@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00303_TYSY_M: (2014-09-04 )
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
Atome Classification :
(33 SA)
.........10........20........30........40........50...-.....60...-.....70........80........90........100.......--110.......--------------------------------------120.......130.......140------------------........--------150.......160.......170.......180.......190...--..---..---200.......210.......220.......230.......240.......250.......260.......270.......280...--------..---..290.......300.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
V
V
G
S
E
L
Q
S
D
A
Q
Q
L
S
AEAPRH
G
E
L
Q
Y
L
R
Q
V
E
H
I
L
RCGFKKEDRTGTG
T
L
S
V
F
G
-
M
Q
A
R
Y
SLRDE-FPL
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
IKGST
N
A
K
E
L
SSKG
V
R
I
WDANG
S
R
--
D
F
L
D
S
LGFSA--------------------------------------RQEGDLGPVYGF
Q
W
R
HFGAEYK-------------------DMDSDYSG--------Q
G
V
D
Q
L
Q
K
V
I
D
T
IKTNPDD
R
R
I
I
M
C
AWNPKDL
P
L
MALP
P
C
H
A
L
C
Q
F
--
Y
V
---VN---G
E
L
S
C
Q
L
Y
QRSGDMGLGV
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
TGLQPGD
F
V
H
TLGD
A
H
I
Y
L
NHIE
P
L
K
I
Q
L
QREPRPF
P
K
L
K
I
L
R
K
VETIDDF--------KV---
E
D
F
Q
I
EGYNPH
P
T
I
K
M
E
MAV
26
PsiBlast_CBE
95.68
100%
-113
- C7 -
4EB4
9
TYSY_MOUSE
A:
[1-307]
M
L
V
V
G
S
E
L
Q
S
D
A
Q
-------
R
H
G
E
L
Q
Y
L
R
Q
V
E
H
I
L
R
C
G
F
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
R
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
A
--------------------------------------
R
Q
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
K
-------------------
D
M
D
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
K
I
L
R
K
V
E
T
I
D
D
F
--------
K
V
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
91
HHSearch
94.06
100%
-117
- C7 -
4EZ8
4
TYSY_MOUSE
A:
[21-307]
--------------------
R
H
G
E
L
Q
Y
L
R
Q
V
E
H
I
L
R
C
G
F
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
R
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
A
--------------------------------------
R
Q
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
K
-------------------
D
M
D
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
K
I
L
R
K
V
E
T
I
D
D
F
--------
K
V
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
22
PsiBlast_CBE
92.69
100%
-119
- C7 -
4EIN
3
TYSY_MOUSE
B:
[21-306]
--------------------
R
H
G
E
L
Q
Y
L
R
Q
V
E
H
I
L
R
C
G
F
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
R
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
A
--------------------------------------
R
Q
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
K
-------------------
D
M
D
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
K
I
L
R
K
V
E
T
I
D
D
F
--------
K
V
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
-
39
PsiBlast_CBE
92.66
97%
-124
- C7 -
1RTS
3
TYSY_RAT
B:
[21-303]
--------------------
Q
H
G
E
L
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
R
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
A
--------------------------------------
R
Q
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
D
Y
K
-------------------
D
M
D
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
T
I
D
D
F
--------
K
V
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
----
38
PsiBlast_CBE
92.56
97%
-120
- C7 -
2TSR
3
TYSY_RAT
A:
[21-301]
--------------------
Q
H
G
E
L
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
R
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
A
--------------------------------------
R
Q
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
D
Y
K
-------------------
D
M
D
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
T
I
D
D
F
--------
K
V
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
------
40
PsiBlast_CBE
92.41
97%
-123
- C7 -
1RTS
3
TYSY_RAT
A:
[21-300]
--------------------
Q
H
G
E
L
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
R
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
A
--------------------------------------
R
Q
