@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00342_G6PI_R: (2014-09-05 )
MAALTRNPQFQKLQQWHREHGSELNLRHLFDTDKERFNHFSLTLNTNHGHILLDYSKNLVTEEVMHMLLDLAKSRGVEAARESMFNGEKINSTEDRAVLHVALRNRSNTPIVVDGKDVMPEVNKVLDKMKAFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPRVWFVSNIDGTHIAKTLACLNPESSLFIIASKTFTTQETITNAETAKDWFLLSAKDPSTVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLAMLGIWYINCFGCETQAVLPYDQYLHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKSTEEARKELQAAGKSPEDLMKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGVVWDINSFDQWGVELGKQLAKKIEPELDGSSPVTSHDSSTNGLINFIKQQREAKIQ
Atome Classification :
(29 SA)
.........10........20........30........40.....--...50........60........70........80........90........100.......110........120.......130.......140.......150.......160.......170....-----...180.......190.......200.......210.......220.......230..-----.....240.......250.......260.......270.......280........290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.....-.---.420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.----..----....540.......550......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAALTRNP
Q
F
Q
K
L
Q
Q
W
H
R
EHGSELN
L
R
H
LFDT
D
K
E
RF
N
H
F
S
L
T
L
NT--NH
G
H
I
L
L
DYSKNL
V
T
E
E
V
M
H
M
L
L
D
L
A
K
SR
G
V
E
A
A
R
E
SMFNGEKINSTED
R
A
V
L
H
V
A
LRNRSNT
P
-
I
V
VDG
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
RSGDWKGYTGK
T
I
T
D
V
I
N
IGIGGSD
L
G
P
L
M
V
T
E
A
LKPYSS-----GG
P
R
V
W
F
V
SNID
G
T
H
I
A
K
T
L
ACLNPES
S
L
F
I
I
ASKTFTTQETITNAETA
K
D
W
F
L
L
SAK-----
D
P
S
T
V
A
K
H
F
V
A
LSTN
T
A
K
V
K
EFGI
D
P
Q
N
M
F
E
F
W
D
WVGG
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
VG
F
D
N
F
E
Q
L
L
SG
A
H
W
M
D
Q
HFRTTPLEKNA
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
FGCETQAVL
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
QQGDMESNG
K
Y
I
TKSGARVDHQTG
P
I
V
WGEPGTN
G
Q
H
A
F
Y
Q
L
I
HQGTKMIPC
D
F
L
I
PVQTQH
P
I
R
-K---GL
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
MKGK
S
T
E
E
A
R
K
E
L
Q
AAGK
S
P
E
D
L
M
K
LL
P
H
K
VFEGNRPTN
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
WDIN
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
KIEPELDGSS----PV----TSHDSS
T
N
G
L
I
N
F
I
K
Q
Q
R
E
AKIQ
8
PsiBlast_CBE
98.08
99%
-104
- C3 -
1XTB
2
G6PI_RABIT
B:
[2-557]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
Q
Q
W
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
T
--
N
H
G
H
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
A
K
-----
D
P
S
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
S
----
P
V
----
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
I
-
2
PsiBlast_PDB
97.79
99%
-104
- C3 -
1HOX
2
G6PI_RABIT
A:
[2-556]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
Q
Q
W
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
T
--
N
H
G
H
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
A
K
-----
D
P
S
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
S
----
P
V
----
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
--
7
PsiBlast_PDB
97.78
99%
-105
- C3 -
1KOJ
2
G6PI_RABIT
A:
[1-556]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
Q
Q
W
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
T
--
N
H
G
H
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
A
K
-----
D
P
S
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
S
----
P
V
----
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
I
-
9
PsiBlast_CBE
97.77
99%
-101
- C3 -
1HOX
2
G6PI_RABIT
B:
[2-556]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
Q
Q
W
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
T
--
N
H
G
H
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
A
K
-----
D
P
S
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
S
----
P
V
----
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
--
11
PsiBlast_CBE
97.57
99%
-100
- C3 -
1KOJ
2
G6PI_RABIT
B:
[1-556]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
Q
Q
W
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
T
--
N
H
G
H
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
A
K
-----
D
P
S
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
S
----
P
V
----
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
I
-
12
PsiBlast_CBE
97.55
99%
-102
- C3 -
1DQR
2
G6PI_RABIT
B:
[1-555]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
Q
Q
W
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
T
--
N
H
G
H
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
A
K
-----
D
P
S
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
S
----
P
V
----
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
--
1
PsiBlast_PDB
97.55
99%
-104
- C3 -
1G98
2
G6PI_RABIT
A:
[2-556]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
Q
Q
W
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
T
--
N
H
G
H
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
A
K
-----
D
P
S
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
S
----
P
V
----
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
--
4
PsiBlast_PDB
97.29
99%
-102
- C3 -
1XTB
2
G6PI_RABIT
A:
[2-557]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
Q
Q
W
