@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00433_KPCD_H: (2014-09-07 )
MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.-...----------...300....----------------------------.....----------------------------------310..-...---------------..320..--.....330.......340.......350.......360......---.370-.........380.....-.-.390.......400.......410.......420.......430.......440..----......450.......460....-...470.......480.......490.......500.....-..510.......520-----.......530.......540......---.550-.----........560..--....---.570.......580.......590.----.-----.---.---...600.......610.......620..-----.....630.......640.......650--........660.......670....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
P
F
L
R
I
A
FNSYELGSLQAEDEANQ
P
F
C
A
V
K
M
K
E
A
L
S
T
ERGK
T
L
V
QKKPTMYPEWKST
F
D
AHIYE
G
R
V
I
Q
I
V
L
M
R
AAEE
P
V
S
E
V
T
V
G
V
S
V
L
A
E
R
C
KKNNGK
A
E
F
W
L
DLQP
Q
A
K
V
L
M
S
V
Q
Y
F
L
E
DV
D
C
K
Q
S
MRSEDEAKFPTMNRRGAIK
Q
A
K
I
H
Y
I
KNH
E
F
I
A
T
F
FGQ
P
T
F
C
S
V
C
K
D
F
V
W
GLNKQG
Y
K
C
R
Q
C
N
A
A
I
H
K
K
C
I
D
K
I
I
G
R
CTGTAANSRDT
I
F
Q
KERFNIDMP
H
R
F
K
V
HNYMS
P
T
F
C
D
H
C
G
S
L
L
W
G
L
V
KQGL
K
C
E
DCGMN
V
H
H
K
C
R
E
K
V
A
N
L
CGI
N
Q
K
L
L
A
E
A
L
N
Q
-
V
T
Q
----------
R
A
SR--RSDS----------------------------ASSEP----------------------------------V
G
I
YQ-GFE---------------KKTGVAG--EDMQDNSGTYGKIWEGSSKCNI
N
N
F
I
F
H
K
V
LGKGS
F
G
K
V
L
L
G
EL---KG---RG
E
Y
F
A
I
KALKK
D
V
V
L
I-D-DDV
E
C
T
M
V
E
K
R
V
L
T
LAAENP
F
L
T
H
L
I
C
T
FQTK
D
H
L
F
F
V
M
E
F
LNGG
D
L
M
Y
H
IQD-KG----
R
F
E
L
Y
R
A
T
F
Y
A
A
E
I
M
C
G
L
Q
F
L
H
S-KG
I
I
Y
R
D
L
K
L
D
N
V
L
LDRDG
H
I
K
I
A
DFGM
C
K
E
N
IFGESRAST-FCGT
P
D
Y
I
A
P
E
I
L
QG-----L
K
Y
T
F
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
IGQSPF---HG---D----
D
E
D
E
L
F
E
S
IRVDT--PHYP---RWITKE
S
K
D
I
L
E
K
L
F
EREP
T
K
RLG
V
----
T
-----
G
---
N
---
I
K
I
H
P
F
F
KTI
N
W
T
L
L
E
K
RRLEPPFRPKV-----KSPRDYSN
F
D
Q
E
F
L
N
E
K
ARLSYSD
K
N
L
---
I
D
S
M
D
Q
S
A
FAGFSFV
N
P
K
F
E
H
L
LED
33
HHSearch
93.14
50%
-91
- C2 -
3PFQ
1
KPCB_RAT
A:
[102-670]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
K
F
K
I
H
T
Y
S
S
P
T
F
C
D
H
C
G
S
L
L
Y
G
L
I
H
Q
G
M
K
C
D
T
C
M
M
N
V
H
K
R
C
V
M
N
V
P
S
L
C
G
T
D
H
T
E
R
R
G
R
I
Y
I
Q
A
H
I
D
RE
V
L
I
V
V
V
R
D
A
K
N
LV
P
M
D
P
NGLSD
P
Y
V
K
L
K
L
I
PDPKSES
K
Q
K
T
K
T
I
K
S
S
L
N
P
EWN
E
T
F
R
F
QLKESDKD
R
R
L
S
V
E
I
W
D
W
D
LTSR
N
D
F
M
G
S
L
S
F
G
I
S
E
L
Q
K
A
G
V
D
G
W
F
K
L
L
S
Q
E
E
G
E
Y
F
N
V
P
V
P
P
-----------------
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
R
---
K
G
---
T
D
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
Q
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
P
G
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
G
----
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
N
I
W
D
G
V
T
T
K
T
-
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
-----
Q
P
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
F
---
E
G
---
E
----
D
E
D
E
L
F
Q
S
I
M
E
H
N
--
V
A
Y
P
---
K
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
C
GP
E
G
E
-----
R
---
D
---
I
K
E
H
A
F
F
R
Y
I
D
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
-----
S
G
R
-
N
A
E
N
F
D
R
F
F
T
R
H
P
P
V
L
T
P
P
D
Q
E
V
---
I
R
N
I
D
Q
S
E
F
E
G
F
S
F
V
N
S
E
F
L
K
P
---
21
PsiBlast_CBE
81.70
71%
-101
- C2 -
2JED
1
B:
[15-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
----
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
E
-
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
---
H
G
---
Q
----
D
E
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
---
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
----
R
-----
G
---
D
---
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
-----
K
S
---------------
P
R
L
-
F
A
D
R
A
L
---
I
N
S
M
D
Q
N
M
F
R
N
F
-
F
M
N
P
G
M
E
R
L
I
--
1
PsiBlast_PDB
80.92
72%
-116
- C2 -
1XJD
1
A:
[16-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
----
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
T
-
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
---
H
G
---
Q
----
D
E
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
---
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
----
R
-----
G
---
D
---
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