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
D
Y
K
-------------------
D
M
D
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
T
I
D
D
F
--------
K
V
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
36
PsiBlast_CBE
92.35
97%
-118
- C7 -
2TSR
3
TYSY_RAT
C:
[21-301]
--------------------
Q
H
G
E
L
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
R
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
A
--------------------------------------
R
Q
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
D
Y
K
-------------------
D
M
D
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
T
I
D
D
F
--------
K
V
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
------
35
PsiBlast_CBE
92.22
97%
-123
- C7 -
2TSR
3
TYSY_RAT
D:
[21-301]
--------------------
Q
H
G
E
L
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
R
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
A
--------------------------------------
R
Q
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
D
Y
K
-------------------
D
M
D
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
T
I
D
D
F
--------
K
V
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
------
37
PsiBlast_CBE
92.12
97%
-120
- C7 -
2TSR
3
TYSY_RAT
B:
[21-301]
--------------------
Q
H
G
E
L
Q
Y
L
R
Q
V
E
H
I
M
R
C
G
F
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
R
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
A
--------------------------------------
R
Q
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
D
Y
K
-------------------
D
M
D
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
T
I
D
D
F
--------
K
V
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
------
16
PsiBlast_PDB
91.66
92%
-119
- C7 -
1HVY
4
TYSY_HUMAN
A:
[1-288]
-------------------
P
P
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
62
PsiBlast_CBE
91.11
88%
-120
- C7 -
1JU6
3
TYSY_HUMAN
C:
[28-313]
---------------------
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
70
PsiBlast_CBE
90.71
88%
-118
- C7 -
3EJL
1
TYSY_HUMAN
D:
[26-308]
-------------------
P
P
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
-----
63
PsiBlast_CBE
90.64
88%
-119
- C7 -
1JU6
3
TYSY_HUMAN
B:
[28-313]
---------------------
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
61
PsiBlast_CBE
90.63
88%
-119
- C7 -
1JU6
3
TYSY_HUMAN
D:
[28-313]
---------------------
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
75
PsiBlast_CBE
90.35
93%
-121
- C7 -
1I00
3
TYSY_HUMAN
B:
[7-283]
-----------------------
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
6
PsiBlast_PDB
90.15
88%
-119
- C7 -
1JU6
3
TYSY_HUMAN
A:
[28-313]
---------------------
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
60
PsiBlast_CBE
90.10
88%
-117
- C7 -
1JUJ
3
TYSY_HUMAN
B:
[28-313]
---------------------
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
7
PsiBlast_PDB
89.85
88%
-117
- C7 -
1JUJ
3
TYSY_HUMAN
A:
[28-313]
---------------------
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
59
PsiBlast_CBE
89.71
88%
-117
- C7 -
1JUJ
3
TYSY_HUMAN
C:
[28-313]
---------------------
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
76
PsiBlast_CBE
89.63
93%
-120
- C7 -
1I00
3
TYSY_HUMAN
A:
[7-283]
-----------------------
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
1
PsiBlast_PDB
89.54
89%
-118
- C7 -
2RD8
1
TYSY_HUMAN
A:
[26-308]
-------------------
P
P
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
-----
58
PsiBlast_CBE
89.34
88%
-117
- C7 -
1JUJ
3
TYSY_HUMAN
D:
[28-313]
---------------------
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
E
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
15
PsiBlast_PDB
85.41
88%
-136
- C7 -
4E28
1
TYSY_HUMAN
A:
[38-323]
-------------------
P
P
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
-----------------------------------------------------------------
D
L
G
P
V
Y
G
F
Q
W
R
H
F
-----------------------------
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
--
103
HHSearch
84.54
55%
-114
- C7 -
3QG2
2
?