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
T
--
N
H
G
H
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
A
K
-----
D
P
S
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
S
----
P
V
----
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
I
-
6
PsiBlast_PDB
97.20
99%
-103
- C3 -
1DQR
2
G6PI_RABIT
A:
[1-555]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
Q
Q
W
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
T
--
N
H
G
H
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
A
K
-----
D
P
S
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
S
----
P
V
----
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
--
10
PsiBlast_CBE
97.16
99%
-101
- C3 -
1G98
2
G6PI_RABIT
B:
[2-556]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
Q
Q
W
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
T
--
N
H
G
H
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
A
K
-----
D
P
S
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
S
----
P
V
----
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
--
33
PsiBlast_CBE
96.73
89%
-105
- C3 -
2CXO
5
G6PI_MOUSE
B:
[1-557]
M
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
29
PsiBlast_CBE
96.57
89%
-104
- C3 -
2CXQ
5
G6PI_MOUSE
B:
[1-557]
M
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
26
PsiBlast_CBE
96.42
89%
-103
- C3 -
2CXS
5
G6PI_MOUSE
A:
[1-557]
M
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
24
PsiBlast_CBE
96.35
89%
-102
- C3 -
2CXT
5
G6PI_MOUSE
A:
[1-557]
M
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
25
PsiBlast_CBE
96.33
89%
-103
- C3 -
2CXS
5
G6PI_MOUSE
B:
[1-557]
M
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
42
PsiBlast_CBE
96.30
89%
-102
- C3 -
1U0F
12
G6PI_MOUSE
A:
[2-557]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
27
PsiBlast_CBE
96.21
89%
-103
- C3 -
2CXR
5
G6PI_MOUSE
B:
[1-557]
M
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
18
PsiBlast_CBE
96.21
92%
-103
- C3 -
1IAT
1
G6PI_HUMAN
A:
[1-556]
-
A
A
L
T
R
D
P
Q
F
Q
K
L
Q
Q
W
Y
R
E
H
R
S
E
L
N
L
R
R
L
F
D
A
N
K
D
R
F
N
H
F
S
L
T
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
T
E
D
V
M
R
M
L
V
D
L
A
K
S
R
G
V
E
A
A
R
E
R
M
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
L
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
-----
G
G
P
R
V
W
Y
V
S
N
I
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
Q
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
T
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
F
G
C
E
T
H
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
R
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
R
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
M
L
G
A
L
V
A
M
Y
E
H
K
I
F
V
Q
G
I
I
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
A
----
Q
V
----
T
S
H
D
A
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
R
V
-
23
PsiBlast_CBE
96.20
89%
-102
- C3 -
2CXT
5
G6PI_MOUSE
B:
[1-557]
M
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
39
PsiBlast_CBE
96.14
89%
-103
- C3 -
1U0G
7
G6PI_MOUSE
B:
[2-557]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
30
PsiBlast_CBE
96.05
89%
-102
- C3 -
2CXQ
5
G6PI_MOUSE
A:
[1-557]
M
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
34
PsiBlast_CBE
95.98
89%
-101
- C3 -
2CXO
5
G6PI_MOUSE
A:
[1-557]
M
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
31
PsiBlast_CBE
95.98
89%
-103
- C3 -
2CXP
5
G6PI_MOUSE
B:
[1-557]
M
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
13
PsiBlast_CBE
95.94
93%
-102
- C3 -
1NUH
1
G6PI_HUMAN
A:
[2-556]
-
A
A
L
T
R
D
P
Q
F
Q
K
L
Q
Q
W
Y
R
E
H
R
S
E
L
N
L
R
R
L
F
D
A
N
K
D
R
F
N
H
F
S
L
T
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
T
E
D
V
M
R
M
L
V
D
L
A
K
S
R
G
V
E
A
A
R
E
R
M
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
L
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
S
-----
G
G
P
R
V
W
Y
V
S
N
I
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
Q
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
T
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
F
G
C
E
T
H
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
R
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
R
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
M
L
G
A
L
V
A
M
Y
E
H
K
I
F
V
Q
G
I
I
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
A
----
Q
V
----
T
S
H
D
A
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
R
--
32
PsiBlast_CBE
95.87
89%
-102
- C3 -
2CXP
5
G6PI_MOUSE
A:
[1-557]
M
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
28
PsiBlast_CBE
95.72
89%
-103
- C3 -
2CXR
5
G6PI_MOUSE
A:
[1-557]
M
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
40
PsiBlast_CBE
95.71
89%
-102
- C3 -
1U0G
11
G6PI_MOUSE
A:
[2-557]
-
A
A
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
T
--
N
H
G
H
I
L
V
D
Y
S
K
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
Y
S
K
-----
G
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
A
K
-----
D
P
S
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
H
P
I
R
-
K
---
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
G
K
S
P
E
D
L
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K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