----------------------------------------------
Q
N
M
F
R
N
F
S
F
-----------
37
HHSearch
77.14
44%
-109
* C2 *
4GV1
5
AKT1_HUMAN
A:
[3-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
---
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
GS
E
D
A
-----
K
---
E
---
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
-----
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
----
S
MEC
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
--------
39
HHSearch
75.95
44%
-106
- C2 -
4DC2
2
KPCI_MOUSE
A:
[49-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
------
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
T
-
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
I
VGS
N
----
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
----
H
PQT
G
F
A
---
D
---
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
-----
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
---
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
--------
36
HHSearch
75.70
57%
-103
- C2 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
-
D
-
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
R
----
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-----
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
---
E
A
---
E
----
N
E
D
D
L
F
E
A
I
L
N
D
E
--
V
V
Y
P
---
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
----
L
TQGG
E
H
---
A
---
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
-----
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
H
---
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
--------
16
PsiBlast_PDB
75.03
42%
-111
- C2 -
2X39
2
AKT2_HUMAN
A:
[6-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
GP
S
D
A
-----
K
---
E
---
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
-----
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
----------------
Q
E
M
F
E
D
F
D
Y
I
----------
18
PsiBlast_PDB
74.97
42%
-112
- C2 -
1O6L
2
AKT2_HUMAN
A:
[1-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
GPS
D
A
-----
K
---
E
---
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
-----
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
----------------
Q
E
M
F
E
D
F
D
Y
I
----------
14
PsiBlast_PDB
74.83
42%
-112
- C2 -
2JDR
2
AKT2_HUMAN
A:
[6-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
GPSD
A
-----
K
---
E
---
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
-----
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
----------------
Q
E
M
F
E
D
F
D
Y
I
----------
13
PsiBlast_PDB
74.51
42%
-111
- C2 -
2JDO
3
AKT2_HUMAN
A:
[6-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
GP
S
D
A
-----
K
---
E
---
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
-----
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
------------------
M
F
E
D
F
D
Y
I
----------
9
PsiBlast_PDB
74.35
43%
-106
- C2 -
3A8W
1
KPCI_HUMAN
A:
[8-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
------
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
T
-
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D------------
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
HPQ-
T
-----
G
F
A
-
D
---
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
-----
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
---
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
--------
15
PsiBlast_PDB
74.31
42%
-111
- C2 -
2UW9
2
AKT2_HUMAN
A:
[6-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
GP
S
D
A
-----
K
---
E
---
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
-----
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
----------------
Q
E
M
F
E
D
F
D
Y
I
----------
12
PsiBlast_PDB
73.94
42%
-108
- C2 -
1O6K
2
AKT2_HUMAN
A:
[1-330]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
GPS
D
A
-----
K
---
E
---
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
-----
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
---------------
Q
R
T
H
F
P
Q
F
D
Y
-----------
8
PsiBlast_PDB
73.92
43%
-103
- C2 -
3ZH8
4
KPCI_HUMAN
A:
[4-340]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
T
-
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
DIV-----
N
----
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
HPQ-
T
-----
G
F
A
-
D
---
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
-----