A:
[313-608]
-----------
Q
I
Y
N
S
L
K
Y
K
Y
H
P
E
Y
Q
Y
L
N
I
I
Y
D
I
M
M
N
G
N
K
Q
S
D
R
T
G
V
G
V
L
S
K
F
G
-
Y
I
M
K
F
D
L
S
Q
Y
-
F
P
L
L
T
T
K
K
L
F
L
R
G
I
I
E
E
L
L
W
F
I
R
G
E
T
N
G
N
T
L
L
N
K
N
V
R
I
W
E
A
N
G
T
R
--
E
F
L
D
N
R
K
L
F
H
--------------------------------------
R
E
V
N
D
L
G
P
I
Y
G
F
Q
W
R
H
F
G
A
E
Y
T
-------------------
N
M
Y
D
N
Y
E
N
--------
K
G
V
D
Q
L
K
N
I
I
N
L
I
K
N
D
P
T
S
R
R
I
L
L
C
A
W
N
V
K
D
L
D
Q
M
A
L
P
P
C
H
I
L
C
Q
F
--
Y
V
---
F
D
---
G
K
L
S
C
I
M
Y
Q
R
S
C
D
L
G
L
G
V
P
F
N
I
A
S
Y
S
I
F
T
H
M
I
A
Q
V
C
N
L
Q
P
A
Q
F
I
H
V
L
G
N
A
H
V
Y
N
N
H
I
D
S
L
K
I
Q
L
N
R
I
P
Y
P
F
P
T
L
K
L
N
P
D
I
K
N
I
E
D
F
--------
T
I
---
S
D
F
T
I
Q
N
Y
V
H
H
E
K
I
S
M
D
M
A
A
95
HHSearch
84.44
55%
-112
- C7 -
1J3K
2
?
C:
[30-328]
--------
N
D
F
Q
I
Y
N
S
L
K
Y
K
Y
H
P
E
Y
Q
Y
L
N
I
I
Y
D
I
M
M
N
G
N
K
Q
S
D
R
T
G
V
G
V
L
S
K
F
G
-
Y
I
M
K
F
D
L
S
Q
Y
-
F
P
L
L
T
T
K
K
L
F
L
R
G
I
I
E
E
L
L
W
F
I
R
G
E
T
N
G
N
T
L
L
N
K
N
V
R
I
W
E
A
N
G
T
R
--
E
F
L
D
N
R
K
L
F
H
--------------------------------------
R
E
V
N
D
L
G
P
I
Y
G
F
Q
W
R
H
F
G
A
E
Y
T
-------------------
N
M
Y
D
N
Y
E
N
--------
K
G
V
D
Q
L
K
N
I
I
N
L
I
K
N
D
P
T
S
R
R
I
L
L
C
A
W
N
V
K
D
L
D
Q
M
A
L
P
P
C
H
I
L
C
Q
F
--
Y
V
---
F
D
---
G
K
L
S
C
I
M
Y
Q
R
S
C
D
L
G
L
G
V
P
F
N
I
A
S
Y
S
I
F
T
H
M
I
A
Q
V
C
N
L
Q
P
A
Q
F
I
H
V
L
G
N
A
H
V
Y
N
N
H
I
D
S
L
K
I
Q
L
N
R
I
P
Y
P
F
P
T
L
K
L
N
P
D
I
K
N
I
E
D
F
--------
T
I
---
S
D
F
T
I
Q
N
Y
V
H
H
E
K
I
S
M
D
M
A
A
92
HHSearch
84.19
66%
-117
* C7 *
4G9U
7
?