S
----
A
V
----
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
T
K
L
-
54
HHSearch
85.51
59%
-99
- C3 -
1T10
1
G6PI_LEIME
A:
[49-604]
--
S
L
L
N
L
P
A
W
K
R
L
Q
S
L
Y
-
E
K
Y
G
N
D
S
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L
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H
F
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D
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D
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L
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A
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E
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N
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A
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L
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V
A
L
R
N
R
S
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R
P
-
I
I
V
D
G
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D
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M
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N
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I
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G
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D
L
G
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V
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V
T
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A
L
K
P
F
S
K
-----
R
D
L
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C
F
F
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N
V
D
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A
E
V
L
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N
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Y
L
K
E
N
GIS
T
D
G
A
V
A
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F
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A
L
S
T
N
T
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N
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F
A
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
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-
L
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L
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G
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G
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A
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A
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G
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G
Q
H
A
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Q
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T
K
I
I
P
C
D
F
I
G
C
V
Q
T
Q
N
R
V
------
G
D
H
H
R
T
L
M
S
N
F
F
A
Q
T
E
A
L
M
V
G
K
N
A
E
E
V
R
Q
E
L
V
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S
G
M
S
G
D
A
I
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N
M
I
P
H
K
T
F
T
G
S
R
P
S
N
S
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L
V
N
A
L
T
P
R
A
L
G
A
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A
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W
G
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L
G
K
V
L
A
K
S
I
L
P
Q
L
K
S
G
N
----
I
V
----
S
D
H
D
G
S
T
N
G
L
I
N
M
F
N
T
R
A
H
----
62
HHSearch
80.35
45%
-92
- C3 -
3UJH
2
?
A:
[10-566]
---
L
E
Q
C
A
S
H
G
K
L
L
Q
E
K
K
-
K
L
E
K
L
H
L
R
D
L
L
K
D
E
-
A
R
N
D
L
L
I
R
S
T
D
Q
-----
G
V
Y
L
D
F
S
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K
I
T
L
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T
L
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H
L
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N
L
A
H
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T
A
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M
M
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A
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R
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W
Y
L
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H
Y
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D
E
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A
L
G
A
H
F
C
A
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L
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G
L
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N
G
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I
F
F
G
E
P
G
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N
G
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H
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F
Y
Q
L
I
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Q
G
-
R
V
I
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A
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F
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G
F
C
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S
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R
A
I
K
L
K
EEP
V
S
N
H
D
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L
M
S
N
F
F
A
Q
P
D
A
L
A
F
G
K
T
P
E
E
L
R
K
E
----
G
I
P
----
E
K
L
V
P
H
K
T
F
P
G
D
R
P
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C
M
L
L
F
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----