAN
A:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
4
PsiBlast_PDB
86.82
100%
-122
- C9 -
1TB5
1
PDE4B_HUMAN
A:
[16-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
18
PsiBlast_PDB
86.80
99%
-122
- C9 -
1XMY
1
PDE4B_HUMAN
B:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
14
PsiBlast_PDB
86.66
99%
-120
- C9 -
1Y2H
1
PDE4B_HUMAN
A:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
15
PsiBlast_PDB
86.56
99%
-119
- C9 -
1Y2J
1
PDE4B_HUMAN
A:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
13
PsiBlast_PDB
86.28
99%
-122
- C9 -
1XOT
1
PDE4B_HUMAN
A:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
24
PsiBlast_CBE
86.14
100%
-120
- C9 -
1TB5
1
PDE4B_HUMAN
B:
[16-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
16
PsiBlast_PDB
85.98
99%
-119
- C9 -
1XM4
1
PDE4B_HUMAN
A:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
79
HHSearch
85.96
86%
-121
* C9 *
1Y2K
13
PDE4D_HUMAN
A:
[22-347]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
Q
E
D
V
L
A
K
E
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
R
P
L
---
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
N
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
H
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
E
W
Y
Q
S
T
I
P
-------------------------------------------------------------------------------
81
HHSearch
71.84
33%
-101
- C9 -
1ZKL
1
PDE7A_HUMAN
A:
[10-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
N
G
Q
A
K
C
M
L
E
K
V
G
N
W
N
F
D
I
F
L
F
D
R
L
T
N
G
N
S
L
---
V
S
L
T
F
H
L
F
S
L
H
G
L
I
E
Y
F
H
L
D
M
M
K
L
R
R
F
L
V
M
I
Q
E
D
Y
H
S
Q
N
P
Y
H
N
A
V
H
A
A
D
V
T
Q
A
M
H
C
Y
L
K
E
P
K
L
A
N
S
V
T
P
W
D
I
L
L
S
L
I
A
A
A
T
H
D
L
D
H
P
G
V
N
Q
P
F
L
I
K
T
N
H
Y
L
A
T
L
Y
K
---
N
T
S
V
L
E
N
H
H
W
R
S
A
V
G
L
L
R
E
--
S
G
L
F
S
H
L
P
L
E
S
R
Q
Q
M
E
T
Q
I
G
A
L
I
L
A
T
D
I
S
R
Q
N
E
Y
L
S
L
F
R
S
H
L
D
R
G
D
------
L
C
L
E
D
T
R
H
R
H
L
V
L
Q
M
A
L
K
C
A
D
I
C
N
P
C
R
T
W
E
L
S
K
Q
W
S
E
K
V
T
E
E
F
F
H
Q
G
D
I
E
K
K
-
Y
H
L
G
V
S
P
L
C
D
R
H
T
-
E
S
I
A
N
I
Q
I
G
F
M
T
Y
L
V
E
P
L
F
T
E
W
A
R
F
S
N
T
R
L
S
Q
T
M
L
G
H
V
G
L
N
K
A
S
W
K
G
L
Q
--------------------------------------------------------------------------------
84
HHSearch
67.40
31%
-98
- C9 -
2R8Q
1
?
A:
[37-350]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
T
S
P
G
F
N
L
F
E
V
R
E
K
Y
S
-
E
P
M
D
A
A
A
G
V
V
Y
N
L
L
W
N
S
G
L
P
E
K
F
G
C
R
E
Q
T
L
L
N
F
I
L
Q
C
R
R
R
Y
R
-
R
V
P
Y
H
N
F
Y
H
V
V
D
V
C
Q
T
L
H
T
Y
L
Y
T
G
K
A
S
E
L
L
T
E
L
E
C
Y
V
L
L
V
T
A
L
V
H
D
L
D
H
M
G
V
N
N
S
F
Y
L
K
T
D
S
P
L
G
I
L
S
S
A
S
G
N
N
S
V
L
E
V
H
H
C
S
L
A
I
E
I
L
S
D
P
A
A
D
V
F
E
G
L
S
G
Q
D
V
A
Y
A
Y
R
A
L
I
D
C
V
L
A
T
D
M
A
K
H
A
D
A
L
S
R
F
T
E
L
A
T
S
G
-------
F
E
K
D
N
D
T
H
R
R
L
V
M
E
T
L
I
K
A
G
D
V
S
N
V
T
K
P
F
E
T
S
R
M
W
A
M
A
V
T
E
E
F
Y
R
Q
G
D
M
E
K
E
-
K
G
V
E
V
L
P
M
F
D
R
S
K
N
N
E
L
A
R
G
Q
I
G
F
I
D
F
V
A
G
K
F
F
R
D
I
V
G
N
L
F
-
H
G
M
Q
W
C
V
D
T
V
N
S
N
R
A
K
W
Q
E
I
L
D
G
R
-----------------------------------------------------------------------------
42
PsiBlast_CBE
66.75
99%
-22
- C9 -
1XM6
1
PDE4B_HUMAN
B:
[33-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
-
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
-
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
-
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
---------------
G
L
M
E
K
F
Q
F
E
L
T
-----------------------------------------------------
39
PsiBlast_CBE
65.73
99%
-24
- C9 -
1XOS
1
PDE4B_HUMAN
A:
[32-355]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
-
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
-
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
--
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
-
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
89
HHSearch
65.44
32%
-98
- C9 -
1TBF
2
A:
[43-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
----
T
---
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
------
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
-
S
-
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
---------------------------------------------------------------------------------
34
PsiBlast_CBE
64.58
99%
-34
- C9 -
1XLX
1
PDE4B_HUMAN
B:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
-
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
32
PsiBlast_CBE
64.38
99%
-32
- C9 -
1Y2H
1
PDE4B_HUMAN
B:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
-
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
31
PsiBlast_CBE
64.22
99%
-32
- C9 -
1Y2J
1
PDE4B_HUMAN
B:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
-
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
33
PsiBlast_CBE
63.80
99%
-27
- C9 -
1XOT
1
PDE4B_HUMAN
B:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
-
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
40
PsiBlast_CBE
63.70
99%
-23
- C9 -
1XN0
1
PDE4B_HUMAN
B:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
-
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
-
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
-
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
41
PsiBlast_CBE
63.62
99%
-25
- C9 -
1XN0
1
PDE4B_HUMAN
A:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
-
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
-
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
-
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
38
PsiBlast_CBE
61.86
99%
-10
- C9 -
1XLZ
1
PDE4B_HUMAN
B:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
-
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
-
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
35
PsiBlast_CBE
61.65
99%
-11
- C9 -
1XMY
1
PDE4B_HUMAN
A:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
-
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
-
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
37
PsiBlast_CBE
61.28
99%
-11
- C9 -
1XM4
1
PDE4B_HUMAN
B:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
-
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
-
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------
36
PsiBlast_CBE
60.59
99%
-10
- C9 -
1XMU
1
PDE4B_HUMAN
B:
[33-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
---
T
-
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
-
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
-
R
G
M
E
I
S
P
M
C
D
K
H
T
-
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
-
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
-------------------------------------------------------------------------------