A:
[31-313]
------------------
Y
V
N
Q
E
E
L
N
Y
L
N
Q
L
K
D
I
I
D
H
G
V
R
K
N
D
R
T
G
I
G
T
L
S
T
F
G
-
T
Q
S
R
Y
C
L
R
D
D
I
F
P
L
L
T
T
K
R
V
F
W
R
G
V
V
E
E
L
L
W
F
I
S
G
S
T
N
A
K
Q
L
S
E
K
N
V
N
I
W
D
G
N
S
S
R
--
E
F
L
D
S
R
G
L
Y
N
--------------------------------------
Y
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
C
P
Y
S
-------------------
S
M
T
A
D
Y
K
G
--------
K
G
Y
D
Q
L
Q
Q
C
I
K
M
I
R
E
E
P
E
S
R
R
I
I
M
T
A
W
N
P
C
D
L
E
K
V
A
L
P
P
C
H
C
F
V
Q
F
--
Y
V
---
A
D
---
G
E
L
S
C
Q
M
Y
Q
R
S
A
D
M
G
L
G
V
P
F
N
I
A
S
Y
S
L
L
T
R
M
I
A
H
I
T
S
L
K
P
G
F
F
I
H
T
I
G
D
A
H
V
Y
L
T
H
V
D
A
L
K
V
Q
M
E
R
K
P
R
P
F
P
K
L
K
I
L
R
N
V
E
N
I
D
D
F
--------
R
A
---
E
D
F
E
L
I
N
Y
K
P
Y
P
K
-------
96
HHSearch
84.01
63%
-110
- C7 -
1F28
3
TYSY_PNECA
A:
[3-297]
--------------------
N
A
E
E
Q
Q
Y
L
N
L
V
Q
Y
I
I
N
H
G
E
D
R
P
D
R
T
G
T
G
T
L
S
V
F
A
P
S
P
L
K
F
S
L
R
N
K
T
F
P
L
L
T
T
K
R
V
F
I
R
G
V
I
E
E
L
L
W
F
I
R
G
E
T
D
S
L
K
L
R
E
K
N
I
H
I
W
D
A
N
G
S
R
--
E
Y
L
D
S
I
G
L
T
K
--------------------------------------
R
Q
E
G
D
L
G
P
I
Y
G
F
Q
W
R
H
F
G
A
E
Y
I
-------------------
D
C
K
T
N
Y
I
G
--------
Q
G
V
D
Q
L
A
N
I
I
Q
K
I
R
T
S
P
Y
D
R
R
L
I
L
S
A
W
N
P
A
D
L
E
K
M
A
L
P
P
C
H
M
F
C
Q
F
--
Y
V
H
I
P
S
N
NH
R
P
E
L
S
C
Q
L
Y
Q
R
S
C
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
C
M
I
A
H
V
C
D
L
D
P
G
D
F
I
H
V
M
G
D
C
H
I
Y
K
D
H
I
E
A
L
Q
Q
Q
L
T
R
S
P
R
P
F
P
T
L
S
L
N
R
S
I
T
D
I
E
D
F
--------
T
L
---
D
D
F
N
I
Q
N
Y
H
P
Y
E
T
I
K
M
K
M
S
I
99
HHSearch
80.96
54%
-110
- C7 -
3NRR
10
?
A:
[220-515]
-----------
V
A
C
P
G
V
R
I
R
N
H
E
E
F
Q
Y
L
D
I
L
A
D
V
L
S
H
G
V
L
K
P
N
R
T
G
T
D
A
Y
S
K
F
G
-
Y
Q
M
R
F
D
L
S
R
S
-
F
P
L
L
T
T
K
K
V
A
L
R
S
I
I
E
E
L
L
W
F
I
K
G
S
T
N
G
N
D
L
L
A
K
N
V
R
I
W
E
L
N
G
R
R
--
D
F
L
D
K
N
G
F
T
D
--------------------------------------
R
E
E
H
D
L
G
P
I
Y
G
F
Q
W
R
H
F
G
A
E
Y
L
-------------------
D
M
H
A
D
Y
T
G
--------
K
G
I
D
Q
L
A
E
I
I
N
R
I
K
T
N
P
N
D
R
R
L
I
V
C
S
W
N
V
S
D
L
K
K
M
A
L
P
P
C
H
C
F
F
Q
F
--
Y
V
---
S
D
---
N
K
L
S
C
M
M
H
Q
R
S
C
D
L
G
L
G
V
P
F
N
I
A
S
Y
S
I
L
T
A
M
V
A
Q
V
C
G
L
G
L
G
E
F
V
H
N
L
A
D
A
H
I
Y
V
D
H
V
D
A
V
T
T
Q
I
A
R
I
P
H
P
F
P
R
L
R
L
N
P
D
I
R
N
I
E
D
F
--------
T
I
---
D
D
I
V
V
E
D
Y
V
S
H
P
P
I
P
M
A
M
S
A
104
HHSearch
77.87
52%
-114
- C7 -
4DQ1
2
TYSY_STAAM
A:
[9-317]
-----------------------
D
A
A
Y
H
S
L
C
E
E
V
L
E
I
G
N
T
R
N
D
R
T
N
T
G
T
I
S
K
F
G
-
H
Q
L
R
F
D
L
S
K
G
-
F
P
L