S
G
E
---------------
Q
L
T
P
D
D
D
D
I
---
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
--------
17
PsiBlast_PDB
73.36
42%
-110
- C2 -
2XH5
2
AKT2_HUMAN
A:
[6-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
---
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
GP
S
D
A
-----
K
---
E
---
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
-----
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
----------------
Q
E
M
F
E
D
F
D
Y
I
----------
42
HHSearch
70.35
35%
-93
- C2 -
4AW2
3
MRCKA_RAT
A:
[69-408]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
---
K
N
---
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
-
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
----
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
GGK
G
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
---
Y
A
---
E
----
S
L
V
E
T
Y
G
K
I
M
N
H
K
ER
F
Q
F
P
TQV
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
R
L
G
Q
----
N
-----
G
I
E
-
D
---
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
E
V
-----
S
S
P
T
D
T
S
N
F
D
V
D
--------------------
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
------
46
HHSearch
69.86
37%
-97
- C2 -
3C4Z
1
RK_BOVIN
A:
[179-511]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
-
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
-
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
-
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
G
-----
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
---
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
--
V
T
Y
P
---
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
----
R
DGSC-
D
---
G
---
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
RTVYA
K
N
----
G
A
F
S
-------
G
-
V
------
A
---
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
--------
41
HHSearch
68.68
40%
-108
- C2 -
4L42
1
KS6B1_HUMAN
A:
[13-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GPG
D
A
-----
G
---
E
---
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--------------------------------------------
E
M
F
R
D
F
E
Y
I
A
D
--------
45
HHSearch
67.23
39%
-88
- C2 -
1RDQ
4
KAPCA_MOUSE
E:
[36-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
T
-
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
-----
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
---
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LKNG
V
-----
N
---
D
---
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-----
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
E
---------
K
C
G
K
E
F
T
E
F
-------------
38
HHSearch
66.62
44%
-112
- C2 -
2R5T
1
SGK1_HUMAN
A:
[32-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
----
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
---
Y
S
---
R
----
N
T
A
E
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
---
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
----
K
-----
D
D
F
M
E
---
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
-----
S
G
-----------------------------------------------------
54
HHSearch
64.42
42%
-97
- C2 -
4L3J
1
KS6B1_HUMAN
A:
[14-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
---
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GPG
D
A
-----
G
---
E
---
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
-----
Q
S
-----------------------------------------------------
55
HHSearch
64.27
43%
-106
- C2 -
3UBD
1
KS6A3_MOUSE
A:
[15-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
---
I
S
GSD
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
-
D
-
R
V
------
D
I
L
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
Y
S
-
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
---
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
GPD
G
V
-----
E
---
E
---
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------
20
PsiBlast_PDB
64.15
43%
-107
- C2 -
3HDM
1
SGK1_HUMAN
A:
[38-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
----
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
---
Y
S
---
R
----
N
T
A
E
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
---
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
----
K
-----
D
---
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
-----
S
G
-----------------------------------------------------