L
T
T
K
K
V
S
F
K
L
V
A
T
E
L
L
W
F
I
K
G
D
T
N
I
Q
Y
L
L
K
Y
N
N
N
I
W
N
E
W
A
F
E
--
N
Y
I
K
S
D
E
Y
N
G
PDMTDF
G
H
R
A
L
S
D
P
E
F
N
E
Q
Y
K
E
Q
M
K
Q
F
K
Q
R
I
L
E
D
D
T
F
A
K
Q
F
G
D
L
G
N
V
Y
G
K
Q
W
R
D
W
V
D
---------------------------
K
D
G
--------
N
H
F
D
Q
L
K
T
V
I
E
Q
I
K
H
N
P
D
S
R
R
H
I
V
S
A
W
N
P
T
E
I
D
T
M
A
L
P
P
C
H
T
M
F
Q
F
--
Y
V
---
Q
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
A
D
I
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
L
I
A
K
E
C
G
L
E
V
G
E
F
V
H
T
F
G
D
A
H
I
Y
S
N
H
I
D
A
I
Q
T
Q
L
A
R
E
S
F
N
P
P
T
L
K
I
N
S
D
-
K
S
I
F
D
I
--------
N
Y
---
E
D
L
E
I
V
D
Y
E
S
H
P
A
I
K
A
----
108
HHSearch
74.69
53%
-119
- C7 -
4FQS
3
TYSY_MYCTU
A:
[2-263]
------------------------
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
----------------------------------------------------
S
D
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
A
---------------------------
P
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
L
A
D
-
R
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
A
V
106
HHSearch
70.84
40%
-102
- C7 -
3V8H
5
?
A:
[5-318]
-----------------------
M
K
Q
Y
L
D
L
V
R
T
I
L
D
T
G
T
W
Q
S
N
--
G
I
R
T
I
G
I
P
G
-
A
M
L
R
F
D
L
Q
Q
G
-
F
P
A
V
T
T
K
K
L
A
F
K
S
A
I
G
E
L
V
G
F
L
R
A
T
R
S
A
A
E
F
R
A
L
G
C
K
V
W
D
A
N
A
N
E
N
A
Q
W
L
A
--
N
P
Y
R
--------------------------------------
R
G
A
D
D
L
G
D
V
Y
G
V
Q
W
R
R
W
P
G
-
Y
K
V
L
DAHA
D
A
Q
I
A
D
A
T
S
R
G
F
R
I
V
A
R
F
E
E
G
G
A
D
K
V
L
L
H
K
A
I
D
Q
L
R
D
C
L
D
T
I
V
R
D
P
S
S
R
R
I
L
F
H
G
W
N
P
A
V
L
D
E
I
A
L
P
A
C
H
L
L
Y
Q
F
L
P
N
V
---
E
R
---
R
E
I
S
L
C
L
Y
I
R
S
N
D
V
G
L
G
T
P
F
N
L
A
E
G
A
A
L
L
T
L
V
G
R
L
T
G
Y
S
P
R
W
F
T
Y
F
I
G
D
A
H
I
Y
E
N
Q
L
D
M
L
K
Q
Q
L
E
R
E
P
F
E
S
P
R
L
E
L
A
E
R
V
P
D
Y
A
K
T
GKYEPQWL
E
R
VEP
S
D
F
T
L
V
G
Y
R
H
H
---------
80
PsiBlast_CBE
63.06
92%
-20
- C7 -
1HVY
4
TYSY_HUMAN
C:
[1-288]
-------------------
P
P
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
-
G
V
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
79
PsiBlast_CBE
61.94
92%
-19
- C7 -
1HVY
4
TYSY_HUMAN
D:
[1-288]
-------------------
P
P
H
G
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
-
G
V
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
S
R
--
D
F
L
D
S
L
G
F
S
T
--------------------------------------
R
E
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
A
E
Y
R
-------------------
D
M
E
S
D
Y
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V